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Peran Kadar Hormon Estrogen pada Perempuan Obesitas Sebagai Faktor Terganggunya Siklus Menstruasi Hasvia Berliani; Desmawati Desmawati; Bobby Indra Utama
Majalah Kedokteran Andalas Vol 46, No 2 (2023): Online April 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i2.p428-435.2023

Abstract

Objectives: This study aims to determine the role of estrogen hormone levels in obese women as a factor in disrupting the menstrual cycle. Method: This Systematic Literature Review is based on articles from journals obtained through Pubmed, Science Direct and Google Scholar searches, referring to the topics that have been determined. The research articles used were selected with inclusion and exclusion criteria. Result: Obesity has a detrimental effect on the human body, including reproductive health. In particular, obese women are disturbed by the pituitary-ovarian-hypothalamic axis and often suffer from menstrual dysfunction leading to anovulation and infertility. Women with high levels of fat in their bodies will affect the hormone estrogen because apart from the ovaries, estrogen will also be produced by adipose tissue, making estrogen abnormal and tend to be high. This unbalanced hormone production can cause disturbances in the menstrual cycle. Conclusion: High estrogen levels cause the feedback to FSH to be disrupted so that it does not reach peak levels and interferes with follicle growth which causes the prolongation of the menstrual cycle (Oligomenrhea).
Kehamilan Dengan Kanker Paru Mikhail Nurhari; Bobby Indra Utama
Majalah Kedokteran Indonesia Vol 68 No 10 (2018): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, V
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.68.10-2018-214

Abstract

Background: Pulmonary cancer is the most prevalent malignancy in the world. Management of cancer in pregnancy creates a dilemma. Patients who choose to continue her pregnancy have to delay her cancer treatment in order to protect the fetus.Objectives: To review the case of pulmonary cancer in pregnancy presented in M. Djamil Central General Hospital Padang.Case: A 24-year-old woman came to the M. Djamil Central General Hospital Padang on September 12th 2017 with diagnosis of G2P1A0L1 37-38 weeks of term pregnancy + history of previous CS + Pulmonary Cancer. Patients have been diagnosed with Pulmonary Cancer based on bronchoscopy. Chemotherapy was initially planned for 9 times, but after the third chemotherapy the patient was known to be pregnant. Patient was encouraged to terminate her pregnancy but the patient refused and chose to continue the pregnancy.Conclusions: Pregnancy with Pulmonary cancer raises its own problems in its management. Practitioners must provide optimal treatment for the mother while protecting the fetus.
Obstructed Hemivagina and Ipsilateral Renal Anomaly (OHVIRA): Case report Bobby Indra Utama; Poldo Reinaldo; Puspita Sari
Andalas Obstetrics And Gynecology Journal Vol. 6 No. 2 (2022)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.6.2.173-178.2022

Abstract

Background: Hemivaginal obstruction syndrome and ipsilateral renal anomalies are known as Herlyn-Werner-Wunderlich syndrome (HWWs) or better known by the acronym OHVIRA (Obstructed Hemivagina and Ipsilasteral Renal Anomaly). It occurs as a result of complete failure of the Müllerian ducts to fuse and accounts for about 5% of Müllerian duct anomalies. Initial manifestations usually appear as a result of secretions accumulating within the hemivaginal obstruction. Patients with HWWs can come with complaints of lower abdominal pain, severe dysmenorrhea, pelvic or vaginal mass, abnormal vaginal discharge, acute urinary retention, fever or vomiting. Therefore, careful diagnosis and appropriate management of this condition is desirable. The objective of the study was to report on the management of the obstruction due to HWWs. Case Report: A 12-year-old patient was admitted to the gynecology ward of Dr. M. Djamil Central General Hospital from polyclinic with abdominal pain since 4 months before being admitted to the hospital. The pain gets worse every day before menstruation and decreases when given painkillers. Bleeding from the vagina often recurs with blackish color, a little smelly since the 1 month ago. Conclusion: OHVIRA syndrome is a triad characterized by hemivaginal obstruction and agenesis of the ipsilateral kidney (OHVIRA) and uterus in the delphys. Clinical symptoms in general are cyclic dysmenorrhea, palpable mass due to accumulation of menstrual flow, and severe pelvic pain which can later develop into a persistent form as a result of prolonged retention of menstrual secretions, obstructed hemivagina. Management options are surgical resection of the obstructed vaginal septum and drainage.
Correlation Of Perineal Rupture With Women's Quality Of Life Post-Vaginal Delivery Ayu Anissa Bahri; Bobby Indra Utama; Hafni Bachtiar
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (333.226 KB) | DOI: 10.36418/syntax-literate.v7i5.6949

