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Fluor Albus Characteristics Associated with Sexually Transmitted Infection (STI) in Makassar Pregnant Women Haruna, Nadyah; Hatta, Mochammad; Hamid, Firdaus; Madjid, Baedah; Patellongi, Ilhamjaya; Farid, Monika Fitria
Al-Sihah : The Public Health Science Journal Volume 15, Nomor 2, July-December 2023
Publisher : Program Studi Kesehatan Masyarakat UIN Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/al-sihah.v15i2.38797

Abstract

Sexually Transmitted Infection (STI) is a common condition with increased prevalence among pregnant women and can negatively affect the fetus. According to WHO, a total of 374 million new cases of STI are projected to occur in 2020, including gonorrhea (82 million), syphilis (7.1 million), and trichomoniasis (156 million). Therefore, this study aimed to determine the relationship between the characteristics of vaginal discharge (fluor albus) in pregnant women and STI. The descriptive method was used with a cross-sectional design, and the procedures were conducted in May 2023. The sample population comprised all pregnant women with ANC in Makassar during the study period. Vaginal swabs were obtained from 127 pregnant women who were willing to participate and had vaginal discharge. The results showed that 53 participants reported having physiological flour albus, while 74 had pathological symptoms. Itching and odor were reported to be the most common clinical signs associated with patients' abnormal vaginal discharge, followed by itching, pain, and odor. Furthermore, a significantly high prevalence of the condition was observed among pregnant women aged 20-30 years. Based on the results, the predominant symptom of fluor albus was itching and odor when combined with microorganisms that caused STI. Several pregnant women with clinical complaints also had microorganisms apart from those associated with STI. These results indicated the pressing need to develop additional testing in pregnant women with fluor albus, particularly those with concomitant symptoms.
Pengaruh Intermittent Fasting terhadap Penurunan Ekspresi mRNA Gen Tumor Necrosis Factor-Alpha pada Mencit (Mus Musculus) Basir, Muhammad; Hatta, Mochammad; As’ad, Suryani; Patellongi, Ilhamjaya
Proceedings Series on Health & Medical Sciences Vol. 7 (2025): Proceedings of the 1st National Seminar on Global Health and Social Issue (LAGHOSI)
Publisher : UM Purwokerto Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pshms.v7i.1454

Abstract

Saat ini perkembangan berbagai penyakit degeneratif sangat pesat. Pesatnya perkembangan penyakit tersebut telah mendorong masyarakat luas untuk memahami dampak yang ditimbulkannya. Intermittent fasting bisa membantu mencegah munculnya kanker (salah satu penyakit degeneratif) karena selama puasa sel-sel tubuh berada dalam mode protektif sehingga menjaga tubuh dari serangan penyakit. Intermittent fasting mengurangi status inflamasi tubuh dengan menghambat ekspresi sitokin proinflamasi terutama Tumor Necrosis Factor Alpha (TNF-?). Penelitian ini bertujuan menguji pengaruh intermittent fasting terhadap ekspresi mRNA gen TNF-?. Penelitian ini adalah experiment dengan rancangan Pretest-Posttest with Control Group untuk menguji adanya pengaruh intermittent fasting terhadap ekspresi mRNA Gen TNF-?. Subyek penelitian ini adalah 10 ekor mencit yang dibagi 2 kelompok yaitu kelompok perlakuan (intermittent fasting) dan kelompok kontrol. Penelitian dilaksanakan di Laboratorium Imunologi dan Biologi Molekuler Bagian Mikrobiologi Fakultas Kedokteran Universitas Hasanuddin Makassar sebagai tempat pemeliharaan dan perawatan hewan coba serta pemeriksaan ekspresi mRNA Gen TNF-?. Penelitian dilaksanakan selama 30 hari. Hasil penelitian memperlihatkan adanya penurunan rerata nilai ekspresi mRNA gen TNF-? subyek sebelum dan setelah intermittent fasting dengan nilai ?=0,013 (?<0,05) menunjukkan bahwa ada pengaruh yang bermakna antara intermittent fasting terhadap penurunan ekspresi mRNA Gen TNF-?. Kesimpulannya terjadi penurunan ekspresi mRNA gen TNF-? setelah intermittent fasting.