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All Journal Microbiology Indonesia Indonesian Journal of Urology Jurnal Berkala Epidemiologi Indonesian Journal of Tropical and Infectious Disease Belitung Nursing Journal J-Dinamika: Jurnal Pengabdian Kepada Masyarakat JURNAL KESEHATAN MERCUSUAR Majalah Biomorfologi (Biomorphology Journal) CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Jurnal Pengabdian Masyarakat dalam Kesehatan International Islamic Medical Journal Narra J Jurnal Ilmiah Kesehatan (JIKA) Makara Journal of Health Research
Juniastuti Juniastuti
Department Of Microbiology, Medical Faculty, Universitas Airlangga, Surabaya Indonesia-Japan Collaborative Research Center For Emerging And Re-emerging Infectious Diseases Institute Of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia
Religion Humanities Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Helicobacter pylori sabA, hopQ and hom genotypes as potential genetic biomarkers for gastric mucosal inflammation Hunowu, Ramdan; Fauzia, Kartika A.; Alfaray, Ricky I.; Dewi, Selva R.; Juniastuti, Juniastuti; Yamaoka, Yoshio; Miftahussurur, Muhammad
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.1917

Abstract

Helicobacter pylori infection drives heterogeneous gastric pathologies, yet genotype-phenotype correlations in diverse populations remain underexplored. The aim of this cross-sectional study was to investigate the associations between H. pylori virulence genotypes (sabA, hopQ, hom family) and histopathological severity in gastric mucosa among 113 Indonesian dyspepsia patients (mean age: 49.6 years; male predominance: 64.6%). Whole-genome sequencing characterized virulence genotypes, while histopathological grading system using the Updated Sydney System assessed inflammation, atrophy, and bacterial density in the antral and corporal gastric regions. Phylogenetic analysis elucidated strain relatedness. Key genotype frequencies included sabA "on" (40.6%, 43/106), hopQ type I (53.7%, 43/80), and homCL (82.4%, 75/91). Statistical analysis revealed sabA "on" status significantly associated with elevated antral bacterial density (odds ratio (OR) 2.70 and 95% confidence interval (95%CI) 1.10–6.60, p=0.027). The homC variants (homCL/homCS) demonstrated robust associations with chronic inflammation severity (OR: 3.04; 95%CI: 0.99–9.36, p=0.046) and atrophy progression (OR: 4.78; 95%CI: 1.00–22.86, p=0.035), in contrast to the hopQ genotype, which showed no histopathological association. These findings indicated that sabA and homC as critical determinants of gastric microenvironment modulation, potentially through sabA-mediated colonization efficiency and homCL-babA synergistic interactions. While histological profiles predominantly indicated mild atrophy, widespread severe chronic inflammation signals latent progression risks.
Co-Authors A.A. Ketut Agung Cahyawan W Achmad Ardianto, Achmad Adhiningsih, Yunita Ratri Adiana Mutamsari Witaningrum Adnyana , I Made Dwi Mertha Ahmad Suryawan Aksono HP., Eduardus Bimo Al Karina, Citra Alfaray, Ricky I. Alimsardjono, Lindawati Alpha Fardah Athiyyah Ana Bilah, Aisah Nur Andy Darma Annisa Fira Salsabila Asmarawati, Tri Pudy Budi Utomo Deby Kusumaningrum Desi Fitriani Dewi, Selva R. Dian Marcia, Dian Doddy M. Soebadi Dominicus Husada Dwi Endraswari, Pepy Dwiyanti Puspitasari, Dwiyanti Edward M Putera, Edward M Eko Budi Koendhori, Eko Budi Faisal Faisal Fathmawati Fathmawati Fatimah Arief Fauzia, Kartika A. Fedik Abdul Rantam Fikri Sasongko Widyatama Firmansyah, Joedhistira Bayu Fitria, Anisa Lailatul Florentina Sustini HAK HOTTA HAK HOTTA Hana Heny Arwati Herman Kosasih HERNOMO ONTOSENO KUSUMOBROTO Hunowu, Ramdan I Gusti Made Reza Gunadi Ranuh Ilma Dzurriyyatan Toyyibah Itja Firdarini, Itja Khairul Bariyah, Khairul Laura Navika Yamani Lindarto, Wira Widjaya M. Qushay, M. Maharani, Aussie Tahta Mahmudatul Muna, Nafdzu Maria I Lusida, Maria I MARIA INGE LUSIDA Maria Inge Lusida MARIA INGE LUSIDA MOCHAMAD AMIN MOCHAMAD AMIN Mochamad Yusuf Alsagaff MOCHAMMAD THAHA Moses Tende Stephens Muhammad Faizi Muhammad Miftahussurur Muna, Nafdzu Makhmudatul Musofa Rusli Nasronudin Nasronudin Nur Rochmah Nurul Wiqoyah, Nurul Pepy Dwi Endraswari, Pepy Dwi Peter Chilaque Dossen Prihartini Widiyanti Priyo B Purwono, Priyo B Priyo Budi Purwono Rebekah Setiabudi, Rebekah Retno Handajani Retno Pudji Rahayu Retno Wahyunitisari, Manik Rusli , Musofa Sardjono, Lindawati Alim Septyawati, Ratna Setiawan, Firman Siti Qamariyah Khairunisa, Siti Qamariyah SOETJIPTO . SOETJIPTO . Sri Subekti Sudarmo, Subijanto Marto Sukmawati Basuki Sulistiawati Sunaryo Hardjowijoto Takako Utsumi TAKAKO UTSUMI TAKAKO UTSUMI Taufik Indrawan Tomohiro Kotaki, Tomohiro Vermasari, Naritha Wahyunitisari, Manik Retno Wiwin Retnowati YOSHIHIKO YANO YOSHIHIKO YANO Yoshio Yamaoka, Yoshio YOSHITAKE HAYASHI YOSHITAKE HAYASHI Yunita Ratri Adhiningsih Zayyin Dinana