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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Althea Medical Journal Nutri-Sains: Jurnal Gizi, Pangan dan Aplikasinya Molecular and Cellular Biomedical Sciences (MCBS) Journal of Health Sciences JURNAL ILMIAH OBSGIN : Jurnal Ilmiah Ilmu Kebidanan & Kandungan MEDIC MEdical Dedication Proceedings Series on Health & Medical Sciences Nursing Information Journal Jurnal Penyuuhan dan Pemberdayaan Masyarakat (JPPM) Conferences of Medical Sciences Dies Natalis Journal of Artificial Intelligence and Digital Business Journal of Medical Studies Prosiding Seminar Hukum Aktual Fakultas Hukum Universitas Islam Indonesia Jurnal Intelek Dan Cendikiawan Nusantara Jurnal Imiah Pengabdian Pada Masyarakat (JIPM) Indonesian Journal of Biomedicine and Clinical Sciences Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran Jurnal Hukum dan Pendidikan Kewarganegaraan
Citra Maharani
Universitas Jambi
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Journal : Molecular and Cellular Biomedical Sciences (MCBS)

 1 
Angiotensin-Converting Enzyme Genetic Polymorphism rs4343 as Risk of Diabetic Nephropathy in Jambi-Malay Population Elfiani, Elfiani; Puspasari, Anggelia; Arif, Cut Wulan; Maharani, Citra; Ali, Zulkhair; Suhaimi, Novadian; Effendi, Ian; Suprapti, Suprapti; Shafira, Nyimas Natasha Ayu
Molecular and Cellular Biomedical Sciences Vol 8, No 1 (2024)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v8i1.410

Abstract

Background: Diabetic nephropathy (DN) is one of the frequent complications of type II diabetes mellitus (T2DM) in Jambi province. Controlling blood glucose and blood pressure does not guarantee DN prevention, since genetic factors may also contribute to this disease. Multi-ethnic studies showed that one of the strongest genetic factors associated with DN was single nucleotide polymorphism rs4343 of angiotensin-converting enzyme (ACE) gene. Study regarding phenotype-genotype association of ACE rs4343 and DN has not yet been performed in Jambi Province, which is dominated by Malay ethnicity. This study was conducted to reveal the association between ACE rs4343 and the risk of DN in the Jambi-Malay population.Materials and methods: This was a cross-sectional study involving 75 subjects (44 with DN and 31 without DN) who suffered from T2DM and hypertension. DN was defined as albumin to creatinine ratio (ACR) ≥30 mg/g. Genotyping was performed with one-step tetra amplification refractory mutation system-polymerase chain reaction (PCR) using specific primer for ACE rs4343. Bivariate and multivariate analyses were performed to analyze the genetic risk for DN.Results: The bivariate analysis showed the proportion of DN subjects was higher than non-DN within the AG genotype (11:1) than within the AA (33:30) genotype. This difference was statistically significant (p=0.012; OR (95% CI): 10.00 (1.22-82.15)). Multivariate analysis showed that AG genotype (p=0.047; OR (95% CI): 10.04 (1.03-97.31)) and uncontrolled blood pressure (p=0.001; OR (95% CI): 6.72 (2.08-21.71)) were the risk factors of DN in the Jambi-Malay population.Conclusion: Polymorphism of ACE rs4343 is a risk factor of DN in the Jambi-Malay Population.Keywords: rs4343, angiotensin-converting enzyme gene, diabetic nephropathy, Malay, Jambi
TC Genotype of rs17782313 Near MC4R Gene Increases Obesity Risk Maharani, Amrina; Puspasari, Anggelia; Maharani, Citra; Enis, Rina Nofri; Aurora, Wahyu Indah Dewi; Halim, Rita
Molecular and Cellular Biomedical Sciences Vol 9, No 3 (2025)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v9i3.655

