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Journal : Universa Medicina

Protective effect of ethanolic Feronia elephantum Correa fruit extract on high-fat diet induced steatohepatitis in rats Diarti, Maruni Wiwin; Harmi, Khoviya Yuwina Selinada; Ahsani, Dwi Nur
Universa Medicina Vol. 40 No. 1 (2021)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2021.v40.36-44

Abstract

BACKGROUND A high-fat diet can lead to hyperlipidemia which will end up as liver damage (steatohepatitis). Ethanolic Feronia elephantum Correa fruit extract (EFEC) has an antioxidant activity which is expected to overcome hyperlipidemia in the liver. The objective of this study was to determine the effects of EFEC on liver function and morphological changes in rats.METHODSThis was an experimental study with a post-test only group design. A total of 20 male Wistar rats aged 2-4 months were randomized into 5 groups, A= negative control, B= positive control (high fat diet + 10 mg/kgBW simvastatin), C = high fat diet + 500 mg/kgBW EFEC fruit extract, D = high fat diet + 600 mg/kgBW EFEC, and E = high fat diet + 700 mg/kgBW EFEC). High-fat diet was given for 4 weeks (quail egg yolks, 10ml/200gBW). EFEC was administered for 4 weeks after induction of hypercholesterolemia. Examination of liver serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) was performed on rat blood serum and histopathological examination was carried out using steatohepatitis grading. One way ANOVA test and Post-Hoc Tamhane’s test were used to analyze the data. RESULTSAdministration of EFEC at 700 mg/kgBW improved the liver enzymes (p=0.00 for SGPT and SGOT) and steatohepatitis grading in high-fat diet induced rats (mild condition, E = 75% vs A = 100% mild)CONCLUSIONEthanolic Feronia elephantum Correa fruit extract at 700 mg/kgBW was able to improve steatohepatitis in high-fat diet induced rats.
Co-Authors Achmad Fathoni Aini, Aini Aji Kresnapati, I Nyoman Bagus Anak Agung Istri Sri Wiadnyani Aprilla, Annisa Suci Arjita, I Putu Dedy Atmojo, Joko Tri Ayu Anulus Dewi, Lale Budi Kusuma Dewi, Luh Putu Rahayu Candra Dramawan, Awan Drs.Urip Duarsa , Artha Budi Susila Dwi Nur Ahsani Erdianti Nursahar Erlin Yustin Tatontos Farhataini, Annisa Fauzi, Iswari Fihiruddin, Fihiruddin Getas, I Wayan Gunaifi, Aan Habib Sasiwimbe Hadi, Aprilia Khairunnisa Haerani, Irma Haris Widita Harmi, Khoviya Yuwina Selinada Hasanah, Nurul Hikmatil Herawati, Lale Heny I Gede Angga Adnyana I Nyoman Purna I Putu Bayu Agus Saputra I Wayan Sali Indah Lestari, Indah Iswidhani, Iswidhani Kresnapati, I Nyoman Bagus Aji Lina Sundayani Mardiatuz Zahra masniati masniati Mutiara Rachmawati Suseno Nila, Intan Mustika Nurhidayati Nurhidayati Nurul Inayati Pancawati Ariami Pauzi, Iswari Pauzi, Iswari Wiwin Putra, I Gede Ari Permana Putri, Lilia Danina Rahayuningsih, Christ Kartika RAI WIADNYA, IDA BAGUS Resnhaleksmana, Dr.Ersandhi Resnhaleksmana, Ersandhi Retno Handayani Rohmi, Rohmi Safitri, Wiwin Safitri, Wiwin Salleh, Mohd Nazil Salsabila, Wa’dah Sholihah, Ica Pasi Sintia Dewi, Ni Kadek Siti Zaetun, Siti Soewignjo Soemohardjo Suhaema Suhaema Sukmana, Dhika Juliana Sulaimah, Rabi'unnisa Sulaimah, Rabi’unnisa Supliana, Yurika Tatontos, Erin Yustin Taufikurrahman, Arief Toyyibah, Zurriatun Troef Sumarno Urip Urip Urip, Urip Weny Astuti Widianto, Aris Yudha Anggit Jiwantoro Yunan Jiwintarum Zaeniati, Baiq Lely Zainal Fikri, Zainal Zainul Mutaqin