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All Journal Jurnal Akuntansi & Auditing Indonesia Majalah Kedokteran Bandung e-Journal Pustaka Kesehatan Jurnal Sains dan Teknologi Althea Medical Journal Jurnal Sumberdaya Alam dan Lingkungan Journal of Agromedicine and Medical Sciences Jurnal Pendidikan Biologi Indonesia Biology, Medicine, & Natural Product Chemistry MNJ (Malang Neurology Journal) Al-Jabar : Jurnal Pendidikan Matematika Jurnal Penelitian Politik Medical Laboratory Technology Journal BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Solidaritas Jurnal Respirasi (JR) Medika Kartika : Jurnal Kedokteran dan Kesehatan Jurnal ABDINUS : Jurnal Pengabdian Nusantara Bestuurskunde: Journal of Governmental Studies JKKI : Jurnal Kedokteran dan Kesehatan Indonesia DHeJA Jurnal Ekonomika Manajemen Dan Bisnis Adopsi Teknologi dan Sistem Informasi Jurnal Manajemen Teknologi dan Sistem Informasi JURNAL ILMIAH SAINS TEKNOLOGI DAN INFORMASI Eksekusi: Jurnal Ilmu Hukum dan Administrasi Negara Jurnal Farmasi SYIFA BERBAKTI: Jurnal Pengabdian Kepada Masyarakat Saber: Jurnal Teknik Informatika, Sains dan Ilmu Komunikasi Jurnal Pengabdian Masyarakat dan Riset Pendidikan Jurnal Kesehatan dr. Soebandi Ardhi: Jurnal Pengabdian dalam Negri Pelayanan Unggulan: Jurnal Pengabdian Masyarakat Terapan Inflasi : Jurnal Ekonomi, Manajemen dan Perbankan Jurnal Ekonomi, Manajemen, Akuntansi Journal of Indonesian Social Sciences and Humanities
Rosita Dewi
Fakultas Kedokteran Universitas Jember
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : e-Journal Pustaka Kesehatan

 1 
Efektivitas Ekstrak Artemisia vulgaris L. sebagai Hepatoprotektor pada sel-sel Hati Tikus yang Diinduksi Niasin Laily Rahmawati; Erma Sulistyaningsih; Rosita Dewi
Pustaka Kesehatan Vol 6 No 2 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i2.7617

Abstract

The niacin in energy drinks has metabolic product that cause oxidative stress and liver damage, while the liver damage can be prevented by hepatoprotective agents. Scoparone in Artemisia vulgaris L. can act as a hepatoprotector by its antioxidant effect. This study aimed to investigate the effectivity of Artemisia vulgaris L. extract as a hepatoprotector in wistar hepatocytes induced by niacin. This study used 25 male rats which were divided into 5 groups: normal, the negative control, the positive control, the treatment group I, and II. Treatment was conducted for 28 days. The samples were terminated and the hepatocyte were prepared for histological examination. Histological appearance was catagorized as mild, moderate, and severe damage with or without inflamatory cells activity. The data analysis by Kruskal Wallis showed significant difference (p<0,001). Further analysis by Mann Whitney revealed significantly difference (p<0,05) between normal group and all groups, negative control group and positive control group, and positive control group and treatment group I, but not significantly difference between negative control group and treatment group I, negative control group and treatment group II, positive control group and treatment group II, and between treatment groups. The study concluded that the effectivity of Artemisia vulgaris L. extract has not been proven as a hepatoprotector but further study is needed to draw a definite conclusion. Keywords: energy drink, niacin, Artemisia vulgaris L., hepatoprotector
Efek Hepatoprotektif Ekstrak Etanol Brokoli (Brassica oleracea L. var. italica) terhadap Kerusakan Histologis Sel Hati Tikus Wistar yang Diinduksi DMBA (Hepatoprotective Effect of Ethanolic Extract of Broccoli (Brassica oleracea L. var. italica) on the Histologically Damage of Wistar Rats Liver Cell Induced by DMBA) Muhtar Ady Kusuma; Elly Nurus Sakinah; Rosita Dewi
Pustaka Kesehatan Vol 5 No 1 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

DMBA (7,12-Dimethylbenz(α)antracene) is one of Polycyclic Aromatic Hydrocarbon’s form that is abundant on air pollution, i.e. automobile exhaust, cigarette smoke, and wood stoves. DMBA is metabolized in liver result in DMBA-DE. DMBA-DE is a free radical compound that has hepatotoxic effect. Broccoli contains flavonoid that has antioxidant effect. It can stabilize DMBA-DE radical compound. This research was conducted to investigate the hepatoprotective effect of ethanolic extract of broccoli on the damage of rat’s liver cells induced by DMBA. This research used 30 white male rats that was divided into 6 groups: normal control (aquadest), positive control (DMBA) and the treatment groups(using brocolli ethanolic extract with dose : 250, 500, 1000, and 2000 mg/kgBB). The treatment was given for 7 days followed by single-dose DMBA 15 mg/kgBB induction in the 8th day. Histological appearance of liver cells were examined on the 12th day. Data were analyzed by using Kruskal Wallis test followed by Mann Whitney. The result showed that there was a significant difference among the groups with p<0.05. In conclusion, there were some differences of hepatoprotective effect of broccoli ethanolic extract on the histologically damage of rats liver cells induced by DMBA. Keywords: ethanolic extract of broccoli, DMBA, histopathology, hepatoprotective
Perbandingan Komplikasi dan Keluaran antara Persalinan Pervaginam dan Seksio Sesaria pada Ibu dengan Riwayat Seksio Sesaria di RSD dr. Soebandi Jember Gilang Vigorous Akbar Eka Candy; Dita Diana Parti; Rosita Dewi
Pustaka Kesehatan Vol 6 No 3 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i3.9780

