Article Per Year (5 Year)
p-Index From 2021 - 2026
5.134
P-Index
This Author published in this journals
All Journal HAYATI Journal of Biosciences SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung Althea Medical Journal Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Pharmaceutical Science and Technology MEDISAINS ODONTO Dental Journal Universa Medicina Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Narra J The Avicenna Medical Journal Indonesian Journal of Cancer Journal of Health and Nutrition Research Makara Journal of Health Research Contemporary Journal on Business and Accounting Odonto dental journal Narra X International Journal of Cell and Biomedical Science Indonesian Journal of Biomedicine and Clinical Sciences Biosaintifika: Journal of Biology & Biology Education Indonesian Journal of Medical and Pharmaceutical Science
Agung Putra
Faculty of Medicine Universitas Islam Sultan Agung, Semarang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

Published : 44 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : MEDISAINS

 1 
In vivo study on the effect of noni leaf extract cream (Morinda Citrifolia L) on PDGF and TNF-α levels in cut wounds Sari, Shintia Devi Arum; Mulyani, Sri Priyantini; Putra, Agung; Setiawan , Eko
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 23 No. 3 (2025)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v23i3.25252

Abstract

ABSTRACT Background: Skin wounds damage the structure and epithelial tissue, resulting in scar tissue formation. Prolonged wound healing or excessive body response will inhibit the normal process and produce unaesthetic scar tissue. Many plant extracts and their active components can accelerate the wound healing process, Noni leaf extract has antioxidant activity and accelerates wound healing. Objective: This study aims to determine the effect of noni leaf extract cream (Morinda Citrifolia L) on TNF-α and PDGF levels in Wistar rats with incised wounds. Method: A laboratory experimental study with a post-test only control group design. Consisting of five treatment groups, namely the healthy rat group (KS), Negative group (KN) rats with incised wounds without treatment, positive group (KP) rats with incised wounds that were smeared with povidone-iodine cream, treatment group 1 (P1) rats that were smeared with 20% noni leaf extract cream, and treatment group 2 (P2) rats that were smeared with 40% noni leaf extract cream, treatment for 3 days then examined the levels of TNF-α and PDGF skin tissue using the ELISA method. Results: The average TNF-α levels showed a significant difference between groups p of 0.000 (p <0.05) with the One way anova test, the highest average in group (KN) 220.68 pg / mL, there was a decrease in all treatment groups with the lowest TNF-α levels in group (KP) 76.59 pg / mL. The average results of TNF-α levels showed a significant difference of p 0.000 (<0.05) with the One-way ANOVA test, the group without intervention (KP) had the lowest PDGF levels while the group (P2) experienced the highest increase in PDGF levels. Conclusion: Administration of noni leaf extract cream with doses of 20% and 40% had an effect on reducing TNF-α levels and increasing PDGF levels in Wistar rats with incised wounds.
Co-Authors Agus Widyatmoko, Agus Alif, Iffan Amalina, Nur D. Amalina, Nur Dina Amin, Mustafa M. Andavania, Sheila Jessica Andreas, Yana Antari, Arini Dewi Azizah Retno Kustiyah Cahyani, Dini Cahyani, Elvana Cahyono, Erwin Budi Candra Satria Irawan, Risky Catharina Suharti Chodidjah Chodidjah Chodijah , Chodijah Darlan, Dewi M. Daulay, Rini S. Delfitri Munir Dewi, Alisia Martha Dirja, Bayu T. Dirja, Bayu Tirta Djannah, Durrotul Edi Dharmana Eko Setiawan Eko Setiawan Erna Mutiara Evita Mayasari Fahreza, Rakha Fatmawati, Dian Fikriya Novita Sari Firman Alamsyah Fristiani, Yeni Ghaisani, Shabrina Syifa Ginting, Andi R. Hadi Sarosa Haitamy, Mohammad Nurrizki Handoyo, Frigi Eko Hariani, Nova Putri Hasanal, Ihdina Hanifa Hasannuri, Tarrayuana Rhamadia Heri Nugroho HS, Zakariya Husain, Sofian A. Hutabarat, Nenny Lynda Caroline Hutagalung, Ananta Ibrahim, Sugeng Ignatius Riwanto, Ignatius Intan, Yulice Soraya Nur Irawan Mangunatmadja Irawan, Risky Chandra Irawan, Risky Chandra Satria Isfandiari, Adelia Bayu Iskandar Japardi Jessika, Cleveria Khan, Ahmed Faheem Kuntardjo, Novalia Lusiana Lusiana Mardiana, Ana Maryanti Maryanti Mawarini, Melisa Septi Minidian Fasitasari Muchaeroni, Isa Anshori Muhar, Adi Muradi Noka, Isara Abda Nugraha, Dendi Krisna Nur Anna Chalimah Sadyah NURUL HIDAYAH Pasongka, Zenitalia Pramukarso, Dodik Tugasworo Pramukarso Prasetio, Ardi Prasetyowati Subchan, Prasetyowati Prawitasari, Salindri Purwaningsih, Hesti Rahardja, Carolina Kiwik Rarastoeti Pratiwi Rozi, Muhammad F. Rusda, Muhammad Sa’dyah, Nur Anna C Sari, Shintia Devi Arum Selamat Budijitno Setiawan , Eko Setyo Trisnadi Setyo, Trisnadi Shafia, Arina Sisca Silvana, Sisca Sitompul, Faya Nuralda Sri Priyantini Sri Priyantini Mulyani Sri Sofyani, Sri Subchan, Prastyowati Sulistami, Siska Marlina Sulistyo, Sona Sunarto, Hadi Sutrisman, Intan Permatasari Suwandi Ng Syamsunarno, Mas Rizky Syamsunarno, Mas Rizky A.A Taskworo, Dodik Taufiq R Nasihun, Taufiq R Titiek Sumarawati Tjipta, Arya Trisnasi, Setyo Utami, Wulan Dyah Yasmine Azzahara, Salma Yayun Siti Rochmah Yustianingsih, Vivi