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All Journal BALI MEDICAL JOURNAL (BMJ) Journal of Islamic Pharmacy MNJ (Malang Neurology Journal) Majalah Obstetri dan Ginekologi The Indonesian Biomedical Journal JIEET (Journal of Information Engineering and Educational Technology) Pharmaceutical Journal of Indonesia Majalah Kedokteran Neurosains JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Indian Journal of Forensic Medicine & Toxicology Cermin Dunia Kedokteran AKSONA Indonesian Journal of Cancer Neurona Cermin Dunia Kedokteran Folia Medica Indonesiana
Mohammad Hasan Machfoed
Departemen Neurologi FK Universitas Airlangga/RSUD Dr. Soetomo, Surabaya
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Peran Diabetes Melitus pada Gejala Klinis Osteoartritis Lutut Riska Puspasari; Hanik Badriyah Hidayati
Cermin Dunia Kedokteran Vol 47 No 4 (2020): Interna
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v47i4.369

Abstract

Osteoartritis (OA) adalah penyakit sendi degeneratif kronik progresif yang umum dan menyebabkan gangguan mobilitas sendi, sehingga membatasi aktivitas sehari-hari. Hiperglikemia kronik pada DM diduga dapat meningkatkan peradangan sendi dan degradasi kartilago yang meningkatkan risiko kejadian OA dan progresivitasnya. Hasil observasi pada pasien OA lutut di unit rawat jalan saraf RSUD Dr Soetomo Surabaya menunjukkan pasien OA lutut dengan intensitas berat lebih banyak pada penderita DM. Osteoarthritis (OA) of the knee is a common degenerative joint disease which limits daily activities. Many studies suggest a significant relationship between diabetes mellitus (DM) and OA. Chronic hyperglycemia in DM is suspected to increase joint inflammation and cartilage degradation which increases the risk of OA events and their progression. Observations in the neurological outpatient unit of Dr. Soetomo Public Hospital Surabaya showed that worse knee OA were more likely to develop among DM patients.
Retrospective Analysis of Numerical Pain Rating Scale (NPRS) Scores in Diabetic Neuropathy Patients Receiving Gabapentin and Non-Gabapentin Therapies at an Indonesian Tertiary Hospital Novianto, Rifky Alif; Hidayati, Hanik Badriyah; Novida, Hermina; Bodová, Klára
Current Internal Medicine Research and Practice Surabaya Journal Vol. 6 No. 2 (2025): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v6i2.66470

Abstract

Introduction: Diabetic neuropathy is a common complication of diabetes, affecting over half of patients and frequently leading to diabetic neuropathic pain (DNP), which can be difficult to treat. Gabapentin is commonly used as a first-line therapy for DNP and works by modifying calcium channels to reduce pain. This study aimed to evaluate and compare Numerical Pain Rating Scale (NPRS) profiles in DNP patients receiving gabapentin and non-gabapentin therapies at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Methods: This retrospective study analyzed the medical records of 24 DNP patients at Dr. Soetomo General Academic Hospital from January to December 2023. The inclusion criteria comprised patients diagnosed with diabetic neuropathy, according to the International Statistical Classification of Diseases, Tenth Revision (ICD-10) code E11.4, and treated for pain using gabapentin and/or other therapies. Patients with incomplete records or unrelated neuropathic conditions were excluded. The data encompassed NPRS scores, demographics, diabetes mellitus duration, pain characteristics, drug types, doses, and therapy durations. Results: Among 24 patients, the majority were female (54.1%) and over 60 years old (58.3%), with a diabetes duration of 6–10 years (54.1%). Tingling was the most frequently observed symptom (75%). Gabapentin administered as monotherapy (1×300 mg) was the predominant treatment (56.5%) and provided the greatest reduction in NPRS scores (7 points) after 4–12 weeks. Combination therapies showed smaller reductions. Conclusion: Gabapentin used as monotherapy is effective for managing DNP, especially over 4–12 weeks. Patients with long-standing diabetes, particularly older adults, are the most affected and benefit from targeted therapy.   Highlights: 1. This study evaluates the demographic, clinical, and therapeutic profiles of patients with diabetic neuropathic pain, focusing on gabapentin and non-gabapentin therapies.2. Novel insights into the distribution of therapies and numerical pain rating scale (NPRS) scores among patients offer a foundation for optimizing pain management strategies.3. This research contributes to identifying patterns in drug efficacy and therapy duration, particularly with the administration of gabapentin for managing diabetic neuropathic pain.
Clinical Symptoms of Patients with Early-Stage and Advanced-Stage Ovarian Cancer Shofwana, Haura Almash Aulia; Hidayati, Hanik Badriyah; Saraswati, Wita; Tjokroprawiro, Brahmana Askandar
Indonesian Journal of Cancer Vol 18, No 3 (2024): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i3.1134

