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DIFFERENCES IN INTERFERON GAMMA LEVELS IN TREATMENT OF TUBERCULOSIS IN INTENSIVE PHASE AND ADVANCED PHASE Rachmad Bayu Kuncara; SY. Didik Widiyanto; Ririh Jatmi Wikandari; Wiwit Sulistyasmi
Jurnal Biosains Pascasarjana Vol. 26 No. 1 (2024): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v26i1.2024.72-76

Abstract

Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis complex (MTBC). Anti-tuberculosis drugs given to active TB sufferers consist of 3 or 4 combinations. Tuberculosis treatment is divided into intensive phase treatment (2 weeks) and continuation phase (16 weeks / 4 months). Interferon gamma (IFN γ) is a protein belonging to the cytokine family which plays a role in eliminating MTB bacteria through a cell-mediated immunity mechanism. The aim of this study was to analyze differences in gamma interferon levels in the intensive phase and advanced phase of tuberculosis treatment. This research method is an analytical observational study with a cross-sectional design (cross sectional study). The research design used was a randomized post test only control group design. Data were analyzed using the Kruskal Wallis test with statistical test results obtained with a p value of 0.033 (> 0.05), meaning there was a difference in IFN γ levels in the intensive phase and advanced phase of tuberculosis treatment.
Gambaran Kadar Hemoglobin pada Calon pendonor Usia lebih Dari 46 Tahun di UDD PMI Kabupaten Jepara Luthfia, Alya; Wikandari, Ririh Jatmi; Widodo, Widodo
Jaringan Laboratorium Medis Vol 6, No 1 (2024): May 2024
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v6i1.11437

Abstract

Blood donation is the process of taking a portion of blood from a healthy person then giving it to the person who needs blood. Hemoglobin level examination is one of the donor selection checks to find out whether someone is successful or not to donate blood. A person can donate blood if the hemoglobin level shows a result of 12.5 g / dL – 17 g / dL. A person's hemoglobin level can be influenced by age, because as we get older many organ functions that do not work optimally so that they experience a decrease in Hb levels. The purpose of this study was to measure hemoglobin levels in prospective donors aged more than 46 years at UDD PMI Jepara Regency. This type of research uses a quantitative approach with a cross-sectional descriptive study research model taken from the SIMDONDAR database. The population in this study is all potential donors at UDD PMI Jepara Regency in December 2023-January 2024. The data obtained were analyzed univariately. Based on the results of the study, it was found that the majority of prospective donors showed normal hemoglobin levels as many as 480 prospective donors (94.86%), and more prospective donors who had blood type O (+) as many as 187 prospective donors (36.96%), most prospective donors were male as many as 342 prospective donors (67.59%), and the majority of prospective donors were declared to have passed the donor selection as many as 480 prospective donors (94.86%). The impact of the research results obtained by UDD PMI Jepara Regency is that officers are aware of the importance of socializing to the community how important it is to maintain hemoglobin levels before donating blood and recruiting donors from various ages of prospective donors in the Jepara Regency area.
Faktor Risiko Terjadinya Anemia pada Pasien Tuberculosis Paru dalam Fase Pengobatan Rosidah, Umi; Auliya, Qurrotu Ayuni; Wikandari, Ririh Jatmi; Widiyanto, Santo Yoseph Didik
Jaringan Laboratorium Medis Vol 6, No 2 (2024): November 2024
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v6i2.12268

