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Selfi Handayani
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Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Estimation of Stature Using Demispan Length and Femur Length of Students from Faculty of Medicine UNS Surakarta Itsna Ulin Nuha; Selfi Handayani; Zulaika Nur Afifah
Nexus Kedokteran Komunitas Vol 6, No 1 (2017): Nexus Kedokteran Komunitas
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Background: In forensic medicine, identification is often performed in cases of homicide, suicide, bombings, terrorist attacks, wars, plane crashes, road accidents, and natural disasters such as tsunamis, earthquakes and floods. Stature is the linear dimension of a complex anatomy consisting of a skull, vertebral column, pelvis and lower extremities. Overall, the length of the upper and lower leg bones is directly proportionate to the height of the human body. Predictor of demispan length is not influenced by age, is easy to measure without distress while the length of the femur is the best correlation with stature. This study aims to determine the correlation between stature with demispan length and stature to the length of the femur, as well as obtaining stature estimation formula. Methods: This research was an observational analytical study with cross sectional approach. The subjects of this study were 100 students from Faculty of Medicine UNS with a minimal age of 21 years old for male and 20 years old for female. Data was collected by measuring stature, demispan length and femur length. The data was analyzed by Pearson correlation test and simple linear regression test. Results: Data analysis showed a very strong correlation between stature and demipsan length which had value of r=0.903, p<0.05 for right arm and r=0.901, p<0.05 for left arm. There was very strong correlation between stature and femur length with the value of r=0.909, p<0.05 for right foot and r=0.911, p<0.05 for left foot. Simple linear regression analysis obtained stature estimation formula using demispan length and femur length. Conclusions: There are correlation between stature and demispan length, and also stature and femur length. Both of those independent variables could obtain stature estimation formula. Keywords: estimation of stature; demispan length; femur length
The Correlation between Physical Activity and Working Memory Capacity on Medical Student of Sebelas Maret University Hernowo Setyo Utomo; Selfi Handayani; Nanang Wiyono
Nexus Kedokteran Komunitas Vol 5, No 2 (2016): Nexus Kedokteran Komunitas
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: Physical activity affects brain structure and function through 3 common mechanisms: angiogenesis; neurogenesis; and regulation of neurotrophic factors. Working memory capacity is one aspect of brain function describing human intelligent which is affected by the structure and function of the brain. The aim of research was to prove that physical activity could affect working memory capacity. Methods: This research was a cross-sectional observational analytic. It had been done at Medical Faculty of Sebelas Maret University on July, 2014. The data was collected by using purposive sampling method. All responden had to fill questionnaire of Lie Scale Minnesota Multiphasic Personality Inventory (L-MMPI) in order to know the honesty level, International Physical Activity Questionnaire (IPAQ) to measure the level of physical activity during a week and reading span test to measure working memory capacity. The final result of restricted samples was 105. The data was analyzed by Spearman Correlation Test. Results: IPAQ score showed that 15.24% samples were in low level physical activity, 50.47% were in medium level physical activity, and 34.29% were in high level physical activity. Reading span test result were 93.33% samples were in high working memory capacity and the other 6.67% were in low working memory capacity. Both variables then examined by Spearman correlation test with p result 0.441 and r = -0.076 Conclusions: There is unsignificant statistic correlation between physical activity and working memory capacity on Medical Student of Sebelas Maret University Keywords: physical activity, working memory capacity, medical student
Pengaruh Elektroakupuntur Titik Weishu (BL 21) dan Zusanli (ST 36) terhadap Perbaikan Mukosa Pylorus Tikus yang Dipapar Bising Intermittent Paksi Suryo Bawono; . Balgis; Selfi Handayani
Nexus Biomedika Vol 3, No 1 (2014): Nexus Biomedika
Publisher : Nexus Biomedika

