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The potential of betle leaf (Piper betle L.) against Staphylococcus aureus to cure mastitis: A systematic review Jannata, Rahma Winahyu; Prihantono, Prihantono; Idris, Irfan
Babali Nursing Research Vol. 4 No. 3 (2023): July
Publisher : Babali Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37363/bnr.2023.43269

Abstract

Mastitis is a problem in breastfeeding causes nutritional deficiencies in the baby. Staphylococcus aureus is one of the bacteria that causes mastitis. Betle leaf (Piper betle L.) has been used in several health problems and has antimicrobial activity. This study aims to explore the potential of betel leaf (Piper betle l.) against Staphylococcus aureus to cure mastitis. A systematic review was carried out according to the PRISMA guidelines. Searches were conducted in three databases namely PubMed, Google Scholar, and Science Direct. Search using keywords according to the Mesh term, namely 'betle leaf (Piper betle l.)', 'Staphylococcus aureus' and 'Mastitis'. 198 articles were found in a database search. 8 studies were analyzed. All studies found that both types of pipers betle, both green and red, showed positive effects in the treatment of mastitis. Processing techniques, storage, and certain concentrations such as boiling temperature affect the optimum inhibition zone of bacteria. The addition of certain formulas also increases the antimicrobial activity. The use of antibiotics and betel leaf extract can be used simultaneously to treat mastitis. Betle leaf (Piper betle L.), has a positive effect on the management of mastitis, but processing techniques, concentrations, and adjuvants need to be studied further.
The Effect of Sterilization on Vitamin D Levels in Male and Female Rats Pratiwi, Hamria; Idris, Irfan; Sari, Dwi Kesuma
Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research) VOLUME 6 No.1, JANUARY 2022
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Sterilization is an operation that can prevent reproduction and is useful as a treatment. Sterilization is done by removing the reproductive organs, in males it is called orchiectomy and in females it is called ovariohysterectomy which causes a decrease in the production of reproductive hormones. Previous studies have proven a physiologic relationship between reproductive hormones and vitamin D activation, but there is no information on the effect of sterilization on vitamin D levels. This study aimed to determine the effect of sterilization on vitamin D levels. This study was experimental with a Posttest-Only Control Group design. design. A total of 24 wistar rats consisting of 12 male rats and 12 female rats and each were divided into two groups, 6 female rats sterilized (ovariohysterectomy), 6 female rats non-sterilized, 6 male rats sterilized (orchiectomy) and 6 male rats non-sterilized. -sterilization. Wistar rats that were 10 weeks old were transferred to their respective cages and given regular feed to all groups of rats for 7 days as an adaptation process, after which sterilization was carried out in the sterilization group. After 6 weeks post-treatment, the rats were 17 weeks old and then blood was taken for examination of Vitamin D levels using the elisa method which was carried out at Hum-Rc Hasanuddin University Hospital. The results showed that the mean value of vitamin D levels in the ovariohysterectomy group was lower than in the non-sterilized group and was significant (Mann-Withney, p<0.05). The orchiectomy group was also lower than in the non-sterlized group and not significant (Independent T test, p> 0.05). It can be concluded that sterilization can reduce vitamin D levels in pets. Keywords: Sterilization, Ovariohysterectomy, Orchiectomy, and Vitamin D
Pengaruh Pemberian Minuman Sopi Mayang Beralkohol terhadap Jumlah Spermatozoid, Pada Tikus Putih (Rattus norvegicus) Jantan Sanaky, Marliyati; Idris, Irfan; Rafiah, Siti; Arsyad, Aryadi
MAHESA : Malahayati Health Student Journal Vol 4, No 11 (2024): Volume 4 Nomor 11 (2024)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v4i11.15041