Abstract

Tuberculosis lungs is disease infectious disease caused by bacteria Mycobacterium tuberculosis. Tuberculosis is still a disease become threat health Indonesian society which  leads to illness , disability and death tall so that need existence mitigation. Research objectives know factor risk the occurrence of anemia in patients tuberculosis lungs in phase treatment . Study This is study retrospective analytic case control Study carried out at the Community Health Center Very Beautiful Subdistrict Genuk City of Semarang. Population all TB patients who are undergo treatment at the Community Health Center Bangetayu. Research sample This from the total population namely 34 case and control patients. The results of 34 respondents case control there is level hemoglobin in patients Tuberculosis lungs with anemia (case) as many as 17 respondents experienced decline hemoglobin levels, namely man with an average hemoglobin level of 12.2 gr/dL (7 respondents), women with The average hemoglobin level was 10.6 gr/dL (2 respondents). A total of 17 respondents non - anemic control , namely the majority is normal with type sex Woman with an average Hemoglobin level of 12.61 gr/dL (17 respondents ). Based on characteristics what kind sex male 29.41% and gender sex women 11.76%. Decrease hemoglobin levels , namely man with an average hemoglobin level of 12.2 gr/dL (5 respondents), women with average hemoglobin level 10.6 gr/dL (2 respondents). Based on characteristics of the type sex women 70.59% (24 respondents) and men 29.41% (10 respondents). Based on characteristics age category adults 64.71% (22 respondents), elderly 23.53% (8 respondents), infants and children 11.76% (4 respondents), and adolescents 0.00% (0 respondents). The results of the bivariate test of hemoglobin levels, age , and type sex there is connection between hemoglobin levels, age, and type sex to Pulmonary Tuberculosis patients in phase treatment. The most influential risk factor o to the occurrence of anemia in patients with pulmonary tuberculosis in phase treatment namely on the variables type sex that is own risk of 3,429. Next followed by variables hemoglobin levels that have risk of 0.370. Age No there is factor risk the occurrence anemia in pulmonary tuberculosis patients in phase treatment. The conclusion of this study is that hemoglobin levels and sex are risk factors for anemia in patients with pulmonary tuberculosis in the treatment phase. Anemia can affect the diagnosis, prognosis, complications, and response to tuberculosis therapy, so that tuberculosis patients can maintain nutritional intake and therapy compliance to suppress the progression of the disease.
Optimalisasi Kesehatan Lansia melalui Senam Lansia, Pemeriksaan Tekanan Darah, Gula Darah dan Asam Urat Wikandari, Ririh Jatmi; Rosidah, Umi; Auliya, Qurrotu A’yuni; Qomariyah, Nurul
Jurnal Pengabdian Masyarakat Bangsa Vol. 3 No. 3 (2025): Mei
Publisher : Amirul Bangun Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59837/jpmba.v3i3.2347

Abstract

Seiring bertambahnya usia, lansia mengalami penurunan fungsi fisiologis yang meningkatkan risiko penyakit tidak menular (PTM) seperti hipertensi, diabetes melitus, artritis, dan penyakit jantung. Data menunjukkan bahwa kasus PTM di Indonesia terus meningkat, dengan hipertensi dan diabetes sebagai penyakit terbanyak. Gaya hidup tidak sehat menjadi faktor utama penyebabnya. Diabetes pada lansia juga sering tidak terdeteksi karena gejalanya tidak khas. Selain itu, lansia juga rentan terhadap penyakit jantung koroner dan gangguan kognitif. Di wilayah mitra, masih banyak lansia yang tidak rutin memeriksakan tekanan darah, gula darah, dan asam urat, serta kurang mengikuti aktivitas fisik seperti senam. Oleh karena itu, dibutuhkan intervensi untuk meningkatkan kesadaran dan derajat kesehatan lansia melalui kegiatan pemeriksaan serta senam rutin. Tujuan kegiatan pengabdian kepada Masyarakat untuk meningkatkan kesadaran lansia mengenai pentingnya menjaga kesehatan. Metode pangabdian melalui penyuluhan tentang pentingnya menjaga pola makan, aktivitas fisik (senam lansia), dan pemeriksaan kesehatan rutin (pemeriksaan tekanan darah, gula darah serta asam urat). Khalayak sasaran adalah lansia laki-laki dan perempuan usia 60-90 tahun, sebanyak 40 orang. Peserta kegiatan Sebagian besar adalah Perempuan. Hasil pemeriksaan Kesehatan menunjukkan 38 orang (95%) lansia memiliki kadar gula darah normal, 5% mengalami diabetes. Hasil pemeriksaan tekanan darah, sebanyak 20 orang (50%), lansia mengalami hipertensi dan kadar asam urat tinggi sebanyak 34 orang (85%). Sebagian besar lansia mengalami hipertensi, diabetes, dan hiperuremia.
Perbedaan Jumlah Trombosit Pada Pasien TB Sebelum dan Setelah 1 Bulan Mengonsumsi Obat Anti TB Taqarrasya, Asa; Wikandari, Ririh Jatmi; Rosidah, Umi
Jaringan Laboratorium Medis Vol 7, No 1 (2025): May 2025
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v7i1.12798

