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All Journal Jurnal Periodic Jurusan Kimia UNP Jurnal Konseling dan Pendidikan KOVALEN: Jurnal Riset Kimia Jurnal Penelitian Pendidikan IPA (JPPIPA) Sains Natural: Journal of Biology and Chemistry JURNAL PENDIDIKAN TAMBUSAI FONDATIA EDUKATIF : JURNAL ILMU PENDIDIKAN JURNAL PENDIDIKAN MIPA Pelita Eksakta Jurnal Paedagogy Edunesia : jurnal Ilmiah Pendidikan Edukimia Hydrogen: Jurnal Kependidikan Kimia Jurnal Simki Pedagogia Afeksi: Jurnal Penelitian dan Evaluasi Pendidikan Jurnal Pijar MIPA Prisma Sains: Jurnal Pengkajian Ilmu dan Pembelajaran Matematika dan IPA IKIP Mataram Tsaqofah: Jurnal Penelitian Guru Indonesia MASALIQ: Jurnal Pendidikan dan Sains International Journal of Educational Research Excellence (IJERE) Duta Pharma Journal Chimica Didactica Acta : Journal of Chemistry and Chemistry Education
Suryani, Okta
Departemen Kimia, Fakultas Matematika Dan Ilmu Pengetahuan Alam Universitas Negeri Padang
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Engineering Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Social Sciences Other

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Development of an acid-base e-module based on discovery learning and integrated with interactive learning media to improve chemistry literacy Novalina Panja Putri Panjaitan; Andromeda Andromeda; Alizar Alizar; Okta Suryani
Jurnal Konseling dan Pendidikan Vol. 14 No. 2 (2026): JKP
Publisher : Indonesian Institute for Counseling, Education and Therapy (IICET)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29210/1225100

Abstract

Low levels of students’ chemical literacy indicate the need for innovative learning resources, particularly for abstract and quantitative topics such as acid–base chemistry. This study aimed to develop and evaluate a Discovery Learning-based acid–base e-module integrated with interactive learning media. This Educational Design Research employed the Four-D (4-D) model. The study involved 16 students and four chemistry teachers in the needs analysis, six expert validators, two chemistry teachers and 30 students in practicality testing, and 26 Grade XII students in effectiveness testing. Chemical literacy was measured using a 15-item test with excellent internal consistency (Cronbach’s α = 0.95). Data were analyzed using Aiken’s V, percentage scores, N-gain, Shapiro–Wilk, and paired-samples t-test. The e-module obtained an Aiken’s V of 0.83, indicating validity, while practicality scores were 94.44% for teachers and 91.20% for students, with a combined score of 92.82%, categorized as very practical. The mean chemical literacy score increased from 5.42 to 61.14, with an N-gain of 0.59, categorized as moderate. The paired-samples t-test showed a significant difference between pretest and posttest scores, t(25) = 20.00, p < .001. The developed e-module is therefore a valid and highly practical learning resource that provides preliminary evidence of its potential to improve students’ chemical literacy in acid–base chemistry.
Efektivitas LKPD Stoikiometri Berbasis Project-Based Learning dengan Memanfaatkan Limbah Organik terhadap Hasil Belajar Peserta Didik Fase E SMA/MA Mila Juliana Harefa; Okta Suryani
TSAQOFAH Vol 5 No 4 (2025): TSAQOFAH: Jurnal Penelitian Guru Indonesia
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/tsaqofah.v5i4.6196

