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The effect of betle (Piper betle L.) leaf juice pretreatment on the pharmacokinetics of propranolol on male white rat Agung Endro Nugroho; Arief Rahman Hakim
Indonesian Journal of Pharmacy Vol 14 No 4, 2003
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (307.452 KB) | DOI: 10.14499/indonesianjpharm0iss0pp169-176

Abstract

Drug interaction phenomenon, between drugs on drug and ford (fruit, vegetables on others), can happen in drug therapy of a disease due to the existence of compounds other than the drug (fruits, vegetables or drink). This interaction can alter and affect the action and effect of the drug. The aim of the research is to study an interaction between betle leaf (a vegetable ) and propranolol, which is a beta-blocker with a high hepatic extraction ratio, in male white rat. The study was conducted by employing a completely randomized design in male wistar inbreed rat (aged 2-2.5 months, 150-250 g). The animals in group I were given propranolol with an oral single dose of 7.5 mg/kg BW (control group) and in group II were given pretreatment with betle leaf juice dose of 17 mL/kg BW at an hour prior propranolol administration. After collected at some certain times, the drug concentration on bloods were analyzed with a Spectropflurometer.The results shown that pretreatment of betle leaf juice did not affect the absorption rate constant (Ka) significantly (P>0.05), and increase the total clearence (ClT) and volume of distribution in steady state (Vdss) significantly (P<0.05). The increasing of both ClT and Vdss caused alteration of the secondary pharmacokinetics parameters of propranolol and these derivates significantly(P<0.05) except the mean residence time value (MRT). This it is concluded that the pretreatment of betle leaf juice with the dose of 17 mL/kg BW affect the pharmacokinetics of propranolol or decrease the propranolol concentration in blood.Key words : propranolol, betle leaf, pharmacokinetics and drug interaction
Feasibility of transdermal transport of atenolol by combination of iontophoresis and oleic acid pretreatment Akhmad Kharis Nugroho; Arief Rahman Hakim; Marlyn Dian Laksitorini; Fajar Rakhmatullah; Eny Masruriati
Indonesian Journal of Pharmacy Vol 22 No 1, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (400.814 KB) | DOI: 10.14499/indonesianjpharm0iss0pp65-72

Abstract

Atenolol  has  a  low  oral  bioavailability  and  a  short  elimination  half-life. Therefore,  alternative  route  and  delivery  system  is  important.  Transdermal iontophoresis,  i.e.  a  systemic  drug  delivery  via  the  skin,  implementing  a  low intensity  of  electrical  current,  is  one  attractive  candidate.  This  study  evalu ated feasibility  of  atenolol  transdermal  transport  when  iontophoresis  is  applied  after enhancer  pretreatment.  There  were  4  formulas  prepared;  2  implemented iontophoresis  for  3  hours  (current  density:  0.25  mA/cm2)  while  the  others  did not  use  iontophoresis.  The  enhancer  was  oleic  acid  (5  or  10%  as  a  mixture  in propylene  glycol)  with  duration  of  pretreatment  of  one  hour.  Transport  was evaluated  in  the  diffusion  studies  across  the  fresh  rat  skin  in  a  static-vertical diffusion system. Data were analyzed based on the numeric convolution method to  obtain  simulated  Cp  profiles  as  well  as  AUC  of  Cp  profiles.  Based  on  the simulated Cp, the best transport was achieved in Formula 3, where iontophoresis is  performed  across  the  skin,  pretreated  with  5%  oleic  acid  for  one   hour.  The value  of  simulated  Cp  indicated  achievement  of  therapeutics  level  of  atenolol, suggesting the feasibility of the atenolol delivery by iontophoresis.Key words : atenolol, transdermal, iontophoresis, enhancer
Profile of sulphacetamide pharmacokinetics on uranyl nitrate-induced renal failure rats Djoko Wahyono; Arief Rahman Hakim; Agung Endro Nugroho
Indonesian Journal of Pharmacy Vol 18 No 3, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (180.141 KB) | DOI: 10.14499/indonesianjpharm0iss0pp117-123