Abstract

Background: Perineal rupture are the second cause of postpartum hemorrhage that can occur in almost every vaginal delivery. According to WHO (2011), almost 90% of vaginal deliveries experience perineal tears, with or without an episiotomy. This situation contributes to the emergence of complaints of pelvic floor dysfunction in the future, resulting in a decrease in the quality of life both emotionally and physically in women. To assess, classify, and treat pelvic floor dysfunction, the Pelvic Floor Distress Inventory Index-20 can be used. This study aims to determine the relationship between perineal rupture and women's quality of life after vaginal delivery based on the Pelvic Floor Distress Inventory-20 (PFDI-20) score. This study was comparative cross sectional. The study was conducted at the Network Hospital of Obstetrics & Gynecology Residency Program, Medical Faculty of Andalas University, started from August 2020 until the number of samples is met. The sample of this study was 96 post-vaginal women who were selected by consecutive sampling, ie 48 respondents with vaginal delivery with perineal rupture and 48 respondents without perineal rupture. Quality of life was measured through interviews with the PFDI-20 questionnaire and perineal rupture were grouped from medical record data. Data were analyzed using chi-square test. The average age of the research respondents was 29.34 ± 5.91 years with the youngest age being 18 years. Most of the respondents were mutiparaous (70.%) with the highest degree of perineal rupture was grade 2. Most of the respondents (70.8%) felt that their quality of life was disturbed. Statistically, there was a significant relationship between perineal rupture and women's quality of life after vaginal delivery (p < 0.05). In Conclusion, there was a significant relationship.
Pengaruh Kadar Vitamin D dan Tumor Necrosis Factor Alpha terhadap Kehamilan Normal Trimester 1 dan Abortus Spontan Olivia Oktaviani Prastiwi; Bobby Indra Utama
Andalas Obstetrics And Gynecology Journal Vol. 7 No. 2 (2023)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.7.2.391-404.2023

