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All Journal JURNAL GIZI INDONESIA Jurnal Neutrino : jurnal fisika dan aplikasinya Journal of Biomedicine and Translational Research Berkala Kedokteran Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Entomologi Indonesia Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Jurnal Health Sains Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Locus Penelitian dan Pengabdian Makara Journal of Science Indonesian Journal of Medical Chemistry and Bioinformatics Journal of Global Pharma Technology JURNAL BIOLOGI PAPUA Indonesian Journal of Biomedicine and Clinical Sciences
Dwi Anita Suryandari
Departement Of Medical Biology, Faculty Of Medicine, Universitas Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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Anopheles species diversity and potential vectors of zoonotic malaria in Central Kalimantan, Indonesia: Diversitas spesies Anopheles dan vektor potensial malaria zoonotik di Kalimantan Tengah, Indonesia Permana, Dendi Hadi; Asih, Puji Budi Setia; Suryandari, Dwi Anita; Murhandarwati, Elsa Herdiana; Rozi, Ismail Ekoprayitno; Syahrani, Lepa; Kartapradja, Hannie Dewi Hadyani; Hidayah, Najdah; Bahrani; Irdayanti; Juliawaty, Rita; Coutrier , Elisabeth Farah Novita; Syafruddin, Din
Jurnal Entomologi Indonesia Vol 22 No 3 (2025): November
Publisher : Perhimpunan Entomologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5994/jei.22.3.165

Abstract

Zoonotic malaria is an emerging public health issue in Indonesia, particularly in regions with significant forest cover and frequent interaction between humans and non-human primates. Information regarding the diversity and behaviour of mosquito vectors in these areas is very limited. This study aims to identify the diversity and bionomics of mosquitoes, particularly Anopheles sp., across five ecologically diverse locations in Palangkaraya, Central Kalimantan, to gain an understanding of their potential role in zoonotic malaria transmission. Cross-sectional entomological surveys were conducted during November 2022 (during the rainy season) and October 2024 (at the beginning of the rainy season). Adult mosquitoes were collected using human landing catches (HLC) from 18:00 to 06:00, and larval habitats were surveyed and characterized following the WHO protocol. A total of 1,278 mosquitoes were collected from six genera, with Anopheles letifer Sandosham dominating the Anopheles group (97%), particularly in swampy secondary forests, such as Nyaru Menteng. This species exhibited peak outdoor biting activity shortly after dusk and late at night, posing a greater risk to those outside or in unscreened homes. Larval surveys conducted at 48 sites revealed Anopheles larvae in 27% of habitats, predominantly in swamps (67% positive). Although no significant associations were found with environmental factors, natural and semi-natural water bodies appear key to sustaining vector populations. These findings highlight the ecological flexibility of An. letifer and its potential impact on zoonotic malaria transmission in forest-edge communities. Vector control strategies should include integrated methods, such as larval source management and community-based interventions, particularly in peat swamp regions where interactions between humans and non-human primates are frequent.
In Silico Analysis of Centella asiatica Phytochemicals Targeting the KEAP1–NRF2 Pathway as Potential Radioprotective Agents Aghisna Binurillah Sulaeman; Dwi Anita Suryandari; Luluk Yunaini; Fadilah Fadilah
Jurnal Locus Penelitian dan Pengabdian Vol. 5 No. 6 (2026): JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v5i6.5759

Abstract

Ionising radiation induces excessive oxidative stress and cellular damage, necessitating the discovery of effective radioprotective agents. The KEAP1–NRF2 pathway plays a central role in antioxidant defence, making KEAP1 inhibition a promising strategy for enhancing NRF2 activation. Centella asiatica contains diverse bioactive compounds with reported antioxidant and cytoprotective properties; yet their potential as direct KEAP1 inhibitors remains underexplored. This study aimed to evaluate the molecular interactions of Centella asiatica phytochemicals with KEAP1 using in silico approaches, in order to identify potential natural radioprotective candidates. Thirty-six bioactive compounds from Centella asiatica were subjected to molecular docking against the KEAP1 Kelch domain (PDB ID: 4L7B) using AutoDockTools 1.5.7. Ligand–protein interactions were visualised using LigPlot+ and PyMOL. Pharmacokinetic and toxicity profiles were predicted using DeepPK and admetSAR, including assessments of drug-likeness, intestinal absorption, CYP inhibition, and toxicity endpoints. Three compounds demonstrated strong binding affinities below –8 kcal/mol: acetylursolic acid (–8.88 kcal/mol), campesterol (–8.55 kcal/mol), and ursolic acid (–8.15 kcal/mol). All three interacted with the key KEAP1 residue Arg415, with additional interactions involving Ser363 (acetylursolic acid and ursolic acid) and Ser508 (campesterol). ADME–Tox analysis indicated favourable pharmacokinetic profiles, good intestinal absorption, non-mutagenic and non-carcinogenic predictions, and overall compliance with Lipinski's Rule of Five, notwithstanding a single LogP violation. Acetylursolic acid, campesterol, and ursolic acid exhibit strong binding to critical KEAP1 residues and demonstrate favourable pharmacokinetic and safety profiles, suggesting their potential as natural radioprotective agents through modulation of the KEAP1–NRF2 pathway. Further in vitro and in vivo studies are warranted to validate their radioprotective efficacy.
Association of vitamin D receptor and group-specific component gene polymorphisms with type 2 diabetes mellitus among Javanese in Jakarta Veronica Shinta Setiadi; Dwi Anita Suryandari; Wina Sinaga
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 14, No 2 (2026): June
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.14.2.173-183

