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Thyroid Crisis and Septic Suspected Sepsis in the First Trimester of Pregnancy Mahmudah Hidayati; Banundari Rachmawati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 26, No 3 (2020)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i3.1535

Abstract

A normal pregnancy with physiological and hormonal changes can change thyroid function, accordingly, there are difficulties to establish the diagnosis of thyroid abnormality. The prevalence of hyperthyroidism in pregnancy is 0.6%. Approximately 1-2% of hyperthyroidism develops into a thyroid crisis. Knowledge of the diagnosis of the thyroid crisis in a pregnant female is very important to avoid complications. The 22-year-old female of thirteen weeks presented with vomiting, since two days before hospitalized, weakness, and decreased consciousness. During treatment, patients had diarrhea, melena, and was irritable. Physical examination showed blood pressure of 136/112 mmHg, pulse of 110 times/minute, respiration of 24 times/minute, and temperature of 38.3oC. Exophthalmos was found at the patient's eyes, but there was no enlargement of the thyroid and the patient often screamed hysterically. Routine urine examination showed proteinuria 1+, blood 3+, leukocytes 1+ in urinalysis, FT4 35.18 pmol/L and TSH <0.05 uIU/mL, leukocytes 15.2 x103/uL, SGOT 245 U/L, SGPT 366 U/L. The final diagnosis of this patient is a thyroid crisis and suspect sepsis in the first trimester of pregnancy. Thyroid Receptor Antibody (TRAb) examination should be performed to assure Graves disease or hyperthyroidism due to pregnancy (transient hyperthyroidism) as the cause.
KADAR ASAM URAT SERUM DAN KOMPONEN SINDROM METABOLIK MI Diah P; Banundari Rachmawati; Purwanto AP
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 20, No 3 (2014)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v20i3.469

Abstract

The incidence of metabolic syndrome (MetS) is significantly increasing. The elevated serum uric acid (SUA) level is correlated with the metabolic risk of cardiovascular. The relationship between SUA levels and components of MetS has been inconsistent. The aim of this study was to know the correlation between SUA level and component of MetS by analyzng. This study was a cross-sectional design conducted on healthy people at the Medical Check Up (MCU) Clinic, Dr. Moewardi Hospital, Surakarta from June 2012 until February 2013. MetS was defined according to the 2005 International Diabetes Federation (IDF) criteria. The statistical analysis was done by Student’s T test, Pearson or Spearman correlation coefficients. The researchers considered p<0.05 as statistically significant with a 95% confidence interval. A total of 80 healthy subjects, (range 19–57 years) were enrolled into this study. MetS was diagnosed in 40 persons where men (62.5%) were more than women and the non-MetS in women (62.5%) were more than men. In this study, a positive correlation was found between SUA and systolic blood pressure, diastolic blood pressure and waist circumference (Pearson r=0.354, 0.495, 0.399, respectively, p<0.05) in women, but not in men. The SUA was positively correlated with systolic blood pressure, diastolic blood pressure and waist circumference, particularly in women. A long term study is needed to investigate the consequence of increasing the SUA level in metabolic disorders and hormonal influences as well.
SERUM ZINC AND C-REACTIVE PROTEIN LEVELS AS RISK FACTORS FOR MORTALITY IN SYSTEMIC INFLAMMATORY RESPONSE SYNDROME Dwi Retnoningrum; Banundari Rachmawati; Dian Widyaningrum
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 24, No 1 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v24i1.1147