Abstract

Latar Belakang: Abortus masih merupakan masalah besar dalam pelayanan obstetri karena merupakan salah satu penyebab kematian ibu dan janin sampai saat ini. Kekurangan vitamin D mempengaruhi kehamilan dan dapat berdampak terhadap risiko komplikasi pada ibu hamil dan pada pertumbuhan janin. Tumor necrosis factor-alpha (TNF-α) adalah sitokin Th1 multifungsi dan sangat penting untuk kontrol awal kejadian abortus. Tujuan penelitian ini melihat apakah terdapat perbedaan kadar vitamin D, dan TNF-α pada pasien kehamilan normal trimester 1 dan pasien dengan kejadian abortus.Metode: Desain penelitian adalah potong-lintang. Penelitian ini dilakukan pada Maret 2022 hingga selesai penelitian di Poliklinik Obstetri dan Ginekologi, PONEK RSUP Dr. M. Djamil Padang, Rumah Sakit Universitas Andalas, Rumah Sakit dr. Reksodiwiryo Padang, RSUD M Zein Painan, RSUD Pariaman untuk pengambilan sampel darah. Pemeriksaan kadar 1,25 dihidroksi vitamin D3, TNF-α serum maternal dilakukan di Laboratorium Biomedik Universitas Andalas Padang. Sampel penelitian ini adalah seluruh ibu hamil trimester 1 dan ibu dengan abortus berjumlah 44 orang. Teknik pengambilan sampel dengan consecutive sampling. Analisis data univariat dan bivariat dengan menggunakan uji T-independen (p<0,05) pada taraf signifikansi dan uji Mann-whitney berdasarkan distribusi data. Hasil: primipara lebih banyak pada kehamilan normal yaitu 19 orang (86,4%) dan abortus paritas multipara lebih banyak yaitu 12 orang (54,5%). Rerata kadar serum 1,25 dihidroksi vitamin D3 sebesar 52,81 ng/ml dan rerata kadar TNF-α sebesar 351,07 ng/ml. Terdapat perbedaan bermakna pada kadar 1,25 dihidroksi vitamin D3 antara kehamilan normal dengan kehamilan abortus dengan p value 0,047. Perbedaan kadar TNF-α antara abortus dan kehamilan normal didapatkan p value 0,108.Kesimpulan: Terdapat perbedaan bermakna pada kadar vitamin D antara kehamilan normal dengan kehamilan abortus. Tidak terdapat perbedaan bermakna pada kadar TNF-α antara kehamilan abortus dengan kehamilan normal.
Skene Duct Cyst in Childhood: A Case Report Agung Wijaya Kusuma; Bobby Indra Utama; Yulia Margaretta Sari
Andalas Obstetrics And Gynecology Journal Vol. 7 No. 2 (2023)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.7.2.446-452.2023

Abstract

Introduction. Vaginal cysts are uncommon and may be either congenital or acquired. the most common vaginal cysts is a urothelial cyst or a paraurethral cyst. With an incidence of 1 in every 2000–7000 live births, paraurethral cysts are an uncommon cause of interlabial mass in newborns and account for less than 0.5 per cent of all congenital urinary system anomalies. Study Purpose. This report describes a rare Vaginal cyst in a child at the posterior vaginal wall.. Results.this is a case report study about a girl 1-year-8-months old with vaginal cyst since the age of 2 months. Physical examination and ultrasound finding revealed a cystic mass size 3x3x1 cm in posterolateral of the right vaginal wall extended to right periurethral. Management of this case was extirpation of the vaginal cyst.Conclusion. A vaginal cyst is an uncommon case in a child. Vaginal cysts have several possible etiologies, such as possibly embryological origin, ectopic inclusion tissue or possibly due to urological abnormalities. Diagnosis requires a thorough understanding of diagnostic possibilities and a systematic evaluation. This patient has been treated with surgical excision due to a high success rate.
Mayer-Rokitansky-Küster-Hauser syndrome Arga Kafi Perdana Kusuma; Bobby Indra Utama
Andalas Obstetrics And Gynecology Journal Vol. 7 No. 2 (2023)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.7.2.488-494.2023

Abstract

Mayer–Rokitansky–Küster–Hauser syndrome (MRKH) is a syndrome characterized by uterine, cervix, and the two third of upper vagina aplasia which is the cause of incomplete development of the Müllerian duct. Reported a case of woman 28 years old, patient has not menstruated until now. The phenotype of the patient appears to be female, and with normal stature. Breast, axilla dan pubic hair distribution, fatty in buttocks and thigh developed normally. Fallopian tubes, uterine and 2/3 upper part of vagina were not formed. On gynecological clinical examination, found vaginal introitus with a vaginal sonde was 2 cm. On abdominal ultrasound examination, the uterus was seen as a line, right ovary measuring 2.93 x 2.59 cm and left ovary measuring 2.52 x 2.28 cm. The patient then underwent a diagnostic laparoscopic procedure, and found both right and left ovaries within normal limits, intact tubes, but no uterus was visible. Patient are planned for vaginoplasty.
Hematometra Ec Stenosis Of The Cervix Of The Uterus: A Case Report Yenny Mayang Sari; Bobby Indra Utama
Andalas Obstetrics And Gynecology Journal Vol. 7 No. 2 (2023)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.7.2.460-466.2023