Abstract

The low learning outcomes of students on stoichiometry material highlight the need for the development of contextual and applicative learning media. This study aims to determine the effectiveness of using student worksheets (Lembar Kerja Peserta Didik, LKPD) based on project-based learning that incorporates the use of organic waste in improving the learning outcomes of phase E students at the senior high school (SMA/MA) level. The research design employed a quasi-experimental approach using a pretest-posttest model with two groups: an experimental class and a control class. The instruments used were pretest and posttest assessments to measure learning improvement. The t-test results showed a value of 5.17 > 2.01, indicating a significant difference between the experimental and control groups. Thus, the use of project-based LKPD integrating environmental issues through organic waste utilization was proven effective in enhancing student learning outcomes. The study concludes that a contextual, project-based learning approach can serve as an innovative alternative in teaching chemistry, particularly in stoichiometry. The implications of this research encourage educators to design LKPDs that are not only theoretical but also practical and relevant to everyday life.
Studi In Silico Senyawa Aktif Gambir (Uncaria gambir) sebagai Inhibitor KRAS G12D pada Kanker Pankreas Yulianti, Vioni; Suryani, Okta
MASALIQ Vol 6 No 3 (2026): MASALIQ: Jurnal Pendidikan dan Sains
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/masaliq.v6i3.9742

Abstract

Although pancreatic cancer, particularly PDAC with the KRAS G12D mutation, has been the focus of various studies, research specifically evaluating the potential of active compounds from Uncaria gambir as KRAS G12D inhibitors through an in silico approach remains limited. This study aimed to analyze the binding affinity, drug-likeness profile, and ADMET parameters of active compounds from Uncaria gambir against the KRAS G12D protein. This study used a computational approach through molecular docking and virtual screening designs involving seven test compounds with the KRAS G12D protein structure (PDB ID: 7RPZ), using MRTX1133 as a positive control. The data were analyzed based on binding affinity, RMSD, Lipinski’s Rule of Five, Veber parameters, and ADMET evaluation. The results showed that roxburghine had the highest affinity (−6.7780 kcal/mol), but did not meet Lipinski’s criteria and was indicated to be hepatotoxic. Gambirine and isogambirine were detected as mutagenic and hepatotoxic, whereas quercetin was considered the most prospective because it had a binding affinity of −5.1256 kcal/mol, an RMSD of 1.0570 Å, and interactions with GLU63, HIS95, and GLN99 residues through H-acceptor bonds, accompanied by a superior pharmacokinetic and safety profile. The conclusion of this study confirms that active compounds from Uncaria gambir, particularly quercetin, have the potential to be further explored as candidate KRAS G12D inhibitors in pancreatic cancer, while also providing an initial contribution to the development of natural compounds based on computational approaches in anticancer research.
Studi In Silico Senyawa Turunan Kumarin sebagai Inhibitor Janus Kinase 1 (JAK1) pada Penyakit Rheumatoid Arthritis Tsuraya, Nur Aini; Suryani, Okta
MASALIQ Vol 6 No 3 (2026): MASALIQ: Jurnal Pendidikan dan Sains
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/masaliq.v6i3.9743

Abstract

Rheumatoid arthritis is a chronic autoimmune disease involving activation of the Janus kinase 1 (JAK1) pathway, making JAK1 a potential target in drug development. This study aims to evaluate the potential of coumarin derivative compounds as JAK1 inhibitors in silico. This study used a computational approach through the molecular docking method to predict ligand–protein interactions, evaluation of physicochemical properties based on Lipinski’s Rule of Five, and ADMET analysis to assess pharmacokinetic and toxicity profiles. The results show that all compounds had negative binding affinity values, ranging from -6.5379 to -6.9271 kcal/mol, indicating stable ligand–protein interactions, although these values were still lower than the positive control Tofacitinib, with a value of -7.3968 kcal/mol. All compounds met the criteria of Lipinski’s Rule of Five, but ADMET analysis showed variations in pharmacokinetic and toxicity profiles. Compound 3 showed the best balance between activity, stability, and safety, whereas compounds 1 and 2 showed potential mutagenicity. The conclusion of this study emphasizes that compound 3 has the potential to be further developed as a JAK1 inhibitor candidate. The implications of this study indicate the importance of structural optimization and further experimental validation to improve the effectiveness and safety of coumarin derivative compounds as therapeutic candidates for rheumatoid arthritis.
Studi In Silico Turunan Kumarin dari Daphne mezereum sebagai Inhibitor EGFR pada Kanker Paru-Paru Sari, Roja Seppurnama; suryani, Okta
MASALIQ Vol 6 No 3 (2026): MASALIQ: Jurnal Pendidikan dan Sains
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/masaliq.v6i3.9744