Abstract

Kondisi Systemic Inflammatory Response Syndrome (SIRS) berkebahyaan terjadinya sepsis dan kegagalan multi organ. Inflamasidapat menyebabkan terjadinya redistribusi zinc ke jaringan sehingga terjadi penurunan kadar zinc plasma. Kadar CRP pada SIRSmeningkat sebagai respons peningkatan protein tahap akut. Tujuan penelitian ini untuk mengetahui apakah kadar zinc dan CRP serummerupakan faktor kebahayaan kematian di pasien SIRS. Penelitian observasional analitik dengan pendekatan kohort prospektif di 30pasien SIRS berusia 27–64 tahun. Kadar zinc serum diperiksa dengan metode atomic absorbance spectrophotometer (AAS) dan CRPserum dengan metode latex agglutination immunoassay menggunakan alat autoanaliser. Kejadian kematian subjek dinilai setelah 28hari perawatan. Data dilakukan uji statistik Chi-Kwadrat, bila tidak memenuhi maka dilakukan uji alternatif Fisher. Besarnya nilaifaktor kebahyaan dilakukan perhitungan kebahayaan relatif. Rerata kadar zinc dan CRP berturut-turut 81,24 ± 8,72 μg/dL, dan 8,13± 8,12 mg/dL. Kematian dalam 28 hari adalah 33,3%. Penelitian ini menunjukkan bahwa kadar zinc plasma < 80 μg/dL bukanmerupakan faktor kebahayaan terjadinya kematian (p=0,114), sedangkan kadar CRP ≥ 10 mg/dL merupakan faktor kebahayaanterjadinya kematian di pasien SIRS (RR=3,28, 95% CI 1,33-8,13, p=0,015). Kadar zinc plasma bukan merupakan faktor kebahayaanterjadinya kematian pada SIRS, sedangkan kadar CRP merupakan faktor kebahayaan terjadinya kematian di pasien SIRS.
PACKED RED CELL DENGAN DELTA Hb DAN JUMLAH ERITROSIT ANEMIA PENYAKIT KRONIS (Packed Red Cells with Delta Hb and Erythrocytes in Anemia of Chronic Disease) Novita Indayanie; Banundari Rachmawati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 3 (2015)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i3.1270

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Anemia chronic disease is the second common cause after iron deficiency anemia with hemoglobin levels below the referencevalue. The pathogenesis of anemia should be determined for treatment. Hematinics and or erythropoietin are other treatments besidestransfusion. The transfusion is started when Hb≤7g/dL. The PRC transfusion of 4ml/kg could increase Hb level by 1 g/dL, or 1 unit andcould increase 3–5% of hematocrit. The objective of this study was to know the correlation of PRC unit with delta Hb and erythrocytesin anemia of chronic disease. The 60 samples examined were from patients of the Kariadi Hospital Semarang suffering from anemia ofchronic disease and who were transfused with PRC from January up to March 2014. The study subjects comprised 28 men (46.7%) and32 women (53.3%), with a mean age of 47 years. The number of PRC given was between one (1) to four (4) units. The mean delta Hbwas 3.48 and the mean delta erythrocytes was about 1.03 (0.1 to 2.3). There was a significant correlation between PRC units and deltaHb (r:0.856, p:0.000), as well as delta erythrocytes (r:0.716, p:0.000). Based on this study, it can be concluded that PRC units have avery strong correlation with delta Hb and as well as with delta erythrocytes in patients suffering from anemia of chronic disease
COMPARISON OF GLYCEMIC STATE IN PATIENTS WITH AND WITHOUT HYPERURICEMIA Corrie Abednego; Banundari Rachmawati; Muji Rahayu
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 24, No 1 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v24i1.1153

