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All Journal Jurnal Periodic Jurusan Kimia UNP Jurnal Konseling dan Pendidikan KOVALEN: Jurnal Riset Kimia Jurnal Penelitian Pendidikan IPA (JPPIPA) Sains Natural: Journal of Biology and Chemistry JURNAL PENDIDIKAN TAMBUSAI FONDATIA EDUKATIF : JURNAL ILMU PENDIDIKAN JURNAL PENDIDIKAN MIPA Pelita Eksakta Jurnal Paedagogy Edunesia : jurnal Ilmiah Pendidikan Edukimia Hydrogen: Jurnal Kependidikan Kimia Jurnal Simki Pedagogia Afeksi: Jurnal Penelitian dan Evaluasi Pendidikan Jurnal Pijar MIPA Prisma Sains: Jurnal Pengkajian Ilmu dan Pembelajaran Matematika dan IPA IKIP Mataram Tsaqofah: Jurnal Penelitian Guru Indonesia MASALIQ: Jurnal Pendidikan dan Sains International Journal of Educational Research Excellence (IJERE) Duta Pharma Journal Chimica Didactica Acta : Journal of Chemistry and Chemistry Education
Suryani, Okta
Departemen Kimia, Fakultas Matematika Dan Ilmu Pengetahuan Alam Universitas Negeri Padang
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Engineering Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Social Sciences Other

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Development of E-LKM on Colloid Materials Based on Science Technology and Society to Improve Creative Thinking Skills Melinda Sari; Okta Suryani; Mawardi
Jurnal Penelitian Pendidikan IPA Vol 11 No 2 (2025): February
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i2.8887

Abstract

This study aims to develop E-LKM based on Science Technology Society (STS) on colloid material and analyze its validity and practicality in improving students' creative thinking skills. The method used in this research is Research and Development (R&D) with the 4D model, but this research is limited only to the development stage, namely validity and practicality tests. The define stage was carried out by analyzing student needs, curriculum, and relevant colloid concepts. At the design stage, the E-LKM was designed by integrating the STS model. The develop stage includes validation by a team of five experts and practicality testing by two lecturers and Chemistry Education students. The research instruments consisted of interviews, questionnaires, validation sheets, and practicality instruments. The results of the validity test using Aiken's V in terms of material and media obtained 0.89 and 0.93 in the valid category. The results of the practicality test conducted by lecturers and students were 90.15% and 92% with a very practical category. The assessment was carried out based on four aspects of creative thinking: fluency, flexibility, originality, and elaboration, which showed an increase after the use of E-LKM. The results of this study prove that the STS-based E-LKM on colloid material is valid and practical and has the potential to improve students' creative thinking skills. Further research can examine its effectiveness in understanding chemical concepts and its application to other topics
Studi In Silico Senyawa Aktif Gambir (Uncaria gambir) sebagai Inhibitor KRAS G12D pada Kanker Pankreas Vioni Yulianti; Okta Suryani
MASALIQ Vol 6 No 3 (2026): MEI
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/masaliq.v6i3.9742

Abstract

Although pancreatic cancer, particularly PDAC with the KRAS G12D mutation, has been the focus of various studies, research specifically evaluating the potential of active compounds from Uncaria gambir as KRAS G12D inhibitors through an in silico approach remains limited. This study aimed to analyze the binding affinity, drug-likeness profile, and ADMET parameters of active compounds from Uncaria gambir against the KRAS G12D protein. This study used a computational approach through molecular docking and virtual screening designs involving seven test compounds with the KRAS G12D protein structure (PDB ID: 7RPZ), using MRTX1133 as a positive control. The data were analyzed based on binding affinity, RMSD, Lipinski’s Rule of Five, Veber parameters, and ADMET evaluation. The results showed that roxburghine had the highest affinity (−6.7780 kcal/mol), but did not meet Lipinski’s criteria and was indicated to be hepatotoxic. Gambirine and isogambirine were detected as mutagenic and hepatotoxic, whereas quercetin was considered the most prospective because it had a binding affinity of −5.1256 kcal/mol, an RMSD of 1.0570 Å, and interactions with GLU63, HIS95, and GLN99 residues through H-acceptor bonds, accompanied by a superior pharmacokinetic and safety profile. The conclusion of this study confirms that active compounds from Uncaria gambir, particularly quercetin, have the potential to be further explored as candidate KRAS G12D inhibitors in pancreatic cancer, while also providing an initial contribution to the development of natural compounds based on computational approaches in anticancer research.
Studi In Silico Senyawa Turunan Kumarin sebagai Inhibitor Janus Kinase 1 (JAK1) pada Penyakit Rheumatoid Arthritis Nur Aini Tsuraya; Okta Suryani
MASALIQ Vol 6 No 3 (2026): MEI
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/masaliq.v6i3.9743

