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All Journal BALI MEDICAL JOURNAL (BMJ) Journal of Islamic Pharmacy MNJ (Malang Neurology Journal) Majalah Obstetri dan Ginekologi The Indonesian Biomedical Journal JIEET (Journal of Information Engineering and Educational Technology) Pharmaceutical Journal of Indonesia Majalah Kedokteran Neurosains JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Indian Journal of Forensic Medicine & Toxicology Cermin Dunia Kedokteran AKSONA Indonesian Journal of Cancer Neurona Cermin Dunia Kedokteran Folia Medica Indonesiana
Mohammad Hasan Machfoed
Departemen Neurologi FK Universitas Airlangga/RSUD Dr. Soetomo, Surabaya
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Effectiveness of Triamcinolone and Lidocaine in Patient with Piriformis Syndrome – A Case Series Setianti, Ariani Rahayu; Hidayati, Hanik Badriyah
Pharmaceutical Journal of Indonesia Vol 5, No 1 (2019)
Publisher : Brawijaya University

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Abstract

Piriformis syndrome (PS) has been documented as a contributory cause for sciatica, buttock, and low back pain. The worldwide incidence of PS would be about 2,4 million per year. The management of piriformis syndrome includes injection of the piriformis muscle with local anesthetic and steroid, however, the study for the effectiveness of the combination is lacking especially in Indonesian population. This case illustrates the effectiveness reduction of triamcinolone in combination with lidocaine measured by Visual Analogue Scale (VAS) in patient suffered from PS. 
DEMENTIA IN DR. SOETOMO GENERAL HOSPITAL SURABAYA: A SYNTHETIC REVIEW OF ITS CHARACTERISTICS Imami, Nabilah Hasna; Haryono, Yudha; Sensusiati, Anggraini Dwi; Hamdan, Muhammad; Hidayati, Hanik Badriyah
MNJ (Malang Neurology Journal) Vol. 7 No. 1 (2021): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2021.007.01.3

Abstract

Background: Dementia is a clinical syndrome characterized by progressive loss of cognitive function in elderly people interferes  the ability to function independently. The number of elderly patients increased so fast in worldwide. The prevalence of dementia rapidly increases due to increasing of population. Aging demographic transition is proceeding rapidly especially in China, India, and Latin America, where dementia is rapidly becoming the major public health problem. Demographic data of elderly patients of dementia in Indonesia is still a little. Dementia’s research data in Indonesia were only obtained  from Bali and Yogyakarta, while data from Surabaya were not obtained. Our research data is taken from Dr. General Hospital Soetomo Surabaya, East Java, Indonesia. This study is important for dementia epidemiological data and baseline data for further treatment of dementia patients in Surabaya.Objective: The purpose of this study to determine the characteristics profile of elderly patients  with dementia in Dr. Soetomo General Hospital Surabaya, East Java, Indonesia.Methods: Sampling was done with purposive sampling by observing the medical records of patients in the period of January 2017 to December 2017 based on inclusion and exclusion criterias that have been set. The data was taken from the patient's medical record which had been written and examined by neurologists from the neurology department in the neurobehaviour sub-department of Dr. Soetomo Surabaya.Results: The majority of dementia patients are men (51,7%); the age group which is most at risk for dementia is between age of  75-79 years; most of the patients are jobless; more than half of patients are high school graduates; and Vascular Dementia (VaD) is the type of dementia that  most people suferredConclusion: This characteristic’s data of dementia can be used for providing information about dementia to make public health care provides a better facillities and treatment for elderly patients to prevent dementia burden.
NUMERIC RATING SCALE ANALYSIS OF TRIGEMINAL NEURALGIA PATIENTS BEFORE AND AFTER MICROVASCULAR DECOMPRESSION Fitri Amelia, Elena Ghentilis; Turchan, Agus; Rehatta, Nancy Margarita; Hidayati, Hanik Badriyah
MNJ (Malang Neurology Journal) Vol. 7 No. 1 (2021): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2021.007.01.4