Abstract

Background : Cervical stenosis has been defined as a narrowing of the endocervical canal preventing passage of a 2.5-mm Hegar or Pratt dilator. Stenosis of the external cervical os has been described as an external os diameter of less than 4.5mm. Symptoms of cervical stenosis are dependent on the degree of endocervical canal obstruction and the patient's menopausal status. Those patients with severe or complete obstruction of the endocervical canal can experience hematometra with scant or sporadic menstrual flow, amenorrhea, dysmenorrhea, chronic pelvic pain, and infertility.Case Report : A 16-year-old woman was consulted from Pediatric with cervix stenosis with haematometra wich had been noticed since a month ago. Menarche at the age 13 years, regular and slightly pain menstruation every month. The result of MRI examination represented bilateral hematometra and hematocolpos ec suspected cervical stenosis. The management of this case was cervical dilatation and cervical tube installation. Conclusion : Cervical stenosis is a caused of menstrual complaint which is characterized by slightly pain while menstruation, hematometra and hematocolpos. 
Relationship between Serum Magnesium Status and the Incidence of Preeclampsia at 8 Padang Primary Health Care Hifzhillah Fajriati; Bobby Indra Utama; Nurhayati Nurhayati
Andalas Obstetrics And Gynecology Journal Vol. 8 No. 1 (2024)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.8.1.592-598.2024

Abstract

Introduction: Preeclampsia is one of the main causes of maternal morbidity and mortality, with its etiology and pathophysiology not fully understood. Several studies have shown that magnesium plays an important role in preeclampsia. Magnesium plays a role in modulating endothelial function. Decreased serum magnesium levels in pregnancy can trigger endothelial dysfunction that has an impact on the occurrence of preeclampsia.Objective: Determine the relationship between serum magnesium status with incidence of preeclampsia in pregnant women at 8 Padang Primary Health Care.Method: An observational analytic with cross-sectional design. Sampling was carried out using total sampling technique from research master data at 8 Padang Primary Health Care for period June 2019 – May 2020. The total sample was 45 pregnant women who met the inclusion and exclusion criteria. Data were analyzed using Fisher’s.Result: The serum magnesium status of pregnant women in the 8 Padang Primary Health Care was dominated by normal serum magnesium status (91.1%) and only 8.9% of pregnant women had preeclampsia. Fisher’s test showed that there was a significant relationship between serum magnesium status and the incidence of preeclampsia (p-value = 0,034).Conclusion: There is a significant relationship between serum magnesium status and preeclampsia (with overlook the factors of previous preeclampsia history, family history of preeclampsia, and magnesium intake during pregnancy). Hypomagnesemia status in pregnant women can exacerbate the occurrence of preeclampsia.
DIFFERENCES OF FIBRONECTIN LEVELS IN FIRST TRIMESTER NORMAL PREGNANCY AND MISCARRIAGE Maisarah Fadhilah; Bobby Indra Utama; Tofrizal Tofrizal
Andalas Obstetrics And Gynecology Journal Vol. 8 No. 1 (2024)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.8.1.647-652.2024

