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All Journal Jurnal Periodic Jurusan Kimia UNP KOVALEN: Jurnal Riset Kimia Jurnal Penelitian Pendidikan IPA (JPPIPA) Sains Natural: Journal of Biology and Chemistry JURNAL PENDIDIKAN TAMBUSAI FONDATIA EDUKATIF : JURNAL ILMU PENDIDIKAN JURNAL PENDIDIKAN MIPA Pelita Eksakta Jurnal Paedagogy Edunesia : jurnal Ilmiah Pendidikan Edukimia Hydrogen: Jurnal Kependidikan Kimia Jurnal Simki Pedagogia Afeksi: Jurnal Penelitian dan Evaluasi Pendidikan Jurnal Pijar MIPA Prisma Sains: Jurnal Pengkajian Ilmu dan Pembelajaran Matematika dan IPA IKIP Mataram Tsaqofah: Jurnal Penelitian Guru Indonesia MASALIQ: Jurnal Pendidikan dan Sains International Journal of Educational Research Excellence (IJERE) Duta Pharma Journal Chimica Didactica Acta : Journal of Chemistry and Chemistry Education
Suryani, Okta
Departemen Kimia, Fakultas Matematika Dan Ilmu Pengetahuan Alam Universitas Negeri Padang
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Engineering Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Social Sciences Other

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Pendekatan Pedagogis Inovatif pada Tabel Periodik untuk Mahasiswa Kimia Semester Pertama di Universitas Negeri Padang. Irfan Ananda Ismail; Mawardi Mawardi; Okta Suryani; Munadia Insani; Mulyanti Mulyanti
Jurnal Penelitian Pendidikan IPA Vol 9 No 12 (2023): December
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i12.5623

Abstract

This study developed innovative approaches to chemistry education for first-year students at the State University of Padang in the era of Industry 4.0. The research utilized the Plomp development model to formulate a method based on the Flipped Classroom paradigm with a Guided Inquiry Syntax. The resulting content was validated by five Chemistry lecturers at UNP, indicating its innovative and pertinent material depth. The content's practicality achieved a value of 90%, suggesting its ease of application and relevance for students. The systematic presentation enhances students' understanding of the Periodic System. This research offers valid and practical solutions to challenges in chemistry education, using creative content as an innovative strategy to provide a teaching tool that enhances students' understanding of complex concepts. The study's practicality stage demonstrates that the developed content is easy to apply and relevant for students, making it a valuable addition to chemistry education
Development of the Acid-Base Module Based on Problem Based Learning with Ethnochemisty to Improve Students Science Literacy Ability Puji Pebrianti; Andromeda; Yerimadesi; Hardeli; Okta Suryani
Jurnal Penelitian Pendidikan IPA Vol 10 No 8 (2024): August
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i8.8582

Abstract

This study aims to produce an acid-base module based on ethnochemical problem-based learning to improve students' scientific literacy skills, analyze the validity and practicality of the module and analyze the effectiveness of the acid-base module based on ethnochemical problem-based learning to improve students' scientific literacy skills. The type of research used is Research and Development (R&D) with a 4-D development model. The 4-D development model consists of 4 stages of development, namely define, design, develop and disseminate. The research instruments used are interview sheets, questionnaires, validation instruments, practicality instruments and effectiveness instruments. The validity test uses the Aiken's V formula. The results of the construct and content validity tests were 0.88 and 0.89 with a valid category. The results of the module practicality test carried out by teachers and students were 91.25% and 90.65% with a very practical category. The effectiveness test of the module was carried out using the N-Gain test and obtained a result of 0.71 in the high category. The results of the study indicate that a valid, practical and effective acid-base module based on ethnochemical problem-based learning has been obtained in improving students' scientific literacy skills.
Development of E-LKM on Colloid Materials Based on Science Technology and Society to Improve Creative Thinking Skills Melinda Sari; Okta Suryani; Mawardi
Jurnal Penelitian Pendidikan IPA Vol 11 No 2 (2025): February
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i2.8887

