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All Journal Jurnal Sain Veteriner SAINS DAN MATEMATIKA Prosiding Seminar Biologi Health Science Journal of Indonesia Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Urology agriTECH Indonesian Journal of Biotechnology INDONESIAN JOURNAL OF PHARMACY BERITA BIOLOGI Dental Journal (Majalah Kedokteran Gigi) The Indonesian Biomedical Journal Universa Medicina Medical Laboratory Technology Journal Molecular and Cellular Biomedical Sciences (MCBS) Molekul: Jurnal Ilmiah Kimia Oto Rhino Laryngologica Indonesiana INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Narra J Proceeding Biology Education Conference Cermin Dunia Kedokteran Nutrisia Medical and Health Journal Jurnal Pandu Husada
Sofia Mubarika Haryana
Departement Of Histology And Biology Cell, Faculty Of Medicine, Public Health And Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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CEA and Cyfra 21-1 linked to serial miRNA expressions of advanced-stage non-small cell lung cancer in Indonesia Hanafi, Arif Riswahyudi; Jayusman, Achmad Mulawarman; Imelda, Priscillia; Alfasunu, Serafim; Sadewa, Ahmad Hamim; Pramono, Dibyo; Heriyanto, Didik Setyo; Haryana, Sofia Mubarika; Kresno, Siti Boedina
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 4 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005504202303

Abstract

Globally, lung cancer is one of the cancers leading to dead, dominated by non-small cell lung cancer (NSCLC). In a previous study has shown those serial miRNA expressions (miR-148, miR-34, miR-222, and miR-155) had prognostic value in advanced-stage NSCLC patients. Meanwhile, CEA and Cyfra 21-1, pulmonary tumor markers, are sometimes considered in the Department of Pulmonology, Dharmais Cancer Hospital, Jakarta, although they are not used in routine clinics for prognostication. Both miRNA and CEA-Cyfra 21-1 are valuable biomarkers in NSCLC. This study aimed to evaluate their correlation between CEA and/or Cyfra 21-1 with miRNA expressions in NSCLC patients. It was a cohort retrospective study using data from the previous study. The correlation between variables was analyzed by Spearman-rho. A positive correlation was observed between CEA and Cyfra 21-1 with miR-148, miR-222, and miR-155 [(CEA: p=0.00369, r=0.522; p=0.00242, r=0.542; p 0.00106, r=0.576) (Cyfra: 21-1= p 0.01252, r=0.378; p=0.00035, r=0.519; p=0.01532, r=0.368)]. In conclusion, CEA and Cyfra 21-1 correlate with miR-148, miR-222, and miR-155 expressions in advanced-stage NSCLC.
Development of nanocomplex mimic‐hsa‐miR‐143‐3p loaded exosome (exo‐miR) to inhibit viability, migration and proliferation of triple‐negative breast cancer Nilasari, Fita; Haryana, Sofia Mubarika; Nugrahaningsih, Dwi Aris Agung; Satriyo, Pamungkas Bagus
Indonesian Journal of Biotechnology Vol 29, No 4 (2024)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijbiotech.92817

