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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Alchemy : Journal of Chemistry The Journal of Pure and Applied Chemistry Research Jurnal Agroekoteknologi CHEMPUBLISH JOURNAL JOURNAL ONLINE OF PHYSICS Jurnal Teknologi Laboratorium Chimica et Natura Acta Indonesian Food Science and TechnologyJournal Pharmacology and Clinical Pharmacy Research Jambura Journal of Chemistry PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal IPTEK Bagi Masyarakat Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan International Journal of Hydrological and Environmental for Sustainability Makara Journal of Science Jurnal Pengabdian Pada Masyarakat Molekul: Jurnal Ilmiah Kimia Journal of The Indonesian Society of Integrated Chemistry Jurnal Sains dan Kesehatan
Madyawati Latief
Prodi Kimia Fakultas Sains dan Teknologi Universitas Jambi
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Journal : Makara Journal of Science

 1 
Isolation and Characterization of Ethyl Acetate Fraction from Abroma augusta L as an Anti-Inflammatory Agent Latief, Madyawati; Tarigan, Indra Lasmana; Muhaimin, Muhaimin; Amanda, Hilda; Yulianti, Nike Desvi
Makara Journal of Science Vol. 25, No. 2
Publisher : UI Scholars Hub

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Abstract

Abroma augusta is a bush plant that lives on the edge of the river. This plant is commonly used as an anti-inflammatory drug for joints and broken bones. It contains several secondary metabolites, such as alkaloids, triterpenoids, steroids, and flavonoids, which exhibit anti-inflammatory activity. UV-visible (UV-Vis) spectrophotometry of isolate 1.3 indicated absorption at a maximum wavelength of 282 nm. The wavelength suggested that the electron transition π–π* is the absorption of UV spectra typical for triterpenoid compounds that have chromophores in the form of non-conjugated double bonds. FT-IR spectrophotometer characterization data from isolate 1.3 revealed the presence of triterpenoid compounds having carboxyl groups C-O (ester), C-(CH3)2 (gem-dimethyl), carbonyl C = O esters, and C-H (alkyl). Analyses of UV-Vis, FT-IR, GC-MS, 1H-NMR, and 13C-NMR spectra showed that the compound obtained was the triterpenoid β-amyrin. Activity test demonstrated that isolate 1.3 with a 10 mg dose showed stronger anti-inflammatory activity than the positive control of sodium diclofenac.
Synthesis of Carboxymethyl Cellulose from Nypa fruticans for Coating Metformin on Zn-Based Metal-Organic Framework Nanohybrid as a Bionanocomposite Drug Delivery System Delviani, Delviani; Maharani, Viola Giary Rizkillah; Shadrina, Putri Nur; Warni, Tri; Azizah, Regina Wan; Tarigan, Indra Lasmana; Latief, Madyawati
Makara Journal of Science
Publisher : UI Scholars Hub

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Diabetes is a common and rapidly spreading disease that affects 6.6% of the world’s population. Metformin hydrochloride (HCl) is an effective oral pharmacological treatment for type 2 diabetes mellitus (T2DM) patients because of its capability to reduce glucose levels and the risk of hypoglycaemia. However, gastrointestinal sensitivities to this drug can cause diarrhoea, nausea, vomiting and stomach ache. An alternative is controlled release technology by coating metformin with carboxymethyl cellulose (CMC) and zinc-metal-organic framework (Zn-MOF) through the encapsulation method. Therefore, this study aimed to coat metformin formulations using CMC in a Zn-MOF to control release into the body and minimise the side effects related to doses. The results showed that CMC/metformin@Zn-MOF encapsulation had a controlled blood sugar lowering effect and stable healing effectiveness even at a low concentration of 1:10 of local metformin. In vitro, the released concentrations from local metformin tablets and CMC/Metformin@Zn-MOF were 199.50 ppm of 500 ppm and 42.182 ppm of 50 ppm, with release percentages of 39.90% and 84.364%, respectively. This study found that metformin masking using CMC and Zn-MOF maximally produced a modified release formula along the intestine by reducing the concentration to increase tolerability in lowering blood sugar effectively for T2DM patients with minimal side effects.
Co-Authors -, Maison Addion Nizori Ahmad Fadhil, Ahmad Alfi Khatib, Alfi Alrizal, Alrizal Amanda, Dwi Rahma Amanda, Hilda Ardhica, Jammes Arum, Dewi Azizah, Regina Wan Bela, Anisa Budiyati Ichwan Bulan, Catherine Putri Delviani, Delviani Dewi, Tribuana Tungga Elis Kartika Ermadani Ermadani Faizar Farid Farah, Farah Fisesa, Anggun Tri Helmina Mandalahi, Helmina Hengky Irawan, Hengky Heriyanti Heriyanti, Heriyanti Husna, Naimul Indra Lasmana Tarigan Jamaludin Al-Anshori Kharisma, Tiara Lince Muis Lizawati Lizawati Lucky Zaehir Maulana Maharani, Viola Giary Rizkillah Marbun, Sarah Aknesia Masruri Masruri Melani, Fitria Muhaimin Muhaimin Nabila, Annisa Candra Natasya, Dian Nelson Nurjannah, Sofia Nurul Huda Oktavioni, Marsella Pebralia, Jesi Prabawa, Satria Prahandika, Graha Puspitasari, Ratih Dyah Putri Maya Sari Putri, Silvi Ayudiah Putri, Yunika Eka qurrota aini Rahayu, Rosi Rahmasari, Nadia Ramadhan, Ilham Ifandi Razai, Tengku Said Resta, Ichy Lucya Restina Bemis, Restina Riany, Hesti Saharin, Siti Munirah Samsidar Samsidar Sari, Tika Shadrina, Putri Nur Silvi Leila Rahmi Sinurat, Julius Alvin Novensius Suci, Ulan Susanto, Nindita Clourisa Amaris Sutrisno, Sustrisno Sutrisno, Sutrisno Tambunan, Betharia Juli Mas Tarigan, Indra L. Uce Lestari Warni, Tri Wulan Safitri, Wulan Yoza Fendriani Yulianti, Nike Desvi Yusnaidar, Yusnaidar Yusof, Yus Aniza Zulnita, Anis