Article Per Year (5 Year)
p-Index From 2021 - 2026
10.533
P-Index
This Author published in this journals
All Journal Jurnal Periodic Jurusan Kimia UNP KOVALEN: Jurnal Riset Kimia Jurnal Penelitian Pendidikan IPA (JPPIPA) Sains Natural: Journal of Biology and Chemistry JURNAL PENDIDIKAN TAMBUSAI FONDATIA EDUKATIF : JURNAL ILMU PENDIDIKAN JURNAL PENDIDIKAN MIPA Pelita Eksakta Jurnal Paedagogy Edunesia : jurnal Ilmiah Pendidikan Edukimia Hydrogen: Jurnal Kependidikan Kimia Jurnal Simki Pedagogia Afeksi: Jurnal Penelitian dan Evaluasi Pendidikan Jurnal Pijar MIPA Prisma Sains: Jurnal Pengkajian Ilmu dan Pembelajaran Matematika dan IPA IKIP Mataram Tsaqofah: Jurnal Penelitian Guru Indonesia MASALIQ: Jurnal Pendidikan dan Sains International Journal of Educational Research Excellence (IJERE) Duta Pharma Journal Chimica Didactica Acta : Journal of Chemistry and Chemistry Education
Suryani, Okta
Departemen Kimia, Fakultas Matematika Dan Ilmu Pengetahuan Alam Universitas Negeri Padang
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Engineering Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Social Sciences Other

Published : 87 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 87 Documents
Search

 5   6   7   8   9 
The Effect of Science and Technology-Based LKPD on Material and Its Changes on Student Motivation and Learning Outcomes Siti Nur Wahyuningsih; Okta Suryani; Desy Kurniawati; Riga
Jurnal Penelitian Pendidikan IPA Vol 12 No 3 (2026): In Progress
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v12i3.14324

Abstract

This study aimed to develop Science, Technology, and Society (STS)-based student worksheets (LKPD) on the topic of substances and their changes and to examine their effectiveness in improving the motivation and learning outcomes of tenth-grade students at SMKN 1 Timpeh. This development research employed the Plomp Model, which consists of Preliminary Research, Prototyping Phase, and Assessment Phase. The participants were 32 tenth-grade students, comprising 21 students in the experimental class and 11 students in the control class. The instruments included validation sheets, practicality questionnaires, a learning motivation questionnaire, and a learning outcomes test. The data were analyzed using descriptive and inferential statistics. The results indicated that the worksheets were valid, with Aiken’s V scores of 0.86 for content, 0.90 for presentation, 0.88 for language, and 0.88 for contextual aspects, with an average of 0.88. The worksheets were also very practical, with teacher and student practicality scores of 93%. In the Assessment Phase, the experimental class showed significantly higher motivation and learning outcomes than the control class (p = 0.012). Therefore, the developed worksheets are valid, practical, and effective for chemistry learning.
In Silico Analysis of Imidazole Derivatives Targeting Estrogen Receptor Alpha as Anti-Breast Cancer Candidates Suri, Atika; Suryani, Okta
KOVALEN: Jurnal Riset Kimia Vol. 12 No. 1 (2026): April Edition
Publisher : Chemistry Department, Mathematics and Natural Science Faculty, Tadulako University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/kovalen.2026.v12.i1.18031