Abstract

Tuberculosis (TB) is still one of the infectious diseases with the highest mortality rate in the world. WHO stated that Indonesia is the third country in the world with the most TB cases. Semarang is the third province in Indonesia with the highest TB cases. Although the mortality rate is high, in reality TB can be treated and prevented. Anti-TB drugs as TB treatment agents can cause side effects, one of which is a decrease in the number of platelets. The purpose of this study was to determine the difference in the number of platelets in TB patients before starting treatment and after one month of treatment with Anti-TB drugs. The study population was new tuberculosis patients. The study sample was taken according to the established criteria and obtained as many as 24 people, who were examined twice, namely before treatment and after 1 month of treatment. The results of this study stated that the average number of platelets before starting TB treatment was 340.875 cells/μL and after one month of treatment with Anti-TB drugs was 281.958 cells/μL. The Wilcoxon test showed a P value = 0.009. There was a significant difference in the number of platelets before starting TB treatment and after one month of treatment with Anti-TB drugs. TB treatment can affect blood conditions, including platelets. Thus, patients and their families are expected to better  understand the importance of carrying out routine checks and not stopping treatment without medical consultation.
Gambaran Infeksi Telur Cacing Soil Transmitted Helminths Pada Petani Bunga Safitri, Oktaviani Windy; Wikandari, Ririh Jatmi
Jaringan Laboratorium Medis Vol. 1 No. 2 (2019): November 2019
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v1i2.5883

Abstract

STH infection is an infection transmitted by intestinal nematodes through the soil. Flower farmers are one of the most vulnerable jobs infected with STH eggs because this work is directly related to the soil. Most of the work as flower farmers is in the Bandungan area because the area is suitable for flower plantations. The purpose of study to describe Soil Transmitted Helminths infection on flower farmers in Jetis Village, Bandungan Subdistrict, Semarang. This study was descriptive observational (non-experimental) research using cross sectional approach. Samples studied were 23 respondents. Feces examination conducted on 23 samples obtained 1 sample (4,3%) infected STH eggs of hookworm species and 22 samples (95,7%) not infected STH eggs. Only 1 flower farmer (4,3%) from 23 flower farmers in Jetis Village, Bandungan Sub-district was infected by Soil Transmitted Helminths egg.
Hubungan Antara Higiene Sanitasi Terhadap Kontaminasi Telur Cacing Non STH Pada Sayur Lalapan di Warung Makan Setyowatiningsih, Lilik; Wikandari, Ririh Jatmi; Surati, Surati
Jaringan Laboratorium Medis Vol. 4 No. 1 (2022): May 2022
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v4i1.8325

Abstract

Fresh vegetables can be a source of transmission of worm infections to humans. The behavior of washing fresh vegetables that are not good by housewives and sellers of fresh vegetables in food stalls becomes large in transmitting worm infections if there are worm eggs that are still attached to fresh vegetables. The most common contamination found in fresh vegetables were eggs of the intestinal nematode Soil Transmitted Helminths (STH) as well as non-STH and trematodes. The purpose of this study was to determine the relationship between sanitation hygiene and contamination of non-STH worm eggs in fresh vegetables at food stalls in Semarang City. This type of research is an observational study with a cross sectional approach. Based on the results of laboratory tests, from a total of 165 samples examined, eggs of non-STH worms with species of Fasciola sp and Toxocara sp were found in 45 food stalls selling fresh vegetables. Based on bivariate analysis, there was no significant relationship between personal hygiene (p = 0.071) and environmental sanitation (p = 0.334) on contamination of non-STH worm eggs in fresh vegetables in food stalls in Pedurungan District, Semarang.
Kontaminasi Soil Transmitted Helminths (STH) pada Daun Bawang (Allium fistulosum L.) Cahyaningrum, Dwi Ratna; Wikandari, Ririh Jatmi
Jaringan Laboratorium Medis Vol. 4 No. 2 (2022): November 2022
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v4i2.8351

