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Kajian Sistematis Potensi Interaksi Obat-Obat Herbal Terhadap Enzim Sitokrom P450 (Cyp450) Dan Implikasi Klinisnya pada Pasien Kanker yang Menjalani Kemoterapi Pamungkas, Bayu; Andriadi, Andhini Dwi; Fajry, Zaidan Al
Jurnal Ners Vol. 10 No. 1 (2026)
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.51601

Abstract

Abstrak Latar belakang: Penggunaan obat herbal bersamaan dengan kemoterapi semakin meningkat di kalangan pasien kanker. Beberapa herbal diketahui memengaruhi aktivitas enzim sitokrom P450 (CYP450), yang berperan penting dalam metabolisme obat antikanker. Perubahan aktivitas enzim ini dapat menimbulkan interaksi farmakokinetik yang berdampak pada efektivitas maupun toksisitas terapi. Tujuan: Kajian sistematis ini bertujuan menilai potensi interaksi obat-herbal terhadap isoenzim CYP450 serta implikasi klinisnya pada pasien kanker. Metode: Penelusuran literatur dilakukan melalui ScienceDirect, MDPI, Frontiers, BMC, dan Nature dengan kata kunci “herbal-drug interaction”, “cytochrome P450”, dan “anticancer drugs”. Artikel yang disertakan mencakup studi in vitro, in vivo, observasional, dan laporan kasus yang meneliti efek herbal terhadap CYP1A2, CYP2C9, CYP2C19, CYP2D6, dan CYP3A4. Hasil: Sepuluh artikel memenuhi kriteria inklusi. Herbal seperti St. John’s wort, Ginkgo biloba, Panax ginseng, Curcuma longa, dan Allium sativum terbukti memengaruhi aktivitas CYP3A4 dan CYP2D6. Simpulan dan saran: Herbal dapat memodulasi aktivitas CYP450 sehingga memengaruhi efektivitas dan keamanan kemoterapi. Diperlukan skrining penggunaan herbal sebelum terapi serta penelitian klinis lanjutan untuk memperkuat bukti hubungan ini. Kata Kunci: interaksi obat-herbal, sitokrom P450, kemoterapi, pasien kanker, farmakokinetik.. Abstract Background: The concurrent use of herbal medicines and chemotherapy is increasingly common among cancer patients. Many herbs are known to affect cytochrome P450 (CYP450) enzyme activity, which plays a crucial role in the metabolism of anticancer drugs. Altered CYP450 activity may lead to pharmacokinetic interactions that impact drug efficacy and toxicity. Objective: This systematic review aims to evaluate the potential herb–drug interactions involving CYP450 isoenzymes and their clinical implications in cancer patients undergoing chemotherapy. Methods: Literature was retrieved from ScienceDirect, MDPI, Frontiers, BMC, and Nature using the keywords “herbal-drug interaction,” “cytochrome P450,” and “anticancer drugs.” Eligible studies included in vitro, in vivo, observational, and case reports investigating the effects of herbs on CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4. Results: Ten studies met the inclusion criteria. Herbs such as St. John’s wort, Ginkgo biloba, Panax ginseng, Curcuma longa, and Allium sativum were found to modulate CYP3A4 and CYP2D6 activity. Conclusion and recommendation: Herbal medicines can significantly alter CYP450-mediated drug metabolism, affecting chemotherapy safety and efficacy. Patient screening and further large-scale clinical trials are recommended. Keywords: herb–drug interaction, cytochrome P450, chemotherapy, cancer patients, pharmacokinetics
Efektivitas Terapi Metformin Terhadap Penurunan Skor Nafld pada Pasien Diabetes Melitus Tipe 2 dengan Hepatosteatosis Andriadi, Andhini Dwi; Pamungkas, Bayu; Fajry, Zaidan Al
Jurnal Ners Vol. 10 No. 1 (2026)
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.51606