Abstract

Breast cancer represents the highest number of cancer cases in Indonesia, with triple‐negative breast cancer (TNBC) being a common subtype (10–15%). MicroRNAs play a role in cancer epigenetics and contributing as core factors to the disease. The expression of miR‐143‐3p have been found to be lower in breast cancer samples from Yogyakarta and Central Java. It is known that miR‐143‐3p functions as a tumor suppressor in breast cancer, and its overexpression corresponds with an increased survival rate. The structure of miRNA is quickly degraded, an enhanced delivery system for miRNA is required. Exosomes are indeed emerging as natural delivery agent. A new approach represents that exosomes will be transfected with mimic‐hsa‐miR‐143‐3p yield an exo‐miR. The research aimed to examine how exo‐miR affects viability, migration, and proliferation using 4T1 cell line. The Exo‐Fect‐based method was used to transfect mimic‐hsa‐miR‐143‐3p into exosomes. The MTT assay, wound healing assay, and colony formation assay were used as functional assay. The MTT assay revealed that 7.5 µL/ 250,000 particles exo‐miR obtained a lower percentage of cell viability (58%) than the control (99.7%). The wound healing assay showed that transfection of 37.5 µL/ 1,250,000 particles exo‐miR was able to suppress migration by the percentage of wound closure (67%) compared to the control (100%). Exo‐miR also had a significant (p < 0.001) effect on colony‐forming abilities, as shown by fewer colonies (32) compared to the control (132). This findings demonstrated that exo‐miR represents a promising targeted approach in cancer therapy.
Microrna Profile of Plasma Exosomes by Nanostrings in Early Onset Compared Late Onset Preeclampsia: Preliminary Study Sumawan, Herman; Pradjatmo, Heru; Hadiati, Diah Rumekti; Mubarika, Sofia; Giantari, Ifrinda
Medical and Health Journal Vol 5 No 1 (2025): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2025.5.1.17598