Abstract

Kidney is a vital organ which has main function to maintain the body homeostasis. The role of kidney is the excretion (elimination) of waste product, and if there is pathologically a renal failure so will change the drug pharmacokinetics and in turn change it’s potency. The present study evaluated the effect of uranyl nitrate-induced renal failure on the pharmacokinetics profiles of sulphacetamide in rats.The study was conducted by employing a completely randomized design in male Wistar in bred rat (aged 2-2.5 months, 150-250 g). The animals in group I were given sulphacetamide sodium with an oral single dose 100.0 mg/kg BW (control group) and in group II were given pretreatment with uranyl nitrate at 3 days before sulphacetamide administration.After collected at some certain times, the drug concentrations on bloods were analyzed by an ultraviolet spectrophometer. The results have shown that uranyl nitrate-induced renal failure decreased the primer pharmacokinetics parameter i.e. total clearance (ClT) and volume of distribution in steady state (Vdss), significantly (P<0.05). The decreasing of these parameter could cause alteration of the secondary pharmacokinetics parameters of sulphacetamide and these derivates i.e. Cmax, tmax, AUC0-240, AUC0-inf, MRT, K and t1/2 elimination significantly (P<0.05). According from the results, it is concluded that uranyl nitrate-induced renal failure affected the pharmacokinetics of sulphacetamide or could increase the sulphacetamide concentration in blood.Key words : sulphacetamide, pharmacokinetics, renal failure, uranyl nitrate
Uji Ketersediaan Hayati Tablet Parasetamol dan Tablet Teofilin pada Kelinci DJOKO WAHYONO; ARIEF RAHMAN HAKIM
JURNAL ILMU KEFARMASIAN INDONESIA Vol 7 No 1 (2009): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (955.89 KB)

Abstract

The objective of this research is to evaluate the bioavailability of paracetamol tablet to Panadol and theophyllin tablet to Bronsolvan in rabbits. The study Was conducted employing a same subject design using male rabbits which were divided into 2 groups (5 rabbits for each group). The group I was given a single oral antipyretic tablet (paracetamol 500 mg) and the group H was given a single oral antiasthmatic tablet (theophyllin 130 mg). After Wash out period, the group I Was given asingle oral Panadol tablet (paracetamol 500 mg) and the group ll Was given a single oral Bronsolvan tablet (theophyllin 150 mg). Serial blood samples were taken at various interval time for HPLC analysis of unchanged form of paracetamol and theophyllin in blood. Based on the data of the concentration over the time, the pharmacokinetic parameters (Cmaks, tmaks, and AUC0- ̴ ) were determined and compared using statistic analysis paired t test with 95% degree of comidence. The results indicated that the bioavailability of antipyretic and antiasthmatic tablet is not significantly difference to the respective controls (P>0,05).
Parameter Standar Ekstrak Etanol Stelechocarpus burahol Dalam Pengembangan Bahan Baku Obat Purwatiningsih Purwatiningsih; Arief Rahman Hakim; Indah Purwantini
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 7 No. 2 (2020)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v7i2.5632

