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All Journal TEKNIK Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Penelitian Kesehatan Suara Forikes Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Halaman Olahraga Nusantara : Jurnal Ilmu Keolahragaan Oceana Biomedicina Journal Biomolecular and Health Science Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Oceana Biomedicina Journal Indonesian Journal of Cancer Buletin Pengabdian Strada Jurnal Ilmiah Kesehatan (SJIK)
Siti Khaerunnisa
Department Of Medical Biochemistry, Faculty Of Medicine, Airlangga University, Surabaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Education Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Moderate Intensity Exercise Effect Reproductive Cycle on High Calories Diet in Mice (Mus Musculus) Gebyar Catur Wahyuning Rohmawati; Lilik Herawati; Siti Khaerunnisa; Astika Gita Ningrum
Halaman Olahraga Nusantara : Jurnal Ilmu Keolahragaan Vol 5, No 1 (2022): Halaman Olahraga Nusantara (Jurnal Ilmu Keolahragaan)
Publisher : Universitas PGRI Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (434.803 KB) | DOI: 10.31851/hon.v5i1.6328

Abstract

Asupan glukosa yang berlebihan dapat menyebabkan penimbunan lemak yang dapat meningkatkan aromatisasi androgen menjadi kadar estrogen. Kadar estrogen yang tinggi dapat mengganggu umpan balik sekresi GnRH, memperpanjang siklus reproduksi, dan mempengaruhi rahim. Sebagai suatu kondisi, sangat penting untuk mendorong olahraga ringan untuk mengurangi akumulasi lemak dan mengembalikan fungsi GnRH. Latihan fisik yang baik memiliki durasi istirahat yang cukup sehingga intensitas, frekuensi, dan waktu yang dibutuhkan tepat. Penelitian ini bertujuan untuk melihat bagaimana pengaruh asupan glukosa terhadap berat badan dan rahim dengan atau tanpa olahraga ringan. Penelitian ini merupakan penelitian eksperimen. Tikus betina sehat, dibagi menjadi 3 kelompok, kontrol negatif, diet tinggi kalori, dan diet tinggi kalori dengan olahraga sedang. Pemberian diet tinggi kalori menggunakan sonde dekstrosa 40% sebanyak 0,325 ml/g BB. Olahraga sedang adalah renang dengan beban 6% BB. Mencit berenang bersama 3 kali seminggu selama 4 minggu. Durasi renang minggu pertama 5 menit, minggu kedua 7 menit, minggu ketiga 11 menit dan minggu keempat 15 menit. Hasil dari penelitian ini adalah berat uterus (p=0,051) tidak menunjukkan perbedaan yang signifikan antar kelompok. Namun, berat uterus pada kelompok diet tinggi kalori (0,19gr) lebih tinggi daripada diet tinggi kalori dengan kelompok olahraga sedang (0,14 gr) dan kontrol negatif (0,11 gr). Hasil swab vagina (p=0,045) terdapat hubungan yang bermakna antar kelompok. Oleh karena itu, asupan glukosa dengan atau tanpa olahraga ringan mempengaruhi siklus reproduksi tetapi tidak mempengaruhi berat rahim. Mencit berenang bersama 3 kali seminggu selama 4 minggu. Durasi renang minggu pertama 5 menit, minggu kedua 7 menit, minggu ketiga 11 menit dan minggu keempat 15 menit. Hasil dari penelitian ini adalah berat uterus (p=0,051) tidak menunjukkan perbedaan yang signifikan antar kelompok. Namun, berat uterus pada kelompok diet tinggi kalori (0,19gr) lebih tinggi daripada diet tinggi kalori dengan kelompok olahraga sedang (0,14 gr) dan kontrol negatif (0,11 gr). Hasil swab vagina (p=0,045) terdapat hubungan yang bermakna antar kelompok. Oleh karena itu, asupan glukosa dengan atau tanpa olahraga ringan mempengaruhi siklus reproduksi tetapi tidak mempengaruhi berat rahim. Mencit berenang bersama 3 kali seminggu selama 4 minggu. Durasi renang minggu pertama 5 menit, minggu kedua 7 menit, minggu ketiga 11 menit dan minggu keempat 15 menit. Hasil dari penelitian ini adalah berat uterus (p=0,051) tidak menunjukkan perbedaan yang signifikan antar kelompok. Namun, berat uterus pada kelompok diet tinggi kalori (0,19gr) lebih tinggi daripada diet tinggi kalori dengan kelompok olahraga sedang (0,14 gr) dan kontrol negatif (0,11 gr). Hasil