Abstract

The number of cesarean section in Indonesia is 9,8% and approaching cesarean limit suggested by WHO which is 10%. The most common reason for cesarean section is prior cesarean. Cesarean section has higher maternal mortality risk compared to vaginal delivery. Vaginal delivery with prior cesarean has higher complication risk compared to cesarean section. Maternal complications and neonatal outcomes are important to decide delivery methods. Maternal complications that can be compared are postpartum infection, postpartum hemorrhage, and uterine rupture. Neonatal outcomes that can be compared are APGAR score and neonatal birth injury. This study aimed to compare maternal complications and neonatal outcomes between vaginal delivery and cesarean section in women with prior cesarean section. There was a significant difference in the incidence of postpartum infection (p=0.01) and neonatal birth injury (p=0.05). There was no significant difference in APGAR score and the incidence of postpartum hemorrhage. There was no uterine rupture observed. In conclusion, vaginal delivery is a viable option for pregnant woman with prior cesarean.
Hubungan antara Aktivitas Fisik dan Kejadian Demensia pada Lansia di UPT Pelayanan Sosial Lanjut Usia Jember Adi Darma Effendi; Alif Mardijana; Rosita Dewi
Pustaka Kesehatan Vol 2 No 2 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Demensia merupakan penyakit pada lansia yang bermanifestasi terhadap kemunduran kemampuan intelektual. Di Indonesia, prevalensi demensia pada lansia berusia 65 tahun adalah 5 persen dari populasi lansia. Prevalensi meningkat menjadi 20 persen dari lansia yang berusia 85 tahun ke atas. Kategori lansia berusia 65 tahun ke atas di Indonesia pada tahun 2003, sebanyak 11.280.000. Jumlah ini diperkirakan akan meningkat menjadi 29 juta pada tahun 2013 atau 10 persen dari populasi. Ada beberapa faktor yang mempengaruhi penurunan memori salah satunya adalah aktivitas fisik . Aktivitas fisik secara teratur telah terbukti dapat mengurangi risiko demensia, termasuk penyakit Alzheimer sebesar 50 %. Penelitian ini menggunakan jenis penelitian analitik observasional dengan desain cross sectional. Variabel yang diamati adalah tingkat demensia pada lansia dan aktivitas fisik yang dilakukannya. Responden kemudian diukur menggunakan instrumen kuisioner MMSE (Mini Mental State Examination). Populasi dalam penelitian ini adalah semua lansia yang tinggal di UPT Pelayanan Sosial Lanjut Usia Jember sebanyak 43 responden. Hasil penelitian dengan uji Spearman Rho menunjukkan bahwa nilai signifikansi = 0,00 (p 0,05 > 0,000). Terdapat hubungan yang bermakna antara aktivitas fisik dengan kejadian demensia pada lansia di UPT Pelayanan Sosial Lanjut Usia Jember. Kata kunci: aktivitas fisik, demensia.
Efek Antiangiogenik Ekstrak Etanol Buah Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl.) pada Membran Korio Alantois (CAM) Embrio Ayam Roat Yeti Mustafida; Al Munawir; Rosita Dewi
Pustaka Kesehatan Vol 2 No 1 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Angiogenesis is the growth of new blood vessels that are used to supply nutrients and oxygen including cancer cells. Phaleria macrocarpa contains tannin, saponin, alkaloid, and flavonoid, known as an antiangiogenesis. This study determined the antiangiogenic effects of ethanolic extract of Phaleria macrocarpa on chorio allantoic membrane of chicken embryos. The antiangiogenesis trials used chorio allantoic membrane of 9 days chicken embryos. There were 5 groups, negative control group [K(-)] and 4 treatment groups (P), each group containing 4 eggs. K(-) group using aquadest and tween 80%; P groups with ethanolic extract of Phaleria macrocarpa at a concentration 10 ug/µL, 40 ug/µL, 80 ug/µL, 160 ug/µL for P1, P2, P3, dan P4 respectively. The number of new blood vessels on chorio allantoic membrane were K(-): (42.5 ± 14.57), P1: (28.25 ± 3.59), P2: (28.5 ± 1.73), P3: (15 ± 4.32), and P4: (6.5 ± 1.73). In conclusion, the ethanolic extract of phaleria macrocarpa has an antiangiogenic effect on chorio allantoic membran by decreasing the number of new blood vessels.Keywords: angiogenesis, Phaleria macrocarpa, ethanolic extract, chorio allantoic membrane