Abstract

Rheumatoid arthritis is a chronic autoimmune disease involving activation of the Janus kinase 1 (JAK1) pathway, making JAK1 a potential target in drug development. This study aims to evaluate the potential of coumarin derivative compounds as JAK1 inhibitors in silico. This study used a computational approach through the molecular docking method to predict ligand–protein interactions, evaluation of physicochemical properties based on Lipinski’s Rule of Five, and ADMET analysis to assess pharmacokinetic and toxicity profiles. The results show that all compounds had negative binding affinity values, ranging from -6.5379 to -6.9271 kcal/mol, indicating stable ligand–protein interactions, although these values were still lower than the positive control Tofacitinib, with a value of -7.3968 kcal/mol. All compounds met the criteria of Lipinski’s Rule of Five, but ADMET analysis showed variations in pharmacokinetic and toxicity profiles. Compound 3 showed the best balance between activity, stability, and safety, whereas compounds 1 and 2 showed potential mutagenicity. The conclusion of this study emphasizes that compound 3 has the potential to be further developed as a JAK1 inhibitor candidate. The implications of this study indicate the importance of structural optimization and further experimental validation to improve the effectiveness and safety of coumarin derivative compounds as therapeutic candidates for rheumatoid arthritis.
Studi In Silico Turunan Kumarin dari Daphne mezereum sebagai Inhibitor EGFR pada Kanker Paru-Paru Roja Seppurnama Sari; Okta suryani
MASALIQ Vol 6 No 3 (2026): MEI
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/masaliq.v6i3.9744

Abstract

Lung cancer is one of the leading causes of cancer-related death worldwide and is often associated with overexpression of the Epidermal Growth Factor Receptor (EGFR), making the development of EGFR inhibitors an important therapeutic strategy. This study aims to evaluate the potential of coumarin derivatives from Daphne mezereum as EGFR inhibitor candidates in lung cancer therapy using an in silico approach. This study used computational methods, including molecular docking to analyze binding affinity and ligand–protein interactions, drug-likeness evaluation based on Lipinski’s rule, and ADMET analysis to predict pharmacokinetic properties and toxicity. The results show that all compounds had RMSD values ≤ 2 Å, with a re-docking value of 1.1614 Å, indicating the validity of the method. Compound 2 showed the highest binding affinity and optimal interaction with the Met769 residue in EGFR, which plays a role in lung cancer cell proliferation, but it did not meet Lipinski’s criteria and had a less optimal ADMET profile. Conversely, compound 3 (umbelliferone) showed a balance between affinity, drug-likeness, and a good ADMET profile, including high absorption and non-toxic properties. The conclusion of this study emphasizes that compound 3 is more prospective as a lung cancer drug candidate, while compound 2 (7-hydroxycoumarin-5,8-di-β-D-glucopyranoside) has potential as a lead compound for further optimization. These findings contribute to the development of EGFR-targeted therapy based on coumarin derivatives and emphasize the importance of computational approaches in efficient and rational drug design.
In Silico Analysis of Imidazole Derivatives Targeting Estrogen Receptor Alpha as Anti-Breast Cancer Candidates Atika Suri; Okta Suryani
KOVALEN: Jurnal Riset Kimia Vol. 12 No. 1 (2026): April Edition
Publisher : Chemistry Department, Mathematics and Natural Science Faculty, Tadulako University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/kovalen.2026.v12.i1.18031

Abstract

Breast cancer is one of the leading causes of mortality among women worldwide and is frequently associated with the overexpression of Estrogen Receptor alpha (ERalpha). This study aimed to evaluate the potential of imidazole derivatives as anticancer candidates targeting ERalpha (PDB ID: 3ERT) using an In Silico approach. Ten imidazole derivatives were analyzed through Lipinski’s Rule of Five screening, ADMET prediction, and molecular docking studies, with 4-hydroxytamoxifen employed as the positive control. Lipinski screening indicated that all compounds met the drug-likeness criteria. ADMET prediction revealed that most compounds exhibited good intestinal absorption (HIA > 85%) and adequate Caco-2 permeability, with no predicted hepatotoxicity. Molecular docking results showed that all compounds had RMSD values below 2angstroms, indicating stable interactions with the receptor. Among the tested compounds, 1-(2-Phenyl-2-propoxyethyl)-1H-imidazole demonstrated the best binding affinity (-6.3103 kcal/mol) among the imidazole derivatives; however, this value remained lower than that of the positive control, 4-hydroxytamoxifen (-8.6492 kcal/mol), which served as the primary benchmark for binding affinity comparison. Ligand–receptor interactions involved key amino acid residues within the active site of the 3ERT protein. Based on these findings, 1-(2-Phenyl-2-propoxyethyl)-1H-imidazole (compound 9) shows potential as a promising breast anticancer candidate and is recommended for further investigation through In vitro and in vivo experiments are required to verify its biological activity and evaluate its safety profile.
Development of an acid-base e-module based on discovery learning and integrated with interactive learning media to improve chemistry literacy Novalina Panja Putri Panjaitan; Andromeda Andromeda; Alizar Alizar; Okta Suryani
Jurnal Konseling dan Pendidikan Vol. 14 No. 2 (2026): JKP
Publisher : Indonesian Institute for Counseling, Education and Therapy (IICET)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29210/1225100