Abstract

Soil Transmitted Helminths (STH) infection is still a health problem in Indonesia. This infection is caused by intestinal nematodes which in its transmission require soil media. Vegetables can be a medium of transmission of STH. STH transmission occurs when the soil is contaminated with STH worm eggs and the worm eggs stick to vegetables. In addition, STH contamination can occur in traditional markets with poor sanitation such as humid rooms, floors with lots of puddles, muddy water, and improper placement of waste. The aim of the study was to describe the contamination of Soil Transmitted Helminths on Scallion (Allium fistulosum L.). This research is a descriptive research, the examination of worm eggs is done by indirect method with sedimentation technique. The research sample was taken from 25 traders. Leeks contaminated with STH as many as 15 (60%) samples from 25 traders. The type of STH found was hookworm rhabditiform larvae. There is STH contamination in leeks sold at the Bangetayu market, Semarang City. To avoid the risk of being infected with STH, people are expected to consume vegetables that have been cooked.
Korelasi Kadar Kolesterol Total dan Tekanan Darah pada Orang Dewasa di Bangetayu Kota Semarang Wikandari, Ririh Jatmi; Purlinda, Devi Etivia; Ichsan, Burhanudin
Jaringan Laboratorium Medis Vol. 5 No. 1 (2023): May 2023
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v5i1.9379

Abstract

Non-communicable diseases (NCDs) are the largest contributor to death in the world. The prevalence of NCDs tends to increase. Hypertension is one of the non-communicable diseases with the largest proportion in Semarang. High cholesterol levels will accumulate in  the arteries, causing the arteries to stiffen, so the heart tries hard to pump blood through these blood vessels, and can cause blood pressure to rise (hypertension). Some risk factors that can increase blood pressure, such as high salt intake, overweight or obesity, alcohol consumption, lack of physical activity, stress and smoking. Lack of physical activity can increase cholesterol levels in the body which is a risk factor for cardiovascular disease (coroner's heart disease dan stroke). Age affects the occurrence of hypertension. With age the risk of developing hypertension is greater. The purpose of the study was to determine the relationship between cholesterol and blood pressure in adults in Bangetayu, Semarang City. This study uses a cross-sectional approach. Research samples are in the community of  Bangetayu Kota Semarang. Research Tools and Materials include lanceolate, alcohol swab, cholesterol strips, digital sphygmomanometers, POCT cholesterol and capillary blood.  Research data obtained from the results of checking cholesterol levels and blood pressure. The results of this study were processed using SPSS 20 software with data analysis using Chi Square (α=5%) and presented descriptively about the relationship of cholesterol levels with blood pressure in adults. The results of statistical analysis show a p-value > 0.05 which means that there is no significant relationship between variables and vice versa. The results showed that there was no relationship between blood pressure and cholesterol.
Faktor-faktor Risiko Kelainan Kadar Hemoglobin pada Pengendara Ojek Motor Online di Kawasan Industri Tanjung Mas Kota Semarang Setyowatiningsih, Lilik; Wikandari, Ririh Jatmi
Jaringan Laboratorium Medis Vol. 5 No. 2 (2023): November 2023
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v5i2.9564

Abstract

Air pollution can affect health conditions, CO and Pb are one of the compositions of vehicle exhaust gases that are dangerous. Online motorcycle taxi drivers have a high risk of exposure to pollutants. This research aims to determine the risk factors that affect hemoglobin levels in online motorcycle taxi drivers in the Tanjung Emas Area of Semarang City. The method used observational analytics with a cross-sectional approach. The total population in this study was 55 respondents and the number of respondents was determined using total sampling. Based on the results of examining hemoglobin levels using a hematology analyzer, of 55 respondents, 47 respondents had normal hemoglobin levels and 8 respondents had abnormal hemoglobin levels. The results of the Chi square test on smoking status have a significant relationship (p=0.04) to the blood hemoglobin level of online motorcycle taxis in the Tanjung Emas Area of Semarang city while in the status of Education, length of work, and knowledge there is no significant relationship (>0.05) to the hemoglobin level of online motorcycle taxi drivers in the Tanjung Emas Area of Semarang City. The conclusion of this study is that there is a significant relationship between smoking status and hemoglobin levels of online motorcycle taxi drivers in the Tanjung Emas Area of Semarang City and there is no significant relationship between education factors, length of work time, and knowledge of hemoglobin levels of online motorcycle taxis in the Tanjung Emas Area of Semarang City.