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All Journal International Journal of Public Health Science (IJPHS) Majalah Kedokteran Bandung Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Medical Journal of Indonesia Jurnal NERS Biomedika The Indonesian Journal of Public Health Buletin Farmatera Jurnal Respirasi (JR) Journal Orthopaedi and Traumatology Surabaya (JOINTS) Majalah Biomorfologi (Biomorphology Journal) AKSONA Jurnal Keperawatan Soedirman (The Soedirman Journal of Nursing) Folia Medica Indonesiana
Viskasari P. Kalanjati
Departemen Anatomi Dan Histologi, Fakultas Kedokteran Universitas Airlangga
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Jurnal NERS

 1 
GABRA6 and SLC6A4 genotypes are correlated with the fasting blood glucose and physical fitness in the seemingly healthy young adults Viskasari P Kalanjati; Mariana Wahjudi; Kusuma E. Purwantari; Visuddho; Peppy Nawangsasi; Rury T. Oktariza; Krisnawan A. Pradana; Dzanuar Rahmawan; Bambang E. Suwito
Jurnal Ners Vol. 18 No. 1 (2023): MARCH 2023
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jn.v18i1.43770

Abstract

Introduction: We examined environmental and genetic factors potentially correlated with the blood glucose and physical fitness in Kediri, East Java, Indonesia to elucidate the predominant cardiovascular disease risk. Methods: This was a cross-sectional study on 68 adults aged 18-22 years. Direct interview was conducted to get socio-economy,  daily diets (rice/ R, snacks and sweets/ SS, veggies and fruits/ VF), daily activity (locomotors and non-locomotors) data. Peripheral blood-GABRA6 and SLC6A4 polymorphisms, fasting blood glucose (FBG), blood pressure, 3 fitness parameters (1 min push-up, 3 minutes step up, pulse rate after 3 minutes step-up) were measured by 2 independent and pre-trained medical doctors. Kruskal-Wallis, Chi-Square, and eta-coefficient tests were used to seek differences between genotypes and correlation strength between variables, respectively (significant if p<0.05). Results: Both gene's genotypes showed significant correlations with the FBG (p=0.042, p=0.013, respectively); GABRA6 polymorphism significantly correlated with SU (p=0.033). There was a significant difference in the FBG between 2 VF subgroups (p=0.02). Strongest association was found between FBG and SLC6A4 (η=0.3); PR and GABRA6 (η=0.168), PU and SLC6A4 (η=0.38); SU and Locomotors (η=0.237). Conclusions: In these seemingly healthy young adults, daily diets and the genotypes of both genes have a good association with the FBG and physical fitness levels.
Co-Authors Abdurachman Abdurachman Abdurachman Abdurachman Abdurachman Aditya, Dwi Martha Nur Akbar, Ghifar Al Muqsith Alfi Amelinda Andi Muh Rahul Alfaidin Andra Rizqiawan Anna Lewi Santoso Annette d’Arqom, Annette Anung Putri Illahika Arlia Ayu Damayanti Arsyi, Danial Habri Avida Marisa Ilmi Azlin Muhammad Mohd Yasin Balogun, Olubunmi Bambang E. Suwito Bambang E. Suwito Bambang Edi Suwito Brilianti, Natasya Nurvita Damayanti, Arlia Ayu Desy Purwidyastuti Dewi Ratna Sari Dewi Sekarsari Dewi, Arni Kusuma Dion K. Dharmawan Dion Krismashogi Dharmawan Dzanuar Rahmawan Dzanuar Rahmawan Ellen Satya Pratiwi Etha Dini Widiasi Farabi, Moh. Reza Ferdian rizky Hutomo Fidiana H. Hoediyanto Haryanto Alimsardjono HERAWATI, LILIK Hidayaturrahmi, Hidayaturrahmi Hutomo, Ferdian rizky Ida Lestari Harahap Intan Anggun Pratiwi Irmawan Farindra Irvinia Septarizka Putri Radjamin Iswan Abbas Nusi Jason Lefranda Jocelino Siswanto Jongky H. Prajitno Joni Wahyuhadi, Joni Krisnawan A. Pradana Krisnawan A. Pradana Kurniawaty, Yuni Kusuma E. Purwantari Kusuma Eko Purwantari Lucky Prasetiowati Machin, Abdulloh Made Pury Pratiwi Mahdi, Rayhan B Mahrus A Rahman, Mahrus A Mariana Wahjudi Mayang Rizki Anggraeni Melbiarta, Rezy R. Melbiarta, Rezy Ramawan Meutia Maulina Nasution, Muhammad Husni Fansury Noer Halimatus Syakdiyah Nurina Hasanatuludhhiyah Oktariza, Rury Tiara Othman, Zulhabri Ovin Nada Saputri Pamungkas, Dimas Bathoro Bagus Peppy Nawangsasi Permana, Putu Bagus Dharma Pradana, Krisnawan Andy Prajitno, Jongky H. Prastiya I. Gunawan Prastiya Indra Gunawan Pratiwi, Ellen Satya Pratiwi, Octaviana Galuh Raden Argarini Rahadian I Susilo Rahmawan, Dzanuar Reza Maulana Rezy R. Melbiarta Rezy Ramawan Melbiarta Rimbun Rimbun Risdiansyah Risdiansyah Rury T. Oktariza Sakina Sakina Salim, Yusuf Soetjipto Soetjipto Susila, I Made Dwi Yudiartana Putra Syamhadi, Maya Rahmayanti Taya Elsa Savista Tirthaningsih, Ni Wajan Visuddho Warda Elmaida Rusdi Wardhana, Teddy Heri Winnie Nirmala Santosa Yudhono, Anggit Satriyo Yusuf Salim Yusuf Salim Zulhabri Othman