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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN MEDIA MEDIKA INDONESIANA JURNAL GIZI INDONESIA Jurnal Kedokteran Diponegoro Journal of Nutrition College Jurnal Biotek Medisiana Indonesia Journal of Biomedicine and Translational Research Jurnal Kesehatan The Indonesian Biomedical Journal AcTion: Aceh Nutrition Journal Media Medika Muda Medica Hospitalia Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) World Nutrition Journal Medica Arteriana (Med-Art) Indonesian Journal of Applied Research (IJAR) Diponegoro International Medical Journal (DIMJ)
Banundari Rachmawati
Department Of Clinical Pathology, Faculty Of Medicine, Universitas Diponegoro, Semarang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Low sEng Level in Preeclampsia with MFTHFR Gene Polymorphism Suggesting a Protective Factor Pramono, M. Besari Adi; Faradz, Sultana MH; Suhartono, Suhartono; Susanto, Hardhono; Rachmawati, Banundari; Pramono, Noor
Journal of Biomedicine and Translational Research Vol 11, No 3 (2025): December 2025
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v11i3.29375

Abstract

Background: Preeclampsia is one of the most serious complications of pregnancy and the leading cause of maternal and fetal mortality. Various studies have shown that Glutathione Peroxidase (GPx) deficiency and increased Soluble endoglin (sEng) level are consistently associated with the incidence of preeclampsia. Several studies also show the role of MTHFR A1298C and C677T gene polymorphisms in preeclampsia.Objective: This study investigated association between blood GPx, sEng levels, MTHFR A1298C and C677T gene polymorphisms in Preeclampsia.Methods: This analytic observational case-control study was conducted on 70 cases of preeclampsia and 70 controls. Blood GPx and sEng levels were measured using Enzyme Linked Immunosorbent Assay (ELISA). MTHFR A1298C and C677T gene polymorphism was genotyped using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). The data obtained were analyzed using the Mann-Whitney U test, chi-square test, and independent T-test.Results: There were no significant differences in GPx levels or MTHFR A1298C/C677T genotype distribution between groups. sEng levels were significantly higher in the preeclampsia group than controls (p=0.001). ROC analysis identified a cut-off of 7.75 ng/mL. Among preeclampsia patients, those with the MTHFR 1298AC/CC genotypes had lower sEng levels than wildtype (p=0.027), suggesting a potential protective effect. No association was found for C677T.Conclusion: We found no significant difference in GPx level, MTHFR A1298C and C677T gene polymorphism between preeclampsia and control group. Soluble endoglin (sEng) level in the preeclampsia group (mean: 11.0±5.22) were significantly different (p=0.001) compared to the control group (mean: 8.1±5.31). Increased level of sEng is associated with incidence of preeclampsia. A key finding in this study is the significantly lower sEng levels observed in preeclampsia patients carrying the MTHFR 1298AC and 1298CC alleles compared to the control group (p=0.027). This indicates a protective factor where in preeclampsia with MTHFR gene alleles 1298AC and 1298CC sEng levels are lower compared to wildtype.
CORRELATION BETWEEN FASTING BLOOD GLUCOSE LEVELS AND SERUM TRIGLYCERIDE AND HDL CHOLESTEROL LEVELS IN ELDERLY PATIENTS WITH TYPE 2 DIABETES MELLITUS Dwi Retnoningrum; Salma Tyas Salsabila; Banundari Rachmawati; Nyoman Suci Widyastiti
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 2 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i2.52982

Abstract

Background: Blood glucose levels over normal limits are a hallmark of diabetes mellitus (DM), a chronic metabolic disease with several causes. Disorders in lipid metabolism can result from type 2 diabetes mellitus. This study investigated the correlation between fasting blood glucose (FBG) levels and serum triglyceride and HDL cholesterol in elderly people with type 2 diabetes. Objectives: To prove that in elderly people with type 2 diabetes mellitus, FBG levels are correlated with serum triglyceride and HDL cholesterol levels. Methods: A cross-sectional study of 46 secondary data on elderly patients with diabetes mellitus at Diponegoro National Hospital in Semarang. data analysis using Pearson's correlation test (p<0.05). Results: The Pearson’s correlation test between fasting blood glucose levels and triglyceride levels was p = 0.076, and serum HDL cholesterol was p = 0.270 in elderly patients with type 2 diabetes mellitus. Conclusion: There is no correlation between FBG levels and serum triglyceride and HDL cholesterol levels in elderly people with type 2 diabetes mellitus.
Co-Authors Agustina L.N. Aminin Ahmad Reza Ajoekesoema, Tanti Andreas Arie Setiawan Andrew Johan Asri Ragil Kemuning Asti, Herniah Basti Andriyoko Budi Mulyono Corrie Abednego Crisdayani, Carissa Putri Cynthia Citra Darmono SS Devi Ermawati Dian Widyaningrum Dian Widyaningrum Djuara P Lubis Driyah, Srilaning Dwi Retnoningrum Dwi Retnoningrum Dwi Retnoningrum Edi Dharmana Edward Kurnia Setiawan Limijadi Edward Kurnia Setiawan Limijadi Edward Kurnia Setiawan Limijadi, Edward Kurnia Setiawan Elida Soviana Febe Christianto Fifin Luthfia Rahmi Hardhono Susanto Herniah Asti Wulanjani Hertanto Wahyu Subagio Ida Parwati Ignatius Riwanto, Ignatius Indranila Kustarini Samsuria Indriani Silvia Innawati Jusup Kartika, Nadini Kurniawati, Dewi M Lisyani Budipardigdo Suromo Luciana Sutanto Lusiana Batubara M. Besari Adi Pramono, M. Besari Adi Mabruratussania Maherdika Mahmudah Hidayati Meita Hendrianingtyas Meita Hendrianingtyas Melkior Krisna Arondaya MI Diah P Mila Niqi Itami Mohammad Sulchan Muchlis Ahsan Udji Sofro Muh Agus Barliyan Muji Rahayu Nadini Kartika Niken Puruhita Noor Pramono Novita Indayanie Novitasari, Sherly Nyoman Suci Widyastiti Nyoman Suci Widyastiti Permatasari, Narulita Dyah Prihartiwi Purnamasari Probosuseno Probosuseno, Probosuseno Purnama, Yugi Hari Chandra Purwanto AP Putri Theresia LA Bancin Resty Ryadinency Retnaningsih - Ria Triwardhani Riansari, Anugrah Riwanto Salma Tyas Salsabila Samsuria, Indranila K Sanjaya Santoso Santoso Jaeri Santoso Jaeri Soeharyo Hadisaputro Sofyan Harahap Subandhini Arika Pradati Suhartono Suhartono, Suhartono Suharyo Hadisaputro Sukartini, Ninik Sulistiana Jhon Desel Sultana MH Faradz Sunarti Surohadi, Natra D. Syaravina, Elita Theresia Ilyan Tjokorda Gde Dalem Pemayun Tri Indah Winarni Tri N. Kristina, Tri N. Triwardhani, Ria Tulaar, Angela B. M. Wicaksono, Maulana Akbar Wicaksono, Muhammad Agung Wibowo Yenny Yulianti Yoanita Pratiwi Budiwiyono Yuswo Supatmo