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Journal : Journal of Health Sciences

The Role of Angiotensinogen rs699 in Diabetic Nephropathy Among Type 2 Diabetes Mellitus Patients with Uncontrolled Postprandial Glucose Levels Anggelia Puspasari; Devy Afriyanti; Huntari Harahap; Citra Maharani; Elfiani Elfiani
Jurnal Ilmiah Kesehatan Vol 15 No 03 (2022): Jurnal Ilmiah Kesehatan (Journal of Health Science) 
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (293.568 KB) | DOI: 10.33086/jhs.v15i03.2681

Abstract

Diabetic Nephropathy (DN) is the most common complication of Type 2 Diabetes Mellitus (T2DM), leading to the highest mortality rate of DM complications. However, its etiology is still questionable. Hyperglycemia, hypertension, and particular genetic susceptibility are associated with DN. Not all patients with uncontrolled hyperglycemia suffer DN. Thus, genetic susceptibility may be a risk factor for DN. The genetic variant of angiotensinogen rs699 is known to be associated with the risk of DN with inconsistent results between ethnicities. This study aims to reveal the correlation between the AGT rs699 with the incidence of diabetic nephropathy among type-2 diabetes mellitus patients with uncontrolled postprandial glucose levels in the Jambi Malay ethnicity. This study was observational analytic research with a cross-sectional design. It used 48 DNA samples from type-2 diabetes mellitus patients with uncontrolled postprandial glucose levels. The authors took 24 DNA samples from patients with DN and 24 without DN (as a control group). The genotyping method used ARMS-PCR specific for AGT rs699. Subjects with the CT genotype had a lower risk for diabetic nephropathy than the CC genotype, but it was not statistically significant (p=0.247; OR=0.508; 95%CI=0.160-1.607). In addition, subjects with the T allele (p=0.331; OR=0.621; 95%CI-0.237-1.630) had a lower risk for diabetic nephropathy than the C allele, but it was not statistically significant. In conclusion, Angiotensinogen rs699 is not a risk factor for diabetic nephropathy among type-2 diabetes mellitus patients with uncontrolled postprandial glucose levels in the Jambi Malay ethnicity.
Co-Authors Agus Anggiana Ahmad Hamim Sadewa Ahmad Syauqy Ahmad Syauqy Alamri, Fahrial Alhadi, Annisa Alya Dwiva Juhari Amatullah, Afifah Amelia Dwi Fitri Amelia Dwi Fitri Amelia Dwi Fitri Amelia Dwi Fitri, Amelia Dwi Amri, Fahrial Al An Aldia Asrial Andrea Zulius Anarta Anggelia Puspasari Annissa Delfira Arif, Cut Wulan Arinda Triagita Armaidi Darmawan Aryanti, Nindya Asro Hayani Harahap Azzahra Sarah Fatimah Ramadhanti Bachrudin Syaroni Bagya Agung Prabowo, Bagya Agung Bernhard Arianto Purba Betty Marlina Budi Justitia Budi Justitia Bulqis, Ratu Defriani Dwiyanti, Defriani Devy Afriyanti Dhea Assyifa Dhea Olivia Putri Effendi, Ian Ekaputri, Tia Wida Elfiani Elfiani Elfiani Elga Lauza Evelyna Ellysa Shalsabella Erny Kusdiyah Esa Indah Ayu, Esa Indah Eva Yuniritha, Eva Fanny Annisa Fazarrosy Fitriyanti Gian Mariana Hadi, Desta Asmara Hana Nurul Qur’ani Hasmita, Debby Hasneli, Hasneli Helfira Citra Herlambang Herlambang Herlambang Herlambang Herlambang Herlambang HERLAMBANG HERLAMBANG Herman, Sriyana Huntari Harahap Ika Setyawati Ilham Rizqi Ariyandi Irfannuddin Irfannuddin Irlianissa, Mutiara Iskandar, Mirna Marhami Ismi Nurwaqiah Ibnu Jamilatul Rizqiyah Khairunnisa, Dhia Fairuz Kusumawati, Diana Maharani, Amrina Maulana Haikal An Nur Miftahurrahmah Miftahurrahmah, Miftahurrahmah Muhamad Reza Muhammad Basir Muhammad Iqbal Fasa Mus, Rosdiana Mustamin Mustamin Nalanwal, Khayla Nurul Izza Nyimas Natasha Ayu Shafira Pramudji Hastuti Prasetyawan, Riyan Dwi Prio Wibowo Rahma, Syawalya Rara indah Oktaviani Renaldi Rizki Nugraha Retno Wulansari Rina Nofri Enis Rita Halim Rita Halim Rusli Shandra Khaerunissa Sri Darningsih Suhaimi, Novadian Supartono Suprapti Suprapti Syamsuriyati, Syamsuriyati Syarif Syifa Energi Maulana Syukur, Astian Nathaniel Tarawifa, Susan Tengku Arief Buana Perkasa Tia Wida Ekaputri Virginsia, Sonya Vivekanantharasa, Raveenthiran Vivi Fadhilah Safitri Wahyu Indah Dewi Aurora Wilma Wilma, Wilma Winiesti Melani Putri Zita Andini Sabillah Zulkhair Ali