Abstract

Background: Trigeminal Neuralgia is a common condition of facial pain and its significantly affect patients’ daily life. Microvascular decompression is one of the interventional pain management for trigeminal neuralgia. There is still a little data obtained on evaluation of facial pain after microvascular decompression in Indonesia.   Objective: This research aimed to evaluate facial pain after microvascular decompression of  trigeminal neuralgia patients in Dr. Soetomo General Hospital, PHC Hospital, and Bangil General Hospital, Indonesia.Methods: The research design was a pretest-posttest with total sampling. Data were obtained from medical records from January 2018 until June 2019. Researches used Numeric Rating Scale (NRS) as pain measurement. The data obtained were analyzed by descriptive statistical test, normality test, and paired t-test.Results: Trigeminal Neuralgia patients that has been treated with microvascular decompression have an average facial reduction from 7.33±2.29 to 1.89±3.41 with p = 0.001. This result showed that the microvascular decompression has significantly reduce facial pain in patients with trigeminal neuralgia.Conclusion: Microvascular decompression significantly reduce the facial pain of trigeminal neuralgia patients.
Swimming Improves Memory Function and Decreases N-Methyl-D-Aspartate in Ageing Rats Hanik Badriyah Hidayati; Purwo Sri Rejeki; Lilik Herawati; Susi Wahyuning Asih; Suhartati Suhartati; Siti Khaerunnisa
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16883

Abstract

A single Memory impairment substantially reduces the quality of life in the elderly. It is associated with thealteration of neurotrophic (NT) factors, such as brain-derived neurotrophic factor (BDNF) and glutamatereceptor N-methyl-D-aspartate (NMDA). Exercise is often used to reduce cognitive impairment. Previousstudies show that the benefits of aerobic exercises on such impairments are correlated with increasing BDNFand preventing the production of NMDA. However, some results remain controversial. Thus, the associationbetween exercise and Memory was addressed by examining increases in BDNF and the reduction of NMDAin ageing rats. The study used a randomized, post-test-only controlled group of 30 male one-year-old ageingRattus norvegicus divided into three groups, namely, K0 (control) and K1 and K2 (aerobic swimmingexercise). K1 and K2 animals differed in the frequency of exercise, which is three and four sessions perweek, respectively. Memory was assessed using Y-maze performance. BDNF and NMDA were analyzedusing enzyme-linked immunosorbent assays. A significant improvement in memory function and reductionin the NMDA level were observed in K1 and K2 group rats (p = 0.001; p = 0.041). No significant impact onthe BDNF levels was observed (p = 0.387). Swimming may boost Memory by reducing the NMDA levelbut not by increasing BDNF. Swimming is a promising method for preventing or delaying memory loss indegenerative brain diseases. Further investigation is needed to fully understand underlying mechanisms.
Effectiveness of Triamcinolone and Lidocaine in Patient with Piriformis Syndrome – A Case Series Setianti, Ariani Rahayu; Hidayati, Hanik Badriyah
Pharmaceutical Journal of Indonesia Vol 5, No 1 (2019)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Piriformis syndrome (PS) has been documented as a contributory cause for sciatica, buttock, and low back pain. The worldwide incidence of PS would be about 2,4 million per year. The management of piriformis syndrome includes injection of the piriformis muscle with local anesthetic and steroid, however, the study for the effectiveness of the combination is lacking especially in Indonesian population. This case illustrates the effectiveness reduction of triamcinolone in combination with lidocaine measured by Visual Analogue Scale (VAS) in patient suffered from PS. 
Peran Diabetes Mellitus pada Gejala Klinis Osteoartritis Lutut Puspasari, Riska; Hidayati, Hanik Badriyah
Cermin Dunia Kedokteran Vol 47, No 4 (2020): Arthritis
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v47i4.386

Abstract

OA adalah penyakit sendi degeneratif kronik progresif yang umum dan menyebabkan gangguan mobilitas sendi sehingga membatasi aktivitas sehari-hari. Hiperglikemia kronik pada DM diduga dapat meningkatkan peradangan sendi dan degradasi kartilago yang meningkatkan risiko kejadian OA dan progresivitasnya. Hasil observasi pada pasien OA lutut di unit rawat jalan saraf RSUD Dr Soetomo Surabaya menunjukkan pasien OA lutut dengan intensitas berat lebih banyak pada penderita DM.Osteoarthritis (OA) of the knee is a common degenerative joint disease which limits daily activities. Many studies suggest a significant relationship between diabetes mellitus (DM) and OA. Chronic hyperglycemia in DM is suspected to increase joint inflammation and cartilage degradation which increases the risk of OA events and their progression. Observations in the neurological outpatient unit of Dr Soetomo Public Hospital Surabaya showed that worse knee OA were more likely to develop among DM patients.
BEKAM SEBAGAI TERAPI ALTERNATIF UNTUK NYERI Hanik Badriyah Hidayati,* Mohammad Hasan Machfoed,* Kuntoro,** Soetojo,*** Budi Santoso,**** Suroto,
NEURONA Vol. 36 No. 2 Maret 2019
Publisher : Neurona Majalah Kedokteran Neuro Sains