Abstract

Lung cancer is one of the leading causes of cancer-related death worldwide and is often associated with overexpression of the Epidermal Growth Factor Receptor (EGFR), making the development of EGFR inhibitors an important therapeutic strategy. This study aims to evaluate the potential of coumarin derivatives from Daphne mezereum as EGFR inhibitor candidates in lung cancer therapy using an in silico approach. This study used computational methods, including molecular docking to analyze binding affinity and ligand–protein interactions, drug-likeness evaluation based on Lipinski’s rule, and ADMET analysis to predict pharmacokinetic properties and toxicity. The results show that all compounds had RMSD values ≤ 2 Å, with a re-docking value of 1.1614 Å, indicating the validity of the method. Compound 2 showed the highest binding affinity and optimal interaction with the Met769 residue in EGFR, which plays a role in lung cancer cell proliferation, but it did not meet Lipinski’s criteria and had a less optimal ADMET profile. Conversely, compound 3 (umbelliferone) showed a balance between affinity, drug-likeness, and a good ADMET profile, including high absorption and non-toxic properties. The conclusion of this study emphasizes that compound 3 is more prospective as a lung cancer drug candidate, while compound 2 (7-hydroxycoumarin-5,8-di-β-D-glucopyranoside) has potential as a lead compound for further optimization. These findings contribute to the development of EGFR-targeted therapy based on coumarin derivatives and emphasize the importance of computational approaches in efficient and rational drug design.
Studi In Silico Molekuler Turunan Kumarin sebagai Kandidat Inhibitor ER-α pada Antikanker Payudara Wardani, Laura; Suryani, Okta
MASALIQ Vol 6 No 6 (2026): MASALIQ: Jurnal Pendidikan dan Sains
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/masaliq.v6i6.12250

Abstract

Cancer is one of the leading causes of death worldwide, prompting the development of new candidate therapeutic agents. Coumarin derivatives have potential anticancer activity, but their pharmacokinetic characteristics, toxicity, and binding affinity for the target receptor require evaluation. This study aims to evaluate the suitability of 11 coumarin derivatives as candidate anticancer agents based on Lipinski’s Rule of Five, absorption, distribution, metabolism, excretion, and toxicity (ADMET) profiles, and binding affinities predicted through molecular docking. The study was conducted in silico through compound screening, docking method validation, and analysis of interactions with the target receptor. Validation by redocking the native ligand to the 3ERT receptor structure yielded an RMSD value of 0.696 Å, supporting the method’s ability to reproduce the native ligand’s binding pose. Of the 11 compounds evaluated, 6 passed screening and underwent further analysis through molecular docking. The analysis showed that suberosin had the best predicted binding affinity among the compounds that passed screening, with an estimated binding free energy (ΔG) of −6.3707 kcal/mol and a predicted inhibition constant (Kᵢ) of 21.4175 μM. Based on the screening and molecular docking results, suberosin is the most promising coumarin derivative candidate among the compounds analyzed. These findings provide a computational basis for prioritizing suberosin for in vitro and in vivo testing as a candidate anticancer agent.
Sintesis dan Karakterisasi Fotokatalis TiO2/Cu Menggunakan Lampu UV Syawal, M Ichlas; Suryani, Okta
MASALIQ Vol 3 No 6 (2023): MASALIQ: Jurnal Pendidikan dan Sains
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/masaliq.v3i6.2088

