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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Medula Jurnal Kesehatan Holistic Jurnal Dunia Kesmas JKM (Jurnal Kebidanan Malahayati) Jurnal Ilmu Kedokteran dan Kesehatan Community Development Journal Reswara: Jurnal Pengabdian Kepada Masyarakat JK Unila (Jurnal Kedokteran Universitas Lampung) Jurnal Kedokteran Raflesia ADMA: Jurnal Pengabdian dan Pemberdayaan Masyarakat Jurnal Pengabdian Pada Masyarakat Poltekita: Jurnal Pengabdian Masyarakat JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai
Novita Carolia
Bagian Farmakologi, Fakultas Kedokteran, Universitas Lampung
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Transportation Veterinary Other

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Journal : Medula

 1 
Differences in Obesity Status on Blood Pressure at Panjang Health Center Bandar Lampung City Putri, Syalika Dianisa; Carolia, Novita; Graharti, Risti; Oktarlina, Rasmi Zakiah; Wahyuni, Ari
Medula Vol 14 No 7 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i7.1282

Abstract

Obesity continues to be a major health problem worldwide and has become an epidemic that has worsened over the past 50 years. Obesity has a prevalence that continues to increase every year due to unhealthy lifestyles and energy intake that is greater than energy expenditure. Obesity is closely related to the habit of consuming high-fat foods, which can increase the risk of increased blood pressure. Several studies have found that a 15% increase in body weight can cause an 18% increase in blood pressure. The results of the 2018 Indonesian Basic Health Research showed that the prevalence of obesity in the Indonesian population aged 18 years and over reached 21.8%. The purpose of this study was to determine the difference in obesity status on blood pressure at the Panjang Health Center, Bandar Lampung City. This study used an observational analytical method with a cross-sectional approach. The population in this study were obese patients registered at the Panjang Health Center, Bandar Lampung City in the period August 2023 to August 2024. The total number of research subjects who met the inclusion and exclusion criteria was 113 research subjects obtained from medical records of obese patients at the Panjang Health Center, Bandar Lampung City in the period August 2023-August 2024. Data are presented in a distribution table and analyzed using the Mann-Whitney test. The results showed a P value of 0.001 which indicated that there was a difference in the effect of obesity status on blood pressure status at the Panjang Health Center, Bandar Lampung City.
Terapi Non-Farmakologi pada Pasien Insomnia: A Literature Review Putri, Meilani; Daulay, Suryani Agustina; Carolia, Novita; Sukohar, Asep
Medula Vol 14 No 9 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i9.1262

Abstract

Insomnia is a condition characterized by difficulty initiating sleep despite having adequate time and opportunity. Globally, the majority of insomnia sufferers are women, with approximately 10% of the world’s population estimated to experience severe insomnia. The management of insomnia typically begins with the principles of Consultation, Information, and Education (CIE). In cases of severe insomnia, further intervention often involves pharmacological therapy through medication. The primary class of drugs prescribed for insomnia patients generally belongs to the benzodiazepine group, which acts as a central nervous system depressant, muscle relaxant, and sedative. However, pharmacological treatment should always be complemented with non-pharmacological therapy. Notably, non-pharmacological interventions serve as the first-line treatment for patients with mild to moderate insomnia. This review article aims to evaluate the effectiveness of various non-pharmacological therapies for managing insomnia, which is recognized as the most prevalent sleep disorder worldwide. The literature review was conducted by searching databases such as PubMed, Google Scholar, and ScienceDirect using the keywords “Insomnia,” “Therapy,” and “Non-Pharmacological.” Based on the search results, seven relevant articles were selected for review. The findings from these studies indicate that effective non-pharmacological interventions for insomnia management include Cognitive Behavioral Therapy for Insomnia (CBT-I), hypnotherapy, audiovisual stimulation, aerobic and endurance exercises, acupuncture, and Pre-Sleep Dim Light Therapy (LT).
Identifikasi Kandungan Senyawa Aktif dan Penentuan Massa Jenis Ekstrak Etanol Daun Jambu Air (Syzygium aqueum) Naufal, Muhammad Ariq; Susianti; Daulay, Suryani Agustina; Carolia, Novita
Medula Vol 14 No 9 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i9.1320