Abstract

This study aims to develop E-LKM based on Science Technology Society (STS) on colloid material and analyze its validity and practicality in improving students' creative thinking skills. The method used in this research is Research and Development (R&D) with the 4D model, but this research is limited only to the development stage, namely validity and practicality tests. The define stage was carried out by analyzing student needs, curriculum, and relevant colloid concepts. At the design stage, the E-LKM was designed by integrating the STS model. The develop stage includes validation by a team of five experts and practicality testing by two lecturers and Chemistry Education students. The research instruments consisted of interviews, questionnaires, validation sheets, and practicality instruments. The results of the validity test using Aiken's V in terms of material and media obtained 0.89 and 0.93 in the valid category. The results of the practicality test conducted by lecturers and students were 90.15% and 92% with a very practical category. The assessment was carried out based on four aspects of creative thinking: fluency, flexibility, originality, and elaboration, which showed an increase after the use of E-LKM. The results of this study prove that the STS-based E-LKM on colloid material is valid and practical and has the potential to improve students' creative thinking skills. Further research can examine its effectiveness in understanding chemical concepts and its application to other topics
Studi In Silico Senyawa Aktif Gambir (Uncaria gambir) sebagai Inhibitor KRAS G12D pada Kanker Pankreas Vioni Yulianti; Okta Suryani
MASALIQ Vol 6 No 3 (2026): MEI
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/masaliq.v6i3.9742

Abstract

Although pancreatic cancer, particularly PDAC with the KRAS G12D mutation, has been the focus of various studies, research specifically evaluating the potential of active compounds from Uncaria gambir as KRAS G12D inhibitors through an in silico approach remains limited. This study aimed to analyze the binding affinity, drug-likeness profile, and ADMET parameters of active compounds from Uncaria gambir against the KRAS G12D protein. This study used a computational approach through molecular docking and virtual screening designs involving seven test compounds with the KRAS G12D protein structure (PDB ID: 7RPZ), using MRTX1133 as a positive control. The data were analyzed based on binding affinity, RMSD, Lipinski’s Rule of Five, Veber parameters, and ADMET evaluation. The results showed that roxburghine had the highest affinity (−6.7780 kcal/mol), but did not meet Lipinski’s criteria and was indicated to be hepatotoxic. Gambirine and isogambirine were detected as mutagenic and hepatotoxic, whereas quercetin was considered the most prospective because it had a binding affinity of −5.1256 kcal/mol, an RMSD of 1.0570 Å, and interactions with GLU63, HIS95, and GLN99 residues through H-acceptor bonds, accompanied by a superior pharmacokinetic and safety profile. The conclusion of this study confirms that active compounds from Uncaria gambir, particularly quercetin, have the potential to be further explored as candidate KRAS G12D inhibitors in pancreatic cancer, while also providing an initial contribution to the development of natural compounds based on computational approaches in anticancer research.
Studi In Silico Senyawa Turunan Kumarin sebagai Inhibitor Janus Kinase 1 (JAK1) pada Penyakit Rheumatoid Arthritis Nur Aini Tsuraya; Okta Suryani
MASALIQ Vol 6 No 3 (2026): MEI
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/masaliq.v6i3.9743

Abstract

Rheumatoid arthritis is a chronic autoimmune disease involving activation of the Janus kinase 1 (JAK1) pathway, making JAK1 a potential target in drug development. This study aims to evaluate the potential of coumarin derivative compounds as JAK1 inhibitors in silico. This study used a computational approach through the molecular docking method to predict ligand–protein interactions, evaluation of physicochemical properties based on Lipinski’s Rule of Five, and ADMET analysis to assess pharmacokinetic and toxicity profiles. The results show that all compounds had negative binding affinity values, ranging from -6.5379 to -6.9271 kcal/mol, indicating stable ligand–protein interactions, although these values were still lower than the positive control Tofacitinib, with a value of -7.3968 kcal/mol. All compounds met the criteria of Lipinski’s Rule of Five, but ADMET analysis showed variations in pharmacokinetic and toxicity profiles. Compound 3 showed the best balance between activity, stability, and safety, whereas compounds 1 and 2 showed potential mutagenicity. The conclusion of this study emphasizes that compound 3 has the potential to be further developed as a JAK1 inhibitor candidate. The implications of this study indicate the importance of structural optimization and further experimental validation to improve the effectiveness and safety of coumarin derivative compounds as therapeutic candidates for rheumatoid arthritis.
Studi In Silico Turunan Kumarin dari Daphne mezereum sebagai Inhibitor EGFR pada Kanker Paru-Paru Roja Seppurnama Sari; Okta suryani
MASALIQ Vol 6 No 3 (2026): MEI
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/masaliq.v6i3.9744