Abstract

Background: Ovarian cancer is a malignant neoplasm originating from ovarian cells with different histological types depending on the subtype. It can affect women of all ages. Ovarian cancer ranks third in terms of incidence among diagnosed female cancer patients, following breast and cervical cancer. Ovarian cancer often doesn’t present specific/clear symptoms. As a result, only a small number of patients are diagnosed at an early stage (20%). The study aimed to analyze the clinical complaints experienced by ovarian cancer patients, both in early and advanced stages before diagnosis. Methods: This descriptive cross-sectional study analyzes clinical complaints before the diagnosis of early and advanced-stage ovarian cancer patients. The study was conducted in the Gynecology-Oncology inpatient ward at Dr. Soetomo Regional General Hospital in 2021, utilizing medical record data. Results: A total of 98 patients (21 patients with early-stage, and 77 patients with advanced-stage) were analyzed. The majority of the patients are aged 45-58 years (49%), work as homemakers (32.7%), and are married (63.3%). The three most common complaints experienced by subjects with early-stage ovarian cancer were abdominal/pelvic pain (23.8%), abdominal/pelvic pressure (28.6%), and abdominal distension (42.9%), while in patients with advanced-stage ovarian cancer were abdominal/ pelvic pain (32.7%), abdominal distension (42.9%), and abdominal discomfort (bloating, early satiety, feeling of fullness, frequent belching, heartburn, nausea and vomiting) (44.2%). Conclusions: The three most common clinical complaints among patients before being diagnosed with early and advanced-stage ovarian cancer in the inpatient ward of Dr. Soetomo Regional General Hospital Surabaya in 2021 were similar. The recognition of these complaints and several risk factors are expected to assist in the earlier diagnosis of ovarian cancer.
The Etiology of Paralytic Strabismus at an Indonesian Tertiary Hospital from 2017 to 2022 Azizah, Aulia Rachma Nur; Loebis, Rozalina; Hidayati, Hanik Badriyah; Wahyuni, Indri; Wulandari, Lely Retno
Folia Medica Indonesiana Vol. 60, No. 1
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Highlights: 1. This study investigated the etiology of paralytic strabismus, a condition that requires further research to prevent its incidence, particularly in adults. 2. The findings of this study provided valuable insight into the primary etiology of paralytic strabismus and its underlying factors. Abstract Paralytic strabismus is the most common cause of adult-onset strabismus. It can result from paralysis of the third, fourth, or sixth cranial nerves, either separately or in combination, which are responsible for innervating the ocular motor muscles. Paralysis of these cranial nerves occurs due to congenital disorders, neoplasms, trauma, intracranial processes, idiopathic diseases, and other causes. This study aimed to determine the etiology of paralytic strabismus incidence at the Department of Ophthalmology of Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, between 2017 and 2022. This study employed a retrospective methodology and utilized total sampling. The medical records of patients diagnosed with paralytic strabismus were used to collect secondary data. Out of the total of 282 cases, the most common condition was combined ocular motor cranial nerve palsy, which accounted for 102 (36.2%) cases. The main factors contributing to this condition were neoplasms (37.2%), intracranial processes (25.5%), trauma (25.5%), other causes (8.8%), idiopathic diseases (2%), and congenital disorders (1%). The incidence of third cranial nerve palsy and sixth cranial nerve palsy was equally prevalent, each accounting for 86 (30.5%) cases. Meanwhile, fourth cranial nerve palsy was the least frequent with just eight (2.8%) cases. This study concluded that the most frequent etiology of paralytic strabismus was combined ocular motor nerve paralysis, which primarily results from neoplasms.
Headache in Preeclampsia: Review Article Mulia Dian Sumbawati; Hanik Badriyah Hidayati; Ernawati Ernawati
AKSONA Vol. 5 No. 2 (2025): JULY 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/aksona.v5i2.53273