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Background: Noise is a stressor which can negatively effect to the body.Intermittent noise will give more influence to stomach, namely in the form of an increase in the production of stomach acid that interferes with the mechanism of gastric cytoprotection. Electro-acupuncture on Weishu (BL 21) and Zusanli (ST 36) acupoints has potential to repair damaged mucosal pylorus due to noisy stress.This research aimed to knowthe influence of electro-acupuncture on Weishu (BL 21) and Zusanli (ST 36)acupoints against pyloric mucosal repair of rats exposed to intermittent noise. Methods: This study was laboratory experimental group post-test only designs. Subjects were Rattus norvegicus with inclusion criteria male, Wistar strain, weight 250-300 g, and 2 months old. Subjects were randomly drawn 28 rats, divided into: Group K (control), P1(no time to recover and no electro-acupuncture stimulation), P2 (given time to recover naturally for 30 days) and P3 (stimulated with electro-acupuncture). After adapted for 7 days all subjects of the groups, except group K, were exposed to intermittent noise at 95 dB with one-hour exposure settings, one-hour break for 12 hours within 14 days. Stimulation on Weishu acupoint (BL 21) was conducted at 2-3mA, 1ms duration, 50Hz frequency for 15min, 3mm pierced into the skin. While Stimulation on Zusanli accupoint ( ST 36 ) was done at 2-3mA with 0.5ms duration at 4Hz frequencies for 20min, plugging 3mm into the skin. Next day, all of the subjects were sacrificed by cervical dislocation. Pylorus were taken and histological preparations were made by HE staining. The results were assessed with the Barthel index. Henceforth, the data obtained were tested by statistical tests One Way ANOVA ( ? = 0.05 ) followed by LSD . Results: Based on statistics analysis, there was a significant difference between the groups K-P1, K- P2, K-P3, P1-P2 and P1-P3. In contrast, there was no significant difference between P2 and P3. Conclusion: There was not statistically proven effects ofWeishu point electro-acupuncture (BL 21) and Zusanli (ST 36)against gastric mucosa repair rat intermittent noise, but when seen in the data were the result of a decrease in the degree of mucosal damage. Keywords: Electro-acupunctur Weishu (BL 21) and Zusanli (ST 36) acupoints , intermittent noise , pylorus
Pengaruh Elektroakupunktur Titik Zusanli (ST 36) dan Zhongwan (CV 12) terhadap Perbaikan Gambaran Histologis Duodenum Tikus Putih (Rattus norvegicus) yang Terpapar Bising Intermitten Nur Dwi Fajarini; . Balgis; Selfi Handayani
Nexus Biomedika Vol 3, No 1 (2014): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Background: Intermittent noise can induce stress that stimulates HPA axis to cause damage of duodenum. Acupuncture has already indicated to treat duodenal ulcer. This research studied the effect of electroacupuncture of Zusanli (ST 36) and Zhongwan (CV 12) acupoints to repair histological structure of white rat (Rattus norvegicus) duodenum exposed by intermittent noise. Methods: This was laboratory experimental research with the post test only controlled group design. Subjects were 28 male white rats (Rattus norvegicus), wistar strain, divided into 4 groups randomly. They were control group (K) which was not treated, experimental group 1 (P1) exposed by noise, experimental group 2 (P2) exposed by noise and allowed to have physiologic recovery for 30 days, and experimental group 3 (P3) exposed by noise and treated with electroacupuncture for 30 days. Noise exposure was conducted for 2 weeks with intensity of 95 dB intermittently, 1 hour on, 1 hour off, for 12 hours daily. Electroacupuncture was done by pricking acupuncture needle perpendicularly at Zusanli (ST 36) and Zhongwan (CV 12) acupoints, then, connected to 2 mA electrostimulation at 10 Hz continuous wave for 15 minutes, 10 times for therapy. At the end of experiment their duodenums were taken and prepared for histological study by paraffin block method and stained with Hematoxillin Eosin (HE). The histological structure of duodenal mucosa was observed and assessed for the damage with Barthel Manja mucosal integrity score. The data were analized by One-Way ANOVA test (?=0.05) and continued by Post Hoc Multiple Comparisons using Least Significant Differences (LSD) test (?=0.05). Results: One Way Anova test showed significant differences of duodenal mucosa damage among the four groups p=0.000. LSD test showed significant differences between K-P1 (p=0.000), K-P2 (p=0.000), K-P3 (p=0.000), P1-P2 (p=0.007), P2-P3 (p=0.000), but not between P1-P3 (p=0.235). Conclusions: Electroacupuncture of Zusanli (ST 36) and Zhongwan (CV 12) acupoints repaired histological structure of white rat (Rattus norvegicus) duodenum exposed by intermittent noise. Keywords: Intermittent noise, Electroacupuncture, Zusanli and Zhongwan acupoints, Duodenum
Perbedaan Rasio Rentang Lengan-Tinggi Badan pada Mahasiswa Laki-laki dan Perempuan FK Universitas Sebelas Maret Annisa Budiastuti; Selfi Handayani; Hardjono .