Abstract

Water apple (Syzygium aqueum) is a plant widely utilized by publics for both consumption and medicinal purposes. Traditionally, it is used as an alternative treatment for diarrhea, headaches, and cough. The method to maximize the potential of water apple leaves is by extracting the active compounds in it. These extracts have potential as antioxidants, anti-inflammatory, anti-cholesterol, antidiabetics, and antidiarrheal agents. Previous studies have shown that water apple leaves contain various active compounds such as alkaloids, flavonoids, terpenoids, saponins, and phenolics. This research aimed to analyze the active compounds and determine the density of the water apple leaf extract. The study was conducted as a laboratory-based experimental research at the Botany Laboratory, FMIPA University of Lampung. The method employed was maceration of water apple leaves using 96% ethanol as a solvent, followed by qualitative phytochemical tests and density determination. Qualitative tests conducted included assessments for flavonoids, terpenoids, tannins, saponins, phenolics, alkaloids, and steroids. The density of the extract was determined by measuring the mass of the extract using an analytical balance and dividing it by its volume. The results showed that maceration using 96% ethanol yielded 110.62 grams of extract with a yield percentage of 11.062%. Phytochemical tests revealed the ethanol extract contained flavonoids, phenolics, tannins, saponins, alkaloids, and steroids. The density of the ethanol extract was calculated to be 0.9209 g/mL.
Profile of Melanoma and Non-Melanoma Skin Cancer based on Histopathology Results Zulfa, Fathimah; Windarti, Indri; Sutarto; Carolia, Novita
Medula Vol 14 No 9 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i9.1342

Abstract

Skin cancer is an abnormal condition in the structure of the skin that arises because the skin loses the ability to regenerate periodically. Skin cancer is high risk in people who live in tropical countries such as Indonesia. All provinces in Indonesia receive evenly distributed sunlight including Lampung province. Lampung Province is an agricultural province with the dominance of the population working in agriculture and marine sectors. Agriculture and marine sectors workers get continuous and long-term exposure to UV rays so that they are at high risk of skin disorders, one of them is skin cancer. This study was conducted in August-December 2024 in the medical record from Dr. H. Abdul Moeloek Hospital Bandar Lampung. This study was observational and was conducted by collecting data and univariate analysis on medical record data of skin cancer patients including the type of skin cancer, age, gender ], and location of tumor growth of skin cancer patients. The results showed that the most common type of skin cancer diagnosed at Dr. H. Abdul Moeloek Bandar Lampung Hospital in the 2019-2024 period was non-melanoma skin cancer (squamous cell carcinoma followed by basal cell carcinoma). The most common age of skin cancer patients is ≥40 years old, female and the location of tumor growth is mostly in the head and neck area.
Fotokimia dan Farmakologi Daun Alpukat (Persea americana mill.) pada Aktivitas Antihipertensi Husnandari, Aqila; Carolia, Novita; Putri, Giska Tri; Rahmanisa, Soraya
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1246

Abstract

Hypertension is the number one generative disease in the world that has blood pressure of more than 140/90 mmHg. Hypertension without therapy will become chronic and complicated. Therapy carried out for a long period of time causes a fairly high risk factor so that herbal therapy becomes an alternative. This literature review aims to determine the photochemistry and pharmacology of avocado leaves (Persea americana mill.) On antihypertensive activity. Photochemistry contained in avocado leaves can lower blood pressure in the form of flavonoids, saponins, tannins, alkaloids, steroids, and terpenoids. The method used is to review journal articles that have been published in Google Scholar and Pubmed. Using keywords such as "photochemistry, pharmacology, avocado leaves, and antihypertensive activity" 231 scientific articles and journals were obtained. This review article uses 10 selected scientific articles and journals. Experimental studies show that there are pharmacological functions that fight hypertension, which means that they can lower blood pressure.
Keberadaan Bakteri Coliform dan Escherichia coli dalam Sumber Air Bersih Sebagai Penyebab Diare pada Rumah Tangga: Literature Review Fathia, Nauriel; Utama, Winda Trijayanthi; Marcellia, Selvi; Carolia, Novita
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1293