Abstract

Ekstrak etanol daun Kepel (Stelochocarpus burahol) dilaporkan memiliki potensi untuk menurunkan kadar asam urat darah pada tikus dan tidak berbeda nyata dari allopurinol (P <0,05). Penelitian ini bertujuan untuk menentukan parameter standar simplisia dan ekstrak etanol daun Kepel untuk pengembangan bahan baku obat. Standarisasi simplisia dilakukan untuk menentukan parameter non-spesifik dan spesifik serta kandungan kimia ekstrak. Parameter non-spesifik terdiri dari kadar air, susut pengeringan, kadar abu, kadar senyawa larut air dan kadar senyawa larut ethanol, kontaminasi logam berat, mikroba dan pestisida. Sedangkan parameter non-spesifik untuk ekstrak kental dan kering adalah semua parameter tersebut kecuali kadar ekstrak. Parameter khusus meliputi profil TLC dan kandungan flavonoid total. Kandungan flavonoid Total dihitung setara dengan jumlah kuersetin dalam gram per 100 g sampel. Hasil penelitian menunjukkan bahwa simplisia dan ekstrak etanol daun Kepel memenuhi standar sesuai yang ditetapkan oleh Farmakope Herbal Indonesia baik untuk parameter non-spesifik maupun spesifik. Berdasarkan pemeriksaan, simplisia mengandung total flavonoid 0,52% b/b, sedangkan ekstrak kental dan kering daun kepel masing-masing mengandung 13,04 b/b dan 11,02% b/b. Disimpulkan bahwa ekstrak etanol daun kepel memenuhi standar sesuai Farmakope Herbal Indonesia.
A Rapid and Simple High-Performance Liquid Chromatographic Method for Determination of Levofloxacin in Human Plasma Dion Notario; Sudibyo Martono; Zullies Ikawati; Arief Rahman Hakim; Fathul Jannah; Endang Lukitaningsih
Indonesian Journal of Chemistry Vol 17, No 1 (2017)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (431.483 KB) | DOI: 10.22146/ijc.23552

Abstract

A simple and rapid high-performance liquid chromatography method was developed and validated for quantifying LEV in human plasma. Chromatographic separation was performed under isocratic elution on a Luna Phenomenex® C18 (150 × 4.6 mm, 5 µm) column. The mobile phase was comprised of acetonitrile, methanol, and phosphate buffer 25 mM pH 3.0 (13:7:80 v/v/v) and pumped at a flow rate of 1.5 mL/min. Detection was performed by UV detector at a wavelength of 280 nm. Samples were pre-treated with acetonitrile followed by centrifugation, evaporation, and reconstitution step. The method proved linear (r = 0.995), sensitive (LLOQ and LOD was 1.8 and 0.6 µg/mL respectively), accurate (% error above LLOQ ≤ 12% and LLOQ ≤ 20%), precise (RSD ≤ 9%), robust in the ranges of 1.8-28.8 µg/mL, rapid (separation time not more than 10 min), and simple (use no organic additive in mobile phase). The method was showed reliable for quantifying LEV in human plasma.
Problems, Challenges, and Opportunities to Achieve Social Justice Availability of Oil Fuel Energy in Lacked, Front, and Remote Regions of Indonesia Arief Rahman Hakim
Budapest International Research and Critics Institute-Journal (BIRCI-Journal) Vol 5, No 2 (2022): Budapest International Research and Critics Institute May
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birci.v5i2.5502

Abstract

This study aims to to describe the implementation of the values of the Basic Constitution of the State, namely the 1945 Constitution Article 33 paragraphs 2 and 3 as well as the Fifth Precepts of Pancasila, namely "social justice for all Indonesian people" towards the readiness and security of energy, especially fuel oil for people in disadvantaged, frontier and outermost areas of Indonesia, because with the vast territory of the Unitary State of the Republic of Indonesia, there are challenges in providing energy in underdeveloped, frontier and outermost areas and how opportunities to realize this role. The supply of fuel oil in underdeveloped, frontier and outermost areas. Fuel Oil is often obtained by illegal means, illegal activities of misuse of fuel oil (BBM) are carried out by the community either by purchasing, transporting or storing to fulfill fuel needs because of the need for availability. Fuel is a basic need of the community in order to encourage their economic needs. Meanwhile, the government has not been able to fully guarantee the availability of fuel oil in the disadvantaged, frontier and outermost areas of Indonesia.  At the end of the discussion, this article discusses how the Government as the regulator should include a sustainable approach so that the Disadvantaged, Frontier and Remote Areas can fulfill their rights in the availability of Oil Fuel Energy.
Analisis Implementasi Kurikulum Merdeka Belajar Kampus Merdeka pada Prodi PGSD UNIKAMA Cicilia Ika Rahayu Nita; Farida Nur Kumala; Nyamik Rahayu Sesanti; Arief Rahman Hakim; Andika Gutama
DWIJA CENDEKIA: Jurnal Riset Pedagogik Vol 6, No 2 (2022): DWIJA CENDEKIA: Jurnal Riset Pedagogik
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (341.993 KB) | DOI: 10.20961/jdc.v6i2.58417

