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All Journal Althea Medical Journal MAJALAH ILMIAH WIDYA Biology, Medicine, & Natural Product Chemistry Mutiara Medika: Jurnal Kedokteran dan Kesehatan Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Medika Malahayati YARSI Medical Journal Majalah Kesehatan Pharmamedika Majalah Sainstekes Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan Science Midwifery Indonesian Journal of Global Health research Babali Nursing Research Medical Scope Journal (MSJ) Jurnal Locus Penelitian dan Pengabdian JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Info Abdi Cendekia Junior Medical Journal Eduvest - Journal of Universal Studies Jurnal Ruhul Islam
Diniwati Mukhtar
Faculty Of Medicine, Yarsi University, Jakarta, Indonesia
Religion Aerospace Engineering Automotive Engineering Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Journal : Babali Nursing Research

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NGS-Based Insights into the Oral Microbiome and Glycemic Control in Pediatric Type 1 Diabetes Mellitus: A Literature Review Maharsi, Eri Dian; Sudarmono, Pratiwi Pudjilestari; Mukhtar, Diniwati; Fadilah, Fadilah
Babali Nursing Research Vol. 6 No. 4 (2025): October
Publisher : Babali Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37363/bnr.2025.64513

Abstract

Introduction: Type 1 Diabetes Mellitus (T1DM) in children is associated with significant alterations in the oral microbiome that can influence glycemic control and oral health. This study aimed to synthesize current evidence on the composition of the oral microbiome in children with T1DM using Next-Generation Sequencing (NGS) and its association with glycemic parameters. Methods: A structured literature review was conducted on studies published between 2020 and 2025 that utilized 16S rRNA sequencing to compare the oral microbiome of children with T1DM and healthy controls. Results: Across the included studies, dysbiosis was consistently observed, characterized by increased pathogenic taxa (Prevotella, Veillonella) and decreased protective genera (Streptococcus), which correlated with elevated HbA1c levels and poor metabolic control. These findings suggest that hyperglycemia-driven shifts in the oral microbiome may exacerbate inflammation and oral disease risk, potentially forming a bidirectional relationship between glycemic regulation and microbial imbalance. Conclusion: Oral microbiome profiling shows promise as a non-invasive indicator of glycemic status in children with T1DM. Further standardized, longitudinal studies in local populations, particularly in Indonesia, are recommended to validate these findings and support the integration of oral microbiome monitoring into pediatric diabetes management.
Co-Authors Aan Royhan Aan Royhan Aan Royhan Ainur Rahmah, Nunung Alqudsi, Hade Irhas Amsaka, Azha Azzuna Anisya Fitriah Astalia Maisya Adhitama Astiwara, Endy M Astiwara, Endy Muhammad Astuti Giantini Awairaro, Tirsa Persila Budiman, Dicky Dewi, Intan Keumala Dian Noor Aristi Dicky Wahyudi Dita Safira Dita Safira Salsabila Endah purnamasari Endang Purwaningsih Endy Muhammad Istiwara Fadilah , Fadilah Fadilah Fadilah, Fadilah Farah Zahida Fatimah Eliana Taufik Febri Irwansyah Ferlianti, Rika Fitriani, Hasna L. Haddad, Desi Ariyani Hasna Luthfiah Hasna Luthfiah Fitriani Hasna Luthfiah Fitriani Helwiah Umniyati Himmi Marsiati Himmi Marsiati Hutabarat, Andrea Ivana Allicia Intan Keumala Dewi Irfan Syarif, Irfan Karina A Ridwan Karina Ajeng Ridwan Lelosutan, Syafruddin Lena Fitriyana Linda Weni Linda Weni M Arsyad Ma'sum, Ali Maharsi, Eri Dian Manik, Sabarina Elfrida Marsiati, Himmi Melasari Marantika Melia Puji Pratami Muhammad Arsyad Muhammad Astiwara, Endy Muhammad Iqbal Thamrin Muhammad Samsul Mustofa Mustofa, M Samsul Naila Nur Fauziah Novia Suci Ramadhanti Nunung Ainur Rahmah Nursabur, Bistamy Muhammad Nurwijayanti Pd, Fanny Ratnasari prastina sari, Putri Agnia Pratiwi Pujilestari Sudarmono Puspita, Switania Putri Putra Pangraizan, Farel Q Qomariyah Qomariyah Qomariyah Qomariyah Sachrowardi Retno Noviar Dhani Ridwan, Karina A. D. A. Ridwan, Karina Ajeng Sakura Muhammad Tola Samsul Mustofa, Muhammad Siti Helmyati Sri Wuryanti Sudarmono, Pratiwi Pudjilestari Susmiarsih Panjiasih, Tri Taufik, Fatimah Eliana Tjandra Yoga Aditama Tunru, Insan Sosiawan Tw, Afrizal Wan Nedra Widiastari, Erina Febriani Yulia Suciati Yusnidar, Amirah