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Abstract

IS STILL A WORLDS PROBLEM CURRENT PAIN TREATMENT IS STILL UNSATISFACTORY DUE TO ITS CHRONICITY AND EXISTING DRUGS SIDE EFFECTS DUE TO DISSATISFACTION WITH THE EXISTING TREATMENT MANY PATIENTS ARE CHOOSING A TRADITIONAL THERAPY FOR THEIR PAIN TREATMENT CUPPING THERAPY IS ONE OF THE TRADITIONAL THERAPIES THAT IS WIDELY USED TO RELIEVE PAIN
Detrimental Effect of Alprazolam on Sperm Viability ofMice (Mus musculus) Exposed to Chronic Unpredictable Mild Stress Intan Indah Permatasari; Reny I’tishom; HanikBadriyah Hidayati; Irwanto
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15805

Abstract

Objective: This study aims to investigate the effect of alprazolam administration on sperm viability of mice (Mus musculus) strain Balb/C following CUMSfor 53 days. Method: This study used a true experimental design through randomization. Control group kept undisturbed without treatment and therapy throughout 60 days. K1 and K2 were exposed to a 53 day period of CUMS along with 7-day pretreatment adaptation. K2 was adapted for a week, stressed for 53 days along with cotreatment of alprazolam (4 mg/kg BW). Results: K1 and K2 showed insignificant improvement of sperm viability (p > 0.05).Meanwhile, K0 and K1 showed significant value compared to K2 (p<0.05). K2 showed little increase of sperm viability in CUMS group along with subsequent treatment of alprazolam. Conclusion: Overall, the results indicate an insignificant effect of alprazolam on sperm viability of CUMS-induced mice.
The Effect of Thymoquinone Administration on Local Immunoglobulin-G Levels of Rattus norvegicus Strain Wistar Sciatic Nerve Crush Injury Model Valentinus Besin; Abdul Hafid Bajamal; Mohammad Hasan Machfoed; Jusak Nugraha; Budi Utomo; Paulus Budiono Notopuro
The Indonesian Biomedical Journal Vol 14, No 1 (2022)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v14i1.1772

Abstract

BACKGROUND: Immunoglobulin-G (IgG) is a product of the initial response to secondary immune response, which accumulates in distal segment of the nerve after crush injury. Thymoquinone modulates the adaptive immune response. Effect of thymoquinone administration on local IgG levels of Rattus norvegicus Wistar rats sciatic nerve crush injury model has not been elucidated.METHODS: This was an experimental study, with 63 Rattus norvegicus Wistar rats that divided into 9 groups. Three groups were given placebo, 3 groups were given 100 mg/kg/day thymoquinone, and 3 groups were given 250 mg/kg/day thymoquinone. The rats were terminated based on the assigned group at 5x24, 6x24, and 7x24 hours and then the IgG levels were measured using sandwich enzyme-linked immunosorbent assay (ELISA).RESULTS: There was a significant difference in IgG levels after administration of 100 and 250 mg/kg/day thymoquinone at 5x24 hours and 7x24 hours post-injury compared to the rats that were given no treatment. A significant difference of IgG levels was also found after administration of 100 mg/kg/day thymoquinone group at 6x24 hours post-injury. Critical point of decreasing local IgG of all groups happened at 6x24 hours after injury, however, there was no significant difference in the median levels of thymoquinone at doses of 100 mg/kg and 250 mg/kg.CONCLUSION: Local IgG levels in distal segment of the sciatic nerve crush injury is lower in rats that were given 100 mg/kg thymoquinone treatment compared to the rats that receive no thymoquinone treatment since 5x24 hours after injury. Thymoquione administration should be given immediately after the crush injury until before 6x24 hours post-injury to decrease antibodies in degeneration process.KEYWORDS: thymoquinone, immunoglobulin-G, crush injury, sciatic nerve
Efficacy of Acetaminophen Plus Amitriptyline Compared to Acetaminophen to Reduce Pain Intensity in Nonspecific Chronic Lower Back Pain Nita Kurniawati1, Isti Suharjanti2, Muhammad Hamdan2, Joseph Ekowahono Rahardjo2, Djohan Ardiansyah2
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3202