Abstract

Penelitian ini bertujuan untuk menganalisis implementasi kurikulum Merdeka Belajar Kampus Merdeka (MBKM) pada mahasiswa PGSD Unikama. Penelitian ini merupakan penelitian survey. Responden dari penelitian ini adalah 13 dosen, 386 mahasiswa dan 17 mitra prodi yang berada pada lingkungan Universitas PGRI Kanjuruhan Malang Teknik pengambilan sampel yang digunakan adalah sampling purposive. Teknik analiisis data yang digunakan adalah analisis kuantitatif deskriptif. Hasil penelitian menunjukkan prodi PGSD UNIKAMA telah menerapkan program MBKM dengan mengacu pada 6 BKP, mahasiswa dan dosen telah mengetahui program MBKM. Implementasi Progra MBKM menunjukkan dampak positif terhadap peningkatan IKU  dan CPL sikap, pengetahuan, keterampilan umum dan khusus mahasiswa PGSD UNIKAMA. Oleh sebab itu penting bagi prodi untuk melakukan peninjauan kurikulum secara berkala untuk mengakaji kurikulum yang telah dilaksanakan dengan pengintegrasian program MBKM.
SOSIALISASI DAN PELATIHAN MASSIE OPE OLIE OURSES (MOOC) UNIVERSITAS PGRI PALANGKA RAYA Arief Rahman Hakim; Sumiatie Sumiatie; Rosmawiah Rosmawiah; Liberti Natalia Hia; Eny Susilowati; Silvia Arianti
Jurnal Pengabdian Kepada Masyarakat Agri Hatantiring Vol 1, No 1 (2021): Jurnal PKM Agri Hatantiring
Publisher : Jurnal Pengabdian Kepada Masyarakat Agri Hatantiring

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59900/pkmagri.v1i1.20

Abstract

MOOCs, atau Massie Open Online Courses adalah perkuliahan daring yang menaarkan akses terbuka melalui internet secara gratis atau dengan biaya kecil. Peserta MOOC dapat mencapai angka yang sangat tinggi, hingga lebih dari 100,000 pelajar dalam aktu yang bersamaan. MOOC juga terbuka, yang berarti baha siapapun, dimanapun dapat mendaftarkan diri untuk mendapatkan perkuliahan tersebut. Selain itu, MOOC juga dilaksanakan melalui internet, dan seringkali memiliki materi yang mirip dengan mayoritas perkuliahan daring uniersitas. Pengurus Besar Persatuan Guru Republik Indonesia (PB PGRI) akan memprakarsai pembentukan MOOC yang merupakan konsorsium seluruh Perguruan Tinggi yang bernaung di baah bendera PGRI. MOOC PGRI tersebut akan di lounching pada tanggal 12 Pebruari 2021 (12022021) Mengingat peranan penting MOOC dalam pembelajaran di era Merdeka Belajar, Kampus Merdeka maka perlu dilaksanakan sosialisasi dan pelatihan Massie Open Online Couses (MOOC) di lingkungan Uniersitas PGRI Palangka Raya. Diharapkan adanya sosialisasi dan pelatihan ini, Peserta mampu mengenal MOOC dan Manfaatnya bagi PendidikanPengajaran, Peserta mampu membuat akun pada MOOC, Peserta mampu mengikuti kuliah pada berbagai uniersitas dalam dan luar negeri, Peserta mampu membuka dan memiliki akun PAYPAL.
Analisis Kualitas Jaringan Internet Dengan Sinyal 4G LTE Dengan Metode QOS Arief Rahman Hakim; Neilcy Tjahjamooniarsih; Dedy Suryadi
Journal of Electrical Engineering, Energy, and Information Technology (J3EIT) Vol 9, No 2: Juli 2021
Publisher : Faculty of Engineering, Universitas Tanjungpura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/j3eit.v9i2.48187

