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All Journal Althea Medical Journal MAJALAH ILMIAH WIDYA Biology, Medicine, & Natural Product Chemistry Mutiara Medika: Jurnal Kedokteran dan Kesehatan Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Medika Malahayati YARSI Medical Journal Majalah Kesehatan Pharmamedika Majalah Sainstekes Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan Science Midwifery Indonesian Journal of Global Health research Babali Nursing Research Medicra (Journal of Medical Laboratory Science/Technology) Medical Scope Journal (MSJ) Jurnal Locus Penelitian dan Pengabdian JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Jurnal Riset Rumpun Ilmu Kesehatan (JURRIKES) Info Abdi Cendekia Jurnal Indonesia Sosial Sains Junior Medical Journal Eduvest - Journal of Universal Studies Jurnal Ruhul Islam
Diniwati Mukhtar
Faculty Of Medicine, Yarsi University, Jakarta, Indonesia
Religion Aerospace Engineering Humanities Astronomy Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : Althea Medical Journal

 1 
Effect of Vitamin D Supplementation on Irisin, Telomerase, Klotho, and Tumor Necrosis Factor-alpha (TNF-α) in Elderly: A Quasi-Experimental Study Mukhtar, Diniwati; Rahmah, Nunung Ainur; Wuryanti, Sri; Marsiati, Himmi; Haddad, Desi Ariyani; Manik, Sabarina Elfrida; Weni, Linda; Nursabur, Bistamy Muhammad; Hutabarat, Andrea Ivana Allicia; Puspita, Switania Putri
Althea Medical Journal Vol 12, No 3 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n3.4286

Abstract

Background: Vitamin D plays a crucial role in aging by regulating mitochondrial function, inflammation, oxidative stress, and telomere stability. Vitamin D deficiency is common among the elderly and is linked to accelerated aging. Biomarkers such as irisin, telomerase, klotho, and tumor necrosis factor-alpha (TNF-α) are associated with aging processes. This study aimed to evaluate the effect of vitamin D supplementation on these biomarkers in elderly individuals.Methods: This quasi-experimental pretest-posttest study was conducted in Kadugadung Village, Banten, Indonesia from Maret to September 2024.  A total of 47 healthy elderly individuals (≥60 years) were recruited using purposive sampling. The treatment group (n=25) received 800 IU/day of vitamin D for 20 days, whereas the control group (n=22) received none. Blood samples were collected before and after the intervention to measure serum irisin, telomerase activity, klotho, and TNF-α. Baseline variables included body mass index (BMI), blood pressure, hemoglobin, hematocrit, blood glucose, cholesterol, and uric acid. Data were analyzed using paired and independent statistical tests.Results: Vitamin D supplementation significantly increased serum irisin levels (p=0.016), meanwhile no significant changes were observed in telomerase activity (p=0.128), klotho (p=0.819), or TNF-α (p=0.098). In the treatment group, blood glucose was correlated positively with TNF-α (r=0.423, p<0.05), whereas cholesterol was correlated negatively with TNF-α (r=-0.51, p<0.01). Furthermore, telomerase activity was correlated positively with irisin (r=0.348, p<0.05)Conclusion: Vitamin D supplementation at 800 IU/day significantly enhances serum irisin, but does not affect telomerase, klotho, or TNF-α. These findings suggest a potential role of vitamin D in modulating aging-related biomarkers. Correction Notice: This article has been corrected. See the Erratum published in Althea Medical Journal, Volume 12, Number 4 (2025).
Effect of Vitamin D Supplementation on Irisin, Telomerase, Klotho, and Tumor Necrosis Factor-alpha (TNF-α) in Elderly: A Quasi-Experimental Study Mukhtar, Diniwati
Althea Medical Journal Vol 12, No 4 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Co-Authors Aan Royhan Aan Royhan Aan Royhan Afifah Herlianti, Lucy Ainur Rahmah, Nunung Alqudsi, Hade Irhas Amsaka, Azha Azzuna Anisya Fitriah Astalia Maisya Adhitama Astuti Giantini Awairaro, Tirsa Persila Budiman, Dicky Dewi, Intan Keumala Dian Noor Aristi Dicky Wahyudi Dita Safira Dita Safira Salsabila Endah purnamasari Endang Purwaningsih Endang Purwaningsih Endy Muhammad Astiwara Endy Muhammad Istiwara Ernanda, Hafid Fachry Abda El Rahman Fadilah , Fadilah Fadilah Fadilah, Fadilah Farah Zahida Fatimah Eliana Taufik Febri Irwansyah Fenie Oktafiani Budi Ferlianti, Rika Fitriani, Hasna L. Haddad, Desi Ariyani Hakim, Jasir Hasna Luthfiah Hasna Luthfiah Fitriani Hasna Luthfiah Fitriani Helwiah Umniyati Himmi Marsiati Himmi Marsiati Hutabarat, Andrea Ivana Allicia Intan Keumala Dewi Irfan Syarif, Irfan Karina A Ridwan Karina Ajeng Ridwan Lelosutan, Syafruddin Lena Fitriyana Linda Weni Linda Weni M Arsyad M Istiwara, Endy Ma'sum, Ali Maharsi, Eri Dian Manik, Sabarina Elfrida Marsiati, Himmi Melasari Marantika Melia Puji Pratami Muhammad Arsyad Muhammad Iqbal Thamrin Muhammad Samsul Mustofa Mustofa, M Samsul nafizha Naila Nur Fauziah Novia Suci Ramadhanti Nunung Ainur Rahmah Nursabur, Bistamy Muhammad Nurwijayanti Pd, Fanny Ratnasari Prameswari, Keisa Yude prastina sari, Putri Agnia Pratiwi Pujilestari Sudarmono Puspita, Switania Putri Putra Pangraizan, Farel Q Qomariyah Qomariyah Qomariyah Qomariyah Sachrowardi Retno Noviar Dhani Ridwan, Karina A. D. A. Ridwan, Karina Ajeng Sakura Muhammad Tola Samsul Mustofa, Muhammad Siti Helmyati Sri Wuryanti Sudarmono, Pratiwi Pudjilestari Susmiarsih Panjiasih, Tri Taufik, Fatimah Eliana Tjandra Yoga Aditama Tunru, Insan Sosiawan Tw, Afrizal Wan Nedra Widiastari, Erina Febriani Yulia Suciati Yusnidar, Amirah