Abstract

Introduction: Miscarriage is a reflection of the low quality of health in pregnant women. The incidence of miscarriage in the world accounts for 23 million (15%) of the 130 million births per year and up to 80% of miscarriages occur in the first trimester of pregnancy. Miscarriage will affect a woman's social, physical, and psychological. The complexity of the negative impact of miscarriage makes it necessary to pay special attention. Biomarker examination is needed to more accurately identify pregnancies at risk of miscarriage before the appearance of clinical symptoms. The use of fetal fibronectin (fFN) levels have been used as a marker of unexpected labor and as evidence of premature rupture of the fetal membranes. Normally fFN can be detected in cervical and vaginal secretions at <20 weeks gestation. The presence of fFN at >22 weeks gestation indicates disruption of the uteroplacental surface. Therefore, if screening for fibronectin levels using the Enzyme-Linked Immunosorbent Assay (ELISA) test can be carried out in the first trimester of pregnancy, there is a high possibility that miscarriage can be prevented.Method: The type of research is analytical observational research with a cross-sectional research design. The stored samples were examined for fibronectin levels using the ELISA test, which included 21 blood serum samples from normal pregnancy patients in the first trimester and 21 miscarriage samples.Results: The results of the ELISA test produced an average first-trimester normal pregnancy fibronectin level of 118.8 ± 18.4 ng/mL while the miscarriage fibronectin level was 208.2 ± 152.0 ng/mL. Data analysis using the Mann-Whitney test obtained a p-value = 0.138, which means there was no significant difference in fibronectin levels between normal pregnancy in the first trimester and miscarriage.Conclusion: This study concludes that fibronectin levels are not specific biomarkers in detecting miscarriage in the first trimester of pregnancy.
Co-Authors Afkara Husna Firdanisa Afriwardi Afriwardi Agung Wijaya Kusuma Almurdi Almurdi Andani Eka Putra Anggra Pramana Arga Kafi Perdana Kusuma Ari Fuad Fajri Aswiyanti Asri Aswiyanti Asri Ayu Anissa Bahri Berriandi Arwan Cintya Andriani Citra Ayu Fitrisia Daan Khambri Desmawati Desmawati Dessy Arisanti Dessy Arisanti Dia Rofinda, Zelly Dia Dian Pertiwi Dian Pertiwi Dio Jainata Elmatris Sy Endrinaldi Endrinaldi Endrinaldi Erda Mutiara Halida Ermawati Ermawati Ester Pakpahan Fauzan F Ferdinal Ferry Fika Tri Anggraini Fiona Dewanti Firdawati Firdawati Firdawati Fitrayeni Fitrayeni Fitrayeni Hafni Bachtiar Hafni Bachtiar Hafni Bachtiar Hafni Bachtiar Hardisman Hasmiwati Hasni Kemala Sari Hasvia Berliani Helmizar Herti Marni Hifzhillah Fajriati Hovlanta Pidingan Hudila Rifa Karmia Hudilla Rifa Karmia Husna Yetti Ichsan Arif Intan Julianingsih Irya, Nada Amelinda Jonas Hansel Tarigan Joserizal Serudji Julizar Julizar Julizar Nazar Laila laila Lini Gustini Maisarah Fadhilah Masrul Meilinda, Agus Mikhail Nurhari Mikhail Nurhari Mikhail Nurhari Mohamad Reza Mohamad Reza Muhammad Iqbal Muhammad Iqbal Muhammad Rudi Setiawan Muhammad Ryfki SA Muhammad Syauqie Nada Amelinda Irya Nanda Tri Martha Nindrea, Ricvan Dana Nissa Prima Sari Nur Indrawati Lipoeto Nur Indrawaty Lipoeto Nur Indrawaty Lipoeto Nurhayani Fatimah Nurhayati, Nurhayati Olivia Oktaviani Prastiwi Poldo Reinaldo Puspita Sari Rafi Yasnova Ranne Balqis Rauza Sukma Rita Rena Regina Erwin Reyhan Julio Azwan Reyhan Julio azwan Reyhan Julio Azwan Rimbun Wahyu Gumilar Rizanda Machmud Rizky Rivonda Bennovry Roslaili Rasyid Susila Sastri Syahredi SA Syamel Muhammad Tofrizal Tofrizal Vaulinne Basyir Widayat Widayat Yanti, Roza Sri Yenny Mayang Sari Yessi Widya Putri Yolanda Syahdia Yulia Margaretta Sari Yulia Margaretta Sari Yuniar Lestari Yusrawati Yusrawati Zelly Dia Rofinda