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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Penelitian Kesehatan Suara Forikes Media Ilmu Kesehatan JPSCR : Journal of Pharmaceutical Science and Clinical Research PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Farmasi Indonesia JFIOnline Jurnal Mandala Pharmacon Indonesia Jurnal Biomedika Health Information : Jurnal Penelitian International Journal of Clinical Inventions and Medical Sciences (IJCIMS) Indonesian Journal of Global Health research Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Abdimas Altruis: Jurnal Pengabdian Kepada Masyarakat East Asian Journal of Multidisciplinary Research (EAJMR) Indonesian Journal of Pharmacy and Natural Product Jurnal Farmasi Indonesia Medical Sains : Jurnal Ilmiah Kefarmasian Kunir: Jurnal Farmasi Indonesia (KJFI) Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Wiwin Herdwiani
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Optimisation and Characterisation of Curcumin Nanoparticles with Chitosan-TPP Combination Using Ionic Gelation Method as a Cut Wound Healer setyawan, Ferdinta D; Kuncahyo, Ilham; Herdwiani, Wiwin
East Asian Journal of Multidisciplinary Research Vol. 3 No. 9 (2024): September 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/eajmr.v3i9.10865

Abstract

Curcumin has low oral bioavailability, low solubility, and is easily degraded, making its clinical application difficult. This study aims to determine the effect of optimum concentration and formula of chitosan and TPP in the preparation of curcumin nanoparticles on particle size, zeta potential, adsorption efficiency, and incision wound healing. The optimisation method used simplex lattice design method. There were 8 draft formulas consisting of a combination of chitosan and TPP. Each formula was tested for zeta potential value, adsorption efficiency, particle morphology, and wound healing ability. The optimum formula was then determined and analysed using the simplex lattice design method. The combination of chitosan and TPP with simplex lattice design gives an influence on curcumin nanoparticles which reduces particle size, gives a negative zeta potential value, increases the sorption efficiency of the active substance (curcumin) and accelerates the healing effect of cut wounds in mice. The proportion of chitosan and TPP that can produce the optimum formula using simplex lattice design on the critical parameters of particle size, zeta potential value, sorption efficiency and wound healing ability is chitosan.
Co-Authors - SUHARTINAH Afrina Fajar Ekowati Aini, Zakiyyah Qurrotul AMINUDIN Ana Indrayati Anita K Apriani, Dwi Wulan ARIKA WIDYARINI Astuty, Meilinda Windy Dian Kresnadipayana Dina Maryati Doso, Tri Elfahmi Elfahmi, Elfahmi Endang Sri Rejeki Firdaus, Muhammad Aisy Akbar Fransiska Leviana Frihani, Assyifa Adelia Galih Kurniawan Ika Purwidyaningrum Ilham Kuncahyo, Ilham Jason Merari Peranginangin Johnes Kalfari Kurniasari, Fitri Lidia Kurniawati Imanuel Lola’ Tulak Rerung lrfan Zamzani Maryati, Dina Maulita Saraswati MELINDA WIDIANINGRUM Merari Peranginangin, Jason Nabila K Nisa, Sabila Alfa Nuraini Harmastuti Opstaria saptarini Patricia Alfayu Velix Puspitasari, Ismi Putri Rinda Pratiwi RA. Oetari Rahayu Rahmawati, Ismi Rendati, Hema Novita Rica Rica Rica Rica, Rica Safitri, Devita Sakinah Sarnia Iriani Lihawa Sari R Sari R, Sari Sarimanah, Jamilah Sarimanah, Jamilah setyawan, Ferdinta D Soemardji AA Syamsul Ma'arif Tan MI Titik Sunarni Titik Sunarni Tri Wijayanti Tri Wijayanti Triana Hertiani Wijayanti, Ifa Rizki Yanti, Masyitah Novia Yolanda Yolanda Yolanda Yolanda, Yolanda Yul Mariyah Zahra Zahra Zahra Zahra Zakiyyah Qurrotul Aini Zamzani, Irfan Zulfah, Khairina