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All Journal Jurnal Sain Veteriner Indonesia Medicus Veterinus Jurnal Presipitasi : Media Komunikasi dan Pengembangan Teknik Lingkungan Jurnal Ilmu Lingkungan Jurnal Pendidikan Teknologi dan Kejuruan Jurnal Ilmu Dasar Jurnal Teknik Elektro Jurnal Ilmu-Ilmu Peternakan (Indonesian Journal of Animal Science) Jurnal Dampak Prosiding Semnastek Jurnal Litbang Industri Jurnal Rekayasa Mesin Jurnal Sport Science Jurnal Bioteknologi & Biosains Indonesia (JBBI) Syntax Literate: Jurnal Ilmiah Indonesia PEDAGOGIA Jurnal Serambi Engineering JP.JOK (Jurnal Pendidikan Jasmani, Olahraga dan Kesehatan) Jurnal Ilmu Peternakan dan Veteriner Tropis (Journal of Tropical Animal and Veterinary Sciences) Jurnal SPORTIF : Jurnal Penelitian Pembelajaran Jurnal Ilmiah Mandala Education (JIME) Jurnal Pembangunan Nagari PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Maenpo : Jurnal Pendidikan Jasmani Kesehatan dan Rekreasi Sport Science and Health jurnal ilmu keolahragaan Jurnal Cahaya Mandalika IGKOJEI: Jurnal Pengabdian Masyarakat Jurnal Kepelatihan Olahraga Jurnal Kesehatan Tambusai Narra J Journal of Students‘ Research in Computer Science (JSRCS) Jurnal Pengabdian Masyarakat Madani Andalasian International Journal of Applied Science, Engineering, and Technology Journal of Informatics and Communication Technology (JICT) Jurnal Litbang Industri Gladi : Jurnal Ilmu Keolahragaan KOMMAS: Jurnal Pengabdian Kepada Masyarakat Jurnal Multidisipliner Bharasa Sports Medicine Curiosity Journal Jurnal Tera Jurnal Kedokteran Hewan BULLET : Jurnal Multidisiplin Ilmu AMMA : Jurnal Pengabdian Masyarakat Jurnal Pembelajaran Bahasa dan Sastra Journal of Civil Engineering and Vocational Education Journal of Informatics and Communication Technology (JICT) Journal of Physical Education and Sport Science (JPESS)
Slamet Raharjo
Jurusan Teknik Mesin, Universitas Andalas Padang
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Comparative analysis of hemotoxic, myotoxic, and inflammatory profiles of Calloselasma rhodostoma and Trimeresurus insularis venoms in mice Aphrodita, Adiva; Sentono, Diva N.; Yudha, Donan S.; Purwestri, Yekti A.; Nuringtyas, Tri R.; Raharjo, Slamet; Wahid, Isra; Rahmi, Sri N.; Wahyudi, Setyanto T.; Sofyantoro, Fajar
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narraj.v5i2.1874

Abstract

Snakebite envenomation remains a significant medical concern, particularly in tropical regions where venomous snakes such as Calloselasma rhodostoma and Trimeresurus insularis are prevalent. Both venoms are known for their potent hemotoxic, myotoxic, and inflammatory effects, yet their differential impacts on systemic physiological pathways remain unclear. The aim of this study was to characterize the hematological, myotoxic, and inflammatory effects of C. rhodostoma and T. insularis venoms in a murine model and to explore their influence on systemic factors such as insulin-like growth factor 1 (IGF-1), which is critical for muscle repair and inflammation regulation. Mice were exposed to varying doses (20–100 µg) of C. rhodostoma and T. insularis venoms. Hematological parameters, muscle degeneration, inflammatory cell infiltration, and plasma IGF-1 levels were assessed to evaluate the venoms' systemic and local effects. Our data indicated that C. rhodostoma venom induced significant changes in blood coagulation, muscle edema, and inflammatory infiltration, with pronounced effects even at lower doses. Conversely, T. insularis venom showed a dose-dependent suppression of IGF-1 levels, highlighting its unique systemic impact. Both venoms caused severe muscle damage, characterized by structural disintegration and increased leukocyte infiltration, with C. rhodostoma eliciting a stronger inflammatory response at lower doses.Snakebite envenomation remains a significant medical concern, particularly in tropical regions where venomous snakes such as Calloselasma rhodostoma and Trimeresurus insularis are prevalent. Both venoms are known for their potent hemotoxic, myotoxic, and inflammatory effects, yet their differential impacts on systemic physiological pathways remain unclear. The aim of this study was to characterize the hematological, myotoxic, and inflammatory effects of C. rhodostoma and T. insularis venoms in a murine model and to explore their influence on systemic factors such as insulin-like growth factor 1 (IGF-1), which is critical for muscle repair and inflammation regulation. Mice were exposed to varying doses (20–100 µg) of C. rhodostoma and T. insularis venoms. Hematological parameters, muscle degeneration, inflammatory cell infiltration, and plasma IGF-1 levels were assessed to evaluate the venoms' systemic and local effects. Our data indicated that C. rhodostoma venom induced significant changes in blood coagulation, muscle edema, and inflammatory infiltration, with pronounced effects even at lower doses. Conversely, T. insularis venom showed a dose-dependent suppression of IGF-1 levels, highlighting its unique systemic impact. Both venoms caused severe muscle damage, characterized by structural disintegration and increased leukocyte infiltration, with C. rhodostoma eliciting a stronger inflammatory response at lower doses.
