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All Journal Jurnal Ilmiah Farmasi LITE: Jurnal Bahasa, Sastra, dan Budaya LiNGUA: Jurnal Ilmu Bahasa dan Sastra Jurnal Pendidikan Dasar Nusantara JAM : Jurnal Aplikasi Manajemen VIVID Journal of Language and Literature Nazharat: Jurnal Kebudayaan Pedagogia: Jurnal Pendidikan INDONESIAN JOURNAL OF PHARMACY InfoTekJar : Jurnal Nasional Informatika dan Teknologi Jaringan JURNAL BIOLOGI INDONESIA DWIJA CENDEKIA: Jurnal Riset Pedagogik Jurnal Bidang Pendidikan Dasar Jurnal Moral Kemasyarakatan JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) ELSE (Elementary School Education Journal) : Jurnal Pendidikan dan Pembelajaran Sekolah Dasar Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Majalah Farmaseutik Indonesian Journal of Chemistry International Journal of Elementary Education JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Onoma: Pendidikan, Bahasa, dan Sastra Jurnal Manajemen Informatika dan Sistem Informasi LINGUA : Jurnal Bahasa, Sastra, dan Pengajarannya TSAQOFIYA : Jurnal Pendidikan Bahasa dan Sastra Arab Abdi Laksana : Jurnal Pengabdian Kepada Masyarakat Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Jurnal Pengabdian kepada Masyarakat Nusantara Jurnal Teknologi Sistem Informasi dan Sistem Komputer TGD Journal of Arabic Literature (Jali) Jurnal Sociopolitico Prosiding Seminar Nasional Program Pengabdian Masyarakat Online Learning in Educational Research Jurnal Pembelajaran, Bimbingan, dan Pengelolaan Pendidikan Jurnal Bangun Abdimas QISTINA: Jurnal Multidisiplin Indonesia Biocaster : Jurnal Kajian Biologi Innovative: Journal Of Social Science Research PKM Maju UDA Jurnal Ilmiah Pangan Halal Jurnal PKM Agri Hatantiring Journal of Electrical Engineering, Energy, and Information Technology ENRICH: Jurnal Pendidikan, Bahasa, Sastra dan Linguistik Jurnal Pengabdian Kepada Masyarakat Hanif Journal of Information Systems (ETTLI) LISANIA: Journal of Arabic Education and Literature Al-Bidayah : jurnal pendidikan dasar Islam Jurnal Multidisiplin Indonesia NOBEL : Journal of Literature and Language Teaching JURNAL NERACA Indonesian Journal of Economics, Business, Accounting, and Management Jurnal Bakti UPPR Jurnal Abdimas Nusantara
Arief Rahman Hakim
Department Of Pharmacology And Clinical Pharmacy, Faculty Of Pharmacy, Universitas Gadjah Mada
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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PENGARUH PRAPERLAKUAN BROKOLI (Brassica oleracea L. var. botrytis L.) TERHADAP FARMAKOKINETIKA RIFAMPISIN PADA TIKUS Wahyono, Djoko; Hakim, Arief Rahman
Jurnal Farmasi Indonesia Vol 3, No 1 (2006)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v3i1.69

Abstract

The research was aimed to observe broccoli (Brassica oleracea L. var. botrytis L.) activities to rifampicin pharmacokinetics in rats. The study was conducted using female Sprague Dawley rats which were divided  into 3 groups (6 rats for each group). The groups were given a single oral rifampicin 50,4 mg/kg BW as a control group and were confered multiple doses oral (once daily for seven days) (P-I) and single dose oral oral (P-II) broccoli 23,43 g/kg BW before treatment with rifampicin. Serial blood samples (0,2 ml) were withdrawn at various interval via the tail vein for HPLC analysis of unchanged rifampicin in blood. From the concentration of rifampicin vs time data  was determined rifampicin pharmacokinetics parameters i.e. Ka, Cmaks, tmaks, AUC0-~, Vdss, t1/2 elimination, ClT and K. The results have shown that the pharmacokinetics values of rifampicin in the animals prefed with broccoli 23,43 mg/kg bw 1 hours prior to single oral administration of the drug did not change significantly (P>0,10). Prefeeding the animals with broccoli 23,43 g/kg bw once daily for 7 consecutive days has increased the total clearance of rifampicin 46,90% (P<0,10). The increase in the total clearance rifampicin due to the compound has decreased Cmaks 36,54% (P<0,10). ABSTRAK Penelitian ini bertujuan untuk mengetahui pengaruh pemberian praperlakuan brokoli (Brassica oleracea L. var. botrytis L.) terhadap farmakokinetika rifampisin pada tikus. Penelitian menggunakan tikus putih betina galur Sprague Dawley yang dibagi menjadi 3 kelompok masing-masing terdiri dari 6 ekor hewan. Kelompok I (kontrol) diberikan  rifampisin secara oral dosis 50,4 mg/kg BB,   kelompok II dan III (perlakuan) diberikan brokoli secara oral dosis 23,43 g/kg BB sekali sehari selama 7 hari (P-I) dan 1 jam sebelum (P-II) diberikan rifampisin dengan dosis yang sama seperti kelompok I. Setelah seluruh hewan mendapatkan perlakuan, pada jam-jam ke- 0,25; 0,5; 1; 1,5; 2;  3; 4; 6; 8; 10; 12, dan 24  diambil cuplikan darah (0,2 ml) dari vena lateralis ekor, guna penetapan kadar rifampisin utuh secara HPLC. Kadar rifampisin utuh dalam darah dihitung berdasarkan kurva baku. Harga-harga parameter farmakokinetika rifampisin (Ka, Cmaks, tmaks, AUC0-~, Vdss, t1/2, ClT dan K) dihitung berdasarkan data kadar rifampisin utuh dalam darah terhadap waktu. Hasil penelitian menunjukkan praperlakuan brokoli satu jam sebelum pemberian rifampisin tidak mempengaruhi farmakokinetika rifampisin (P>0,10), namun pemberian brokoli sekali sehari selama 7 hari sebelum pemberian rifampisin mampu meningkatkan ClT rifampisin sebesar 46,90% (P<0,10). Akibat kenaikan ClT rifampisin tersebut, harga Cmaks mengalami penurunan sebesar 36,54% (P<0,10).