Abstract

ABSTRACT The alcoholic Sopi drink comes from palm trees (Arenga pinnata MERR), a type of palm tree spread throughout almost all of Indonesia. The alcohol in the traditional Sopi drink is ethanol (CH3CH2-OH) from fermented sap. This study aimed to examine the effect of Sopi Mayang drink on the increase in cytochrome P450 mRNA expression, increase in CYP2E1 protein levels and decrease in the number of spermatozoids using male white rats. This research is laboratory experimental, using the Randomized Post-test Only Control Group Design. Giving Sopi Mayang with a dose of 2.7 ml decreased the number of spermatozoids, namely 33,815,000, compared to the control group without giving Sopi Mayang, namely 56,680,000 (p = 0.0001). Sopi Mayang, with a dose of 4.05 ml, decreased sperm count from 33,815,000 to 22,334,775 (p= 0.0001). Sopi Mayang, with a dose of 5.4 ml, decreased sperm count from 22,865,000 to 18,250,309 (p=0.0001). There was a decrease in the number of spermatozoids in mice given Sopi Mayang. Keywords: Alcohol, Sopi Mayang, Spermatozoid, white rats ABSTRAK Minuman Sopi beralkohol berasal dari  pohon Enau/Aren (Arenga pinnata MERR) termasuk salah satu jenis tanaman palma, yang tersebar hampir di seluruh wilayah Indonesia. Alkohol yang terkandung dalam minuman tradisional Sopi adalah etanol (CH2CH3-OH) dari fermentasi nira. Penelitian ini ditujukan untuk melihat pengaruh minuman Sopi Mayang terhadap jumlah peningkatan ekspresi mRNA sitokrom P450, peningkatan kadar protein CYP2E1dan penurunan jumlah spermatozoid dengan menggunakan tikus putih jantan. Penelitian ini adalah eksperimental laboratoris, dengan menggunakan rancangan The Randomized Post-test Only Control Group Design. Pemberian Sopi Mayang dengan dosis 2,7 ml terjadi penurunan jumlah spermatozoid yaitu 33.815.000  dibandingkan dengan kelompok kontrol  tanpa pemberian  Sopi Mayang yaitu 56.680.000 (p = 0,0001). Sopi Mayang dengan dosis 4,05 ml terjadi penurunan jumlah sperma dari 33.815.000 menjadi 22.334.775 (p= 0,0001).  Sopi Mayang dengan dosis 5,4 ml terjadi penurunan jumlah sperma dari 22.865.000 menjadi 18.250.309 (p=0,0001). Terjadi penurunan jumlah spermatozoid, pada tikus yang diberikan Sopi Mayang. Kata Kunci: Alkohol, Sopi Mayang, Spermatozoid, Tikus Putih
PENGARUH ELASTIC BAND EXERCISE TERHADAP RSIIKO JATUH DAN KEKUATAN OTOT TUNGKAI PADA LANSIA DI LEMBAGA KESEJAHTERAAN SOSIAL LANJUT USIA BATARA HATI MULIA KABUPATEN GOWA Nindrahayu, Nindrahayu; Ariyandy, Andi; Idris, Irfan; Abadullah, Meutiah Mutmainnah; Arbaim Hasyar , Andi Rizky
Media Bina Ilmiah Vol. 18 No. 3: October 2023
Publisher : LPSDI Bina Patria

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33758/mbi.v18i3.470

Abstract

Penelitian ini bertujuan untuk mengetahui pengaruh elastic band exercise terhadap risiko jatuh dan kekuatan otot tungkai pada lansia dengan desain quasi eksperimental one group pretest-posttest. Responden dalam penelitian ini berjumlah 21 orang yang akan diberikan intervensi berupa elastic band exercise. Sebelum diberikan intervensi, dilakukan pretest berupa TUG tes untuk menilai skor risiko jatuh dan 30SCS untuk menilai kekuatan otot tungkai pada lansia. Post test dilakukan setelah diberi intervensi 3 kali seminggu selama 5 minggu. Uji Wilcoxon digunakan untuk mengetahui perubahan sebelum dan sesudah pemberian latihan. Hasil penelitian menunjukkan ada penurunan skor risiko jatuh dan peningkatan kekuatan otot tungkai pada responden dengan nilai p=0,000. Skor risiko jatuh mengalami perbaikan dari 15±(11-19) menjadi 10±(9-13), sedangkan kekuatan otot tungkai mengalami peningkatan dari 8±(5-10) menjadi 12±(9-14). Elastic band exercise efektif dalam menurunkan risiko jatuh dan meningkatkan kekuatan otot tungkai pada lansia
Health-Promotion Approaches to Postpartum Hypertension: Systematic Review of Causes and Management in Maternal Health Rauf, Efri Leny; Chalid, St. Maisuri T.; Idris, Irfan; As’ad, Suryani; Jayanti, Ira
Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Vol. 8 No. 12 (2025): December 2025
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/mppki.v9i1.9120

