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The Effect of Matoa (Pometia pinnata) Leaves Ethanol Extract On Reducing Cholestrol Levels In Male Mice (Mus musculus) Haq, Muhammad Naufal Syaiful; Pagarra, Halifah; Muis, Abd.; Salsabila, Shopia
Sainsmat : Jurnal Ilmiah Ilmu Pengetahuan Alam Vol 14, No 1 (2025): Maret
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Negeri Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35580/sainsmat141720372025

This research aims to determine the total phenolic content and antioxidant activity of the ethanol extract of matoa (Pometia pinnata) leaves and their effect on the cholesterol levels of male mice (Mus musculus). To determine the total phenolic content using the Folin-Ciocalteu method and the DPPH method to measure antioxidant activity. The effect of matoa leaf extract on reducing cholesterol levels in mice used a completely randomized design (CRD) with 15 mice divided into 5 treatment groups with 3 replications, namely P1 (Extract 175 mg/kgBW), P2 (Extract 350 mg/kgBW), P3 (Extract 700 mg/kgBW), K+ (Simvastatin 0.10 mg/kgBW), and K- (Na-CMC 1%). Extraction uses the maceration method with 70% ethanol solvent. The total phenolic test results were 26.24872 mgGAE/g. The results of measuring antioxidant activity obtained an IC50 of 1,961 ppm. The results of testing cholesterol levels showed that there was an effect of giving ethanol extract of Matoa (Pometia pinnata) leaves on reducing cholesterol levels in male mice (Mus musculus). Giving ethanol extract of Matoa leaves at a dose of 350 mg/kgBW is effective in reducing cholesterol levels. So it can be concluded that the ethanol extract of Matoa leaves has an effect on reducing cholesterol levels in male mice.

Mengenal Kutil Kelamin: Edukasi dan Pencegahan untuk Kesehatan Reproduksi di Lingkungan Kerja Kampus UNM Parangtambung Idris, Irma Suryani; Pagarra, Halifah; Muis, Abd.; Rachmawaty, Rachmawaty; Hiola, St. Fatmah
JKM: Jurnal Kemitraan Masyarakat Volume 4 Number 1 Juni 2025
Publisher : Program Studi Pendidikan IPA Fakultas MIPA Universitas Negeri Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35580/jkm.v4i1.74087

In Indonesia, the incidence of genital warts continues to increase and is the third largest disease of sexually transmitted infections. The possibility of being infected through sexual intercourse with a partner infected with HPV, either in subclinical form, is 75%. Genital HPV infection generally affects moist mucosa. Microscopic abrasion and repeated trauma can increase infectivity and replication of the virus. The incubation period of HPV is between 8 weeks to 9 months. With these concerns, there is a need for socialization or counseling regarding genital warts, education and prevention, especially in the work environment. This community service was carried out in the UNM Parangtambung Campus Work environment which aims to provide an understanding or education about the dangers of genital warts to reproductive health. The delivery of material in this training was carried out in a classical manner, all participants followed the material presented through lectures, discussions and questions and answers. This activity was attended by the cleaning service on duty at the UNM Parangtambung Campus Work Environment. The results of this community service were responded to well by the participants, the high interest and motivation of the training participants greatly supported the transfer of knowledge and skills from the resource person to the training participants. Keywords: genital warts, education, prevention, cleaning service.

Pelatihan Pembuatan Pupuk Organik Berbahan Dasar Limbah Lontar bagi Kelompok Tani Desa Punagaya, Kecamatan Bangkala, Kabupaten Jeneponto, Sulawesi Selatan Hiola, St. Fatmah; Syamsiah, Syamsiah; Pagarra, Halifah; Muis, Abd.; Taiyeb, A. Mushawwir
JKM: Jurnal Kemitraan Masyarakat Volume 4 Number 1 Juni 2025
Publisher : Program Studi Pendidikan IPA Fakultas MIPA Universitas Negeri Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35580/jkm.v4i1.74238