Abstract

Abstrak Latar belakang: Non-Alcoholic Fatty Liver Disease (NAFLD) merupakan komplikasi metabolik yang umum pada pasien diabetes melitus tipe 2 (DMT2), ditandai oleh akumulasi lemak hati akibat resistensi insulin yang dapat berkembang menjadi steatohepatitis dan fibrosis. Karena belum tersedia terapi farmakologis spesifik, metformin agen sensitisasi insulin golongan biguanid menjadi kandidat potensial untuk menurunkan aktivitas NAFLD melalui perbaikan metabolisme glukosa dan lipid. Tujuan: Menilai efektivitas metformin terhadap penurunan skor aktivitas NAFLD pada pasien DMT2 dengan hepatosteatosis. Metode: Kajian ini menggabungkan hasil uji klinis dan meta-analisis penggunaan metformin 1.500–2.000 mg/hari selama 6–12 bulan. Parameter yang dinilai mencakup kadar ALT, AST, HOMA-IR, trigliserida, serta perubahan NAFLD Activity Score (NAS) melalui temuan histologis atau MRI hati. Hasil: Metformin menurunkan kadar ALT/AST, meningkatkan sensitivitas insulin, dan menurunkan skor NAS rata-rata 2–3 poin. Mekanismenya melalui aktivasi AMPK, penurunan SREBP-1c dan ACC, serta peningkatan oksidasi asam lemak. Simpulan dan saran: Metformin efektif memperbaiki aktivitas NAFLD dan fungsi hati pada pasien DMT2; studi jangka panjang dibutuhkan untuk memastikan dampaknya terhadap fibrosis dan risiko hepatokarsinoma. Kata Kunci: Metformin; Diabetes Melitus Tipe 2; NAFLD; Hepatosteatosis. Abstract Background: Non-Alcoholic Fatty Liver Disease (NAFLD) is a common metabolic complication in type 2 diabetes mellitus (T2DM), characterized by hepatic fat accumulation due to insulin resistance that may progress to steatohepatitis and fibrosis. Since no specific pharmacologic therapy exists, metformin—a biguanide insulin sensitizer emerges as a potential treatment due to its effects on hepatic glucose and lipid metabolism. Objective: To evaluate the efficacy of metformin in reducing NAFLD activity score among T2DM patients with hepatic steatosis. Methods: This review integrates clinical trials and meta-analyses assessing metformin 1,500–2,000 mg/day for 6–12 months. Parameters analyzed included ALT, AST, HOMA-IR, triglycerides, and changes in NAFLD Activity Score (NAS) based on histological or MRI findings. Results: Metformin significantly reduced ALT and AST levels, improved insulin sensitivity, and decreased NAS by an average of 2–3 points. The mechanism involves AMPK activation, downregulation of SREBP-1c and ACC, and enhanced hepatic fatty acid oxidation. Conclusion and recommendation: Metformin effectively improves NAFLD activity and liver function in T2DM patients; long-term studies are required to confirm its role in fibrosis prevention and hepatocarcinoma risk reduction. Keywords: Metformin; Type 2 Diabetes Mellitus; NAFLD; Hepatosteatosis.
Intervensi Komunikasi Ekspresif Berbasis DIR/Floortime untuk Anak Autism Usia Dini Murdiyani, Kenanga Kusuma; Pamungkas, Bayu; Sukinah, Sukinah; Uyun, Hana Qurrotul
Jurnal Obsesi : Jurnal Pendidikan Anak Usia Dini Vol. 9 No. 6 (2025): In Progress
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/obsesi.v9i6.7578

