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All Journal Jurnal Kesehatan Andalas Majalah Obat Tradisional Jurnal Kedokteran Anatomica (Anatomica Medical Journal) Logista: Jurnal Ilmiah Pengabdian Kepada Masyarakat Majalah Kedokteran Andalas Medical and Health Science Journal Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Jurnal Ilmu Kesehatan Indonesia (JIKSI) Innovative: Journal Of Social Science Research Medic Nutricia : Jurnal Ilmu Kesehatan Vitamedica: Jurnal Rumpun Kesehatan Umum Jurnal Sains, Teknologi dan Kesehatan Jurnal Kesehatan
Rahmatini .
Fakultas Kedokteran Universitas Andalas
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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OVERVIEW CHARACTERISTICS AND P2Y12 REACTIVITY UNIT (PRU) VALUES OF ACUTE CORONARY SYNDROME AGE PRODUCTIVE PATIENTS WITH CLOPIDOGREL THERAPY ., Rahmatini; Aliska, Gestina; Syafri, Masrul
Jurnal Ilmu Kesehatan dan Kesehatan Vol 1 No 1 (2017): FEBRUARY
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v1i1.612

Abstract

ABSTRACTBackground: Ischemic heart disease is the leading cause of death and disability in the world with a fairlyhigh portion coming from countries Low- and Middle-Income (LMICs). In Pakistan, 54% patients acutecoronary syndrome (ACS) was resistant to clopidogrel, and no data on clopidogrel resistance on ethnicMinang. This study aims to look at the characteristics and P2Y12 Reactivity Unit (PRU) from ACS patientsin Dr. M. Djamil Hospital, Padang. Methods: This research is a cross sectional study. The effectiveness ofclopidogrel on platelet reactivity identified through examination of PRU value using VerifyNow® with a cutoff point is 208. From the PRU values, it can be classified whether patients resistant or responsive. The studywas conducted in September 2016. Result: From 14 patients with ACS who received clopidogrel, 11 patients(78.57%) are male with 3 female patients (21.43). The mean of age was 53.78 years old. Patients mostlycame from West Sumatra provinces (92,85%) and 7,15% from others. From all of patients head risk factorsof coronary arterial disease. Hipertension was the greatest risk factor. Conclusion: It can be concluded thatmost of the patients were male. From PRU data, 7 patients (50%) were resistant and 7 patients (50%) wereresponse to clopidogrel. Further research is needed with larger numbers of patients and investigatepharmacogenetic profile of CYP2C19 as caused of resistance.
OVERVIEW CHARACTERISTICS AND P2Y12 REACTIVITY UNIT (PRU) VALUES OF ACUTE CORONARY SYNDROME AGE PRODUCTIVE PATIENTS WITH CLOPIDOGREL THERAPY Rahmatini .; Gestina Aliska; Masrul Syafri
Jurnal Ilmu Kesehatan dan Kesehatan Vol 1 No 1 (2017): FEBRUARY
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v1i1.612

Abstract

ABSTRACTBackground: Ischemic heart disease is the leading cause of death and disability in the world with a fairlyhigh portion coming from countries Low- and Middle-Income (LMICs). In Pakistan, 54% patients acutecoronary syndrome (ACS) was resistant to clopidogrel, and no data on clopidogrel resistance on ethnicMinang. This study aims to look at the characteristics and P2Y12 Reactivity Unit (PRU) from ACS patientsin Dr. M. Djamil Hospital, Padang. Methods: This research is a cross sectional study. The effectiveness ofclopidogrel on platelet reactivity identified through examination of PRU value using VerifyNow® with a cutoff point is 208. From the PRU values, it can be classified whether patients resistant or responsive. The studywas conducted in September 2016. Result: From 14 patients with ACS who received clopidogrel, 11 patients(78.57%) are male with 3 female patients (21.43). The mean of age was 53.78 years old. Patients mostlycame from West Sumatra provinces (92,85%) and 7,15% from others. From all of patients head risk factorsof coronary arterial disease. Hipertension was the greatest risk factor. Conclusion: It can be concluded thatmost of the patients were male. From PRU data, 7 patients (50%) were resistant and 7 patients (50%) wereresponse to clopidogrel. Further research is needed with larger numbers of patients and investigatepharmacogenetic profile of CYP2C19 as caused of resistance.
Co-Authors Adila, Qanita Adinda Adinda Amelia Rahayu Amir , Arni Amirah Zatil Izzah Ariani, Novita Ariani, Tutty Ashal, Taufik Ashar, Miranda Asri, Ennesta Atmi, Serly Rahma Ayu Andrian Putri Aziz Djamal Bagus Sedayu Cahyaningtyas Cahyaningtyas Cesar, Afifah Raudhati Dessy Arisanty Dina Arfiani Rusjdi Dzakiyyah, Adzristi Zahrah Effy Huriyati Efrida Efrida Egi Defiska Mulya Elizabeth Bahar Elly Usman Erlina Rustam Eti Yerizel Fathiyyatul Khaira, Fathiyyatul Firdawati Gardenia Akhyar Gestina Aliska Hanum, Fathiya Juwita Hasmiwati Hendra Permana Hirowati Ali, Hirowati Ilham Andhika Zulen Ilmiawati, Ilmiawati Intan, Shinta Ayu Iskandar Syarif Jeanne Mervrayano Julia, Dwi Sabtika Julizar Julizar Julizar Julizar Khairunnisa Imaduddin Kurniawan Sedjahtera Laila Isrona Lubis, Sunarti Luois Joseph Joseph Mahata, Liganda Endo Masrul Syafri Meilisa Rahmawati Miftah Irramah Mohamad Reza Mohamad Reza Mutya Restu Ayu Nadia Rahmah Nadjmir Nadjmir Netti Suharti, Netti Putra, Xavier Novdi Tansyah Putri Sri Lasmini Putri, Biomechy Oktomalio Putri, Rauffi Hayatul Rahma, Adela Rahmadian, Rizki Rahmawati, Meilisa Raihan Afif Salam Rani Aulia Dwi Nanda Rani Aulia Dwi Nanda Rasnaita Marhamah Rauza Sukma Rita Revivo Rinda Pratama Rika Susanti Rina Gustia Rini Gusya Liza, Rini Gusya Rizki Rahmadian Roni Eka Sahputra Roslaili Rasyid Roza Mulyana Rudy Afriant Saptino Miro Sara Fadila Sari, Indah Indria sari, Mutia Satya Wydya Yenny Selfi Renita Rusjdi Septriana Putri Sherly Febrina Susan Insani Putri Syaiful Azmi Syamel Muhammad Taria, Sari Almira Yossy, Vesri Yuli Syafirah Yuliarni Syafrita Yulistini Yusticia Katar Yustini Alioes Zahira, Aisyah Dhia Zelly Dia Rofinda Zoni, Salsa Billa Pratami Zulhar Riyadi