Nexus Biomedika Vol 1, No 2 (2012): Nexus Biomedika
Publisher : Nexus Biomedika

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Background: Height is an important clinical indicator to derive Body Mass Index (BMI) and also to estimate Basal Metabolic Rate (BMR). However, height measurement in someone who cannot stand properly like the elderly or lower ekstremity abnormality may become difficult. Therefore, estimating height with another antropometric measurement may become a solution. In another study, arm span showed the highest correlation with standing height. The different morfologic between male and female also important to find the different estimating height formula. Objectives: This research aimed to know arm span to height ratio data in students from Medicine Faculty 2008 of Sebelas Maret University and the differences of arm span to height ratio between male and female. Methods: This research was an analytical observational research with cross sectional approach. The sample data collected using purposive sampling method within inclusion and exclusion criteria. From the population, 60 samples (30 males and 30 females) chose by simple random sampling method, then measured their height and arm span. Height measured in anatomical position using microtoise staturmeter. Arm span measured using ruler tape from the longest finger in right hand to the longest finger in left hand. All data analyzed using normality test Kolmogorov-Smirnov and followed with t-independent test if the distribution data showed normal. Results : T-independent test result p = 0.03 (p < 0.05). Conclusion: This study found a difference in arm span to height ratio between male and female students in Faculty of Medicine 2008, Sebelas Maret University, Surakarta Keywords: arm span, height, anthropometric measurement, student
Efek Pemberian Sari Buah Belimbing Manis (Averrhoa carambola Linn.)terhadap Kerusakan Histologis Hepar Tikus Putih(Rattus norvegicus) yang Diinduksi Parasetamol Handayani Putri Cahyaningrum; Endang Listyaningsih; Selfi Handayani
Nexus Biomedika Vol 2, No 1 (2013): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Background: Star fruit (Averrhoa carambola Linn.) juice contains flavonoids, epicatechins, proanthocyanidins, and tanins that can protect liver from free radicals. The objectives of this research were to know the effect of star fruit (Averrhoa carambola Linn.) juice to liver histological damage of albino rat induced by paracetamol. Methods: This was laboratory experimental research with post test only controlled group design. Samples were 28 male rats from Wistar type, 2-3 months old and + 200 g of each weight. Samples were divided into 4 groups of 7 rats each. Sampling technique used in this research was incidental sampling. The control group (K) and the first treatment group (P1), rats were administered aquadest for 14 days. The second treatment group (P2), rats were administered star fruits juice with the concentration of 50% 2ml/200 g body weight of rat and the third group (P3), rats were administered star fruits juice with the concentration of 100% 2ml/200 g body weight of rat for 14 days. Paracetamol was administered to groups of P1, P2, and P3 on the 12th, 13th, and 14th day. On the 15th day, rats were sacrificed and their livers were made for preparation with paraffin block method which were stained HE. Liver histological features were assessed based on quantifying of pyknosis, karyorhexis, and karyolysis. Data were analyzed using the One-Way ANOVA test (? = 0.05) and continued with Post Hoc Multiple Comparisons (LSD) test (? = 0.05). Results: Statistically, the One-Way ANOVA test showed that there were significant differences of liver damage score between K P1, K P2, K P3, P1 P2, P1 P3, and P2 P3. Conclusion: Star fruit juice decreased the liver histological damage of albino rat (Rattus norvegicus) induced by paracetamol. Key words: star fruit juice, paracetamol, liver histological damage, albino rat
Relationship Between Dermatoglyphic Patterns and ?-Thalassemia Major Disease Nisa&#039;u Luthfi Nur Azizah; Selfi Handayani; Nanang Wiyono