Abstract

Hiperurisemia merupakan keadaan asam urat yang meningkat dalam serum. Beberapa penelitian melaporkan hiperurisemia menyebabkankerusakan sel beta pankreas dengan mekanisme apoptosis melalui jalur NF-kB serta berhubungan dengan komplikasi mikrovaskular danmakrovaskular pada pasien diabetes. Perbedaan status glikemia (glukosa darah puasa/GDP dan glukosa darah 2 jam post-prandial/GD2PPdan HbA1c) pada pasien dengan dan tanpa hiperurisemia belum banyak diketahui. Tujuan penelitian untuk membuktikan perbedaan statusglikemia pada pasien dengan dan tanpa hiperurisemia. Penelitian retrospektif, 110 pasien yang dibagi menjadi kelompok hiperurisemia dantanpa hiperurisemia. Glukosa darah puasa dan 2 jam PP diperiksa menggunakan metode heksokinase, asam urat dengan metode urikase,HbA1c dengan metode elektroforesis kapiler. Data diuji normalitas data dan perbedaan antara variabel, dianalisis dengan uji Mann-Whitney.Subjek 58 laki-laki dan 52 perempuan, nilai rerata umur pasien 56,36 ± 8,7 tahun. Pasien laki-laki, terdapat perbedaan bermakna statusglikemia (GDP, GD2PP, HbA1c) terhadap kelompok hiperurisemia dan tanpa hiperurisemia, p< 0,05. Pasien perempuan, terdapat perbedaanbermakna status glikemia (GDP dan GD2PP), p< 0,05 serta HbA1c tidak terdapat perbedaan bermakna pada pasien hiperurisemia dan tanpahiperurisemia dengan p=0,084. Terdapat perbedaan bermakna pada status glikemia pasien laki-laki dan perempuan terhadap kelompokhiperurisemia dan tanpa hiperurisemia, kecuali HbA1C pada perempuan. Dibutuhkan penilaian terhadap diet pasien yang dapat mempengaruhikadar asam urat.
PERBEDAAN KADAR UREUM DAN KREATININ PADA ST-ELEVATION MYOCARD INFARCTION (STEMI) DAN NON ST ELEVATION MYOCARD INFARCTION (N-STEMI) Muh Agus Barliyan; Ria Triwardhani; Banundari Rachmawati
Media Medika Muda Vol 2, No 3 (2017)
Publisher : Faculty of Medicine Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Latar belakang: Infark Miokard Akut (IMA) menyebabkan penurunan curah jantung dan aliran darah menuju ginjal sehingga dapat mengakibatkan fungsi ginjal menurun yang dapat dilihat dari kenaikan ureum dan kreatinin. Kenaikan ureum dan kreatinin dapat sebagai petanda laboratorium untuk membedakan antara ST-elevation  myocard infartion (STEMI) dengan non ST elevation myocard infarction (NSTEMI) sehingga mempercepat penanganan dan menurunkan kasus kematian IMA. Tujuan penelitian ini untuk mengetahui apakah terdapat perbedaan kadar ureum dan kreatinin antara pasien STEMI dengan NSTEMI.Metode: Desain penelitian belah lintang, data sekunder diambil dari rekam medik dari bulan Januari - September 2017 di RSUP Dr. Kariadi. Jumlah sampel 80 pasien, digolongkan dua kelompok yaitu STEMI dan NSTEMI berdasarkan pemeriksaan EKG dan enzim jantung (troponin dan CKMB). Kadar ureum dan kreatinin serum diperiksa dengan alat ADVIA 1800. Data dianalisis dengan program statistik SPSS v.15 menggunakan uji beda mann whitney.Hasil: Ada perbedaan bermakna kadar ureum dan kreatinin antara STEMI dan NSTEMI (p=0,010 dan p=0,003). Hal ini dikarenakan kerusakan otot jantung menyebabkan penurunan curah jantung yang menuju ginjal lebih tinggi pada kasus STEMI dibandingkan NSTEMI.Simpulan: Simpulan: Kadar Ureum dan kreatinin lebih tinggi bermakna pada STEMI. Peningkatan kadar ureum dan kreatinin perlu diperhatikan pada kasus infark miokard. Kata Kunci: Ureum, kreatinin, Infark Miokard Akut, STEMI, NSTEMI
Transthyretin, Immature Platelet Fraction, and Mean Platelet Volume in Normotensive and Preeclampsia Pregnancy Asri Ragil Kemuning; Herniah Asti Wulanjani; I Edward Kurnia Setiawan Limijadi; Indranila Kustarini Samsuria; Banundari Rachmawati
The Indonesian Biomedical Journal Vol 14, No 2 (2022)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v14i2.1862

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BACKGROUND: Transthyretin protein experiences misfolding and aggregation in preeclampsia due to placental ischemia and inflammation. Placental endothelial damage occurring in preeclampsia stimulates the production of larger young platelets in the bone marrow and can be reflected by an increase in the immature platelet fraction (IPF) and mean platelet volume (MPV). Since the change in these markers in preeclampsia remains controversial, this study was conducted to analyze the differences in levels of transthyretin, IPF, and MPV as easily accessible markers in normotensive and preeclampsia pregnancies.METHODS: Total subjects included in this study were 32 normotensive and 26 preeclampsia pregnant woman. The measurement of serum transthyretin level was using enzyme-linked immunosorbent assay (ELISA) method. Meanwhile, IPF and MPV levels were measured by using a hematology analyzer with flowcytometry method. Data was statistically analyzed using unpaired T-test and Mann-Whitney, with significancy of p<0.05.RESULTS: Median value of transthyretin in normotensive and preeclampsia pregnancy were 11 (6-30) mg/dL and 9 (5-18) mg/dL. The mean value of IPF in normotensive and preeclampsia pregnancy were 4.56±2.19% and 6.33±2.99%. Mean value of MPV in normotensive and preeclampsia pregnancy were 10.41±0.76 fL and 11.32±1.2 fL. There were significant differences in levels of transthyretin, IPF, and MPV between normotensive and preeclampsia pregnancies (p=0.008, p=0.017, and p=0.002, respectively).CONCLUSION: There are significant differences in transthyretin levels, IPF, and MPV values in normotensive and preeclampsia pregnancies. Therefore, serum transthyretin, IPF, and MPV can be developed as affordable parameters for the diagnosis of preeclampsia.KEYWORDS: preeclampsia, transthyretin, IPF, MPV 
Parathyroid Hormone-25(OH)D and Calcium-Phosphorus Ratio as Osteopenia Risk Factors in Women with Central Obesity Meita Hendrianingtyas; Banundari Rachmawati; Ignatius Riwanto; Budi Mulyono; Suhartono Suhartono; Tri Indah Winarni; Lisyani Budipardigdo Suromo
The Indonesian Biomedical Journal Vol 14, No 2 (2022)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v14i2.1816