This service activity is to improve the ability of partners and be able to develop and add expertise to the community, develop community knowledge about the utilization of palmyra waste so that it has use value for the environment, be able to increase income and reduce fertilizer purchases for agriculture and to develop an attitude of cooperation with others. Utilization of Palmyra waste into liquid organic fertilizer to reduce environmental pollution. The long-term benefits of using liquid fertilizer can improve the physical, chemical and biological properties of the soil. Liquid fertilizer is easy to make and the technology is simple. Lontar (Borassus flabellifer) is one of the typical plants in Jeneponto Regency which has many benefits, one of which is that it can be used as organic fertilizer. This service was carried out on farmer groups in Punagaya village, Bangkala sub-district, Jeneponto district, South Sulawesi, totaling 17 people. The results of this training activity showed that all training participants were very enthusiastic and eager to pay attention and listen to the material about the use of palm waste as organic fertilizer and how to make it delivered by the resource team. Based on the results and discussion of the implementation of activities, it can be concluded that several things including partners in this case the farmer group is able to make organic fertilizer from palm waste, and a partner group is formed that is economically and socially independent through this activity.

Optimization of Pectin Extraction from Pomelo Peels (Citrus maxima) using Response Surface Methodology Pagarra, Halifah; Hartati; Rachmawaty, Rachmawaty; Sahribulan, Sahribulan
Bionature Vol. 25 No. 1 (2024): April-Juni 2024
Publisher : Jurusan Biologi Universitas Negeri Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35580/bionature.v25i1.2340

Pectin is an essential polysaccharide that is usually found in the skin of various fruits and vegetables. It acts as a gelling agent and stabilizer in many food and pharmaceutical industries. This study focuses on the potential of grapefruit peel as a source of pectin. Pectin is isolated from hot grapefruit peel powder (albedo). The aim of this study was to extract pectin from grapefruit peel (albedo), and central composite design (CCD) together with the numerical optimization method of response surface methodology (RSM) was used to optimize the processing parameters, including temperature (60, 80 and 100 ° C), pH (1.5, 2.0 and 2.5 ) and time (60, 90 and 120 min) The findings show that the studied parameters have a major impact on the pectin yield. The resulting second-order polynomial model thoroughly explains the relationship between input and output variables and how the data is varied. The highest pectin yield was 28.45% at optimal conditions achieved: temperature: 100° C; pH: 1.5; and extraction time: 120 minutes. Temperature, pH, and extraction time have their own large impact on pectin yield which has a significant effect.

Antibacterial Activity Test of Matoa (Pometia pinnata) Leaves Ethanol Extract Against Salmonella typhi and Bacillus subtilis Pagarra, Halifah; Taiyeb , Mushawwir; Junda , Muhammad; Musawira; Muhammad Naufal Syaiful Haq; Handayani , Resti
Bionature Vol. 26 No. 1 (2025): April-Juni 2025
Publisher : Jurusan Biologi Universitas Negeri Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35580/bionature.v26i1.7234

This study aims to determine the antimicrobial activity of ethanol extract of matoa leaves (Pometia pinnata) against Salmonella typhi and Bacillus subtilis bacteria. This study began with preparing raw materials in the form of matoa leaves and then extracting the matoa leaves using the maceration method with 70% solvent. After that, the antimicrobial activity test was carried out using the disc diffusion method with four concentration variations, namely 5%, 7.5%, 10%, and 12.5% with a positive control in the form of 50 ppm amoxicillin and a negative control using distilled water, each treatment using three replications. The results in the form of inhibition zones formed were measured using calipers. The data obtained were then analyzed using SPSS 30 with the ANOVA test and further tests in the form of tests. The test results showed that 70% ethanol extract of matoa leaves had an effect on inhibiting the growth of Salmonella typhi and Bacillus subtilis bacteria. The largest inhibition zone in Salmonella typhi was found at a concentration of 7.5% with a diameter of 16.87 mm, while in Bacillus subtilis it was found at a concentration of 12.5% with a diameter of 12.22 mm. Keywords: Pometia pinnata, Antimicrobial activity, Salmonella typhi, Bacillus subtilis

The Effect of Matoa (Pometia Pinnata) Leaf Ethanol Extract on Reducing Blood Sugar Level in Male Mice (Mus Musculus) Induced by Alloxan Pagarra, Halifah; Salsabila, Shopia; Muis, Abd; Naufal Syaiful Haq, Muhammad
Bionature Vol. 26 No. 1 (2025): April-Juni 2025
Publisher : Jurusan Biologi Universitas Negeri Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35580/bionature.v26i1.7361

