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All Journal JURNAL KIMIA SAINS DAN APLIKASI Jurnal Kesehatan Masyarakat Andalas (Andalas Journal of Public Health) Jurnal Kesehatan Andalas Jurnal Penelitian Kesehatan Suara Forikes AcTion: Aceh Nutrition Journal Acta Biochimica Indonesiana Majalah Kedokteran Andalas Contagion: Scientific Periodical Journal of Public Health and Coastal Health Science Midwifery Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Archives Pharmacia Jurnal Ilmu Kesehatan Indonesia (JIKSI) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Journal of Pharmaceutical and Sciences. Jurnal Riset Ilmiah Proceeding International Health Conference
Endrinaldi
Universitas Andalas
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Antibacterial Activity of Endophytic Bacterial Isolates from Kaempferia galanga Leaves Rafifa Ridha; Dira Hefni; Zetryana Puteri Tachrim; Gian Primahana; Jepri Agung Priyanto; Linosefa Linosefa; Adrial Adrial; Endrinaldi Endrinaldi; Muhammad Eka Prastya
Jurnal Kimia Sains dan Aplikasi Vol 27, No 11 (2024): Volume 27 Issue 11 Year 2024
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.27.11.538-548

Abstract

Indonesia has a high biodiversity, which can be relied upon as a potential source of medicinal materials. One of the medicinal plants in Indonesia is Kaempferia galanga, which demonstrates various pharmacological properties, including antibacterial, anti-inflammatory, antioxidant, anticancer, and antiangiogenic effects. However, directly extracting active compounds from plants requires a considerable amount of biomass. To address this challenge, utilizing endophytic bacteria associated with these plants presents a promising alternative. Consequently, the antibacterial activity of endophytic bacterial isolates from K. galanga leaves needs to be investigated. This study is an experimental laboratory investigation conducted in vitro. Two isolates demonstrated antibacterial activity: isolate code DR4 inhibited the growth of Escherichia coli (3 ± 0.5 mm), while isolate DR10 inhibited the growth of four bacteria: Bacillus subtilis (5 ± 0 mm), Staphylococcus aureus (1.5 ± 0.5 mm), Escherichia coli (1 ± 0 mm), and Pseudomonas aeruginosa (1 ± 0 mm). Disc diffusion tests using ethyl acetate extracts of isolate DR10 showed the highest antibacterial activity at a concentration of 10,000 ppm. The Minimum Inhibitory Concentration (MIC) was determined to be 156.2 ppm against B. subtilis, while the Minimum Bactericidal Concentration (MBC) was >625 ppm. Molecular identification showed that isolate DR 10 had 100% similarity to Bacillus sp. TS8. The active compound suspected to have antibacterial properties is pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-3-(2-methylpropyl)-, with the highest abundance.
PENGARUH PEMBERIAN MESENCHYMAL STEM CELL WHARTON’S JELLY TERHADAP KADAR GLUKOSA DARAH PADA TIKUS WISTAR (RATTUS NORVEGICUS) HIPERGLIKEMIA Magza, Dekasih Tria; Endrinaldi, Endrinaldi; Afriani, Nita; Arisanty, Dessy; Welan, Rahmani; Rustam, Erlina
SINERGI : Jurnal Riset Ilmiah Vol. 2 No. 4 (2025): SINERGI : Jurnal Riset Ilmiah, April 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/sinergi.v2i4.1116

Abstract

Diabetes mellitus (DM) is a metabolic disease characterized by blood glucose levels above normal or hyperglycemia caused by defects in insulin secretion, insulin action, or both. This study aims to determine the effect of wharton’s jelly mesenchymal stem cells on blood glucose levels in hyperglycemic Wistar rats (Rattus norvegicus). This research is a laboratory experimental study using a post-test control group design. This research was conducted on 18 male white rats (Rattus norvegicus) which were divided into 3 groups, namely the normal/negative group (K-), the positive control group (K+) which was induced by alloxan, and the three treatment groups (P) which were induced by alloxan, alloxan and given a single dose of 3x106 cells of Wharton’s jelly mesenchymal stem cells for one month. Blood glucose levels were measured using a glucometer every week, from the first week to the 5th week. Data analysis used the Kruskal-Wallis and Mann-Whitney tests. Mean of blood glucose level in the last week with a glucometer in the (P) group was 85.33 mg/dL, lower than that in the (K+) group, namely 551.5 mg/dL. However, the (K-) group was the lowest compared to the (P) and (K+) groups, namely 72.83 mg/dL The data showed that there was a significant difference in blood glucose levels between groups (p<0.05). The conclusion of the study was that the administration of Wharton’s jelly mesenchymal stem cells had an effect on reducing blood glucose levels in hyperglycemic rats
LOGAM-LOGAM BERAT PENCEMAR LINGKUNGAN DAN EFEK TERHADAP MANUSIA Endrinaldi Endrinaldi
Jurnal Kesehatan Masyarakat Andalas Vol 4 No 1 (2009): Jurnal Kesehatan Masyarakat Andalas
Publisher : Faculty of Public Health, Andalas University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24893/jkma.v4i1.42