Abstract

BACKGROUND: Central obesity has a close association with inflammation and the state of bone mass. Osteopenia is an abnormal condition of bone density. Bone mass density is influenced by several factors, such as 25(OH)D, parathyroid hormone (PTH), calcium (Ca) and phosphorus (P). The aim of this study was to evaluate the role of PTH-25(OH)D and Ca-P ratio as risk factors for osteopenia in women with central obesity.METHODS: A cross-sectional study was conducted in September 2020 to March 2021. The total subjects were 130 women aged 25-50 years old with central obesity. The diagnosis of osteopenia was done using dual X-ray absorptiometry (DXA) to measure bone mineral density. Enzyme linked fluorescent assay (ELFA) method was done to measure PTH and 25(OH)D levels, ion selective electrode method to measure Ca, and photometer method to measure P level. The receiver operating characteristic (ROC) curve was used to determine the optimal cut-off value and calculated prevalence ratio (PR) for osteopenia risks, followed by logistic regression analysis.RESULTS: The PR of PTH level was 10.18 (95% CI: 1.15–5.85; p=0.01); the PTH-25(OH)D ratio was 5.12 (95% CI: 1.13–23.19; p=0.04); Ca level was 6.0 (95% CI: 1.33–27.14; p=0.02) and Ca-P ratio was 4.89 (95%CI: 1.33–17.97; p=0.02). The PR for PTH together with Ca level was 18.71 (95% CI: 2.17–160.40; p=0.008).CONCLUSION: The PTH-25(OH)D ratio and the Ca-P ratio are risk factors for the incidence of osteopenia in women with central obesity. A high PTH-25(OH)D ratio and a high Ca-P ratio would have a higher risk of developing osteopenia in this population.KEYWORDS: CRP, PTH-25(OH)D, Ca-P, osteopenia, central obesity, women
Hubungan Jumlah dan Indeks Trombosit (MPV, PDW, P-LCR, dan Plateletcrit) dengan D-Dimer pada Pasien COVID-19 Subandhini Arika Pradati; Banundari Rachmawati
Medica Arteriana (Med-Art) Vol 4, No 1 (2022): Juni 2022
Publisher : University of Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/medart.4.1.2022.49-56

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Latar Belakang:D-dimer digunakan untuk monitoring pasien COVID-19 namun tidak semua rumah sakit dapat melakukannya sehingga diperlukan adanya pemeriksaan alternatif. Jumlah dan indeks trombosit merupakan parameter yang secara otomatis diukur saat pemeriksaan dengan hematology analyzer. Penelitian ini dilakukan untuk mengetahui hubungan antara jumlah dan indeks trombosit dengan D-dimer pada pasien COVID-19.Metode:Penelitian menggunakan desain observasional analitik dengan pendekatan belah lintang. Sampel penelitian ini menggunakan catatan medik dari 33 pasien COVID-19 berusia 30 – 65 tahun dengan teknik consecutive sampling. Penelitian ini dilakukan pada bulan Juni – Agustus 2021 di RSUP dr. Kariadi Semarang. Analisis data dengan uji Pearson dan Spearman dengan nilai signifikansi p < 0,05Hasil: Dari 33 sampel didapatkan hubungan signifikan antara jumlah trombosit, MPV dan PCT dengan D-dimer (p=0,004; dan r=-0,483); (p=0,042; dan r=0,357); (p=0,000; dan r=-0,611). Tidak terdapat hubungan yang signifikan antara PDW dan P-LCR dengan D - dimer (p=0,872; dan r=-0,029); (p=0,899; dan r= 0,023)Kesimpulan:Terdapat hubungan negatif sedang antara jumlah trombosit dengan D-dimer, positif lemah antara MPV dan D-dimer, positif kuat antara PCT dan D-dimer serta tidak terdapat hubungan antara PDW, P-LCR, dengan D-dimer
Effectiveness of Brown Algae Extract to Reduce Serum Malondialdehyde and Protein Carbonyl Levels in Streptozotocin-Induced Sprague Dawley Rats Batubara, Lusiana; Kristina, Tri N.; Rachmawati, Banundari
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 7, No 2 (2016): December 2016
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (334.148 KB) | DOI: 10.30659/sainsmed.v7i2.1172

