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Uji Aktivitas Antibakteri Kombinasi Ekstrak Etanol Daun Miana (Coleus atropurpureus L.) dan Daun Jambu Biji (Psidium guajava L.) terhadap Pertumbuhan Bakteri Escherichia coli Masayu Syarmila Putri Abas; La Ode Aman; Multiani S. Latif; Ishak Isa; Karunita Ika Astuti
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 4 No. 5 (2026): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v4i5.2392

Abstract

This study aimed to determine the antibacterial activity of the combined ethanol extracts of miana leaves (Coleus scutellarioides L.) and guava leaves (Psidium guajava) against Escherichia coli and to evaluate their interaction using the CompuSyn method. This laboratory experimental study employed maceration extraction with 96% ethanol, followed by phytochemical screening, antibacterial testing using the disc diffusion method, One-Way ANOVA, and Combination Index (CI) analysis. The extraction yielded 11.11% for miana leaves and 24.92% for guava leaves. Phytochemical screening confirmed the presence of flavonoids and alkaloids in both extracts. All extract combinations inhibited E. coli growth, producing inhibition zones ranging from 8.10 to 12.75 mm, indicating moderate to strong antibacterial activity. One-Way ANOVA showed no significant differences among treatment groups (p = 0.837). CompuSyn analysis revealed that most combinations exhibited antagonistic interactions (CI > 1), whereas the combination of 10% guava extract and 20% miana extract showed synergistic effects (CI < 1) in two replicates. Overall, the combined extracts demonstrated antibacterial activity against E. coli, although most combinations did not exhibit synergistic interactions.
Co-Authors Ahmad Kadir Kilo Aiyi Asnawi Aiyi Asnawi Aiyi Asnawi Akram La Kilo Alecia Febriani Putri Arfan Arfan Arfan Ariani H. Hutuba Ariani Hutuba Arviani Arviani Asisah, Asisah Astin Lukum Astria Endesei Astuti, Karunita Ika Bumulo, Nuraini Dandi Saputra Halidi Deasy Natalia Botutihe Dilapanga, Windi Dizky Papeo Djuwarno, Endah Nurrowinta Domu, Siti Afdianti Dr. Apt. Hamsidar Hasan S.Si.,M.Si Ellin Febrina Erni Mohamad Faradila Ratu Cindana Haris Munandar Hendri Iyabu Hiola, Faramita Ibrahim, Indriyanti Inrawani Inrawani Ishak Isa Jafar La Kilo Karim, Fadila Kasmawati, Henny Kostiawan Sukamto, Kostiawan La Alio La Alio Lukman A. R. Laliyo Madania, Madania Magfirah Nur Cahyani Mahdalena Sy Pakaya Mangara Sihaloho Mardjan Paputungan Masayu Syarmila Putri Abas Mega Fatimah Rosana Meylani Frisilia Moh. Fajri Mohamad Adam Mustapa Mohamad Aprianto Paneo Mohamad Mustapa Mu'thi Andy Suryadi Muhammad Taupik Multiani S Latif Musa, Weny J.A. Muttaqin, Fauzan Zein Najmah, Najmah Nasrun Pakaya Netty Ino Ischak Nita Suleman Nur Fadillah Pulukadang Nur Isty Fidya Nur Rayani Nur Riska Apriana Nurfadilah M. Kasim Nurfitrah Daud Nurhayati Bialangi Nurvita Abdullah Opir Rumape Otoluwa, Sri Yulanda Pahrun, Abdul Wahab Pakaya, Devina A.p Rani Orelia A. Unga Rayani, Nur Ruslin, Ruslin Sabihi, Ismail Sabora, Ririn S. Sahami, Ulin Saleh, Sri Deltalia Suchi Wulandari Dai Suci Damayanti Suleman Duengo Suryadi, A Mu'thi Andy Syamsul Bahri Teti Sutriyati Tuloli Teti Tuloli Tuloli, Tety Umar, Ahmat Sudir Wayan Ayu Puje Astuti Weny J.A. Musa Widayanti . Widy Abdulkadir Widy Susanti Abdulkadir Wiwin Rewini Kunusa Wiwit Zuriati Uno Yuszda K Salimi Yuszda K. Salimi Yuzda K Salimi Zaenul Wathoni Zulfa K Muslimin Zulkifli B Pomalango