Abstract

Heavy metals are the hazardous substance that produced by industrial waste, included arsenic (As), lead (Pb), mercury (Hg) and cadmium (Cd). That heavy metal could cause acute and chronic body intoxication. Health effects of heavy metal intoxication such as nervous system, kidney, liver, bone, respiratory system, reproductive system, hematopoietic system, cardiovascular, gastrointestinal tract disorders. The manifestation of the toxic effect in tissue and organ is caused by interaction between heavy metal and important cell molecules thus destruct the structure and the function of the cell at the target organ.
PERUBAHAN KADAR KIO3, GARAM BERIODIUM OLEH BUMBU MASAKAN Endrinaldi Endrinaldi
Jurnal Kesehatan Masyarakat Andalas Vol 4 No 2 (2010): Jurnal Kesehatan Masyarakat Andalas
Publisher : Faculty of Public Health, Andalas University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24893/jkma.v4i2.76

Abstract

Telah dilakukan penelitian kadar KI03 (iodium) garam yang bertujuan untuk membuktikan bahwa pemanasan serta berbagai bumbu masakan dapat merusak (mereduksi) KI03 (iodium) garam. Dalampenelitian ini dilakukan penentuan KI03 (iodium) berbagai garam yang beredar di Kota Padang dan penentuan kadar KI03 (iodium) garam yang dicampur dengan berbagai bumbu masakan, menggunakanmetoda iodometri. Hasil penelitian dari enam sampel garam beriodium yang beredar di Kota Padang menunjukan bahwa tiga sampel mempunyai kadar KI03 di atas 40 ppm sedangkan tiga sampel lainnya mempunyai kadar KI03 di bawah40 ppm. Penurunan kadar KIOs garam teijadi secara tidak bermakna (p>0,0 1 ) dalam air yang sudah dipanaskan. Tetapi penurunan kadar KI03 terjadi secara bermakna (p<0,01) pada campuran garam beriodium dengan kuah bumbu cabe, bawang merah, asam jawa, asam galuh dan kunyit yang belum dan telah dipanaskan dan campuran antara garam beriodium dengan kuah bumbu langkuas dan jahe yang telah dipanaskan. Danpenurunan kadar iodium yang paling cepat terjadi pada campuran garam beriodium dengan kuah bumbu cabe, dimana kadar KI03 garam menjadi nol ppm setelah campuran dididihkan selama 5 menit. Penggunaan garam beriodium yaitu dengan cara menambahkan garam beriodium pada makanan sebelum di konsumsi.
Pengaruh Pemberian Mesenchymal Stem Cell Wharton’s Jelly Terhadap Kadar Malondialdehid Tikus Wistar Hiperglikemia Nadhira Isza Qushoyyi; Endrinaldi Endrinaldi; Miftah Irramah; Husnil Kadri; Aswiyanti Asri; Rahmani Welan; Husna Yetti
Jurnal Penelitian Kesehatan SUARA FORIKES 2023
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf14nk112