VALIDASI METODE PENETAPAN KADAR PENTAGAMAVUNON-1 DALAM DARAH SECARA KROMATOGRAFI CAIR KINERJA TINGGI Ningrum, Anita Dwi Juwita; Astini, Siluh Made Yuni; Hakim, Arief Rahman
Jurnal Farmasi Indonesia Vol 4, No 3 (2009)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v4i3.20

Abstract

Pentagamavunon-1 (PGV-1) is curcuminâ??s analogue that reported as analgesic, antioxidant, antiinflamatory, and has antiproliferation activity to breast cancer. The aim of this study is to develop and validate the method for determinating PGV-1â??s concentration in blood by reverse phase HPLC. Analytical method validation include system suitability test, determination of LOD and LOQ, linearity test, accuracy and precisionâ??s determination, stability test of PGV-1 in blood and acetonitrile. Concentration of PGV-1 in blood is measured by HPLC using LiChrosphere® 100 Cartridge RP C18 (125 x 4 mm i.d., 5 μm), mixed mobile phase methanol : buffer acetate 0,05 M pH 3,7 (80:20 v/v), flow rate 0,5 ml/minute, detector Vis-416 nm, and injection volume 80 μl. System suitability tests suggest that separation condition is suitable to analyze PGV-1â??s concentration in blood. The recomended method up to standard selectivity, linearity (corelation coefficient = 0,9999), accuracy, and precision. Value of LOD and LOQ is 4,93 ng/ml and 16,42 ng/ml, respectively. PGV-1 in blood is stable for the first hour. In acetonitrile at room temperature, PGV-1 is stable for 3 hours while storage at 5°C, PGV-1 is stable for 3 days. Therefore, the recomended analytic method is applicable to determine PGV-1â??s concentration in blood. ABSTRAK Pentagamavunon-1 (PGV-1) merupakan analog kurkumin yang telah terbukti berkhasiat sebagai antioksidan, antiinflamasi, dan mempunyai aktivitas antiproliferasi terhadap sel kanker payudara. Penelitian ini bertujuan untuk mengembangkan dan memvalidasi metode penetapan kadar PGV-1 dalam darah secara KCKT fase terbalik. Validasi metode analisis meliputi uji kesesuaian sistem, penentuan LOD dan LOQ, uji linearitas, penentuan akurasi dan presisi, uji stabilitas PGV-1 dalam darah dan asetonitril. Kadar PGV-1 dalam darah ditetapkan menggunakan KCKT dengan kondisi kolom LiChrosphere® 100 Cartridge RP C18 (125 x 4 mm i.d., 5 μm), fase gerak campuran metanol : bufer asetat 0,05 M pH 3,7 (80:20 v/v), kecepatan alir 0,5 ml/menit, detektor Vis-416 nm, dan volume injeksi 80 μl. Uji kesesuaian sistem menunjukkan bahwa kondisi pemisahan sesuai untuk analisis PGV-1 dalam darah. Metode yang diusulkan memenuhi syarat selektivitas, linieritas (rhitung = 0,9999), akurasi dan presisi. Nilai batas deteksi dan kuantitasi yang didapat masing-masing sebesar 4,93 ng/ml dan 16,42 ng/ml. PGV-1 dalam darah stabil hingga jam pertama. Dalam asetonitril pada penyimpanan suhu kamar, PGV-1 stabil selama 3 jam sedangkan pada penyimpanan suhu 5°C, PGV-1 stabil selama 3 hari. Dengan demikian, metode analisis yang diusulkan dapat diaplikasikan untuk menetapkan kadar PGV-1 dalam darah.