Nexus Kedokteran Translasional Vol 4, No 2 (2015): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: ?-Thalassemia major is the most common severe thalassemic disease in the world. Children with ?-Thalassemia major have to be identified and treated soon to prevent the worse prognosis of the disease. One of the screening methods to establish thalassemic diagnosis is by observing dermatoglyphic patterns. The aim of this study was to determine the relationship between dermatoglyphic patterns and ?-Thalassemia major disease. Methods: This study was an observational analytic study with cross sectional design. This study located in Poliklinik Anak and SMF Anak RSUD Dr. Moewardi Surakarta. The sampling technique used purposive sampling based on the characteristics of population that have been known previously. The subjects were 20 patients of ?-Thalassemia major and 20 non- ?-Thalassemia major. Data were obtained through direct scanning the subjects fingerprints using scanner. Statistical analysis used independent-sample t test, Mann-Whitney test and chi square test. Results: From the analysis, this study found there was no significant difference of the ridge count between patients and control group (p > 0.05). However, there was significant difference of the patterns between patients and control group (p < 0.05). The number of whorl patterns in ?-Thalassemia major patients was 53,5%, it greater than that in normal individuals (20,5%). Loop patterns were less frequent in ?-Thalassemia major patients (34%) compared to normal individuals (75,5%). Arch patterns had no significant difference between patients and control group (p > 0.05). Conclusions: There was a significant relationship between dermatoglyphic patterns and ?-Thalassemia major disease. Keywords: ?-thalassemia major, dermatoglyphic, fingerprint
Electroacupuncture attenuates working memory impairement after chronic stress exposure in rat Selfi Handayani; Nanang Wiyono
JURNAL KEDOKTERAN DAN KESEHATAN Vol 4, No 3 (2017)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Abstract

Chronic stress (CS) exposure causes cytogenic and structural changes in the hipocampus which lead to cognitive impairment. Acupuncture has been shown to reduce cortisol secretion and protects hipocampus from stress-related damage. We hypothesize that acupunture can alleviate stress-induced working memory deficit.mthis study aimed to investigate whether electroacupuncture (EA) can improve memory in chronic stress model in rat. This was an experimental study with pretest and postest control group design. Rats were divided randomly into four groups: control group (C), CS group (T1), EA group (T2), and EA plus CS group (T3). Working memory was assessed using Eight-arm radial maze. A marked decrease in working memory was observed in the CS group demonstrated by more working memory correct errors (p=0.020) and incorrect errors (p=0.024) than control group. The CS plus EA rats made fewer working memory correct error (p=0.001) and incorrect error (p=0.000) compared to the CS only group. EA treatment in non-stressed rats did not significantly improve working memory compared to control. Chronic stress decreases working memory in rats. EA treatment at Baihui (DU 20) and Zusanli (ST 36) significantly attenuates stress induced working memory deficits in rats.
Correlation between Forced Vital Capacity and Hemoglobin to VO2 Maximum on People with Yoga Practice Maria Mumtaz; Kiyatno .; Selfi Handayani
Nexus Kedokteran Komunitas Vol 5, No 1 (2016): Nexus Kedokteran Komunitas
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: Yoga is one of sport which affect VO2 maximum. The research objective was to determine the relationship between Forced Vital Capacity and hemoglobin to VO2 maximum on people with Yoga practice. This research also concern on comparing the contribution of Forced Vital Capacity and Hemoglobin value in affecting VO2 maximum. Methods: Thisresearch was a cross-sectional observational analytic. It had been done at Ganep Yoga and Ester Yoga on June to August, 2014. Population are all woman who practice Yoga in Ganep and Ester Yoga. The data were collected by using random sampling method. All responden had to fill informed concern and question related to their health condition. Forced vital capacity was measured with spirometer. VO2 maximum was measured with step-up test. Hemoglobin was measured with EasyTouch Hemoglobin Meter. The data were analized by Pearson Correlation test and Regresion test with Statistical Product and Service Solution (SPSS) 20.0. Results: There were relation between