Abstract

Introduction: Postpartum hypertension remains one of the leading causes of maternal morbidity and mortality worldwide. This condition may persist from gestational hypertension, preeclampsia, or chronic hypertension, and can also develop de novo postpartum. Understanding its etiology, risk factors, and management strategies is essential to improving maternal health outcomes and preventing long-term cardiovascular complications. Methods: This study applied a systematic review design based on the Arksey and O’Malley framework, guided by the PEOS (Population, Exposure, Outcome, Study Design) model. A comprehensive literature search was conducted across PubMed, ScienceDirect, EBSCO, and Google Scholar databases for studies published between 2009 and 2023 using the keywords “postpartum hypertension,” “causes,” and “management.” Out of 120 identified studies, 20 met the inclusion criteria and were critically appraised using the Hawker Quality Assessment tool. Results: Postpartum hypertension is most frequently associated with preeclampsia, chronic hypertension, and gestational hypertension; however, iatrogenic causes such as bromocriptine therapy and excessive sodium intake were also identified. Most women experience a transient rise in blood pressure within the first 5 days postpartum, attributed to increased intravascular volume. The majority of studies emphasized inadequate screening and follow-up during the first week after delivery, with up to one-third of patients remaining untreated. Recent interventions, including digital monitoring systems and eHealth-based self-management, demonstrated improved outcomes in detection and patient adherence. Conclusion: Effective management of postpartum hypertension requires timely diagnosis, structured follow-up, and coordinated transition to primary care for long-term cardiovascular risk reduction. Health-care providers must enhance awareness and clinical competence, as complications from misdiagnosis or undertreatment remain common yet preventable through integrated postpartum surveillance and health-promotion strategies.
Perubahan Elektrokardiografi Post-Intervensi pada Pasien dengan Atrial Septal Defect Secundum: sebuah Studi Observasional Patimang, Yulius; Bastario, Andi Renata; Alkatiri, Abdul Hakim; Armyn, Andi Alief Utama; Idris, Irfan; Amir, Muzakkir; Nguyen, Dat T.; Qanitha, Andriany
Jurnal Kardiologi Indonesia Vol 46 No 4 (2025): October - December, 2025
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1344