swab vagina (p=0,045) terdapat hubungan yang bermakna antar kelompok. Oleh karena itu, asupan glukosa dengan atau tanpa olahraga ringan mempengaruhi siklus reproduksi tetapi tidak mempengaruhi berat rahim. minggu ketiga 11 menit dan minggu keempat 15 menit. Hasil dari penelitian ini adalah berat uterus (p=0,051) tidak menunjukkan perbedaan yang signifikan antar kelompok. Namun, berat uterus pada kelompok diet tinggi kalori (0,19gr) lebih tinggi daripada diet tinggi kalori dengan kelompok olahraga sedang (0,14 gr) dan kontrol negatif (0,11 gr). Hasil swab vagina (p=0,045) terdapat hubungan yang bermakna antar kelompok. Oleh karena itu, asupan glukosa dengan atau tanpa olahraga ringan mempengaruhi siklus reproduksi tetapi tidak mempengaruhi berat rahim. minggu ketiga adalah 11 menit dan minggu keempat adalah 15 menit. Hasil dari penelitian ini adalah berat uterus (p=0,051) tidak menunjukkan perbedaan yang signifikan antar kelompok. Namun berat badan rahim pada kelompok diet tinggi kalori (0,19gr) lebih tinggi daripada diet tinggi kalori dengan kelompok olahraga sedang (0,14 gr) dan kelompok kontrol negatif (0,11 gr). Hasil swab vagina (p=0,045) terdapat hubungan yang bermakna antar kelompok. Oleh karena itu, asupan glukosa dengan atau tanpa olahraga ringan mempengaruhi siklus reproduksi tetapi tidak mempengaruhi berat rahim. 14 gr) dan kelompok kontrol negatif (0,11 gr). Hasil swab vagina (p=0,045) terdapat hubungan yang bermakna antar kelompok. Oleh karena itu, asupan glukosa dengan atau tanpa olahraga ringan mempengaruhi siklus reproduksi tetapi tidak mempengaruhi berat rahim. 14 gr) dan kelompok kontrol negatif (0,11 gr). Hasil swab vagina (p=0,045) terdapat hubungan yang bermakna antar kelompok. Oleh karena itu, asupan glukosa dengan atau tanpa olahraga ringan mempengaruhi siklus reproduksi tetapi tidak mempengaruhi berat rahim. 
Analisa in Silico Kunyit (Curcuma longa) sebagai Inhibitor Murine Double Minute 2 Protein untuk Terapi Glioblastoma Multiforme Benny Iswanto Pantoro; Nancy Margarita Rehatta; Siti Khaerunnisa; Anna Surgean Veterini; Yuani Setiawati
Denta Journal Kedokteran Gigi Vol 3 No 2 (2020): Oceana Biomedicina Journal Volume 3 Issue (No) 2 July - December 2020
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Brain tumor consists of tumor which grows primarily from cells in the brain (primary brain tumor) or systemic tumor which metastasized into the brain (secondary brain tumor). From all types of primary brain tumor, Glioblastoma Multiforme is the most common and the most malignant tumor. In 85% of Glioblastoma Multiforme cases are found a molecular alteration of the tumor suppresor gene p53 pathway, which promotes current studies to focus on this pathway. One of the pathway that can be used as therapeutic model is through inhibiting the murine double minute 2 protein (MDM2), which in itself is a p53 inhibitor. Turmeric (curcuma longa) is one of the traditional plants which is commonly used as herbs and its extracts has been studied to have an anti-cancer properties. This study is an in silico study which evaluate the potential efficacy of turmeric extract as a murine double minute 2 protein inhibitor using AutoDock 4.2 based on the Lamarckian genetic algorithm principle. Docking result shows binding energy ranging from -4.81 kcal/mol to -2.34 kcal/mol, with curcumenol having the lowest binding energy and curcumin having the highest binding energy. This study may be used as a base in further study (consists of in vivo and in vitro) of turmeric extract and its effect as the therapeutic regiments for Glioblastoma Multiforme.
Cervical Cancer Risk Factors Association in Patients at the Gynecologic-Oncology Clinic of Dr. Soetomo Hospital Surabaya Aisyiah Rahmi Putri; Siti Khaerunnisa; Indra Yuliati
Indonesian Journal of Cancer Vol 13, No 4 (2019): December
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (233.052 KB) | DOI: 10.33371/ijoc.v13i4.610