Co-Authors ., Purwantiningsih ., Purwantiningsih A.A. Ketut Agung Cahyawan W Abadi Sanosra Afdayeni, Melia Afitri, Windy Dwi Agung Endro Nugroho Agung Endro Nugroho Agung Endro Nugroho Agung Endro Nugroho Ahmad Syukri Aji Jumiono Akhmad Kharis Nugroho Akhmad Syarif Alva Hendi Muhammad Ananda , Dhimas Aryo Vipha ANDIKA GUTAMA, ANDIKA Anindita, Jessica Arief Nurrochmad Asro Laelani Indrayanti Astini, Siluh Made Yuni Auliana, Diah Fitrotul bin Yahaya, Mohd Firdaus Br Tarigan, Maya Sari Br Tarigan, Yuni Franciska Budi Eko Soetjipto Chaerani, Ika Tania Cicilia Ika Rahayu Nita Daeli, Abiyudin Dedy Suryadi Diana, Ratna Dion Notario Djohar, Hasnul Insani Djoko Wahyono Djoko Wahyono Djoko Wahyono Dwi Agus Setiawan DWI CAHYONO dwi yasa, arnelia Edy Budi Harjono, Edy Budi Edy Meiyanto Endang Lukitaningsih Eny Masruriati Eny Susilowati Fadhil Hasan R, Hans Mokhammad Fadhli, Khairul Fajar Rakhmatullah Faradilla, Aina Noor Ade Farida Nur Kumala Fathul Jannah Fauzi, Soni Fitri, Hidayatul Fotriyodi, Rivon Hakim, Lukman Hakim, Lukman Hanifa, Lulu Fadlina Hanurawan, Fattah Harefa, Sepakat Jaya HARI PURNOMO Hariani, Pipit Putri Haryadi, Nicko Haryanti Butarbutar, Maria Hasibuan, Ahmad Riady Hayati, Farida Helmi Haris Hidayat, Alvonsius Bambang Hulu, Safira I Nyoman Sudana Degeng Ida Ayu Putu Sri Widnyani Idsan, Rakha Satya Imelda Mardayanti Imono Argo Donatus, Imono Argo Indah Purwantini Intan Intan Iratutisisilia, Iratutisisilia Iryanti, Nurlista Iskandar Ladamay, Iskandar Juwita, Dewi Ratna Kasih, Nirvane Zefanya Khusniyah, Farikhatul Kristini, Wanda Kusuma, Muthiara Kusumawati, Dina Ari Lianty, Nozylianty Liberti Natalia Hia Lukman Hakim Lukman Hakim Maharani, Devi Mahmudah, Amirotul M.H Margolang, Khairul Fadhli Margono, Supardjan A. Marissa, Novaria Marlyn Dian Laksitorini Miftahul Huda Moh Salimi Muamaroh, Dzun Nur Nafi’ah Muassomah Muassomah Muhammad Faqih Muhammad Thamrin Nasrulloh Nasrulloh Neilcy Tjahja Mooniarsih Ningrum, Anita Dwi Juwita Norsandy, Dedi Novita Sari Nugroho, Agung Endro Nurhusna, Siti Deviana Rahma Nurul Qomariah Pakpahan, Aston Payung, Jendy Penny Respati Yurisa Poetra, Bilal Ambara Herlando Pradana, Muhammad Yudha Pramudia, Yogha Primasari, Firdhani Satia Pudjono, Pudjono Purba, Rakhmawati Purwatiningsih Purwatiningsih Putri, Hasna Tantowi Qotrunnada, Maulida Hasbiya Qowlits Tsabita, Qonita Qorrie Aini Rahmi, Atika Raihan, Muhammad Retno Murwanti Reynanda, Abbie Riptasari, Rhatna Dewi Rosmawiah Rosmawiah Roziki, Khafid Safitri, Saktya Dea Samrotul Fikriyah Sandiki, Frisilia Dewanti Sandy, Trio May Septianingsih, Aisyah Sesanti, Nyamik Rahayu Sibarani, Edi Budi Harjono Silvia Arianti Simanjuntak, Marthin Yohannes Simanjuntak, Martin Yohannes Siti Nurrohmah SRI RAHAYU Sudibyo Martono Sukmarini, Zhafira Sumiatie Syahrir Akil Tampubolon, Laswandi Tangkasiang, Yos Andy Tri Lestari Triwayuningtyas, Dyah Ugang, Yandi Wahyono, Djoko Wahyono, Djoko Wibowo, Friza Rahmawanto Wulandari, Diana Yaakob, Mohd. Faiz Mohd Yanti, Elyta Vivi Yerry Soepriyanto Yuliana, Palupi Dwi Yulianti Yulianti Yustha, Yulia Zahra, Husna wati Zullies Ikawati