Abstract

Research on miRNA biomarkers in preeclampsia as part of screening, diagnosis, and prognosis has been widely conducted, but the results show contradictory results and vary based on the type of preeclampsia. This study aims to compare the profile of plasma exosome miRNA in early onset compared late onset as a preliminary study to identify the miRNA profile of preeclampsia patients in Indonesia. The study was conducted at Margono Hospital,Indonesia using plasma exosomes samples of three patients with early-onset preeclampsia and three patients with late-onset preeclampsia and processed with NanoStrings. KEGG was used to identify preeclampsia pathophysiological pathways by bioinformatic analysis of DIANA-miRPath v3.0 and microT-CDS v5.0. The results showed that the characteristics of parity, hemoglobin, systolic and diastolic blood pressure, proteinuria and BMI did not differ between EOPE and LOPE. Significantly different variables were the age of the EOPE (28 ± 5.29) vs LOPE (38.67 ± 2.06 mmHg), pregnancy weight gain (10.0 vs 15.33), and fetal weight in EOPE (1550 ± 132 g) vs LOPE (2693 ± 716 g). The results showed that the 24 miRNAs differed significantly. The three highest expression miRNAs in the EOPE group were miR-196b-5p, miR-190a-5p, and miR-515-3p. In contrast, the three lowest expression miRNAs are miR-3179, miR-181a-5p, and miR-15b-5p. Pathway analysis of the upregulated miRNA involved the ErbB signalling pathway, Proteoglycan in cancer, and Lysin degradation. Downregulated miRNA targets involved in the HIPPO signalling pathway, fatty acid biosynthesis, and TGF-β signalling pathway. Conclusions: The preliminary study results indicated significant differences in miRNA expression, suggesting that EOPE is influenced by aggressive cellular signaling and metabolic dysregulation, while LOPE is more linked to the disruption of growth-inhibiting pathways and fatty acid metabolism. These unique miRNAs establish a robust foundation for subsequent validation studies utilizing bigger samples as a prospective biomarker panel.
Co-Authors . Irianianiwati . Suharno Abdurahman Laqif Abdurahman Laqif Addin Trirahmanto Agnes Murdiat Agnes Murdiati Agus Surono Ahmad Ghozali Ahmad Ghozali Ahmad Hamim Sadewa Akbar Satria Fitriawan Akira Hosoyama Akira Hosoyama Alfasunu, Serafim Aminuyati Anwar, Sumadi Lukman Aprilia Indra Kartika Aprilia Indra Kartika Aris Haryanto Aris Haryanto Arsi Palupi Atsushi Yamazoe Atsushi Yamazoe AWM. Boersma Bambang Hariwiyanto Bambang Hariwiyanto Bambang Hariwiyanto Bernadia Branitamahisi Bernadia Branitamahisi Bolhuis RLH Camelia Herdini Christiana Tri Nuryana Christina Hari Nawangsih Priharsanti Christina Prihharsanti Cita Herawati Daan Khambri Damiana Sapta Candrasari Danarto Danarto Danarto Danarto Danarto Danarto Demas Bayu Handika Dessy Arisanty Dewi Agustina Dewi Sahfitri Tanjung Dewi Sahfitri Tanjung Diah Rumekti Hadiati Dibyo Pramono Didik Setyo Heiyanto Didik Setyo Heriyanto Dinna Rakhmina Dwi Aris Agung Nugrahaningsih Dwi Nur Indah Sari Edy Meiyanto Eka Savitri Endang Astuti Endang Astuti Fatma Zuhrotun Nisa Fatma Zuhrotun Nisa Firly Putri Fardhila Hanafi, Arif Riswahyudi Hartopo, Anggoro B. Heru Pradjatmo Hideaki Nojiri Hideaki Nojiri Ibnu G Gandjar, Ibnu G Ibnu G. Gandjar Ibnu G. Gandjar Ibnu G. Gandjar Ibnu G. Ganjar, Ibnu G. Ibnu Purwanto Ida Ayu Preharsini Ida Ayu Preharsini Kusuma Ifrinda Giantari Imelda, Priscillia Indwiani Astuti Indwiani Astuti Indwiani Astuti Indwiani Astuti Indwiani Astuti Iqmal Tahir Irianiwati Widodo Isnatin Miladiyah Iwan Dwiprahasto Iwan Dwiprahasto Jaap Middeldorp Jajah Fachiro JAKA WIDADA Jayusman, Achmad Mulawarman Jumina Jumina Juwita Raditya K. Nooter K. Nooter Ketut Sofjan Firdausi, Ketut Sofjan KV Rao, KV M. Munir Mae S.H. Wahyuningnsih Mae Sri Hartati Wahyuningsih Mark T Hamann, Mark T Mark T. Hamann Mary Astuti Mary Astuti Maya Esther Wullur Moningka Meutia Srikandi Fitria Mohammad Hakimi Nanda Qoriansas Nastiti Wijayanti Nastiti Wijayanti Nastiti Wijayanti Neneng Ratnasari Nilasari, Fita Nooter K Nor Sri Inayati Nor Sri Inayati Novi Febrianti Nur Arfian Nur Arfian Nur Signa Gumilas Oktriani R Oostrum RG Perkasa, DP Pinandi Sri Pudyani Puji Lestari R.L.M. Bolhuis Rachma Greta Perdana Putri Rachma Greta Putri Raden Danarto Renovaldi, Dede Retno Arianingrum Retno Sunarminingsih Sudibyo Rina Triasih Risky Oktriani Ronny Martien S. Sismindari Sagung Rai Indrasari Salugu Masesadji Sari Eka Pratiwi Satriyo, Pamungkas Bagus Sa’adah N Shanti Listyawati Shanti Listyawati SHANTI LISTYAWATI Shinta Hartanto Siregar, Fajri M. Sismindari . Sismindari Sismindari Sismindari Sismindari Siti Boedina Kresno Siti Nur Chasanah Siti Nur Chasanah Soenarto Sastrowiyoto Sri Nuryani Wahyuningrum Sri Nuryani Wahyuningrum Sri Nuryani Wahyuningrum Sri Nuryani Wahyuningrum Sri Suparwitri Stefani Candra Firmanti Subagus Wahyuono Subagus Wahyuono Subagus Wahyuono Subagus Wahyuono Sukarti Moeljopawiro Sumadi, Firasti A.N Sumawan, Herman Susanna Hutajulu Tatsuo Takeya, Tatsuo Teguh Aryandono Tiara Puspita Agustin Tirta wardana Torizal GF Tri Wibawa Triana Hertiani Umar Anggara Jenie Umar Anggara Jenie Wardana T wardana, Tirta Widhiastuti, Stefani Santi Wirsma Arif Harahap Yanwirasti - Yohanes Widodo Wirohadidjojo Yosi B. Murti Yosi Bayu Murti Ysrafil .