Abstract

Background: Cervical cancer ranks fourth of all cancers in women worldwide and linked to human papillomavirus (HPV) infection. Despite the evidence of methods for cervical cancer prevention, such as pap smear test and HPV vaccination, most of the women remain unscreened and never get HPV vaccination. Most cervical cancer cases are not diagnosed early enough, leading to poor outcomes. This study aims to examine the association of risk factors with cervical cancer incidence in Dr. Soetomo Hospital Surabaya and also records the patients’ knowledge of cervical cancer preventions, history of HPV vaccination, and pap smear screening test.Methods: This is a case-control study. Questionnaires were given to 60 newly diagnosed cervical cancer patients and 60 non-cervical cancer patients at The Gynecologic-Oncology Clinic of Dr. Soetomo Hospital Surabaya in the period of March 2016 until August 2016. The analysis was made using bivariate and multivariate logistic regression analysis.Results: The bivariate logistic regression analysis confirmed that parity more than two times (p=0.001), history of birth control pills consumption more than 10 years (p=0.04), passive smoking (p=0.001) and not knowing that cervical cancer can be prevented (p=0.001) were significantly associated to the incidence of cervical cancer. The multivariate logistic regression analysis confirmed that not knowing that cervical cancer can be prevented (OR=6.85), the history of passive smoking (OR=4.04), parity more than two times (OR=2.89) and history of birth control pills consumption more than 10 years (OR=6.52) were the independent factors that were associated with the cervical cancer incidence.Conclusions: Parity more than two times, history of birth control pills consumption more than 10 years, history of passive smoking, not knowing that cervical cancer can be prevented and never having a pap smear test were the factors associated with cervical cancer incidence.
Analisa in Silico Kunyit (Curcuma longa) sebagai Inhibitor Murine Double Minute 2 Protein untuk Terapi Glioblastoma Multiforme Benny Iswanto Pantoro; Nancy Margarita Rehatta; Siti Khaerunnisa; Anna Surgean Veterini; Yuani Setiawati
Oceana Biomedicina Journal Vol 3 No 2 (2020): Oceana Biomedicina Journal Volume 3 Issue (No) 2 July - December 2020
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v3i2.61

Abstract

Brain tumor consists of tumor which grows primarily from cells in the brain (primary brain tumor) or systemic tumor which metastasized into the brain (secondary brain tumor). From all types of primary brain tumor, Glioblastoma Multiforme is the most common and the most malignant tumor. In 85% of Glioblastoma Multiforme cases are found a molecular alteration of the tumor suppresor gene p53 pathway, which promotes current studies to focus on this pathway. One of the pathway that can be used as therapeutic model is through inhibiting the murine double minute 2 protein (MDM2), which in itself is a p53 inhibitor. Turmeric (curcuma longa) is one of the traditional plants which is commonly used as herbs and its extracts has been studied to have an anti-cancer properties. This study is an in silico study which evaluate the potential efficacy of turmeric extract as a murine double minute 2 protein inhibitor using AutoDock 4.2 based on the Lamarckian genetic algorithm principle. Docking result shows binding energy ranging from -4.81 kcal/mol to -2.34 kcal/mol, with curcumenol having the lowest binding energy and curcumin having the highest binding energy. This study may be used as a base in further study (consists of in vivo and in vitro) of turmeric extract and its effect as the therapeutic regiments for Glioblastoma Multiforme.
Correlation Glucose, Uric Acid, and Cholesterol Levels Towards Health Conditions in the Highlands: POCT Approach Arifa Mustika; Yetti Hernaningsih; Puspa Wardhani; Siti Khaerunnisa; Nastasya Nunki; Baiq Nasha Islaeli; Uli Mas'uliyah Indarwati; Musholli Himmatun Nabilah; Teguh Satrio; Alfino Validita Sidiq; Fita Triastuti; Mochammad Reza Desianto; Agil Saputra; Novi Ersanto; Widaninggar Rahma Putri; Desty Indah Sari
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 30 No. 3 (2024)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v30i3.2203

Abstract

Degenerative diseases arise when age increases due to the weakening of the body's physiological condition. The purpose of this study was to measure glucose, uric acid, and cholesterol levels in residents of Segunung Village to improve lifestyles and quality of life. As many as 110 residents of Segunung Village were used as subjects in this cross-sectional study. Glucose, uric acid, and cholesterol levels were measured using Point of Care Testing (POCT). A cut-off value of <200 was used to define high cholesterol levels. Only cholesterol levels showed an increase when compared with reference values, while glucose and uric acid levels were normal. Interestingly glucose was significantly correlated with age (r=0.309, p=0.001). The approach using POCT describes the overall condition of Segunung villagers and can be used as a basis for glucose, uric acid, and cholesterol screening tests.
Peningkatan pengetahuan untuk pencegahan stunting melalui sosialisasi dan demo pembuatan makanan balita berbahan dasar protein hewani bagi kelompok istri peternak sapi pedaging rumahan di Desa Lando, Lombok Timur, Nusa Tenggara Barat [Increasing knowledge for stunting prevention through socialization and demonstration for creating animal protein-based toddler food for a group of wives of home-based beef cattle farmers in Lando Village, East Lombok, West Nusa Tenggara] Qurnianingsih, Ema Ema; Rusyda, Aqila sabila; Hamzah, Arshq Mirza; Rachmawati, Kadek; Humairah, Ira Ira; Lukitasari, Lina; Khaerunnisa, St; Wungu, Citrawati Dyah Kencono; Ummah, Fithriyah Cholifatul Ummah; Kholik, Kholik; Riwu, Katty Hendriana Priscilia; Pradana, Munawer; Yansri, Alifianita Anake; Hidayat, Muhammad; Prabowo, Gwenny Ichsan
Buletin Pengabdian Vol 4, No 3 (2024): Bull. Community. Serv.
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/bulpen.v4i3.40293