Abstract

Background:. Secundum Atrial Septal Defect (ASD) is one of the most common forms of left-to-right shunt congenital heart defect that leads to right-sided overflow inducing geometrical and electrical changes in the right chambers. Electrocardiograms (ECGs) are reliable non-invasive tools to detect various electrical patterns produced by Secundum ASD that can give important clues in diagnostic procedures. After shunt closure, either percutaneously or surgically, normalization of flow ratio will induce reverse remodelling, which is one of the most important prognostic factors after defect closure. Our study aims to detect reverse remodelling in electrical aspects using ECGs in short (< 24 hour) and long term (> 6 months) follow-up after defect closure. Methods: We screened Secundum ASD patients that were admitted to undergo interventional closure percutaneously and surgically at RSUP Dr. Wahidin Sudirohusodo. After the screening process, 54 eligible subjects were enrolled in this study. Baseline characteristic data were obtained from medical record. ECGs measurements were taken at the time of admission for pre-closure baseline data, within 24 hours of closure and beyond 6 months after closure for follow-up data. Each ECGs parameter statistically was compared for pre-closure versus < 24 hour measurement after closure, and < 24 hour versus 6 months measurement after closure using paired T test or Wilcoxon signed-rank test. Results: In analysis of pre-closure vs. < 24 hour after closure data. There was significant reduction in all of the ECGs parameters (P wave amplitude 0.19 ± 0.04 vs. 0.11 ± 0.03 mv (p<0.001), P wave duration 97.78 ± 11.94 vs. 75.35 ± 13.36 ms (p<0.001), PR interval 182.89 ± 26.47 vs. 156.83 ± 21.81 ms (p<0.001), QRS duration 112.97 ± 14.84 vs. 88.31 ± 14.43 ms (p<0.001), QRS axis 107.94 ± 23.00 vs. 95.25 ± 24.62 ˚ (p<0.001), QTc interval 403.84 ± 30.85 vs. 396.80 ± 33.76 ms (p 0.017), R wave V1 amplitude 0.74 ± 0.35 vs. 0.53 ± 0.24 mv (p<0.001). In analysis of < 24 hour vs. > 6 months after closure data. There was also significant reduction in most of the ECGs parameters (P wave duration 75.05 ± 13.82 vs. 69.46 ± 11.84 ms (p<0.001), PR interval 155.53 ± 22.82 vs. 148.30 ± 19.34 ms (p<0.001), QRS duration 89.74 ± 14.02 vs. 85.38 ± 14.22 ms (p<0.001), QRS axis 94.80 ± 23.57 vs. 81.26 ± 22.96 ˚ (p<0.001), QTc interval 396.22 ± 33.70 vs. 384.40 ± 37.87 ms (p 0.020), R wave V1 amplitude 0.51 ± 0.24 vs. 0.32 ± 0.21 mv (p<0.001), except P wave amplitude (0.121 ± 0.03 vs. 0.119 ± 0.03 ms (p 0.321)). Conclusion: Our study showed electrical reverse remodelling in the most of the ECGs parameters after Secundum ASD closure except P wave amplitude in long term follow up.
Integrasi Nilai Moderasi Beragama dalam Proses Belajar Pendidikan Agama Islam di Sekolah Idris, Irfan; Usman, Syahruddin
Sipakatau: Jurnal Pendidikan dan Kebudayaan Vol. 2 No. 4 (2025): Edisi Oktober 2025
Publisher : Jurusan Tarbiyah STAI Al-Gazali Bone

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Abstract

Religious moderation has become an important issue in Islamic religious education amid the reality of social diversity in Indonesia. Islamic Religious Education in schools plays a strategic role in shaping students’ balanced, tolerant, and inclusive religious attitudes. This article aims to examine the integration of religious moderation values in the learning process of Islamic Religious Education in schools. This study employs a literature review approach by analyzing relevant academic sources, including books, journal articles, and educational policy documents. The findings indicate that the integration of religious moderation values can be systematically implemented through the development of contextual learning materials, the application of dialogical and reflective learning methods, and the strengthening of humanistic educational interactions. Such integration contributes to the formation of students’ moderate religious character and their ability to live harmoniously in a diverse society.
Kadar Human Leukocyte Antigen-G Serum Pada Abortus Spontan Dan Kehamilan Normal Allo, Sarjani Linggi; Yetti R, Erni; Tombeg, Zadrak; Rambulangi, Samrichard; Idris, Irfan; Hadi, Anto J.
Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Vol. 2 No. 2 (2019): May 2019
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1717.563 KB) | DOI: 10.56338/mppki.v2i2.567

