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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Penelitian Kesehatan Suara Forikes JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Media Ilmu Kesehatan PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Farmasi Indonesia JFIOnline Jurnal Mandala Pharmacon Indonesia Jurnal Biomedika Health Information : Jurnal Penelitian Science Midwifery International Journal of Clinical Inventions and Medical Sciences (IJCIMS) Indonesian Journal of Global Health research Open Access Indonesian Journal of Medical Reviews Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Abdimas Altruis: Jurnal Pengabdian Kepada Masyarakat Jurnal Multidisiplin Madani (MUDIMA) East Asian Journal of Multidisciplinary Research (EAJMR) Formosa Journal of Science and Technology (FJST) Indonesian Journal of Pharmacy and Natural Product Jurnal Farmasi Indonesia Medical Sains : Jurnal Ilmiah Kefarmasian Kunir: Jurnal Farmasi Indonesia (KJFI) Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Wiwin Herdwiani
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Analysis of Efficient Drug Supply Control at Muhammadiyah Siti Aminah Bumiayu Hospital Using the MMSL Method (Minimum-Maximum Stock Level) Period March – May 2023 Sofia, Anna; Peranginangin, Jason Merari; Herdwiani, Wiwin
Formosa Journal of Science and Technology Vol. 3 No. 8 (2024): August 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/fjst.v3i8.10886

Abstract

Medicine supplies that are too large or small will make hospitals sick loss. These losses can be in the form of drug supply costs enlarges and becomes disturbed smooth running of health services in hospitals. Objective study This For know influence method MMSL to supply drug in a way efficient in Installation Pharmacy RSU Muhammadiyah Siti Aminah Bumiayu. This research design uses quasi-experimental without control, by applying the method studied, namely minimum-maximum stock levels. Sampling using technique which can be obtained from Retrospective data for October 2022 – December 2022 and method application prospectively, namely March 2023 - May 2023 and carry out strategies repair use method Hanlon. All data drug results analysis A B C became the sample for this research. Analysis of inventory value data was carried out, stock value out, dea d stock and ITOR before and after application of the method using test statistics Wilcoxon Signed Rank Test. The inventory value before applying the MMSL method was IDR 289,756,421, and after applying control using the MMSL method it was IDR 184,725,126 , with a value of p=0.002<0.05. The implementation of drug control using the MMSL method shows that there is an influence on the value of drug supplies in the pharmaceutical installation of RSU Muhammadiyah Siti Aminah Bumiayu.
Antibacterial and Antibiofilm Activity Related to the Mechanism of Work of the Active Fraction of Moringa Leaves (Guilandina Moringa L.) to Staphylococcus Aureus Armayanti Rindiarko Hasbrianti; Opstaria; Wiwin Herdwiani
Jurnal Multidisiplin Madani Vol. 4 No. 8 (2024): August 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/mudima.v4i8.11134

Abstract

Biofilm-associated S. aureus bacterial infections are difficult to treat because bacterial cells encased in biofilms can be highly resistant to antibiotics and the immune response of the host. Moringa leaf extract contains active compounds of tannins, saponins, alkaloids, and phenols that have activity as antibacterial and antibiofilm. This study aims to determine the antibacterial activity and of extracts, mechanism of action of the most active fraction of moringa leaf ethanol extract against S. aureus.Extraction of Moringa leaves using maceration method with 96% ethanol solvent, fractionated using n-hexane, ethyl acetate, and water solvents. Antibacterial test using disc diffusion method, followed by dilution test. Observations were made using SEM and AAS. Data from the diffusion test, inhibition of biofilm formation, and biofilm degradation were analyzed using One Way ANOVA. Based on the results of the study, the ethyl acetate fraction is the most active fraction in inhibiting the growth of S. aureus in the diffusion test with an inhibition zone diameter of 15,7 mm at a concentration of 100 mg/mL and a minimum kill concentration value of 25 mg/mL. The water fraction was the most active fraction in inhibiting the formation and degradation of biofilm against S. aureus with an IC50 value of 4,049 ± 0,063 mg/mL and an EC50 value of 4,246 ± 0,050 mg/mL
Cytotoxic Activities and Expression of Protein p53 and Bcl-2 Extract and Fraction of Inggu Leaf (Ruta angustifolia [L.] Pers) to T47D Breast Cancer Cells Ariasti, Mia; Titik Sunarni; Wiwin Herdwiani
Open Access Indonesian Journal of Medical Reviews Vol. 4 No. 2 (2024): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v4i2.538

