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Journal : MAJALAH ILMIAH WIDYA

MAKROFAG PADA JARINGAN ADIPOSA OBES SEBAGAI PENANDA TERJADINYA RESISTENSI INSULIN Mukhtar, Diniwati
MAJALAH ILMIAH WIDYA 2012
Publisher : MAJALAH ILMIAH WIDYA

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Abstract

Obesity has become an epidemic affecting developed and developing countries. Along with the increase in obesity is a parallelincrease in the prevalence of type 2 diabetes, impaired glucose tolerance, and other complications of obesity, such as hypertension.The focus this review is on the role of macrophage in adipose tissue as a marker of insulin resistance in obesity. Insulin resistanceis a central player of obesity related metabolic derangements. An increased number of macrophages resident in human adiposetissue has been reported in obesity. During adipose tissue expansion, hypoxia can occur due to reduced delivery of oxygen to thehypertrophic adipocytes. This hypoxia can cause adipocyte cell death and macrophages can be attracted to adipose tissue tophagocytose these dead adipocytes. The macrophages in adipose tissue are localized around dead adipocytes and form typicalcrown-like structures. Macrophage chemoattractant protein-1 (MCP-1) is a well-known regulator of macrophage recruitment to siteof inflammation. In obesity show increased plasma levels of MCP-1. Exercise has been shown to improve insulin sensitivity in obeseindividuals even in the absence of weight loss. Conclusion: overexpression MCP-1 in human obese was associated with insulinresistance. Exercise training reduced peripheral markers of inflammation, among them MCP-1.
Co-Authors Aan Royhan Aan Royhan Aan Royhan Afifah Herlianti, Lucy Ainur Rahmah, Nunung Alqudsi, Hade Irhas Amsaka, Azha Azzuna Anisya Fitriah Astalia Maisya Adhitama Astuti Giantini Awairaro, Tirsa Persila Budiman, Dicky Dewi, Intan Keumala Dian Noor Aristi Dicky Wahyudi Dita Safira Dita Safira Salsabila Endah purnamasari Endang Purwaningsih Endang Purwaningsih Endy Muhammad Astiwara Endy Muhammad Istiwara Ernanda, Hafid Fachry Abda El Rahman Fadilah , Fadilah Fadilah Fadilah, Fadilah Farah Zahida Fatimah Eliana Taufik Febri Irwansyah Fenie Oktafiani Budi Ferlianti, Rika Fitriani, Hasna L. Haddad, Desi Ariyani Hakim, Jasir Hasna Luthfiah Hasna Luthfiah Fitriani Hasna Luthfiah Fitriani Helwiah Umniyati Himmi Marsiati Himmi Marsiati Hutabarat, Andrea Ivana Allicia Intan Keumala Dewi Irfan Syarif, Irfan Karina A Ridwan Karina Ajeng Ridwan Lelosutan, Syafruddin Lena Fitriyana Linda Weni Linda Weni M Arsyad M Istiwara, Endy Ma'sum, Ali Maharsi, Eri Dian Manik, Sabarina Elfrida Marsiati, Himmi Melasari Marantika Melia Puji Pratami Muhammad Arsyad Muhammad Iqbal Thamrin Muhammad Samsul Mustofa Mustofa, M Samsul nafizha Naila Nur Fauziah Novia Suci Ramadhanti Nunung Ainur Rahmah Nursabur, Bistamy Muhammad Nurwijayanti Pd, Fanny Ratnasari Prameswari, Keisa Yude prastina sari, Putri Agnia Pratiwi Pujilestari Sudarmono Puspita, Switania Putri Putra Pangraizan, Farel Q Qomariyah Qomariyah Qomariyah Qomariyah Sachrowardi Retno Noviar Dhani Ridwan, Karina A. D. A. Ridwan, Karina Ajeng Sakura Muhammad Tola Samsul Mustofa, Muhammad Siti Helmyati Sri Wuryanti Sudarmono, Pratiwi Pudjilestari Susmiarsih Panjiasih, Tri Taufik, Fatimah Eliana Tjandra Yoga Aditama Tunru, Insan Sosiawan Tw, Afrizal Wan Nedra Widiastari, Erina Febriani Yulia Suciati Yusnidar, Amirah