Abstract

ABSTRACTBackground: Type 2 diabetes mellitus (T2DM) is a major public health problem with increasing prevalence globally and in Indonesia, particularly in Jakarta, which has one of the highest prevalence rates, with the Javanese as the predominant ethnic group. Vitamin D deficiency is highly prevalent in this population and has been associated with an increased risk of T2DM.  Vitamin D plays an important role in glucose metabolism by enhancing insulin secretion and improving insulin sensitivity. Polymorphisms in the Vitamin D Receptor (VDR) and Group-Specific Component (GC) genes, which are involved in vitamin D metabolism and function, are hypothesized to influence T2DM risk.Objective: This study aimed to analyze the association between VDR rs2228570 and GC rs7041 gene polymorphisms and T2DM among the Javanese population in Jakarta.Materials and Methods: A comparative cross-sectional study was conducted among 101 Javanese adults (50 T2DM and 51 non-diabetic subjects). Gene polymorphisms were analyzed using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Associations were assessed using Chi-square tests.Results: No significant association was found between VDR rs2228570 and GC rs7041 gene polymorphisms and T2DM.Conclusion: No evidence of association was observed between VDR rs2228570 and GC rs7041 gene polymorphisms and T2DM in this population. These findings highlight the multifactorial nature of T2DM, suggesting that genetic factors related to vitamin D may play a limited role, while environmental and lifestyle factors remain important. Further studies with larger and multi-ethnic populations are needed to better understand the role of vitamin D-related genetic factors in T2DM.Keywords: Type 2 diabetes mellitus; gene polymorphism; Vitamin D Receptor; group-specific component; javanese ethnicity
Co-Authors Achmad K. Harzif Aghisna Binurillah Sulaeman Arief Budiono Arleni Bustami Bahrani Barasila, Atikah Chalida Benedikta D. Saraswati Benedikta Diah Saraswati Budi Wiweko Christina Agusta Deviana Tanifan Corry N. Mahama Coutrier , Elisabeth Farah Novita Dewi Sukmawati Dewi Sukmawati Din Syafruddin Dwi Yanti E. Elsa Herdiana Murhandarwati Fadilah Fadilah Fatimah Eliana Ghaniyyatul Khudri Hadi Sunaryo Hartanto Bayuaji Hidayah, Najdah Irandi Putra Pratomo Irdayanti Juliawaty, Rita Kartapradja, Hannie Dewi Hadyani Khaerunissa Anbar Istiadi Khatimah, Husnul Kristanty, Diyah Kurniati, Mala Luluk Yunaini Mala Kurniati Muchtaruddin Mansyur Muhammad Ilyas Iqbal Nukman Moeloek Nukman Moeloek Nukman Moeloek Panghiyangani, Roselina Permana, Dendi Hadi Pramudianto Pramudianto Prawiningrum, Aisyah Primariadewi Rustamadji Pudji Sari Pudji Sari Puji Budi Setia Asih, Puji Budi Puji Sari Puji Sari Puji Sari Puji Sari Raden Muharam Natadisastra Retno A. Werdhani Ria Kodariah Rozi, Ismail Ekoprayitno Surya Dwira Syahrani, Lepa Trisia Lusiana Amir Umiatin, Umiatin Veronica Shinta Setiadi Widia Bela Oktaviani Wina Sinaga Wisnu Jatmiko Yoel Asmida Yoel Asmida Yuda Nabella Prameswari Yurnadi Yurnadi