Abstract

Tujuan pada penelitian ini adalah untuk menganalisis dan mengetahui kualitas layanan jaringan internet dengan sinyal 4G LTE menggunakan metode QoS (Quality of Service) pada Kantor Bupati Kubu Raya dan untuk mengetahui faktor-faktor pengujian layanan jaringan internet dengan sinyal 4G LTE menggunakan metode QoS (Quality of Service) pada Kantor Bupati Kubu Raya. Metode yang digunakan pada penelitian ini menggunakan metode QoS dengan parameter yang digunakan yaitu Throughput, Jitter, Packet Loss dan Delay. Dari hasil pengukuran dan analisis QoS terhadap jaringan server internet pada Kantor Bupati Kubu Raya maka dapat disimpulkan : (1) Untuk mengukur Quality of Service di Kantor Bupati Kubu Raya parameter-parameter yang digunakan yaitu delay/latency, jitter, packet loss dan throughput dengan menggunakan aplikasi wireshark sebagai tools pengukurannya; (2) Waktu yang dibutuhkan oleh sebuah paket data terhitung dari saat pengiriman oleh transmitter sampai saat diterima oleh receiver (throughput) yaitu saat jam kantor pada hari kedua lantai 1 sebesar 244,338 kbps (Sedang), pada lantai 2 sebesar 404,248 kbps (Sedang), pada lantai 3 sebesar 197,698 kbps (Jelek) dan pada luar Gedung sebesar 142,079 kbps (Jelek); (3) Perbedaan selang waktu kedatangan antar paket di terminal tujuan (delay/latency) yaitu saat jam kantor pada hari kedua lantai 1 sebesar 17,088ms (Sangat Bagus), pada lantai 2 sebesar 13,629ms (Sangat Bagus), pada lantai 3 sebesar 25,957ms (Sangat Bagus) dan pada luar Gedung sebesar 53,824ms (Sangat Bagus).; (4) Banyaknya paket yang hilang selama proses transmisi ke tujuan (packet loss) yaitu saat jam kantor pada hari kedua lantai 1 sebesar 1,5% (Sangat Bagus), pada lantai 2 sebesar 0,9% (Sangat Bagus), pada lantai 3 sebesar 0,7% (Sangat Bagus) dan pada luar Gedung sebesar 0,1% (Sangat Bagus); (5) Jumlah bit yang diterima dengan sukses perdetik melalui sebuah sistem atau media komunikasi (kemampuan sebenarnya suatu jaringan dalam melakukan pengiriman data) (jitter) yaitu saat jam kantor pada hari kedua lantai 1 sebesar 17,087 (Sangat Bagus), pada lantai 2 sebesar 13,628ms (Sangat Bagus), pada lantai 3 sebesar 25,954 (Bagus) dan pada luar Gedung sebesar 53,8131ms (Bagus).