Co-Authors - Afrizal A.A. Ketut Agung Cahyawan W Abd. Rasyid Syamsuri Adadio, Syaputra Rama Adi, Hardian Pamungkas Aflah Hibatullah, Naufal Agung Purniawan, Agung Ahmad Abdullah ahmad yani Ainul Yaqin Salam Airlangga Daulay, Dio Alif Akhrom, Afif Muhammad Akrom, Afif Muhammad Alfarisa Nururrozi, Alfarisa Alfitri Alfitri Aminuyati Andarini, Zahrah Prawita Andi Asmunandar Andini, Siska Ervi Aphrodita, Adiva Ardinal Ardinal Ardinal, Ardinal Assyaumin, Moch. Ian Brilian Aulia Azhar Ayubi, Novadri Azidin, Raja Mohammed Firhad Raja Badaruddin, Helda F. Chairil Syam Claude Mona Airin Daeng, Suharjo Dahlia, Karlina Puspa Dani Ramdani, Dani Darussalam, Ahmad Muttaqin Datrianto, Dwi S. Dean Eka Putri Delvi, Delvi Destri Muliastri Devita Anggraeni Dharma Wangsa Didik Setiyadi Dina Fathia Putri Endang Retnoningsih Fadjar Goembira Fajar Raya Ferdinal Kusuma Bakti Fajar Sofyantoro Fajri, Nor Finta Amalinda Fitriana, Ida Galih Prasetyo Gewe, Rima Senditya Gosy Endra Vigriawan Govendan, Puveanthan Nagappan Guntari Titik Mulyani Hairuddin Haribowo, Nurman Haribowo, Nurman Harisman, Ahmad Syahru Mubarok Hariyati Purwaningsih Hary Purnamaningsih Hastari Wuryastuty Helmi Helmi Heri Purnama Pribadi Heru Surianto Hery Widijanto I Sakan, Gerson Yohanes Ida Tjahajati Ihsan Al Qodar, Muhammad Imam Yunianto Iman, Firdaus Nur Indriyani Rachman Iqbal Rokhim, Mochamad Irkham Widiyono Irmantara Subagio Iskandar R, Iskandar R Isra Wahid Jasin, Rocmat Jauharsah Khoirur Rijal, Muhammad Krisdayanti P, Carinada Oki KURNIAWAN, LYNN KAAT LAURA Luh Putu Ratna Sundari Mahfud, Achmad - Mahmud Yunus Manik, Nengteng Manis, Siti Mariam Maryam, Annisa Masiti, Masiti Matsumoto, Toru Milla, Yunita Apriana Muarif, Samsul Mulyani, Prayitno Musytaqim Nasra Muttaqin, Akhsanul Nabila, Rahma Nofri Dodi Nuringtyas, Tri R. Olivia Andiana Pamungkas, Yualita Putri Permana, Rief Ghulam Satria Pratama, Dedy Aulya Pribadi, David Rinekso Purwestri, Yekti A. Puti Sri Komala Putra, Rifqi Tantyo Putri, Salva Almayda Raharjo, Imannuel Samyo Rahayu Pramadya, Sugeng Rahayu, Ida Rahmat, Indra Chasugih Rahmi, Sri N. Ramadhani, Mungky Ema Rati Yuliarningsih Razkya, Adinda Refi Martha Retno Widyastuti, Retno Rias Gesang Kinanti Rima Senditya Gewe Rini Widayanti Rizki Aziz Rochman Rochiem Rusli, Sfandi Saichudin Saichudin, Saichudin Santuso, Edy Satriawan, Ahmad Ichsan Sentono, Diva N. Setyo Budhi Singgih Saptadi Sitarina Widyarini Sitompul, Yeremia Yobelanno Soedarmanto Indarjulianto Sri Hartati Sri Rahmiwati Yuned Suci Wulandari Sudirman Sudirman Sugiarto, Dinta Suhardiansyah, Agung Budi Suradiradja, Kahfi Suradiradja, Kahfi Heryandi Surendra, Surendra Syafii . Taufiq Ihsan Tiara Wahyuni Trini Susmiati Tulloh, Luthfi Hidayat Ummah, Riza Thoyibatul Uswatun Hasanah Utomo, Al Hadi Vera Surtia Bachtiar Viandry Tetriva Putri Wahyudi, Setyanto T. Wijaya, Rachel Yanuartono, Yanuartono Yanuartono, Yanuartono Yenni Ruslinda Yudha, Donan S. Yuniarto, Andryas Yuriadi Yuriadi, Yuriadi Zagita Andriani Ariska Zainal Abidin