Abstract

Breast cancer is one of the leading causes of mortality among women worldwide and is frequently associated with the overexpression of Estrogen Receptor alpha (ERalpha). This study aimed to evaluate the potential of imidazole derivatives as anticancer candidates targeting ERalpha (PDB ID: 3ERT) using an In Silico approach. Ten imidazole derivatives were analyzed through Lipinski’s Rule of Five screening, ADMET prediction, and molecular docking studies, with 4-hydroxytamoxifen employed as the positive control. Lipinski screening indicated that all compounds met the drug-likeness criteria. ADMET prediction revealed that most compounds exhibited good intestinal absorption (HIA > 85%) and adequate Caco-2 permeability, with no predicted hepatotoxicity. Molecular docking results showed that all compounds had RMSD values below 2angstroms, indicating stable interactions with the receptor. Among the tested compounds, 1-(2-Phenyl-2-propoxyethyl)-1H-imidazole demonstrated the best binding affinity (-6.3103 kcal/mol) among the imidazole derivatives; however, this value remained lower than that of the positive control, 4-hydroxytamoxifen (-8.6492 kcal/mol), which served as the primary benchmark for binding affinity comparison. Ligand–receptor interactions involved key amino acid residues within the active site of the 3ERT protein. Based on these findings, 1-(2-Phenyl-2-propoxyethyl)-1H-imidazole (compound 9) shows potential as a promising breast anticancer candidate and is recommended for further investigation through In vitro and in vivo experiments are required to verify its biological activity and evaluate its safety profile.
Voltammetric Detection of Zn2+ Ions Using a Glassy Carbon Electrode Modified with Napa-Soil-Derived NiAl₂O₄ Septiani, Dhea; Mawardi; Dewata, Indang; Nizar, Umar Kalmar; Suryani, Okta
Hydrogen: Jurnal Kependidikan Kimia Vol. 14 No. 2 (2026): April 2026
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v14i2.20367

Abstract

This study reports the development of a glassy carbon electrode (GCE) modified with NiAl2O4 derived from napa soil for the voltammetric detection of Zn2+ ions. The modified electrode was prepared using a drop-casting method and characterized in 4.0 mM K3[Fe(CN)6] with 0.1 M KCl as the supporting electrolyte. The results showed an increase in oxidation peak current from 19.93 µA (bare GCE) to 26.80 µA and reduction peak current from −19.03 µA to −24.29 µA after modification, indicating enhanced electron transfer. Zn2+ detection was carried out in the concentration range of 1–3 mM, where the reduction peak current increased from −85.49 µA to −170.83 µA with increasing concentration. A linear relationship between concentration and current response was obtained with a regression equation of y = -42.67x – 40.42 and a correlation coefficient (R2 = 0.9907), indicating good linearity of the sensor. The limit of detection (LOD) was calculated to be 0.21 mM. Among the tested supporting electrolytes, 0.1 M KCl provided the highest and most stable current response. Although the modified electrode shows improved performance, the detection range is still limited to the millimolar level, and further studies are required to evaluate selectivity, reproducibility, and applicability in real samples. These findings demonstrate the potential of napa-soil-derived NiAl2O4 as a sustainable and cost-effective material for electrochemical sensing applications.
Efektivitas LKPD Stoikiometri Berbasis Project-Based Learning dengan Memanfaatkan Limbah Organik terhadap Hasil Belajar Peserta Didik Fase E SMA/MA Harefa, Mila Juliana; Suryani, Okta
TSAQOFAH Vol 5 No 4 (2025): JULI
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/tsaqofah.v5i4.6196

Abstract

The low learning outcomes of students on stoichiometry material highlight the need for the development of contextual and applicative learning media. This study aims to determine the effectiveness of using student worksheets (Lembar Kerja Peserta Didik, LKPD) based on project-based learning that incorporates the use of organic waste in improving the learning outcomes of phase E students at the senior high school (SMA/MA) level. The research design employed a quasi-experimental approach using a pretest-posttest model with two groups: an experimental class and a control class. The instruments used were pretest and posttest assessments to measure learning improvement. The t-test results showed a value of 5.17 > 2.01, indicating a significant difference between the experimental and control groups. Thus, the use of project-based LKPD integrating environmental issues through organic waste utilization was proven effective in enhancing student learning outcomes. The study concludes that a contextual, project-based learning approach can serve as an innovative alternative in teaching chemistry, particularly in stoichiometry. The implications of this research encourage educators to design LKPDs that are not only theoretical but also practical and relevant to everyday life.
Studi In Silico Senyawa Aktif Gambir (Uncaria gambir) sebagai Inhibitor KRAS G12D pada Kanker Pankreas Yulianti, Vioni; Suryani, Okta
MASALIQ Vol 6 No 3 (2026): MEI
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/masaliq.v6i3.9742