Co-Authors ., Purwantiningsih ., Purwantiningsih A.A. Ketut Agung Cahyawan W Abadi Sanosra Afitri, Windy Dwi Agung Endro Nugroho Agung Endro Nugroho Agung Endro Nugroho Agung Endro Nugroho Ahmad Syukri Aji Jumiono Akhmad Kharis Nugroho Akhmad Syarif Alva Hendi Muhammad Ananda , Dhimas Aryo Vipha Andi Cudai Nur ANDIKA GUTAMA, ANDIKA Anindita, Jessica Anjarwati Anjarwati Arief Nurrochmad Asro Laelani Indrayanti Astini, Siluh Made Yuni Auliana, Diah Fitrotul bin Yahaya, Mohd Firdaus Br Tarigan, Maya Sari Butarbutar, Maria Haryanti Chaerani, Ika Tania Cicilia Ika Rahayu Nita Daeli, Abiyudin Dedy Suryadi Diana, Ratna Dion Notario Djoko Wahyono Djoko Wahyono Djoko Wahyono Dwi Agus Setiawan DWI CAHYONO dwi yasa, arnelia Edy Budi Harjono, Edy Budi Edy Meiyanto Endang Lukitaningsih Eny Masruriati Eny Susilowati Evradus Badii Fadhil Hasan R, Hans Mokhammad Fadhli, Khairul Fajar Rakhmatullah Faradilla, Aina Noor Ade Farida Nur Kumala Fathul Jannah Fauzi, Soni Fotriyodi, Rivon Gunawan Prayitno Haedar Akib Hakim, Lukman Hakim, Lukman Harefa, Sepakat Jaya HARI PURNOMO Hariani, Pipit Putri Harry Nenobais Haryadi, Nicko Haryanti Butarbutar, Maria Hasibuan, Ahmad Riady Hasibuan, Bulkis Hayati, Farida Helmi Haris Heris Yosua Ramase Rony Hulu, Safira Ida Ayu Putu Sri Widnyani Idsan, Rakha Satya Imono Argo Donatus, Imono Argo Indah Purwantini Intan Intan Iratutisisilia, Iratutisisilia Iskandar Ladamay, Iskandar Jenny Tandi Juwita, Dewi Ratna Kasih, Nirvane Zefanya Khusniyah, Farikhatul Kornelia Kidi Olarne Kristini, Wanda Kusumawati, Dina Ari Laviandhy, Debby Arthi Lianty, Nozylianty Liberti Natalia Hia Lukman Hakim Lukman Hakim Maharani, Devi Mahmudah, Amirotul M.H Margolang, Khairul Fadhli Margono, Supardjan A. Marlyn Dian Laksitorini Moh Salimi Muamaroh, Dzun Nur Nafi’ah Muassomah Muassomah Muhammad Faqih Muhammad Thamrin Nadia Leony L.W Neilcy Tjahja Mooniarsih Ningrum, Anita Dwi Juwita Norsandy, Dedi Nugroho, Agung Endro Nurhusna, Siti Deviana Rahma Nurul Qomariah Pakpahan, Aston Poetra, Bilal Ambara Herlando Pradana, Muhammad Yudha Pramudia, Yogha Primasari, Firdhani Satia Pudjono, Pudjono Purwatiningsih Purwatiningsih Putri, Hasna Tantowi Qotrunnada, Maulida Hasbiya Qowlits Tsabita, Qonita Qorrie Aini Raihan, Muhammad Retno Murwanti Riptasari, Rhatna Dewi Rosmawiah Rosmawiah Roziki, Khafid Safitri, Saktya Dea Samrotul Fikriyah Sandiki, Frisilia Dewanti Sandy, Trio May Sesanti, Nyamik Rahayu Sibarani, Edi Budi Harjono Silvia Arianti Simanjuntak, Marthin Yohannes Simanjuntak, Martin Yohannes Siti Nurrohmah SRI RAHAYU Sudibyo Martono Sukmarini, Zhafira Sumiatie Sumiatie Syahrir Akil Tampubolon, Laswandi Tangkasiang, Yos Andy Tri Lestari Triwayuningtyas, Dyah Ugang, Yandi Wahyono, Djoko Wahyono, Djoko Wibowo, Friza Rahmawanto Wulandari, Diana Yaakob, Mohd. Faiz Mohd Yani, Asnita Yanti, Elyta Vivi Yuliana, Palupi Dwi Yulianti Yulianti Yustha, Yulia Zahra, Husna wati Zullies Ikawati