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Introduction: Brown algae (Sargassum duplicatum) contains bioactive compound with natural antioxidant that may potentially decrease lipid peroxidation and protein oxidation process in diabetes mellitus. Objective: to prove the effectiveness of brown algae extract administration (150mg/kgBW; 300mg/kgBW and 450 mg/kGBW respectively) in reducing serum MDA and PCO levels in streptozotocin-induced sprague dawley rat. Methods: This experiment study used the post test only control group design. Twenty eight (28) Sprague dawley rats induced with Streptozotocin (STZ) 40 mg/kgBW (i.p) were divided into four groups (n=7). The first group was diabetic non treated group (control). The second to fourth groups were the diabetic rats which given brown algae extract (150mg/kgBW; 300mg/kgBW and 450 mg/kgBW respectively) for 30 days. Serum MDA and PCO levels were examined by using ELISA method. Data were analyzed using one way ANOVA.Results: There were no significant differences in serum MDA levels among groups (p=0,405). However, serum PCO level in group administered with 450mg/kgBW of brown algae extract decreased significantly compared to control group (p=0.001), group administered with 150mg/kgBW (p=0.001) and 300mg/kgBW (p=0,037). Conclusion: Administration of brown algae extract did not decrease serum MDA levels significantly. Administration of 450mg/kgBW brown algae extract is effective to decrease serum PCO level significantly.
Co-Authors Agung Aji Prasetyo, Agung Aji Ahmad Reza Ajoekesoema, Tanti Andreas Arie Setiawan Andrew Johan Aryu Candra Asri Ragil Kemuning Asti, Herniah Basti Andriyoko Budi Mulyono Corrie Abednego Crisdayani, Carissa Putri Cynthia Citra Darmono SS Devi Ermawati Dian Widyaningrum Dian Widyaningrum Djuara P Lubis Driyah, Srilaning Dwi Retnoningrum Dwi Retnoningrum Edi Dharmana Edward Kurnia Setiawan Limijadi Edward Kurnia Setiawan Limijadi Edward Kurnia Setiawan Limijadi, Edward Kurnia Setiawan Edwin Basyar Elida Soviana Febe Christianto Fifin Luthfia Rahmi Hardhono Susanto Herniah Asti Wulanjani Hertanto Wahyu Subagio Ida Parwati Ignatius Riwanto, Ignatius Indranila Kustarini Samsuria Indriani Silvia Innawati Jusup Kartika, Nadini Kurniawati, Dewi M Lestari, Sarah Syifa Lisyani Budipardigdo Suromo Luciana Sutanto Lusiana Batubara Mabruratussania Maherdika Mahmudah Hidayati Meita Hendrianingtyas Meita Hendrianingtyas Melkior Krisna Arondaya MI Diah P Mila Niqi Itami Muchlis Ahsan Udji Sofro Muh Agus Barliyan Muji Rahayu Nadini Kartika Niken Puruhita Novita Indayanie Novitasari, Sherly Nyoman Suci Widyastiti Permatasari, Narulita Dyah Prihartiwi Purnamasari Probosuseno Probosuseno, Probosuseno Purnama, Yugi Hari Chandra Purwanto AP Putri Theresia LA Bancin Resty Ryadinency Retnaningsih - Ria Triwardhani Riansari, Anugrah Riwanto Samsuria, Indranila K Sanjaya Santoso Santoso Jaeri Santoso Jaeri Setiawan L, Edward Kurnia Soeharyo Hadisaputro Sofyan Harahap Subandhini Arika Pradati Suhartono, Suhartono Suharyo Hadisaputro Sukartini, Ninik Sulistiana Jhon Desel Surohadi, Natra D. Syaravina, Elita Theresia Ilyan Tjokorda Gde Dalem Pemayun Tri Indah Winarni Tri N. Kristina, Tri N. Triwardhani, Ria Tulaar, Angela B. M. Wardhani, Avriana Pety Wibisono, Agoes Wicaksono, Maulana Akbar Wicaksono, Muhammad Agung Wibowo Yenny Yulianti Yoanita Pratiwi Budiwiyono Yuswo Supatmo