Abstract

Stunting is a condition of failure to thrive in children under five (toddlers) which can hinder the child's physical and mental development. Data from the 2023 Indonesian Health Survey (SKI) shows that the number of stunted toddlers in West Nusa Tenggara (NTB) Province is still quite high, namely 24.6%. Stunting cannot be cured but can be prevented. One of the prevention efforts is to increase the knowledge of mothers or prospective mothers regarding stunting and preventing it by providing food with high nutrition. This Community Service Activity (PKM) was carried out with the aim of educating mothers and wives of home-based beef cattle farmers in Lando Village, East Lombok, NTB about preventing stunting by providing highly nutritious supplementary food (PMT) and stunting detection. The methods used were socialization and demonstration of making toddler food. The results of this PKM activity were that there was a significant increase in participants' knowledge regarding the material being socialized (p0.0001). The conclusion that can be drawn is that There had been an increase in knowledge among PKM participants regarding stunting and preventing stunting through providing food with high protein content.
The Protective Effect of Solanum betaceum Extract on Spermatozoa Vitality Exposed to Lead Acetate in Mice Rima Wirenviona; Reny I’tishom; Siti Khaerunnisa
STRADA : Jurnal Ilmiah Kesehatan Vol. 9 No. 2 (2020): November
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjik.v9i2.297

Abstract

The purpose of this study was to analyze the effect of giving various dosages of Solanum betaceum extract on the vitality spermatozoa mice exposed to lead acetate. This research was true experimental using randomized post-test only control group design. The total sample was 40 mice which were divided into 5 groups. Lead acetate used a dose of 75 mg/kg BW and various extracts of Solanum betaceum namely 100 mg/kg BW, 200 mg/kg BW and 400 mg/kg BW. Acclimatization was carried out for 7 days and continued with maintenance and treatment for 35 days. Statistical tests showed that there was a significant difference with (p=0.026). In conclusion, Solanum betaceum extract can be used as a protective to increase the vitality of spermatozoa exposed to lead acetate
Co-Authors . Kholik Abadiyah Zakiah Kustantina Agil Saputra Aisyiah Rahmi Putri Alfino Validita Sidiq Anak Agung Istri Dalem Cinthya Riris Anak Agung Istri Dalem Cinthya Riris Anna Surgean Veterini Arifa Mustika Astri Dewayani Ayesie Natasha Zulka Baiq Nasha Islaeli Bakhtiar, Arief Benny Iswanto Pantoro Desty Indah Sari Ely Rahmatika Nugrahani Ferdinandus, Euvanggelia Dwilda Fita Triastuti Gagas Gayuh Aji, Gagas Gayuh Gebyar Catur Wahyuning Rohmawati Ginanjar Sasmito Adi Gwenny IP Hamzah, Arshq Mirza Harianto Notopuro HERAWATI, LILIK Humairah, Ira I'tishom, Reny Indah Fahmiyah INDRA YULIATI, INDRA Indri Safitri Kadek Rachmawati Kresnapati, I Nyoman Bagus Aji Lukitasari, Lina Mochammad Reza Desianto Muhammad Hidayat Musholli Himmatun Nabilah Nanda Rachmad Putra Gofur Nany Yuliastuti Nastasya Nunki Ningrum, Astika Gita Novi Ersanto Nurul Jannatul Wahidah Nurul Jannatul Wahidah Nurul, Mochammad Prabowo, Gwenny Ichsan Pradana, Munawer Puspa Wardhani Qurnianingsih, Ema Rehatta, Nancy Margarita Retno Handajani Reza Arta BN Rima Wirenviona Rima Wirenviona Riwu, Katty Hendriana Priscilia Rizki Putra Prastio Rodik Wahyu Indrawan Rusyda, Aqila sabila SOETJIPTO . Sofiah, Amila Sriani, Dewi Suhartati Suhartati Susanti, Nurul Fatimah Susi Wahyuning Asih Sutji Kuswarini Suwandito Suwandito Syafa’ah, Irmi Teguh Satrio Uli Mas'uliyah Indarwati Ummah, Fithriyah Cholifatul Ummah Widaninggar Rahma Putri Wungu, Citrawati Dyah Kencono Yankel Sena Yetti Hernaningsih Yuani Setiawati Zuhrotul Eka Yulis Anggraeni