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All Journal Jurnal Kesehatan Andalas Majalah Obat Tradisional Jurnal Kedokteran Anatomica (Anatomica Medical Journal) Logista: Jurnal Ilmiah Pengabdian Kepada Masyarakat Majalah Kedokteran Andalas Medical and Health Science Journal Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Jurnal Ilmu Kesehatan Indonesia (JIKSI) Innovative: Journal Of Social Science Research Medic Nutricia : Jurnal Ilmu Kesehatan Vitamedica: Jurnal Rumpun Kesehatan Umum Jurnal Sains, Teknologi dan Kesehatan Jurnal Kesehatan
Rahmatini .
Fakultas Kedokteran Universitas Andalas
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : Jurnal Kesehatan

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Effects of Stevia Leaf Extract on Blood Glucose and SOD Activity in Hyperglycemic Rats Zoni, Salsa Billa Pratami; Yerizel, Eti; Rahmatini
Jurnal Kesehatan - STIKes Prima Nusantara Vol 17 No 1 (2026): Jurnal Kesehatan Volume 17 Nomor 1 Tahun 2026 (on progress)
Publisher : LPPM Universitas Prima Nusantara Bukittinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35730/jk.v17i1.1603

Abstract

Background: Hyperglycemia is characterized by elevated blood glucose levels and may induce oxidative stress through excessive production of reactive oxygen species (ROS) that exceed the capacity of antioxidant defense systems. Stevia rebaudiana leaf extract (Stevia rebaudiana) contains antihyperglycemic and antioxidant compounds, including polyphenols and steviol glycosides. Objectives: This study aimed to determine the effect of Stevia leaf extract on blood glucose levels and Superoxide Dismutase (SOD) enzyme activity in hyperglycemic rats (Rattus norvegicus). Methods: This experimental study involved 35 rats divided into a negative control group (K−), a positive control group (K+), and three treatment groups (P1, P2, P3) receiving Stevia rebaudiana extract at doses of 100, 200, and 400 mg/kg body weight. Hyperglycemia was induced using alloxan. Blood glucose levels were measured using a digital analyzer, while SOD activity was assessed colorimetrically. Data were analyzed using the Kruskal–Wallis test followed by the Mann–Whitney test. Results: The mean blood glucose levels in groups K−, K+, P1, P2, and P3 were 93.2 mg/dL, 371.08 mg/dL, 134.3 mg/dL, 130.42 mg/dL, and 113.22 mg/dL, respectively. The mean SOD enzyme activity in groups K−, K+, P1, P2, and P3 were 14.92 U/mL, 13.53 U/mL, 14.57 U/mL, 14.74 U/mL, and 14.93 U/mL, respectively. The P3 group, which received a dose of 400 mg/kgBW, demonstrated the greatest effect on reducing blood glucose levels and increasing SOD activity. Conclusion: Stevia rebaudiana leaf extract significantly reduced blood glucose levels in hyperglycemic rats and showed a tendency to increase superoxide dismutase activity, although the differences in SOD activity were not statistically significant
Co-Authors Adila, Qanita Adinda Adinda Amelia Rahayu Amir , Arni Amirah Zatil Izzah Ariani, Novita Ariani, Tutty Ashal, Taufik Ashar, Miranda Asri, Ennesta Atmi, Serly Rahma Ayu Andrian Putri Aziz Djamal Bagus Sedayu Cahyaningtyas Cahyaningtyas Cesar, Afifah Raudhati Dessy Arisanty Dina Arfiani Rusjdi Dzakiyyah, Adzristi Zahrah Effy Huriyati Efrida Efrida Egi Defiska Mulya Elizabeth Bahar Elly Usman Erlina Rustam Eti Yerizel Fathiyyatul Khaira, Fathiyyatul Firdawati Gardenia Akhyar Gestina Aliska Hanum, Fathiya Juwita Hasmiwati Hendra Permana Hirowati Ali, Hirowati Ilham Andhika Zulen Ilmiawati, Ilmiawati Intan, Shinta Ayu Iskandar Syarif Jeanne Mervrayano Julia, Dwi Sabtika Julizar Julizar Julizar Julizar Khairunnisa Imaduddin Kurniawan Sedjahtera Laila Isrona Lubis, Sunarti Luois Joseph Joseph Mahata, Liganda Endo Masrul Syafri Meilisa Rahmawati Miftah Irramah Mohamad Reza Mohamad Reza Mutya Restu Ayu Nadia Rahmah Nadjmir Nadjmir Netti Suharti, Netti Putra, Xavier Novdi Tansyah Putri Sri Lasmini Putri, Biomechy Oktomalio Putri, Rauffi Hayatul Rahma, Adela Rahmadian, Rizki Rahmawati, Meilisa Raihan Afif Salam Rani Aulia Dwi Nanda Rani Aulia Dwi Nanda Rasnaita Marhamah Rauza Sukma Rita Revivo Rinda Pratama Rika Susanti Rina Gustia Rini Gusya Liza, Rini Gusya Rizki Rahmadian Roni Eka Sahputra Roslaili Rasyid Roza Mulyana Rudy Afriant Saptino Miro Sara Fadila Sari, Indah Indria sari, Mutia Satya Wydya Yenny Selfi Renita Rusjdi Septriana Putri Sherly Febrina Susan Insani Putri Syaiful Azmi Syamel Muhammad Taria, Sari Almira Yossy, Vesri Yuli Syafirah Yuliarni Syafrita Yulistini Yusticia Katar Yustini Alioes Zahira, Aisyah Dhia Zelly Dia Rofinda Zoni, Salsa Billa Pratami Zulhar Riyadi