This research aims to determine the total phenolic content and antioxidant activity of the ethanol extract from Matoa (Pometia pinnata) leaves as well as its effect on blood sugar levels in male mice (Mus musculus) induced with alloxan. To determine total phenolic content using the Folin-Ciocalteu method, and the DPPH method to measure antioxidant activity. The effect of Matoa leaves on blood sugar reduction in mice used a completely randomized design (CRD) with 15 mice divided into 5 treatments with 3 replications: namely P1 (Extract 125 mg/kg BW), P2 (Extract 250 mg/kg BW), P3 (Extract 500 mg/kg BW), K+ (Glibenclamide), and K- (Na-CMC 0.5%). Extraction used the maceration method with 70% ethanol solvent. The results of the total phenolic test showed the presence of phenolics with a value of 26.24872 mg GAE/g. The measurement of antioxidant activity yielded an IC50 value of 1.961 ppm. The results of testing the blood sugar levels showed that there was an effect of giving ethanol extract of Matoa (Pometia pinnata) leaves on reducing blood sugar levels in male mice (Mus musculus). Giving of ethanol extract of Matoa leaves at a dose of 250 mg/kg BW is effective in reducing blood sugar levels. So it can be concluded that the ethanol extract of Matoa leaves has an effect on reducing blood sugar levels in male mice

Pengembangan Nanoemulsi Ekstrak Daun Kelor (Moringa Oleifera) Sebagai Antioksidan, Antibakteri Dan Antiluka Hidayat, Muh Akbar; Hartati, Hartati; Pagarra, Halifah; Sahribulan, Sahribulan
Sainsmat : Jurnal Ilmiah Ilmu Pengetahuan Alam Vol 14, No 1 (2025): Maret
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Negeri Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35580/sainsmat141671352025

This study aims to determine the effect of moringa leaf extract nanoemulsion (Moringa Oleifera Lamk.) on bacterial growth, antioxidant activity and wound healing potential in white rats (Rattus novegicus). The research method includes extraction of Moringa, making nanoemulsion of Moringa leaf extract concentrations of 75, 100 and 125 milligrams. Droplet nanoemulsion using Particle Size Analyzer (PSA), antibacterial with inhibition zone diameter (mm), antioxidant with DPPH (1,1 diphenyl-2-picrylhydrazyl) and measurement of wound healing activity by determining the percentage of wound closure in rats. The study used a completely randomized design (CRD) and Analysis of Variant (ANOVA) test followed by Tukey test. Antioxidant activity obtained IC50 Formula 1 amounted to 157.35 ppm, Formula 2 amounted to 123.40 ppm, Formula 3 amounted to 110.12 ppm, Moringa leaves extract amounted to 58.63 ppm and BHA comparison amounted to 6.84 ppm. Moringa leaf extract and nanoemulsion formula showed good wound healing activity which was faster than the positive control. It is found that moringa leaf extract and nanoemulsion formulation have antibacterial activity against S. aureus and E. coli. The wound healing activity of the nanoemulsion formulation was classified as good in mice with a faster wound healing process than the positive control.

The Effect of Matoa (Pometia pinnata) Leaves Ethanol Extract On Reducing Cholestrol Levels In Male Mice (Mus musculus) Haq, Muhammad Naufal Syaiful; Pagarra, Halifah; Muis, Abd.; Salsabila, Shopia
Sainsmat : Jurnal Ilmiah Ilmu Pengetahuan Alam Vol 14, No 1 (2025): Maret
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Negeri Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35580/sainsmat141720372025

This research aims to determine the total phenolic content and antioxidant activity of the ethanol extract of matoa (Pometia pinnata) leaves and their effect on the cholesterol levels of male mice (Mus musculus). To determine the total phenolic content using the Folin-Ciocalteu method and the DPPH method to measure antioxidant activity. The effect of matoa leaf extract on reducing cholesterol levels in mice used a completely randomized design (CRD) with 15 mice divided into 5 treatment groups with 3 replications, namely P1 (Extract 175 mg/kgBW), P2 (Extract 350 mg/kgBW), P3 (Extract 700 mg/kgBW), K+ (Simvastatin 0.10 mg/kgBW), and K- (Na-CMC 1%). Extraction uses the maceration method with 70% ethanol solvent. The total phenolic test results were 26.24872 mgGAE/g. The results of measuring antioxidant activity obtained an IC50 of 1,961 ppm. The results of testing cholesterol levels showed that there was an effect of giving ethanol extract of Matoa (Pometia pinnata) leaves on reducing cholesterol levels in male mice (Mus musculus). Giving ethanol extract of Matoa leaves at a dose of 350 mg/kgBW is effective in reducing cholesterol levels. So it can be concluded that the ethanol extract of Matoa leaves has an effect on reducing cholesterol levels in male mice.