Abstract

Most of the energy consumed comes from non-renewable fossil fuel resources. Burning fossil fuels has been found to be a major cause of environmental pollution and greenhouse gas emissions, making it the most common energy source. Therefore, renewable and environmentally friendly energy resources are needed, namely sunlight. One way to utilize sunlight is to store it into hydrogen compounds. Hydrogen comes from water through a process of breaking down its molecules which is called water decomposition. Water decomposition uses sunlight and a semiconductor photocatalyst, such as TiO2. In this research, TiO2 doped with Cu metal has been synthesized using UV lamp irradiation. TiO2 has been successfully synthesized. XRD characterization to determine the structure of TiO2. TiO2 has an anatase crystal structure. Then XRF characterization is done to see the percentage of Cu that has been successfully doped. When exposed to a UV lamp for 1 hour, 0.347% Cu was successfully doped. When exposed to a UV lamp for 5 hours, 1.28% Cu was successfully doped.
Co-Authors Ahadul Putra Aini, Faiza Qurrata Aini, Faizah Qurrata Aini, Syamsi Akhmad, Ashta Varan Akila, Alya Akmar, Reza Amien, Nurkholishah Anastasya, Wulanda Andromeda Andromeda Andromeda Annisa, Ananda Suci Aprilia Silviani Harahap Aprilia Susanti, Aprilia Arief Muttaqiin Arrum Permata S. Tuti Atika Suri Aviva Alamanda Baehaqi Batu Bara, Humairoh Azhari Benti Etika, Sri Berlianda, Anisa Chatarina Umbul Wahyuni Dafista, Nara Damiyanti, Damiyanti Darussalam, Rahni Della Rosalynna Stiadi Desy Kurniawati Desy Kurniawati Edi Nasra Ezra Delfianza Fahira, Ade Irma Fajri Ikhsan Fallahu Fauzan Fatia Hamsil Fauziah, Tasya Feliska Amanda Fitri Amelia Fitria Ningsih, Rahmadhani Hakim, Lara Azzahra Hamsil, Fatia Hapzi Ali Hardeli Hardeli Hardeli Haris Prayudha Setyawan Herianto Ifan Rivaldo Ilham Fauzi Imelda, Fitria Indang Dewata Irfan Ananda Ismail Irma Fahira, Ade Iryani Iryani Iswendi iswendi Jasmine, Nalisha Jayawarsa, A.A. Ketut Katonnia, Eka Putri Khairani Novia Kiki Amelia, Kiki Lailatul Rahmi Lazaro Sofian Arif Lendarwati, Yana Maharani, Mellysa Maida, Margarita Claudya Mardhiyatul Khairat Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Melati Alicia Firdaus Melinda Sari Miftahul Khair Mila Juliana Harefa Mulyanti Mulyanti Mulyanti Mulyanti Munadia Insani Naibaho, Sriwahyuni Nofri Yuhelman Novalina Panja Putri Panjaitan Nur ‘Azah Nurisa, Sindya Rahmatul Pangestuti, Annisa Dewi Parbuntari, Hesty Puji Pebrianti Putri, Wiandi Melati Raden Mohamad Herdian Bhakti Rahimmah, Nur Rahmad, Nafisah Yulia Rahmadhani, Melia Rahmi Fadila Rahmi, Zulfiyanti Ramadhan, Muhammad Arvito Ramdhani, Amelia Restu Ananda Reza Akmar Reza Akmar Reza Akmar Riga Riga Riga Riga, Riga Rismi Verawati Rizal, Putri Nadia Romy Dwipa Yamesa Away Ruri Januarita Santia, Andini Sari, Roja Seppurnama Sari, Trisna Kumala Sembiring, Rinawati Siti Nur Wahyuningsih Sonnya Camelia Suci Sukmawati Syawal, M Ichlas Tsuraya, Nur Aini Ulianas, Alizar Ulianas, Alizar Umar Kalmar Nizar Velly, Aglin Verawati, Rismi Vika Aumi Wardani, Laura Yana Lendarwati Yeni, Isra Yerimadesi Yulianti, Vioni Yulinda Sari Z, Martias Zahran, Jihan Fadhilah Zonalia Fitriza