Abstract

Water is an essential necessity for humans on Earth. Its role is crucial for daily activities, including household needs, industry, offices, and food production. In Indonesia, each person is estimated to require approximately 30–60 liters of water per day, whereas in developed countries, the demand per person ranges between 60–120 liters per day. The feasibility of water usage is regulated based on quality characteristics, referred to as water quality. One of the key indicators related to household water quality is biological parameters, particularly concerning the presence of coliform bacteria and Escherichia coli. These bacteria have a fecal-oral entry route, meaning that if consumed in excessive amounts, they can cause gastrointestinal diseases, primarily diarrhea. This study aims to examine the impact of coliform and Escherichia coli contamination in household water sources, leading to diarrhea cases. The research method used is a literature review and analysis. The findings indicate that the presence of Escherichia coli in household water sources, especially in areas with poor sanitation, poses a high health risk, particularly increasing the likelihood of diarrhea. Several factors contribute to this contamination, including the proximity of wells to pollution sources, inadequate waste management, and improper well construction that does not meet safety standards. These conditions suggest that environmental sanitation and the distance between water sources and potential contaminants play a significant role in water quality and public health. Through this study, it is expected that the community will be more aware of the importance of maintaining clean water used for household needs to prevent diarrhea-related diseases.
Pengaruh Ekstrak Buah Adas (Foeniculum vulgare) terhadap Pertumbuhan Bakteri Salmonella typhi Secara In Vitro Akbar, Muhammad Zakky Putra; Wijaya, Sofyan Musyabiq; Carolia, Novita; Sukohar, Asep
Medula Vol 14 No 8 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i8.1271

Abstract

Bacterial infections, especially those caused by Salmonella typhi, are a global health challenge, including in Indonesia, where there is a high prevalence of typhoid fever. Treatment of this infection generally relies on antibiotics, but increasing antibiotic resistance is becoming a big problem. Therefore, there is a need for alternative treatments that are safer and more effective. This study aims to evaluate the ability of ethanol extract of fennel fruit (Foeniculum vulgare) to inhibit the growth of Salmonella typhi. Extraction was carried out using the maceration method using 70% ethanol, followed by evaporation of the solvent to obtain a stock solution. The extract concentrations tested included 5%, 10%, 20%, 40%, and 80%, with distilled water as a negative control and antibiotics as a positive control. Antibacterial testing was carried out using the disk diffusion method on Mueller Hinton Agar media, and the inhibition zone was measured after 48 hours of incubation. The results showed that fennel fruit extract effectively inhibited the growth of Salmonella typhi at an extract concentration of 20%, with the diameter of the inhibition zone increasing as the concentration increased, reaching 4.75 mm at a concentration of 80%. Statistical tests with Kruskal-Wallis showed significant differences between treatments. This research proves that ethanol extract of fennel fruit has antibacterial potential which can be used as an alternative in treating Salmonella typhi infections, especially considering that it is safer than synthetic antibiotics.
Manfaat Ekstrak Buah Adas (Foeniculum vulgare) Terhadap Bakteri Cutibacterium acnes Amourisva, Azqiya Putri; Carolia, Novita
Medula Vol 14 No 8 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i8.1274

Abstract

Fennel fruit (Foeniculum vulgare) is known for its antibacterial properties, making it a promising natural remedy for acne treatment, particularly against Cutibacterium acnes, the primary acne-causing bacterium. The increasing issue of antibiotic resistance highlights the need for safer and more effective natural alternatives. The essential oil of fennel contains major compounds such as anethole (83.64%), fenchone (3.58%), and l-limonene (3.75%), which have been shown to exhibit significant antibacterial activity. Research indicates that a 2% fennel oil concentration produces an inhibition zone of 7.5 mm, while an 8% concentration increases this to 19 mm, demonstrating its effectiveness in inhibiting bacterial growth. In addition to its antibacterial activity, fennel extract also possesses anti-inflammatory properties, which help reduce inflammation and redness caused by acne. Fennel oil-based cream formulations have also been developed, showing good physical stability and strong antibacterial effects against C. acnes. One key advantage of fennel extract is its natural composition, making it safer compared to synthetic antibiotics, which may cause side effects and bacterial resistance. Therefore, fennel extract holds great potential as an active ingredient in anti-acne skincare formulations. However, further research is necessary to confirm its long-term efficacy and applications in cosmetic and pharmaceutical formulations to ensure its safety and benefits for long-term use.
Hubungan Daerah Tempat Tinggal dengan Kejadian Dermatitis Atopik Izdihar, Adinda Fairuz; Sibero, Hendra Tarigan; Graharti, Risti; Carolia, Novita
Medula Vol 14 No 8 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i8.1311