Abstract

Inggu leaves are plants that have been traditionally used as an alternative to cancer treatment. The aim of this study was to determine the cytotoxic activity of extracts, water fraction, ethyl acetate fraction and inggu leaf n-hexane fraction (Ruta angustifolia [L.] Pers) on T47D cells and to determine the effect of protein expression of P53 and Bcl-2 genes on inggu leaf active fraction (Ruta angustifolia [L.] Pers). Extract was obtained through maceration method with ethanol 96% solvent. Ethanol extract was then fractionated with liquid-liquid partition. Cytotoxic tests were performed using T47D breast cancer cells and Vero cells with the MTT assay test method and read the absorbance on ELISA reader. To determine the effect of expression of p53 and Bcl-2, an immunocytochemistry test was carried out. The results showed that the n-hexane extract and fraction of inggu leaves had cytotoxic activity against T47D breast cancer cells with IC50 values of 54,210 and 84,118 µg/mL, while the fraction of water and ethyl acetate fractions had no cytotoxic activity with IC50 value > 100 µg / ml. Inggu leaf extract (Ruta angustifolia [L.] Pers) is able to increase the expression of p53 and inhibit the expression of Bcl-2 at concentrations of 30,19-45,54 µg/mL and n-hexane fraction can increase the expression of p53 and can inhibit the expression of Bcl-2 at concentration 49,96-75,82 µg/mL.
Evaluation of the Implementation of Pharmaceutical Service Standards at the Keerom District Health Center, Indonesia Imba, Farhan; Wiwin Herdwiani; Tri Wijayanti
Open Access Indonesian Journal of Medical Reviews Vol. 4 No. 2 (2024): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v4i2.545

Abstract

Pharmaceutical services are an integral part of health services that focus on optimizing drug use to achieve optimal therapeutic results. Regulation of the Minister of Health of the Republic of Indonesia Number 73 of 2016 concerning Pharmaceutical Service Standards at Health Centers is a reference in providing quality pharmaceutical services. This study aims to evaluate the implementation of pharmaceutical service standards at the Keerom District Health Center. This research uses a descriptive method. Data was collected through questionnaires and observation sheets at 6 Health Centers in Keerom District. Data were analyzed using SPSS to calculate percentages and average values. The research results show that the level of implementation of pharmaceutical service standards at the Keerom District Health Center is in the good category with an average value of 78-84%. The categories with the highest scores are the pharmaceutical preparation management category (84%) and the drug information services category (82%). The category with the lowest score is the quality assurance category (78%). In conclusion, the overall implementation of pharmaceutical service standards at the Keerom District Health Center has reached the good category. Improvement efforts need to be made in several categories, such as quality assurance, to achieve optimal pharmaceutical services.
Literature review of the cytotoxic activity of faloak (sterculia quaddrifida r.br) against t47d and mcf-7 breast cancer cells and its active compounds Seran, Rumaldus; Herdwiani, Wiwin; Sunarni, Titik
Science Midwifery Vol 13 No 6 (2026): February: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i6.2246

Abstract

Faloak (Sterculia quadrifida R.Br) is one of the plants used by the community as a multipurpose drug. Faloak bark herb has long been used by the people of East Nusa Tenggara as a medicinal plant. Empirically, boiled water from the bark of the faloak plant is used by the people of East Nusa Tenggara as a cure for hepatitis, typhus, ulcers, and stamina recovery. The data extraction method used is narrative by grouping similar data from the literature review results according to the size of the results to be presented. The flow of the journal search is about testing the cytotoxic activity of faloak (Sterculia quadrifida R.Br) against T47D and MCF-7 breast cancer cells and the content of their active compounds. From these data, screening, journal eligibility, and monitoring of conformity with inclusion and exclusion criteria were carried out to obtain appropriate journals to conclude the cytotoxic activity of faloak. The results of a literature review showed that faloak (Sterculia quadrifida R.Br) had cytotoxic activity against T47D and MCF-7 breast cancer cells. Chemical compounds that have cytotoxic activity are alkaloids, flavonoids, terpenoids, tannins, naphthoquinone, apigenin, and puerarin. Naptaquinone derivatives 2,3-dihydro-6hydroxy-2-methylenenaphtho [1,2-b] furan-4,5-dione and 2-iminoethyl 2-(2-(1-hydroxypentan-2-yl) phenyl) acetate obtained from the extract or active fraction of faloak bark (Sterculia quadrifida R.Br) showed cytotoxic activity against T47D breast cancer cells. Apigenin compounds were found to be the most effective phytoestrogens in inhibiting the growth of breast cancer cells. Apigenin also has apoptotic effects and induces autophagy in breast cancer cells. an effective proteasome inhibitor in breast cancer cell culture and breast cancer xenografts, and puerarin can increase DUSP1 expression by increasing the expression level of miR-133a-3p in breast cancer cells.
Activity Test of Water Hyacinth (Eichhornia crassipes) Leaf Extract Against Streptozotocin-Nicotinamide-Induced Diabetic Nephropathy in Rats Afandi, Mukhamad; Herdwiani, Wiwin; Wijayanti, Tri
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 13 No. 1 (2026): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v13i12026.112-121