Abstract

Diabetes mellitus is a metabolic disorder characterized by hyperglycemia, which causes damage to tissues and organs through the process of oxidative stress. Malondialdehyde (MDA) as a biomarker of oxidative stress has a significant increase in hyperglycemia. Stem cell therapy can be an option for diabetes mellitus such as Wharton's jelly mesenchymal stem cells. This study aimed to determine the effect of MSC-WJ administration on serum MDA levels of hyperglycemic Wistar rats. This experimental study applied a post-test only design with a control group. The sample consisted of 21 male Wistar rats divided into 3 groups, including the negative control group (K-), namely the group that was only given a standard feed diet, the positive control group (K+), namely the group that was injected with alloxan with a dose of 0.2 ml intraperitoneally, and the treatment group (P), which was the alloxan-induced group, and was given MSC-WJ at a dose of 3 million cells intravenously in the rat tails. In all three groups, blood was taken from the retro orbital plexus to measure serum MDA levels with the TBARS test. The results of the analysis showed that the mean serum MDA levels of the K-, K+, and P groups were 1.83 nmol/ml, 2.97 nmol/ml, and 1.73 nmol/ml, respectively. The results of the comparison test showed a value of p = 0.000. It was concluded that there was a significant difference in serum MDA levels between the three groups, which indicated that MSC-WJ administration could reduce alloxan-induced hyperglycemia Wistar rats serum MDA levels.Keywords: hyperglycemia; malondialdehyde; Wharton's jelly mesenchymal stem cells ABSTRAK Diabetes mellitus adalah gangguan metabolik yang ditandai dengan hiperglikemia, yang menyebabkan kerusakan jaringan dan organ melalui proses stress oksidatif. Malondialdehid (MDA) sebagai biomarker stress oksidatif mengalami peningkatan signifikan pada hiperglikemia. Terapi stem cell dapat menjadi pilihan untuk diabetes mellitus seperti mesenchymal stem cell wharton’s jelly. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian MSC-WJ terhadap kadar MDA serum tikus wistar hiperglikemia. Penelitian eksperimental ini menerapkan rancangan post-test only with control group. Sampel adalah 21 ekor tikus wistar jantan yang dibagi menjadi 3 kelompok, di antaranya kelompok kontrol negatif (K-) yaitu kelompok yang hanya diberi diet pakan standar, kelompok kontrol positif (K+) yaitu kelompok yang diinjeksi aloksan dengan dosis 0,2 ml secara intraperitoneal, dan kelompok perlakuan (P) yaitu kelompok yang diinduksi aloksan, serta diberi MSC-WJ dengan dosis 3 juta sel secara intravena pada ekor tikus. Pada ketiga kelompok dilakukan pengambilan darah dari pleksus retro orbitalis untuk pengukuran kadar MDA serum dengan tes TBARS. Hasil analisis menunjukkan kadar rerata MDA serum kelompok K-, K+, dan P secara berturut-turut adalah 1,83 nmol/ml, 2,97 nmol/ml, dan 1,73 nmol/ml. Hasil uji perbandingan menunjukkan nilai p = 0,000. Disimpulkan bahwa terdapat perbedaan kadar MDA serum yang bermakna di antara ketiga kelompok, yang menunjukkan bahwa pemberian MSC-WJ dapat menurunkan kadar MDA serum tikus wistar hiperglikemia yang diinduksi aloksan.Kata kunci: hiperglikemia; malondialdehid; mesenchymal stem cell wharton’s jelly
Effect of Gaguk fish (Arius thalassinus) cookies on macronutrient and micronutrient intake in anemic adolescent girls Triyunita, Rian; Masrul, Masrul; Endrinaldi, Endrinaldi
AcTion: Aceh Nutrition Journal Vol 10, No 2 (2025): June
Publisher : Department of Nutrition at the Health Polytechnic of Aceh, Ministry of Health

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/action.v10i2.2401

Abstract

Adolescence is a transition period from childhood to adulthood that requires nutritional intake of iron. Children with iron deficiency are highly susceptible to anemia. This study aimed to determine the effect of rainbow gaguk fish (Arius thalassinus) cookies on macro-and micronutrient intake in adolescent girls with anemia. This study used preliminary data from the Bengkulu Provincial Health Office, where many students experienced anemia in one junior high school. In the selection of samples using simple random sampling, 50 g of rainbow gaguk fish biscuits were used. The dependent variable in this study was gaguk fish. The independent variables were the macro-and micronutrient intake. This study employed a quasi-experimental pre-post-test intervention research using a purposive sampling design. Data analysis was performed using the paired t-test and Wilcoxon test at 95% confidence interval (CI). The results showed that before giving fish cookies, energy intake was 44,4%, protein 51,5%, carbohydrate 51,4%, vitamin B12 52,5%, folate 38,5%, iron 54%, and zinc 45,6%; after an increase in energy intake, energy intake was 55,8%, protein 62,3%, carbohydrate 52,1%, vitamin B12 65%, folate 39,1%, iron 74%, and zinc 81,1% (p<0,001). In conclusion, the provision of rainbow biscuits to adolescent girls with anemia improved significantly.
Bioaktivitas dan Efek Kesehatan Bawang Hitam terhadap Enzim Reduktase Hidroksi Metilglutaril-KoA Pada Tikus Putih Jantan Obesitas Ibrahim, Ibrahim; Yerizel , Eti; Endrinaldi, Endrinaldi; Revilla, Gusti
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1039