Abstract

Komunikasi ekspresif merupakan tantangan utama bagi anak autis usia dini, terutama dalam menyatakan keinginan. Pendekatan DIR/Floortime dapat menjadi alternatif cara untuk mengembangkan komunikasi ekspresif pada anak autis usia dini karena berfokus pada pengembangan interaksi emosional. Pendekatan ini masih jarang diterapkan di PAUD nonformal di Indonesia dan minim kajian empiris lokal. Penelitian ini bertujuan mendeskripsikan implementasi intervensi komunikasi ekspresif berbasis DIR/Floortime yang dikombinasikan dengan strategi bermain pada anak ASD usia 7 tahun. Intervensi dilaksanakan dalam delapan sesi, dengan data dikumpulkan melalui observasi, catatan lapangan, dan Vineland Adaptive Behavior Scales-II. Hasil analisis deskriptif menunjukkan peningkatan kemampuan komunikasi ekspresif, yaitu skor 3,0 pada inisiatif berkomunikasi dan menyatakan keinginan, serta 2,0 pada penggunaan bantuan komunikasi visual. Temuan ini menegaskan potensi DIR/Floortime sebagai strategi intervensi efektif di konteks budaya Indonesia dan memberikan implikasi praktis bagi pendidikan inklusif dan pengembangan program PAUD nonformal untuk anak dengan ASD.
The Analysis of Social Values in the Novel Bayanaka Sigrah by Ichamfs14: Analisis Nilai-Nilai Sosial Dalam Novel Bayanaka Sigrah Karya Ichamfs14 Pamungkas, Bayu; Chanafiah, Yayah; Agustina, Emi
Jurnal Korpus Vol 9 No 3 (2025): Desember 2025
Publisher : UNIB Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/jik.v9i3.30891

Abstract

The aim of this research is to describe the social events and social values contained in the novel Bayanaka Sigrah. This research is in the form of a qualitative descriptive study. The approach used is literary sociology. The data source for this research is social events and social values in the novel Bayanaka Sigrah by Ichamfs14. Data collection techniques use library research. Data analysis techniques include reading and understanding, creating a synopsis, describing, reviewing/analyzing, and making conclusions. The results of the research show that the social events contained in the Bayanaka Sigrah novel are about sexual relations outside marriage, harassment of female workers, fraternal bonds between humans, self-eradication from poverty and defamation. The social events above have impacts related to social values. The social values in the Bayanaka Sigrah novel include; gender equality, hard work, empathy, sympathy, concern for others, and compassion.
Co-Authors -, Nugraha -, Suprijanto Abu Bakar Bill Gates Adlin, Defito Agus Ramdani Ainun Jariyah Ali Nurdin Andriadi, Andhini Dwi Angga Damayanto Aradi, Bernadett Chanafiah, Yayah Dedi Setiadi Didin Ahidin Elma Emi Agustina, Emi Ernisa Purwandari Etty Riani Fadli Ramadhan Fajry, Zaidan Al Fathinnaufal, Martsel Fauzan, Yusuf Sigit Ahmad Fawaz, Muhamad Fathur Hamzah, Norhayati Harahap, Khairul Anhar Hermanto Hermanto Hermanto Hutajulu, Bertha Meyke Waty I Gede Muriarka, I Gede I Ketut Dedy Suryawan Idah Hamidah Idayanti Nursyamsi IIN INDAWATI Irwanto, Doli Januar Irwansyah Jul Padri Keanu Rafi Pratama Khoiri, Muhammad Liliana Baskorowati Mahilda Dea Komalasari Mahilda Dea Komalasari, Mahilda Manurung, Mangaraja Mashudi Maulana, Haisyam Misnah Misnah Mudji Susanto Muhammad Aziz Muhammad Raihan Murdiyani, Kenanga Kusuma Nasution, Muhammad Hanafi Niko Priambhodo Nugraha, Irdan Nugraha, Yopi Nur Subkhi Nurhakim, Ridwan Nurtjahjaningsih, Ida Luh Gede Nurwandri, Andri Nuryanti Nuryanti Onah, Ifeanyi Sunday Prima, Jeffry Omega Purba, Epta R Gamar Pratama Kusuma N Rahmat Kurnia Rifgi Pratama, Fadhil Rina Laksmi Hendrati Riwayati, Antin Rochmat Wahab Rustiana Rustiana Sagita, Sri Melati Salim, Nida Muthia Saputra, Dendi Sari, Maya Novita Sari, Rika Sidik Lingga Kusuma Siregar, Paringgonan Sriwahyuningsih, Yulia Sugeng Pudjiono, Sugeng Sugiarni, Alfina Sukinah Sukinah Sumardi Suseno, Adi Susilo, Rinto Sutriyono Syani, Mamay Taryono Taxwim Taxwim Uyun, Hana Qurrotul Velix Renata Wirabuana, Pandu Yudha Adi Putera Yoyok Hendarso Zulfikri Suleman