Abstract

Although pancreatic cancer, particularly PDAC with the KRAS G12D mutation, has been the focus of various studies, research specifically evaluating the potential of active compounds from Uncaria gambir as KRAS G12D inhibitors through an in silico approach remains limited. This study aimed to analyze the binding affinity, drug-likeness profile, and ADMET parameters of active compounds from Uncaria gambir against the KRAS G12D protein. This study used a computational approach through molecular docking and virtual screening designs involving seven test compounds with the KRAS G12D protein structure (PDB ID: 7RPZ), using MRTX1133 as a positive control. The data were analyzed based on binding affinity, RMSD, Lipinski’s Rule of Five, Veber parameters, and ADMET evaluation. The results showed that roxburghine had the highest affinity (−6.7780 kcal/mol), but did not meet Lipinski’s criteria and was indicated to be hepatotoxic. Gambirine and isogambirine were detected as mutagenic and hepatotoxic, whereas quercetin was considered the most prospective because it had a binding affinity of −5.1256 kcal/mol, an RMSD of 1.0570 Å, and interactions with GLU63, HIS95, and GLN99 residues through H-acceptor bonds, accompanied by a superior pharmacokinetic and safety profile. The conclusion of this study confirms that active compounds from Uncaria gambir, particularly quercetin, have the potential to be further explored as candidate KRAS G12D inhibitors in pancreatic cancer, while also providing an initial contribution to the development of natural compounds based on computational approaches in anticancer research.
Studi In Silico Senyawa Turunan Kumarin sebagai Inhibitor Janus Kinase 1 (JAK1) pada Penyakit Rheumatoid Arthritis Tsuraya, Nur Aini; Suryani, Okta
MASALIQ Vol 6 No 3 (2026): MEI
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/masaliq.v6i3.9743

Abstract

Rheumatoid arthritis is a chronic autoimmune disease involving activation of the Janus kinase 1 (JAK1) pathway, making JAK1 a potential target in drug development. This study aims to evaluate the potential of coumarin derivative compounds as JAK1 inhibitors in silico. This study used a computational approach through the molecular docking method to predict ligand–protein interactions, evaluation of physicochemical properties based on Lipinski’s Rule of Five, and ADMET analysis to assess pharmacokinetic and toxicity profiles. The results show that all compounds had negative binding affinity values, ranging from -6.5379 to -6.9271 kcal/mol, indicating stable ligand–protein interactions, although these values were still lower than the positive control Tofacitinib, with a value of -7.3968 kcal/mol. All compounds met the criteria of Lipinski’s Rule of Five, but ADMET analysis showed variations in pharmacokinetic and toxicity profiles. Compound 3 showed the best balance between activity, stability, and safety, whereas compounds 1 and 2 showed potential mutagenicity. The conclusion of this study emphasizes that compound 3 has the potential to be further developed as a JAK1 inhibitor candidate. The implications of this study indicate the importance of structural optimization and further experimental validation to improve the effectiveness and safety of coumarin derivative compounds as therapeutic candidates for rheumatoid arthritis.
Studi In Silico Turunan Kumarin dari Daphne mezereum sebagai Inhibitor EGFR pada Kanker Paru-Paru Sari, Roja Seppurnama; suryani, Okta
MASALIQ Vol 6 No 3 (2026): MEI
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/masaliq.v6i3.9744