Abstract

Background: Diabetes mellitus is a metabolic disorder characterized by hyperglycemia. Chronic hyperglycemia in diabetes causes microvascular complications such as diabetic nephropathy (DN) which can affect kidney function. The parameters of kidney damage due to diabetes are increased levels of albumin and creatinine. Objective: The aim of this study was to determine the effect and effective dose of water hyacinth (Eichhornia crassipes) leaf extract on reducing blood glucose levels, microalbumin, serum creatinine, and improving kidney histopathology in STZ-NA-induced diabetic nephropathy rats. Method: The water hyacinth leaves were dried and made into a fine powder, then extracted using the maceration method using 70% ethanol. The initial testing process prepared 25 rats which were divided into 5 treatment groups, namely the negative group, positive control (Pioglitazone), water hyacinth leaf extract 61.25 mg/kg BW, 122.5 mg/kg BW and 245 mg/kg BW. The test animals were conditioned to be diabetic by being induced by STZ-Na intraperitoneally. Data analysis using One Way Anova and continued testing post hoc test. Results: The results showed that water hyacinth leaf extract at a dose of 245 mg/kg BW was the most effective in reducing microalbumin levels by 19.23% and improving kidney function, and had the potential to reduce blood glucose levels by 11.76% and serum creatinine by 15.04%, although it had not achieved the same effectiveness as the positive control. Conclusion: Water hyacinth leaf extract at a dose of 245 mg/kg BW can reduce blood glucose and microalbumin levels, as well as improve kidney function in diabetic nephropathy rats induced by STZ-Na.
Co-Authors - SUHARTINAH Afandi, Mukhamad AMINUDIN Ana Indrayati Andito, Didik Anita K Apriani, Dwi Wulan ARIKA WIDYARINI Armayanti Rindiarko Hasbrianti Astuty, Meilinda Windy Dian Kresnadipayana Dina Maryati Doso, Tri Elfahmi Elfahmi, Elfahmi Endang Sri Rejeki Firdaus, Muhammad Aisy Akbar Fransiska Leviana Frihani, Assyifa Adelia Galih Kurniawan Ika Purwidyaningrum Ilham Kuncahyo, Ilham Imba, Farhan Jason Merari Peranginangin Johnes Kalfari Kurniasari, Fitri Lidia Kurniawati Imanuel Lola’ Tulak Rerung lrfan Zamzani Maryati, Dina Maulita Saraswati MELINDA WIDIANINGRUM Merari Peranginangin, Jason Mia Ariasti Nabila K Nisa, Sabila Alfa Nuraini Harmastuti Opstaria Opstaria saptarini Patricia Alfayu Velix Puspitasari, Ismi Putri Rinda Pratiwi RA. Oetari Rahayu Rahmawati, Ismi Rendati, Hema Novita Rica Rica Rica Rica, Rica Safitri, Devita Sakinah Sarnia Iriani Lihawa Sari R Sari R, Sari Sarimanah, Jamilah Sarimanah, Jamilah Seran, Rumaldus setyawan, Ferdinta D Soemardji AA Sofia, Anna Syamsul Ma'arif Tan MI Titik Sunarni Titik Sunarni Tri Wijayanti Tri Wijayanti Triana Hertiani Wijayanti, Ifa Rizki Yanti, Masyitah Novia Yolanda Yolanda Yolanda Yolanda, Yolanda Yul Mariyah Zahra Zahra Zahra Zahra Zakiyyah Qurrotul ‘Aini Zamzani, Irfan Zulfah, Khairina