Abstract

Obesity is a condition of abnormality or excess fat accumulation in adipose tissue. HMG-CoA reductase is an enzyme that can catalyse HMG-CoA into mevalonate, which is needed in cholesterol biosynthesis. Inhibition of the HMG-CoA reductase enzyme is an effective drug target mechanism to overcome dyslipidemia. Black garlic, which is high in antioxidants such as SAC, flavonoids, and polyphenols, is an effective mechanism. This study tested the bioactivity and health effects of black garlic on the activity of HMG-CoA reductase enzyme. This type of experimental study on male rats uses a post-test control-only group design. The sample in this study was 25 experimental animals divided into five groups, group negative control with a regular diet, group positive control with a high-fat diet, group treatment 1 with a high-fat diet and black garlic dose of 200 mg/rats, group treatment 2 with a high-fat and black garlic diet dose of 400 mg/rats, and group treatment given a high-fat diet and black garlic dose of 800 mg/rats. The results of the study showed that the average value and standard deviation of HMG-CoA in the negative control group were 1,044 and 0.088, the positive control group 2,136 and 0.487, the 1 group treatment 1,292 and 0.194, the 2 group treatment 1,296 and 0.206 and the three treatment group 1,201 and 0.201 nmol/min/mg protein. Based on the results of the hypothesis test, the significance level for the five groups was 0.004, indicating a significant difference in the average HMG-CoA levels in groups K1, K2, P1, P2, and P3. Black garlic significantly decreased HMG-CoA reductase activity in rats fed a high-fat diet, supporting its potential as a natural therapeutic agent for dyslipidemia management.
Efek Pemberian Mesenchymal Stem Cell Wharton's Jelly (MSC-WJ) terhadap Gambaran Histologi Pankreas Hewan Model Diabetes Melitus Tipe 1 Endrinaldi, Endrinaldi; Tofrizal, Tofrizal; Elmatris, Elmatris; Yarni, Sisca Dwi
Majalah Kedokteran Andalas Vol. 47 No. 2 (2024): MKA April 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v47.i2.p148-155.2024

Abstract

Objective: This study was conducted to determine the effect of administering Mesenchymal Stem Cell Wharton Jelly (MSC-WJ) on the histological appearance of the pancreas of rat in a type 1 diabetes mellitus model. Methods: This research is an experimental research with a Posttest-Only Control Group Design. The sample consisted of 3 groups (Normal, T1DM, T1DM + MSC-WJ). The treatment group was treated with MSC-WJ for 4 weeks. Data analysis used One Way ANOVA and Post Hoc Bonferroni tests. Results: WJ-MSC can increase the mean diameter and area of the islets of Langerhans in the T1DM rat group from 98.08 mm – 126.85 mm and from 4911.95 mm2 – 8995.35 mm2, but this difference is not yet significant (p > 0.05). Conclusion This research shows that there is improvement in pancreatic damage by administering WJ-MSC to diabetic rat due to alloxan induction.
Pengaruh Pemberian Mesenchymal Stem Cell Wharton's Jelly Terhadap Aktivitas Enzim Katalase pada Tikus Wistar Model Hiperglikemia Ramadhani, Dhea Amaliya; Endrinaldi; Putri, Biomechy Oktomalio; Rita, Rauza Sukma; Mahata, Liganda Endo; Dian Pertiwi
Majalah Kedokteran Andalas Vol. 48 No. 2 (2025): MKA April 2025
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v48.i2.p117-124.2025

Abstract

Objective: To determine the effect of Wharton's Jelly (MSC-WJ) mesenchymal stem cells on the activity of the catalase enzyme in hyperglycemic Wistar rats. Methods: This study used 21 male Wistar rats aged 2-3 months with a body weight of 200-300 grams according to the inclusion and exclusion criteria. Mice were divided into 3 groups: negative control (K-), positive control (K+), and treatment (P). Group K- was only given food and drink without being given treatment. The K+ group was injected intraperitoneally with alloxan at a dose of 100 mg/kg BW so that the rats became hyperglycemic. Group P was given an alloxan injection and left for a week, then given MSC-WJ 3x106 cells through the tail vein and left for four weeks. After four weeks, all groups had their blood taken to examine the catalase enzyme. Result: Mean of catalase activity enzyme in the K-, K+, and P groups were 4.22 ± 0.27 units/mg, 2.39 ± 0.19 units/mg, and 3.93 ± 0.45 units /mg, respectively. Conclusion: This shows that the administration of mesenchymal stem cells Wharton's Jelly (MSC-WJ) has an effect on increasing the serum catalase enzyme activity of Wistar rats with hyperglycemia models.
GAMBARAN KLINIKOPATOLOGI POLIP HIDUNG DI POLIKLINIK  THT-KL RSUP DR. M. DJAMIL TAHUN 2019-2021 Dira, Atshyfa Zsazsa; Huriyati, Effy; Rustam, Erlina; Djosan, Al Hafiz; Endrinaldi, Endrinaldi; Intan, Shinta Ayu
SINERGI : Jurnal Riset Ilmiah Vol. 2 No. 5 (2025): SINERGI : Jurnal Riset Ilmiah, Mei 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/sinergi.v2i5.1257