Abstract

Low levels of students’ chemical literacy indicate the need for innovative learning resources, particularly for abstract and quantitative topics such as acid–base chemistry. This study aimed to develop and evaluate a Discovery Learning-based acid–base e-module integrated with interactive learning media. This Educational Design Research employed the Four-D (4-D) model. The study involved 16 students and four chemistry teachers in the needs analysis, six expert validators, two chemistry teachers and 30 students in practicality testing, and 26 Grade XII students in effectiveness testing. Chemical literacy was measured using a 15-item test with excellent internal consistency (Cronbach’s α = 0.95). Data were analyzed using Aiken’s V, percentage scores, N-gain, Shapiro–Wilk, and paired-samples t-test. The e-module obtained an Aiken’s V of 0.83, indicating validity, while practicality scores were 94.44% for teachers and 91.20% for students, with a combined score of 92.82%, categorized as very practical. The mean chemical literacy score increased from 5.42 to 61.14, with an N-gain of 0.59, categorized as moderate. The paired-samples t-test showed a significant difference between pretest and posttest scores, t(25) = 20.00, p < .001. The developed e-module is therefore a valid and highly practical learning resource that provides preliminary evidence of its potential to improve students’ chemical literacy in acid–base chemistry.
Co-Authors Ahadul Putra Aini, Faiza Qurrata Aini, Faizah Qurrata Aini, Syamsi Akhmad, Ashta Varan Akila, Alya Akmar, Reza Amien, Nurkholishah Anastasya, Wulanda Andromeda Andromeda Andromeda Annisa, Ananda Suci Aprilia Silviani Harahap Aprilia Susanti, Aprilia Arief Muttaqiin Arrum Permata S. Tuti Atika Suri Aviva Alamanda Baehaqi Batu Bara, Humairoh Azhari Benti Etika, Sri Berlianda, Anisa Chatarina Umbul Wahyuni Dafista, Nara Damiyanti, Damiyanti Darussalam, Rahni Della Rosalynna Stiadi Desy Kurniawati Desy Kurniawati Edi Nasra Ezra Delfianza Fahira, Ade Irma Fajri Ikhsan Fallahu Fauzan Fatia Hamsil Fauziah, Tasya Feliska Amanda Fitri Amelia Fitria Ningsih, Rahmadhani Hakim, Lara Azzahra Hamsil, Fatia Hapzi Ali Hardeli Hardeli Hardeli Harefa, Mila Juliana Haris Prayudha Setyawan Herianto Ifan Rivaldo Ilham Fauzi Imelda, Fitria Indang Dewata Irfan Ananda Ismail Irma Fahira, Ade Iryani Iryani Iswendi iswendi Jasmine, Nalisha Jayawarsa, A.A. Ketut Katonnia, Eka Putri Khairani Novia Kiki Amelia, Kiki Lailatul Rahmi Lazaro Sofian Arif Lendarwati, Yana Maharani, Mellysa Maida, Margarita Claudya Mardhiyatul Khairat Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Melati Alicia Firdaus Melinda Sari Miftahul Khair Mulyanti Mulyanti Mulyanti Mulyanti Munadia Insani Naibaho, Sriwahyuni Nofri Yuhelman Novalina Panja Putri Panjaitan Nur Aini Tsuraya Nur ‘Azah Nurisa, Sindya Rahmatul Pangestuti, Annisa Dewi Parbuntari, Hesty Puji Pebrianti Putri, Wiandi Melati Raden Mohamad Herdian Bhakti Rahimmah, Nur Rahmad, Nafisah Yulia Rahmadhani, Melia Rahmi Fadila Rahmi, Zulfiyanti Ramadhan, Muhammad Arvito Ramdhani, Amelia Restu Ananda Reza Akmar Reza Akmar Reza Akmar Riga Riga Riga Riga, Riga Rismi Verawati Rizal, Putri Nadia Roja Seppurnama Sari Romy Dwipa Yamesa Away Ruri Januarita Santia, Andini Sari, Trisna Kumala Sembiring, Rinawati Siti Nur Wahyuningsih Sonnya Camelia Suci Sukmawati Syawal, M Ichlas Ulianas, Alizar Ulianas, Alizar Umar Kalmar Nizar Velly, Aglin Verawati, Rismi Vika Aumi Vioni Yulianti Yana Lendarwati Yeni, Isra Yerimadesi Yulinda Sari Z, Martias Zahran, Jihan Fadhilah Zonalia Fitriza