Abstract

Background: There was 90% of Lower back pain (LBP) are non-specific. Acetaminophen is the first an analgesic in the treatment of LBP, but some cases of chronic LBP need additional antidepressant drugs. Amitriptyline is an antidepressant drug often used in cases of pain, but the evidence research in the case of non-specific chronic LBP is still a contradiction. Method: The study was a Double-Blind Randomized Controlled Trial using consecutive sampling admissions. The subjects were divided into 2 groups; acetaminophen plus amitriptyline group and acetaminophen plus placebo group. Results: There was no significant difference in pain intensity of acetaminophen plus amitriptyline and acetaminophen plus placebo groups either statistically or clinically (p = 0.498; OR = 0.667; CI 95% 0.20-2.16; ARR = -0.07 or -7%). The significant improvement of pain intensity in the treatment group Acetaminophen plus Amitriptyline was 24 (72.7%), while in the control group Acetaminophen plus Placebo was 24 (80.0%). In the treatment group was 9 (27.3%) who did not experience a significant improvement in pain intensity, and in the control group was 6 (20.0%). Conclusion: There was no difference in efficacy between acetaminophen plus amitriptyline with acetaminophen plus placebo to reduce pain intensity in non-specific chronic LBP
Co-Authors A.A. Ketut Agung Cahyawan W Abdul Hafid B Abdurachman Abdurachman Agindra, Bani Agus Prihanto Aisyah Shabrina Alia, Safia Amelia, Elena Ghentilis Fitri Andi Kurnia Bintang, Andi Kurnia Arinda Putri Auna Vanadia Askandar Tjokroprawiro atika Atika Aulia Rachma Nur Azizah Awalia Awaliah Azizah, Aulia Rachma Nur Azzahra, Zahwa Arsy Besin, Valentinus Bodová, Klára Budi Riyanto Wreksoatmodjo, Budi Riyanto Budi Santoso Budi Utomo Budi Utomo Chrismawan Ardianto Dede Gunawan, Dede Dion Andriawan Wisnujono Dodik Tugasworo Dwiastri Iris Sarwastuti Elena Ghentilis Fitri Amelia Endah Purwanti Ernawati Ernawati Ernawati, Iin Fahmi Achmad Faisal Fahmi, Achmad Fitri Amelia, Elena Ghentilis Fritz Sumantri Usman, Fritz Sumantri H. Harsono, H. Hapsari Peni Agustin Tjahyaningtijas HERAWATI, LILIK Hermina Novida, Hermina I'tishom, Reny Ilmanita, Dzikrina Imami, Nabilah Hasna Indri Wahyuni Intan Indah Permatasari IRWANTO Jimmy Barus, Jimmy Junaidi Khotib Jusak Nugraha Karimah, Azimatul Kuntoro Kuntoro Kuntoro Kuntoro Kurniawan, Mohammad Lely Retno W Lukas Widhiyanto Machin, Abdulloh Mangestuti Agil Martono Tri Utomo Muhammad Hamdan Muhammad Hamdan Mulia Dian Sumbawati Nabilah Hasna Imami Nadya Rinda Eka Rana Naesilla Naesilla Naim Rochmawati Nila Kurniasari Notopuro, Paulus Budiono Novianto, Rifky Alif Paulus Sugianto Prastiya Indra Gunawan Priya Nugraha Puspasari, Riska Rahayu Nofita Sari Rehatta, Nancy Margarita Rejeki, Purwo Sri Riska Puspasari Riska Puspasari Rivarti, Arina Windri Riza Sulthan, Riza Rozalina Loebis, Rozalina Rusdi Lamsudin, Rusdi S.Pd. M Kes I Ketut Sudiana . Safia Alia Sensusiati, Anggraini Dwi Setianti, Ariani Rahayu Shofwana, Haura Almash Aulia Siti Khaerunnisa Soetojo Soetojo Suhartati Suhartati SUMARNO Suroto Suroto Susi Wahyuning Asih Tamara Audrey Kadarusman Turchan, Agus WITA SARASWATI, WITA Wiyli Yustanti Yetti Hernaningsih YUNI YAMASARI