Abstract

Lung cancer is one of the leading causes of cancer-related death worldwide and is often associated with overexpression of the Epidermal Growth Factor Receptor (EGFR), making the development of EGFR inhibitors an important therapeutic strategy. This study aims to evaluate the potential of coumarin derivatives from Daphne mezereum as EGFR inhibitor candidates in lung cancer therapy using an in silico approach. This study used computational methods, including molecular docking to analyze binding affinity and ligand–protein interactions, drug-likeness evaluation based on Lipinski’s rule, and ADMET analysis to predict pharmacokinetic properties and toxicity. The results show that all compounds had RMSD values ≤ 2 Å, with a re-docking value of 1.1614 Å, indicating the validity of the method. Compound 2 showed the highest binding affinity and optimal interaction with the Met769 residue in EGFR, which plays a role in lung cancer cell proliferation, but it did not meet Lipinski’s criteria and had a less optimal ADMET profile. Conversely, compound 3 (umbelliferone) showed a balance between affinity, drug-likeness, and a good ADMET profile, including high absorption and non-toxic properties. The conclusion of this study emphasizes that compound 3 is more prospective as a lung cancer drug candidate, while compound 2 (7-hydroxycoumarin-5,8-di-β-D-glucopyranoside) has potential as a lead compound for further optimization. These findings contribute to the development of EGFR-targeted therapy based on coumarin derivatives and emphasize the importance of computational approaches in efficient and rational drug design.
Co-Authors Ahadul Putra Aini, Faiza Qurrata Aini, Faizah Qurrata Aini, Syamsi Akhmad, Ashta Varan Akila, Alya Akmar, Reza Amien, Nurkholishah Anastasya, Wulanda Andromeda Annisa, Ananda Suci Aprilia Silviani Harahap Aprilia Susanti, Aprilia Arief Muttaqiin Arrum Permata S. Tuti Aviva Alamanda Baehaqi Batu Bara, Humairoh Azhari Benti Etika, Sri Berlianda, Anisa Chatarina Umbul Wahyuni Dafista, Nara Damiyanti, Damiyanti Darussalam, Rahni Della Rosalynna Stiadi Desy Kurniawati Desy Kurniawati Edi Nasra Ezra Delfianza Fahira, Ade Irma Fajri Ikhsan Fallahu Fauzan Fatia Hamsil Fauziah, Tasya Feliska Amanda Fitri Amelia Fitria Ningsih, Rahmadhani Hakim, Lara Azzahra Hamsil, Fatia Hapzi Ali Hardeli Hardeli Hardeli Harefa, Mila Juliana Haris Prayudha Setyawan Herianto Ifan Rivaldo Ilham Fauzi Imelda, Fitria Indang Dewata Insani, Munadia Irma Fahira, Ade Iryani Iryani Ismail, Irfan Ananda Iswendi iswendi Jasmine, Nalisha Jayawarsa, A.A. Ketut Katonnia, Eka Putri Khairani Novia Kiki Amelia, Kiki Lailatul Rahmi Lazaro Sofian Arif Lendarwati, Yana Maharani, Mellysa Maida, Margarita Claudya Mardhiyatul Khairat Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Mawardi Melati Alicia Firdaus Miftahul Khair Mulyanti Mulyanti Naibaho, Sriwahyuni Nizar, Umar Kalmar Nofri Yuhelman Nur ‘Azah Nurisa, Sindya Rahmatul Pangestuti, Annisa Dewi Parbuntari, Hesty Pebrianti, Puji Putra, Ahadul Putri, Wiandi Melati Raden Mohamad Herdian Bhakti Rahimmah, Nur Rahmad, Nafisah Yulia Rahmadhani, Melia Rahmi Fadila Rahmi, Zulfiyanti Ramadhan, Muhammad Arvito Ramdhani, Amelia Restu Ananda Reza Akmar Reza Akmar Reza Akmar Riga Riga Riga Riga, Riga Rismi Verawati Rizal, Putri Nadia Romy Dwipa Yamesa Away Ruri Januarita Santia, Andini Sari, Melinda Sari, Roja Seppurnama Sari, Trisna Kumala Sembiring, Rinawati Septiani, Dhea Siti Nur Wahyuningsih Sonnya Camelia Suci Sukmawati Suri, Atika Syawal, M Ichlas Tsuraya, Nur Aini Ulianas, Alizar Umar Kalmar Nizar Velly, Aglin Verawati, Rismi Vika Aumi Yana Lendarwati Yeni, Isra Yerimadesi Yulianti, Vioni Yulinda Sari Z, Martias Zahran, Jihan Fadhilah Zonalia Fitriza