Abstract

Atopic dermatitis is a frequently occurring skin inflammation characterized by pruritus and lesions in specific areas such as the face and extremities. The majority of cases manifest during the first year of life, with a high prevalence among children under five years of age. In Europe, 118 million cases were recorded in 2023, whereas in Indonesia, the prevalence reached 10-20% among children and 1-3% among adults. This condition involves an interplay of exogenous and endogenous factors, including environmental exposure, genetic predisposition, immunological mechanisms, and colonization by Staphylococcus aureus. Environmental factors contributing to the incidence of atopic dermatitis include exposure to pollutants such as carbon monoxide, nitrogen dioxide, PM2.5, PM10, and volatile organic compounds (formaldehyde). Such exposure is a significant risk factor for atopic dermatitis in urban areas. This study aimed to analyze the correlation between residential areas and the incidence of atopic dermatitis at RSUD Dr. H. Abdul Moeloek during the period of January 2022 to July 2024. Data were collected from medical records, encompassing a total sample size of 82 patients. The chi-square test revealed a statistically significant relationship between residential area and the occurrence of atopic dermatitis, with individuals residing in urban areas being 0.23 times more likely to develop atopic dermatitis compared to those living in non-urban areas (p=0.02; OR=0.23)
Mekanisme Hiperglikemia Kronis terhadap Densitas Mineral Tulang Dwiputri, Maliya Finda; Larasati, TA; Jausal, Annisa Nuraisa; Carolia, Novita
Medula Vol 14 No 12 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i12.1438

Abstract

Hyperglycaemia or high levels of glucose in the blood is the hallmark of diabetes mellitus. Diabetes mellitus type 2 (DMT2) significantly impacts bone health, leading to a condition known as diabetic bone disease, characterized by decreased bone mineral density and an increased risk of fractures. This condition arises from metabolic disturbances triggered by hyperglycemia, insulin resistance, and inflammatory factors that compromise bone structure. Research indicates that over 35% of DMT2 patients experience reduced bone density, with approximately 20% meeting osteoporosis criteria. The pathophysiology involves several mechanisms, including the accumulation of advanced glycation end-products (AGEs), which hinder bone formation and increase resorption. Insulin deficiency further exacerbates this issue by impairing osteoblast function and reducing the synthesis of key bone matrix proteins like collagen and osteocalcin. Treatment options such as metformin have shown potential in improving bone health, while other medications like sulfonylureas and SGLT-2 inhibitors may have detrimental effects on bone density. Therefore, careful management of diabetes is essential to mitigate the risks of osteoporosis and fractures in patients with DMT2. Ongoing research is needed to deepen the understanding of diabetic bone disease and optimize treatment strategies to protect bone health in these patients.
Co-Authors Adityo Wibowo, Adityo Agustyas Tjiptaningrum Akbar, Muhammad Zakky Putra Amourisva, Azqiya Putri Anggraeni, Liza Ari Wahyuni Asep Sukohar Carolia, Imelda Daulay, Suryani Agustina Dian Isti Angraini Dwi Indria Anggraini Dwiputri, Maliya Finda Efrida Warganegara Efriyan Imantika Erna Kristin Ety Apriliana Fathaniah, Widya Fathia, Nauriel Fitri, Dilla Syahra Noor Fitria Saftarina Giska Tri Putri Hendra Tarigan Sibero Husnandari, Aqila Ihsanti Dwi Rahayu Indri Windarti Isti Anggraini, Dian Isti Angraini, Dian Izdihar, Adinda Fairuz Jausal, Anisa Nuraisa Jausal, Annisa Nuraisa Karyus, Aila Khairun Nisa Liana Sidharti, Liana Marcellia, Selvi Mayasari, Diana Mustofa Mustofa Naufal, Muhammad Ariq Ningrum, Adenias Lutfia Novadela, Nora Isa Tri Nurchairina, Nurchairina Putri, Meilani Putri, Meilani Dwi Putri, Syalika Dianisa Ramadhan, Muhammad Alif Rangga Firdaus Rasmi Zakiah Oktarlina Rasyid, Risneni Risti Graharti Rosa, Emantis Sari, Merry Indah Shabrina, Annisa Firra Sofyan Musyabiq Wijaya Soraya Rahmanisa Sri Waluyo Susianti Sutarto Sutarto Syazili Mustofa TA Larasati Utama, WInda Trijayanti Widarti, Indri Wijaya, Sofyan Winda Trijayanthi Utama, Winda Trijayanthi Wisnugroho, Cahyo Wiwi Febriani Zetira, Zihan Zulfa, Fathimah