Abstract

Highlight: Headache in preeclampsia is classified as a type of secodary headache. Pregnant women with high blood pressure have a 17-fold increased risk of developing secondary headaches. Typical preeclampsia-related headaches are progressive, bilateral (frontal or occipital), throbbing, associated with visual abnormalities, getting worse with elevated blood pressure or exercise, and resistant to over-the-counter drugs..   ABSTRACT Preeclampsia is a multisystem vascular disease characterized by systemic disturbances in maternal endothelial function and symptoms such as arterial hypertension and organ dysfunction, including the kidneys, liver, and brain. A headache is defined as pain or discomfort localized in the head region. Pregnancy-related headaches may have primary causes, such as migraines, but they can also indicate potentially life-threatening secondary causes, including preeclampsia. Pregnant women with high blood pressure have a 17-fold increased risk of developing secondary headaches. Headaches associated with preeclampsia can adversely affect pregnancy and labor, increasing the risk of complications. Preeclampsia headaches can predict eclampsia or seizures 56% sensitivity and 83% specificity. According to research conducted in Indonesia, the majority of preeclampsia patients experienced severe headaches (65.2%), followed by moderate (19.6%), mild (13%), and no headaches (2.2%). Therefore, based on the existing literature, this article intends to compile scientific data on headache pain in preeclampsia patients.  
Co-Authors A.A. Ketut Agung Cahyawan W Abdul Hafid B Abdurachman Abdurachman Agindra, Bani Agus Prihanto Aisyah Shabrina Alia, Safia Amelia, Elena Ghentilis Fitri Andi Kurnia Bintang, Andi Kurnia Arinda Putri Auna Vanadia Askandar Tjokroprawiro atika Atika Aulia Rachma Nur Azizah Awalia Awaliah Azizah, Aulia Rachma Nur Azzahra, Zahwa Arsy Besin, Valentinus Bodová, Klára Budi Riyanto Wreksoatmodjo, Budi Riyanto Budi Santoso Budi Utomo Budi Utomo Chrismawan Ardianto Dede Gunawan, Dede Dion Andriawan Wisnujono Dodik Tugasworo Dwiastri Iris Sarwastuti Elena Ghentilis Fitri Amelia Endah Purwanti Ernawati Ernawati Ernawati, Iin Fahmi Achmad Faisal Fahmi, Achmad Fitri Amelia, Elena Ghentilis Fritz Sumantri Usman, Fritz Sumantri H. Harsono, H. Hapsari Peni Agustin Tjahyaningtijas HERAWATI, LILIK Hermina Novida, Hermina I'tishom, Reny Ilmanita, Dzikrina Imami, Nabilah Hasna Indri Wahyuni Intan Indah Permatasari IRWANTO Jimmy Barus, Jimmy Junaidi Khotib Jusak Nugraha Karimah, Azimatul Kuntoro Kuntoro Kuntoro Kuntoro Kurniawan, Mohammad Lely Retno W Lukas Widhiyanto Machin, Abdulloh Mangestuti Agil Martono Tri Utomo Muhammad Hamdan Muhammad Hamdan Mulia Dian Sumbawati Nabilah Hasna Imami Nadya Rinda Eka Rana Naesilla Naesilla Naim Rochmawati Nila Kurniasari Notopuro, Paulus Budiono Novianto, Rifky Alif Paulus Sugianto Prastiya Indra Gunawan Priya Nugraha Puspasari, Riska Rahayu Nofita Sari Rehatta, Nancy Margarita Rejeki, Purwo Sri Riska Puspasari Riska Puspasari Rivarti, Arina Windri Riza Sulthan, Riza Rozalina Loebis, Rozalina Rusdi Lamsudin, Rusdi S.Pd. M Kes I Ketut Sudiana . Safia Alia Sensusiati, Anggraini Dwi Setianti, Ariani Rahayu Shofwana, Haura Almash Aulia Siti Khaerunnisa Soetojo Soetojo Suhartati Suhartati SUMARNO Suroto Suroto Susi Wahyuning Asih Tamara Audrey Kadarusman Turchan, Agus WITA SARASWATI, WITA Wiyli Yustanti Yetti Hernaningsih YUNI YAMASARI