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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Majalah Kedokteran Bandung Jurnal Keperawatan Jiwa (JKJ): Persatuan Perawat Nasional Indonesia Majalah Obstetri dan Ginekologi Majalah Kesehatan FKUB Warta Ardhia : Jurnal Perhubungan Udara Medical Laboratory Technology Journal Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Care : Jurnal Ilmiah Ilmu Kesehatan Journal of Issues in Midwifery Heart Science Journal Devotion: Journal of Research and Community Service Narra J Indonesian Journal of Perinatology Asian Journal of Health Research Jurnal Info Kesehatan
Bambang Rahardjo
Faculty Of Medicine Universitas Brawijaya Dr. Saiful Anwar General Hospital Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Transportation Veterinary

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Journal : Narra J

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Effective probiotic regimens for bacterial vaginosis treatment and recurrence prevention: A systematic review Udjianto, Udjianto; Sirat, Noorhamdani A.; Rahardjo, Bambang; Zuhriyah, Lilik
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1671

Abstract

Probiotics represent a promising alternative therapy for bacterial vaginosis; however, consensus on the most effective species, strains, and doses remains lacking, and long-term safety data are limited. The aim of this study was to evaluate the effectiveness of probiotics in managing bacterial vaginosis, considering species, strain, clinical outcomes, optimal dosage, duration, and side effects. This study included randomized-controlled trials (RCTs) published in English (2014–2024) on probiotic treatment for bacterial vaginosis, assessing species, strain, dose, duration, and efficacy. A systematic search was conducted on December 20, 2024, in Scopus, Web of Science, and PubMed using the keywords "vaginosis," "bacterial vaginosis," and "probiotic." Data were extracted and synthesized, and study quality was assessed using the Risk of Bias 2 tool, while NVivo 14 software facilitated thematic analysis. The systematic search yielded 1,560 initial records, of which 16 RCTs were included. The findings revealed that Lactobacillus rhamnosus TOM 22.8 (10×10⁹ CFU/day for 10 days) was the most effective strain and dose, significantly improving Nugent scores, vaginal pH, and microbiota composition and reducing bacterial vaginosis recurrence rate. Alternative strains, including L. crispatus, L. plantarum, and L. acidophilus, showed therapeutic potential at doses of 1×10⁸ to 5.4×10⁹ CFU/day for treatment durations ranging from 6 days to 4 months. The reported side effects were mild and self-limiting. This study supports the use of probiotics as an adjunctive or alternative bacterial vaginosis treatment, emphasizing the need for a personalized approach based on patient characteristics. However, limitations such as small sample sizes and heterogeneous outcome measures necessitate further research. Larger, well-designed trials with standardized methodologies are required to refine probiotic recommendations.
Co-Authors A.A. Santi Dewi Abd. Rasyid Syamsuri Agustina Tri Endharti Aldiansyah, Dudy Aldika Akbar, Muhammad Ilham Alim, Fathi Nabila Aloysius Suryawan Amir, Nayla Nabilla Tahta Avwina Andonotopo, Wiku Anggie Diniayuningrum Anggraeni, Yessy Mulyanur Anik Sri Purwanti Anin Indriani Anisa Setyowati Anita Dwi Rahmawati Annisa Jusuf, Annisa Annissa Febriani Astuti, Ludji Aziz, Ali Bachnas, Muhammad Adrianes Baihaqi, Irfani Cholid Tri Tjahjono Cut Meurah Yeni Daniati, Lidya Dewi Azar Nuria Wardani Dewi, Ratih Frastika Dinda Oktia Maghfiroh Edy Mustofa Erna Amin Evert Solomon Pangkahila Fauqo Wildatil Jannah Gusti, Kharisma Ciptaning Harumsari, Stefani Hery Setiawan, Hery Hidayat Sujuti Hikmawan Wahyu Sulistomo I Nyoman Hariyasa Sanjaya I Wayan Subage Ihda Dian Kusuma Ihda Dian Kusuma Indrayanti Indrayanti Indriani, Anin Indriati Dwi Rahayu Irfani Baihaqi Ita Sulistiani Julian Dewantiningrum Kalsumy, Umi Kharisma Ciptaning Gusti Kurjak, Asim Kusworini Handono Lestari, Ni Putu Yunita Sri Lilik Zuhriyah Ludji Astuti Melani Chysti Situmorang Mohammad Saifur Rohman Mosip, Erinus Mukhamad Nooryanto Noviyanti Noviyanti, Noviyanti Nugrahanti Prasetyorini Nur Sophia Matin Nurdiana Nurdiana Nurdiana Nurdiana Nurdiana Nurdiana Nuswil Bernolian Pande Made Dwijayasa Permatasari, Galuh W. Pramono, Mochammad Besari Adi Pratama, Harry Dwi Purba, Irene Silvia Purbandari, Rosalia Puspita Handayani Putra, Ichsan Setya Ratnawati, Linda Regina Ayu Fristiyanti Ryan Saktika Mulyana Sabilla Khaerunissa, Dymphna Safrina Dewi Ratnaningrum Sanarto Santoso Sanggelorang, Margie Cassie Setyowati, Anisa Sirat, Noorhamdani A. Siti Candra Windu Baktiyani Siti Candra Windu Baktiyani Situmorang, Melani Chysti Sri Poeranto, Sri Sri Sulistyowati Sri Winarsih Stanojevic, Milan Subandi Subandi Sugiono, Achmad Sulistiani, Ita Sulistomo, Hikmawan Wahyu Sultanah Zahariah Sumarno . Sumarno Sumarno Sutrisno Sutrisno Talita Nandia Primarintan Tatit Nurseta Tatit Nurseta Theresia Monica Rahardjo Udjianto, Udjianto Wardani, Dewi Azar Nuria Wardani, Diadjeng Setya Wardani, Widya Kusuma Wati, Linda Ratna Wibisono, Hermawan Widyalaksono, Agung Winasih, Sri Wiradnyana, Anak Agung Gede Putra Wiyasa, I Wayan Arsana Yahya Irwanto Yogibuana, Valerinna Yuyun Yueniwati Zahariah, Sultanah