Abstract

Lung cancer is one of the leading causes of cancer-related death worldwide and is often associated with overexpression of the Epidermal Growth Factor Receptor (EGFR), making the development of EGFR inhibitors an important therapeutic strategy. This study aims to evaluate the potential of coumarin derivatives from Daphne mezereum as EGFR inhibitor candidates in lung cancer therapy using an in silico approach. This study used computational methods, including molecular docking to analyze binding affinity and ligand–protein interactions, drug-likeness evaluation based on Lipinski’s rule, and ADMET analysis to predict pharmacokinetic properties and toxicity. The results show that all compounds had RMSD values ≤ 2 Å, with a re-docking value of 1.1614 Å, indicating the validity of the method. Compound 2 showed the highest binding affinity and optimal interaction with the Met769 residue in EGFR, which plays a role in lung cancer cell proliferation, but it did not meet Lipinski’s criteria and had a less optimal ADMET profile. Conversely, compound 3 (umbelliferone) showed a balance between affinity, drug-likeness, and a good ADMET profile, including high absorption and non-toxic properties. The conclusion of this study emphasizes that compound 3 is more prospective as a lung cancer drug candidate, while compound 2 (7-hydroxycoumarin-5,8-di-β-D-glucopyranoside) has potential as a lead compound for further optimization. These findings contribute to the development of EGFR-targeted therapy based on coumarin derivatives and emphasize the importance of computational approaches in efficient and rational drug design.
Co-Authors Ahadul Putra Aini, Faiza Qurrata Aini, Faizah Qurrata Aini, Syamsi Akhmad, Ashta Varan Akila, Alya Akmar, Reza Amien, Nurkholishah Anastasya, Wulanda Andromeda Annisa, Ananda Suci Aprilia Silviani Harahap Aprilia Susanti, Aprilia Arief Muttaqiin Arrum Permata S. Tuti Aviva Alamanda Baehaqi Batu Bara, Humairoh Azhari Benti Etika, Sri Berlianda, Anisa Chatarina Umbul Wahyuni Dafista, Nara Damiyanti, Damiyanti Darussalam, Rahni Della Rosalynna Stiadi Desy Kurniawati Desy Kurniawati Edi Nasra Ezra Delfianza Fahira, Ade Irma Fajri Ikhsan Fallahu Fauzan Fatia Hamsil Fauziah, Tasya Feliska Amanda Fitri Amelia Fitria Ningsih, Rahmadhani Hakim, Lara Azzahra Hamsil, Fatia Hapzi Ali Hardeli Hardeli Hardeli Harefa, Mila Juliana Haris Prayudha Setyawan Herianto Ifan Rivaldo Ilham Fauzi Imelda, Fitria Indang Dewata Irfan Ananda Ismail Irma Fahira, Ade Iryani Iryani Iswendi iswendi Jasmine, Nalisha Jayawarsa, A.A. Ketut Katonnia, Eka Putri Khairani Novia Kiki Amelia, Kiki Lailatul Rahmi Lazaro Sofian Arif Lendarwati, Yana Maharani, Mellysa Maida, Margarita Claudya Mardhiyatul Khairat Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Melati Alicia Firdaus Melinda Sari Miftahul Khair Mulyanti Mulyanti Mulyanti Mulyanti Munadia Insani Naibaho, Sriwahyuni Nofri Yuhelman Nur Aini Tsuraya Nur ‘Azah Nurisa, Sindya Rahmatul Pangestuti, Annisa Dewi Parbuntari, Hesty Puji Pebrianti Putra, Ahadul Putri, Wiandi Melati Raden Mohamad Herdian Bhakti Rahimmah, Nur Rahmad, Nafisah Yulia Rahmadhani, Melia Rahmi Fadila Rahmi, Zulfiyanti Ramadhan, Muhammad Arvito Ramdhani, Amelia Restu Ananda Reza Akmar Reza Akmar Reza Akmar Riga Riga Riga Riga, Riga Rismi Verawati Rizal, Putri Nadia Roja Seppurnama Sari Romy Dwipa Yamesa Away Ruri Januarita Santia, Andini Sari, Trisna Kumala Sembiring, Rinawati Siti Nur Wahyuningsih Sonnya Camelia Suci Sukmawati Suri, Atika Syawal, M Ichlas Ulianas, Alizar Umar Kalmar Nizar Velly, Aglin Verawati, Rismi Vika Aumi Vioni Yulianti Yana Lendarwati Yeni, Isra Yerimadesi Yulinda Sari Z, Martias Zahran, Jihan Fadhilah Zonalia Fitriza