Efek Ekstrak Kulit Mangga Arumanis (Mangifera indica L.) terhadap Paw Licking Time Mencit Putih Jantan yang Diinduksi Formalin (The Effect of Arumanis Mango (Mangifera indica L.) Peel Extract on the Paw Licking Time in White Male Mice Induced by Formalin Rosita Sopwi Nur Lailly; Cicih Komariah; Rosita Dewi
Pustaka Kesehatan Vol 4 No 3 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Mango is one of the plants which have a lot of benefits in pharmacology. Total phenol in its peel is higher than in its flesh with the main component is mangiferin and quercetin which known have activity to inhibit cyclooxygenase 2 (COX-2) enzyme. The inhibition of COX-2 leads to the decrease of the production of prostaglandin (PgE2) so it can reduce pain which marked by the decrease of paw licking time on mice induced by formalin. Formalin-induced pain is divided into two phase: early phase at 0-5th minutes and late phase at 15-30th minutes. The aim of this research was to know the effect of Arumanis mango peel extract to decrease the paw licking time in white male mice. The research design was true experimental. The result of analyses used One Way Anova shows that there were significant difference in each treatment groups with significance p < 0,05. The LSD analysis on late phase showed no significant difference between the fifth treatment group and the positive control group in LSD test. It can be concluded that arumanis mango peel extract has equal effect with natrium diclofenac in decreasing paw licking time on late phase in dosage 26 mg/g. Keywords: mango peel, paw licking time, flavonoid
Co-Authors Adi Darma Effendi Afrina, Cut Agus R Rahman Agustina, Ani Aini, Nada Qurrota Ajeng Margareta Sari Al Munawir Alif Mardijana Amilin Amilin Andriani, Made Prasanti Angga Mardro Raharjo, Angga Mardro Ansari, Rahman Apriani, Susi Aprilia, Annisa Nadya Aprilya Pratiwi, Nadilla Awani Irewati Azham Purwandhono Aziz, Ayu Munawaroh Bintang, Muhammad Farrel Ravidinata Masoga Bi’izzyk, Avie Baldana Cholis Abrori, Cholis Chrisnaji Banindra Yudha Cicih Komariah CPF. Luhulima Damayanti Suhita Dessy Agustina Sari Dewantoro, Dicky Dewi Riniarti Dhiah Anis Salsabila Dina Helianti Dini Agustina Dita Diana Parti Dodo Zaenal Abidin Effiyaldi Eko Subastian Elly Nurus Sakinah, Elly Nurus Erfan Efendi Erma Sulistyaningsih Fahmi Romisa Fitriana, Ani Qotuz Zuhro’ Gianevan, Nicholas Jirezra Gilang Vigorous Akbar Eka Candy Hafidin, Muhammad Ananda Faris Hakiim, Azafilmi Hasyim Asy’ari Hayati Nufus Herdhata Agusta Herniyanti Indriana Kartini Irawan Fajar Kusuma Irawan, Riyant Julius Kalangi Kamila, Vina Zahrotun Khoirul Fahri Arrijal Kholifaturrohmah, Sakinatus Sariroh Kholifaturrohmy, Muhammad Rizqi Laily Rahmawati liza Marlia Luthfiyyah, Nur Atikah M. Ali Shodikin Mahriani Mahriani Maria Ulfa Maulana, Aditha Satria Moch. Agus Krisno Budianto Muhammad Noor Kholid Muhammad Zidan Muhtar Ady Kusuma Munawaroh, Ayu Nadaa Avria Hanum Nindya Shinta Rumastika Nurhaliza, Salsabilla Pelita Sari Pralampita, Pulong Wijang Prasetya, Eky Pribadi , Muhammad Iqbal Putut Pamilih Widagdo, Putut Pamilih Rahami, Nahla Ahmad Rahma, Nafisah Hani Asyifah Rena Normasari Rini Riyanti Roat Yeti Mustafida Rosita Sopwi Nur Lailly Sanda, Fara Fasah Sandy Nur Ikfal Raharjo Sa’diyah, Nindya Audatus septa surya wahyudi, septa surya Setyadi, Hario Jati Shabrina Shahifa Audy Rahima Sheila Rachmania Sheilla Rachmania, Sheilla Sillehu, Sahrir Siti Zaenab Solihin Sidik Sudradjat Sudradjat Sulistyaningsih , Erma Sumadi Susantin Fajariyah Teuku Salfiyadi Tri Nuke Pudjiastuti Widyatmoko, Bondan WINARTI WINARTI Winarti Winarti Yan Sukmawan, Yan Yuli Hermansyah Yuli Hermansyah, Yuli Yunita Armiyanti Zahniar, Zahniar