Forced Vital Capacity and VO2 maximum with r= 0,836 and contribution = 69,88%. There were relation between hemoglobin and VO2maximum with r= 0,883 and contribution = 77,96%. Significance value of VO2 maximum based on Forced Vital Capacity is 0,184 and VO2 maximum based on hemoglobin is 0,155. R value of Regression test in this study is 0,926, this means there is strong relationship between Forced Vital Capacity and hemoglobin to VO2 maximum. Both variable were examined using Pearson correlation test with p result < 0,05. Conclusions: There is a strong positive and significant statistic correlation between Forced Vital Capacity and hemoglobin to VO2 maximum on People who do Yoga practice. Keywords: Forced Vital Capacity, hemoglobin, VO2 maximum, Yoga
Efek Nefroprotektor Ekstrak Daun Kemangi (Ocimum sanctum) Terhadap Kerusakan Sel Ginjal Mencit (Mus musculus) Yang Diinduksi Parasetamol M Abdul Basith; Endang Listyaningsih; Selfi Handayani
Nexus Biomedika Vol 1, No 2 (2012): Nexus Biomedika
Publisher : Nexus Biomedika

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Background: Today, consuming paracetamol as an analgesic antipyretic drugs has increased. Paracetamol which used in inappropriate dose has bad effect to our body, such as nefrotoxic. Basil leaf extract has antioxidant as a protection of free radicals and reducing NAPQI which produced by paracetamol. The objectives of this research are to know the nefroprotector effect and this research will shown the multilevel dose of basil leaf extract as a nefroprotector in the renal cell damage induced by parasetamol. Methods: This was experimental laboratory with the post test only controlled group design. Sample group consisted of male mice Swiss Webster, 2-3 month, + 20 g. Samples divided into 4 groups, each group has seven mice. Mice for control group (K) and the first treatment group (P1) were given aquades for 14 days. The second treatment group (P2) will be given basil leaf extract dose I for 14 days. The third treatment group (P3) will be given basil leaf extract dose II for 14 days. Paracetamol will be given to P1, P2, and P3, with dose 0,1 ml/20 gr weight of mice on the day 12, 13, and 14. Finally on day 15th, mice are sacrificed with neck dislocation then the renal of mice was made preparations with paraffin blocks methods and Hematoxillin Eosin staining. Renal cell damage observed and counted a mount of scored on renal histological karyopyknosis, karyorrhexis, and karyolysis. Data are analized by One-Way ANOVA test (?= 0,05) and continued by Post Hoc Multiple Comparisons test (LSD) (? = 0,05). Results: Result of One-Way ANOVA shown that there was a significant of degree between 4 groups. Result of LSD method there was a significant of degree between K-P1, K-P2, P1-P2, and P1-P3 groups; and also it wasnt a significant of degree between K-P3 and P2-P3. Conclusions: The basil leaf extracts was able to decrease the renal cell damaging of mice and the increase of basil leaf extracts dose followed by the increase of protection effect to the renal cell damaging of mice which is induced by paracetamol. Keywords: basil leaf extract, paracetamol, renal cell damage.
Co-Authors . Balgis . Muthmainah . Muthmainah Agus Sugeng Riyanto Agustina Wulandari Ahmad Isnaini Shidqi Nurhani Annisa Aghnia Rahma Annisa Budiastuti Arif Setyoko Arpin, Wilson Asyiraq, Muhammad Ferdy Balgis . Balgis Balgis Betty Saptiwi Betty Saptiwi Budiyanti, Novita Danus Hermawan Dhoni Akbar Ghozali Diniyati, Hilda Dono Indarto Dwi rahayu Dyah Ratna Budiani Endang Listyaningsih Endang listyaningsih Endang Listyaningsih Enrico Ananda Budiono Fara Ayu Febyawati, Hani Gozali, Dhoni Akbar Handayani Putri Cahyaningrum Harahap, Aletta Khaerunnisa Putri Hardjono . Hastami, Yunia Hernowo Setyo Utomo Ida Nurwati Itsna Ulin Nuha Jarot Subandono Kiyatno . kusnandar kusnandar Kusuma, Pranata Aji Lukman Aryoseto M Abdul Basith Maria Mumtaz Martini Martini Muhammad Afif Muhammad Luthfiyanto Muhammad Syauqi Ridhallah Muhana Fawwazy Ilyas Muthmainah Muthmainah Nanang Wiyono Nisa&#039;u Luthfi Nur Azizah Nur Dwi Fajarini Paksi Suryo Bawono Raditya Perdana Aryasatya Reflioni, Silvi Risya Cilmiaty Risya Cilmiaty A. R. Rosyadah, Prima Aprilia Sarsono Sarsono Siti Marufah Siti Munawaroh Siti Munawaroh slamet Riyadi Slamet Riyadi Susanti, Widia Syania Shabrina Widia Susanti Yundari, Yundari