Uji Pengaruh Ekstrak Etanol Buah Pedada (Sonneratia caseolaris) Terhadap Penurunan Kadar Asam Urat Mencit (Mus musculus) Jantan Handayani, Resti; Pagarra, Halifah; Mu'nisa, A.; Hala, Yusminah
BioEksakta : Jurnal Ilmiah Biologi Unsoed Vol 7 No 3 (2025): BioEksakta
Publisher : Fakultas Biologi Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.bioe.2025.7.3.17337

Buah Pedada (Sonneratia caseolaris) ialah salah satu jenis tanaman mangrove yang memiliki banyak kandungan yang bermanfaat untuk kesehatan manusia. Asam urat adalah adalah salah satu penyakit yang paling banyak dialami karena disebabkan oleh purin yang tinggi di dalam tubuh manusia atau karena faktor makanan. Tujuan dilakukan penelitian ini untuk melihat pengaruh ekstrak etanol buah pedada dalam menurunkan kadar asam urat. Penelitian menggunakan metode rancangan acak lengkap (RAL) dengan jumlah mencit 15 ekor yang dibagi dalam 5 kelompok perlakuan dengan ulangan 3 ulangan yaitu P1 diberi ekstrak etanol buah pedada 150 mg/kgBB, P2 diberi ekstrak etanol buah pedada 250 mg/kgBB, P3 diberi ekstrak etanol buah pedada 350 mg/kgBB, K+ diberi alloporinol 0,26 mg/kgBB, dan K- diberi pakan standar. Pada penelitian ini dilakukan Skrining Fitokimia untuk mengetahui senyawa-senyawa yang terkandung didalam ekstrak etanol buah pedada yang dapat menurunkan kadar asam urat pada mencit. Ekstraksi dilakukan dengan metode maserasi. Hasil uji Skrining Fitokimia ekstrak etanol buah pedada didapatkan beberapa kandungan senyawa yang positif yaitu alkaloid, flavonoid, steroid, saponin, dan tanin. Hasil pengujian pada kadar asam urat menunjukkan adanya pengaruh pemberian ekstrak etanol buah pedada terhadap penurunan kadar asam urat pada mencit (Mus musculus) jantan. Pemberian ekstrak etanol buah pedada dengan dosis 350 mg/kgBB memberikan pengaruh yang paling tinggi untuk menurunkan kadar asam urat. Kata kunci : Asam urat, Hiperusemia, Mus musculus, Sonneratia caseolaris, Skrining fitokimia

ANALISIS KETERLAKSANAAN PRAKTIKUM PEMBELAJARAN BIOLOGI KELAS XI DAN KELENGKAPAN FASILITAS LABORATORIUM DI SMA NEGERI 1 GOWA Nurul Aisyah Syachrul, Wulandari; Pagarra, Halifah; Dwi Putri Ulan Sari Patongai, Dian
Jurnal Biogenerasi Vol. 10 No. 3 (2025): Volume 10 no 3 tahun 2025 terbit september
Publisher : Universitas Cokroaminoto Palopo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30605/biogenerasi.v10i3.6951

This study aims to determine the implementation of biology learning practicums in grade XI and to determine the completeness of biology laboratory equipment and materials at SMA Negeri 1 Gowa. This study is a descriptive study with a mixed methods approach using quantitative and qualitative methods. The subjects of this study were SMA Negeri 1 Gowa, including biology teachers and several students. Data collection techniques were carried out using a questionnaire containing a list of practical lessons in accordance with the learning outcomes in the independent curriculum and a checklist containing a list of laboratory facilities in accordance with the standards of Permendiknas No. 24 of 2007. The results of the study show that the average implementation of biology practicums at SMA Negeri 1 Gowa is 62.5%, which means that the implementation of biology practicums at SMA Negeri 1 Gowa is in the inadequate category. Meanwhile, the completeness of laboratory facilities obtained a score of 70%, which is in the complete category.

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