Abstract

Nasal polyps appear as a round, semi-transparent mass and typically develop in the middle meatus and paranasal sinuses. Histologically, nasal polyps can be divided into two subtypes, eosinophilic and neutrophilic polyps. The recurrence rate of nasal polyps is quite high, with 60-70% of patients experiencing recurrence after undergoing FESS treatment for about 18 months. The purpose of this study was to determine the clinical and histopathological characteristics of patients with nasal polyps at the THT-KL Polyclinic of Dr. M. Djamil Central Hospital in 2019-2021. This study used a descriptive design with total sampling method. The sample in this study consisted of 77 patients who met the inclusion criteria. The results of this study showed that the most frequent clinicopathological characteristics of nasal polyps in the patients were: middle-aged age group (37.66%), male gender (54.5%), sinusitis risk factor (89.61%), bilateral nature of polyps (57.14%), the most common stage was stage II (50.65%), clinical symptom of nasal congestion (98.7%), surgical management (88.31%), neutrophilic histopathological type (84.42%), with a recurrence rate of 19.48%. In conclusion, the most frequent age distribution of patients with nasal polyps was in the 41-60 age group, with the most common male gender, sinusitis risk factor, bilateral type of polyps, the most common stage was stage II, clinical symptom of nasal congestion, the most common management was surgical, histopathological type was neutrophilic, and is recurrent
Co-Authors Adrial Adrial Afriani, Nita Afriwardi Afriwardi Almurdi Almurdi Alvin Muhammad Arni Amir Asrawati Nurdin Asterina Asterina Aswiyanti Asri Aswiyanti Asri Bobby Indra Utama Delmi Sulastri Desmiwati Desmiwati2 Dessy Arisanti Dessy Arisanty Dia Rofinda, Zelly Dia Dian Pertiwi Dira Hefni Dira, Atshyfa Zsazsa Djosan, Al Hafiz Dwi Yulia Effy Huriyati Efrida Efrida Eldi Sauma Elmatris Sy Ennesta Asri Erlina Rustam Erly Erly Ervan Arditya Kusuma Fadil Oenzil Fathoni Afif Feby Febriatama Fitria Ramanda Fortuna, Fory Gardenia Akhyar Gian Primahana Gita Rahmadani Gusti Revilla Hasmiwati Husna Yetti Husnil Kadri Ibrahim Ibrahim Ilham, Nur Muhammad Intan, Shinta Ayu Irrahmah, Miftah Jepri Agung Priyanto Julizar Nazar Linosefa Linosefa Lisma Evareny Magza, Dekasih Tria Mahata, Liganda Endo Masrul Mayetti Mayetti Miftah Irramah Mohamad Reza Muchtar, Masrul Muhammad Eka Prastya Nadhira Isza Qushoyyi Nadia Oktarina Nailatul Fadhila Novita Sari Nur Afrainin Syah Nur Indrawaty Lipoeto Nurhayati Nurhayati Nurul Fadila Oea Khairsyaf P, Anastasya Inayah Nabila Putri, Biomechy Oktomalio Rafifa Ridha Rahmani Welan Raisa Hussein Ramadhani, Dhea Amaliya Rani Afrisetiawati Rauza Sukma Rita Rikarni Rikarni Rizki Amelia Roslaili Rasyid Saptino Miro Saptino Miro, Saptino Sari Handayani Utami Setiawan, Mentari Adinda Sisca Dwi Yarni Siti Utari Agustina Sri Wahyuni Suci Aulia Yude Tofrizal Triyunita, Rian Ulya Uti Fasrini Vitresia, Havriza Yarni, Sisca Dwi Yaumil Fauziah Yerizel , Eti Yuniar Lestari Yusticia Katar Yustini Alioes Zelly Dia Rofinda Zetryana Puteri Tachrim Zulkarnain Edward