Abstract

Background: The genetic variant rs17782313 near the melanocortin-4-receptor gene (MC4R) is one of the robust risk factors for obesity and may be linked to its effect on dietary intake, which has different effect sizes between populations. The association between rs17782313 and obesity and dietary intake has not yet been published with the population from Jambi Malay. This study was conducted to analyze the association of genetic variation of MC4R rs17782313 and dietary intake among the Jambi Malay population.Materials and methods: This study was an unmatched case-control study with 110 subjects, consisting of 55 obese and 55 non-obese individuals. All the subjects were Jambi Malay who reside in Jambi Province and are aged 19-60 years. The MC4R rs17782313 genotype was measured using the tetra amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) method. Dietary data were collected through food recall and analyzed using the NutriSurvey. Bivariate and multivariate analyses were performed.Results: Bivariate analysis showed that subjects with TC genotype increased risk for obesity (p-value: 0.043; OR (95%CI): 3.044 (1.001-9.259). Multivariate analysis adjusted for age, gender and dietary intake, showed similar trends: the TC genotype increased the risk of obesity (p-value: 0.038; OR (95%CI): 3.376 (1.069-10.655). Dietary intake, including total calories, fat, carbohydrate, and protein intake, did not show a statistically significant association with the rs17782313 genotype in obese and non obese groups (p-value>0.05).Conclusion: The TC genotype of rs17782313 near the MC4R gene significantly increases the obesity risk in the Jambi Malay population, independent of dietary intake.Keywords: obesity, MC4R, rs17782313, Malay, Jambi
Co-Authors Agus Anggiana Ahmad Hamim Sadewa Ahmad Syauqy Ahmad Syauqy Alamri, Fahrial Alhadi, Annisa Alya Dwiva Juhari Amatullah, Afifah Amelia Dwi Fitri Amelia Dwi Fitri Amelia Dwi Fitri Amelia Dwi Fitri, Amelia Dwi Amri, Fahrial Al An Aldia Asrial Andrea Zulius Anarta Anggelia Puspasari Annissa Delfira Arif, Cut Wulan Arinda Triagita Armaidi Darmawan Aryanti, Nindya Asro Hayani Harahap Azzahra Sarah Fatimah Ramadhanti Bachrudin Syaroni Bagya Agung Prabowo, Bagya Agung Bernhard Arianto Purba Betty Marlina Budi Justitia Budi Justitia Bulqis, Ratu Defriani Dwiyanti, Defriani Devy Afriyanti Dhea Assyifa Dhea Olivia Putri Effendi, Ian Ekaputri, Tia Wida Elfiani Elfiani Elfiani Elga Lauza Evelyna Ellysa Shalsabella Erny Kusdiyah Esa Indah Ayu, Esa Indah Eva Yuniritha, Eva Fanny Annisa Fazarrosy Fitriyanti Gian Mariana Hadi, Desta Asmara Hana Nurul Qur’ani Hasmita, Debby Hasneli, Hasneli Helfira Citra Herlambang Herlambang HERLAMBANG HERLAMBANG Herlambang Herlambang Herlambang Herlambang Herman, Sriyana Huntari Harahap Ika Setyawati Ilham Rizqi Ariyandi Irfannuddin Irfannuddin Irlianissa, Mutiara Iskandar, Mirna Marhami Ismi Nurwaqiah Ibnu Jamilatul Rizqiyah Khairunnisa, Dhia Fairuz Kusumawati, Diana Maharani, Amrina Maulana Haikal An Nur Miftahurrahmah Miftahurrahmah, Miftahurrahmah Muhamad Reza Muhammad Basir Muhammad Iqbal Fasa Mus, Rosdiana Mustamin Mustamin Nalanwal, Khayla Nurul Izza Nyimas Natasha Ayu Shafira Pramudji Hastuti Prasetyawan, Riyan Dwi Prio Wibowo Rahma, Syawalya Rara indah Oktaviani Renaldi Rizki Nugraha Retno Wulansari Rina Nofri Enis Rita Halim Rita Halim Rusli Shandra Khaerunissa Sri Darningsih Suhaimi, Novadian Supartono Suprapti Suprapti Syamsuriyati, Syamsuriyati Syarif Syifa Energi Maulana Syukur, Astian Nathaniel Tarawifa, Susan Tengku Arief Buana Perkasa Tia Wida Ekaputri Virginsia, Sonya Vivekanantharasa, Raveenthiran Vivi Fadhilah Safitri Wahyu Indah Dewi Aurora Wilma Wilma, Wilma Winiesti Melani Putri Zita Andini Sabillah Zulkhair Ali