Abstract

Adanya penolakan terhadap janin oleh sistim imun ibu karena adanya antigen paternal, diduga menjadi salah satu penyebab abortus oleh karena itu adanya humanleukocyte antigen-g (HLA-G) memegang peran  toleransi imun semialogenik fetus untuk pemeliharaan kehamilan.Penelitian ini bertujuan untuk mengetahui kadar HLAG-G serum pada kehamilan normal dan Abortus dengan metode ELISA.Desain penelitian ini adalah cros-sectional dengan jumlah sampel 50 yang dibagi dalam 2 kelompok yaitu25 abortus dan 25 kehamilan normal. Pengambilan sampel dilakukan secara concequtivesampling.Data dianalisis menggunakan uji Mann-whitneydan Independent-samples T test. Hasil uji statistik diperoleh rerata kadar HLA-G serum ibu abortus lebih rendah (276,08 ±69 ng/L) dibandingkan dengan hamil normal (345,30 ± 73,54ng/L) dengan nilai  p 0,001 <p 0,005. Pada usia ibu 20-35 tahun rerata kadar HLAG  pada kehamilan normal  357,57 ± 71,40 dan kelompok abortus  274,57±85,95 dengan nilai = p 0,015 sedangkan pada usia ibu  <20 dan >35 tahun rerata kadar HLA-G kehamilan normal 306,41±72,26 dan kelompok abortus 276,79±62,68 dengan nilai p=0,034. Umur kehamilan > 14 minggu  pada kelompok hamil normal rerata kadar HLAG  =353,43±78,17 dan kelompok abortus HLA-G = 243,60 +61,77 dengan nilaip =0,003 sedangkan  umur kehamilan 8-14 minggu pada kelompok hamil normal rerata kada HLA-G= 328,01±63,82 dan pada kelompok abortus  288,71±69,22 dengan nilai p=0,185. Paritas 2-3 pada kelompok hamil normal rerata HLA-G=342,87±73,42 dan kelompok abortus rerata HLA-G= 278,35±81,25 dengan nilai p=0,051 sedangkan paritas 1&> 3 pada kelompok hamilan normal rerata kadar HLA-G =350,46±78,57 dan kelompok abortus rerata kadar HLA-G = 274,80 ±64,14 dengan nilai p 0,043. Berdasarkan hasil analisis disimpulkan bahwa kadar serum HLA-G pada kelompok abortus lebih rendah dibandingkan kelompok hamilan normal. 
Co-Authors Abadullah, Meutiah Mutmainnah Abdul Hakim Alkatiri Abustani, Muthiah Adnan, Endy Allo, Sarjani Linggi Am, Nasrudin Amir, Muzakkir Amran, Muhammad Yunus Amru, Khaeriah Andi Kurnia Bintang, Andi Kurnia Andi Rizky Arbaim Hasyar Arief, Nila Ardilla Arif Santoso Ariyandy, Andi Armyn, Andi Alief Utama Arsyad, Muhammad Aryadi Asih, Puji BS. As’ad, Suryani Bahar, Ashari Bastario, Andi Renata Bukhari, Agussalim Dahniarti, Dhany Din Syafruddin Djabir, Yulia Yusrini Djaharuddin, Irawaty Dwi Kesuma Sari Gafur, Rahmi Hadi, Anto J. Halik, Handayani Hammado, Nurussyariah Hasyim, Ammar A. Irawan Yusuf Irma Rahayu, Irma Ismail, Amirah Febrianti Itani, Kei Iyori, Mitsuhiro Jannata, Rahma Winahyu Jayanti, Ira Kasim, Hasim Liong Boy Kurniawan, Liong Boy Mallisa, Hilda Emma Meryana*, A. Kurnia Bintang**, Muh. Akbar**, Susi Aulina**, Yudy Goysal**, Arifin Limoa*** Minarti, Deri Lidya Mulyamin, Winda Nakamura, Kurumi Nguyen, Dat T. Nindrahayu, Nindrahayu Nurisyah, Sitti Paharu, Kabah Patimang, Yulius Pratiwi, Hamria Prihantono, Prihantono Qanitha, Andriany Rafiah, Siti Rambulangi, Samrichard Rauf, Efri Leny RR. Ella Evrita Hestiandari Sanaky, Marliyati Satriana Satriana St. Maisuri T. Chalid Syahruddin Usman, Syahruddin Tadjuddin Chalid, Maisuri Tombeg, Zadrak Wardihan Sinrang, Andi Widaningsih, Yuyun Wuysang, Audry Devisanty Yetti R, Erni Yoshida, Shigeto Yustisia, Ika Yusuf Yenni Zainal, Kartika H.