Article Per Year (5 Year)
p-Index From 2021 - 2026
3.346
P-Index
This Author published in this journals
All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Penelitian Kesehatan Suara Forikes JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Media Ilmu Kesehatan PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Farmasi Indonesia JFIOnline Jurnal Mandala Pharmacon Indonesia Jurnal Biomedika Health Information : Jurnal Penelitian International Journal of Clinical Inventions and Medical Sciences (IJCIMS) Indonesian Journal of Global Health research Open Access Indonesian Journal of Medical Reviews Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Abdimas Altruis: Jurnal Pengabdian Kepada Masyarakat Jurnal Multidisiplin Madani (MUDIMA) East Asian Journal of Multidisciplinary Research (EAJMR) Formosa Journal of Science and Technology (FJST) Indonesian Journal of Pharmacy and Natural Product Jurnal Farmasi Indonesia Medical Sains : Jurnal Ilmiah Kefarmasian Kunir: Jurnal Farmasi Indonesia (KJFI) Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Wiwin Herdwiani
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

Published : 34 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 34 Documents
Search

 1   2   3   4 
Antibacterial and Antibiofilm Activity Related to the Mechanism of Work of the Active Fraction of Moringa Leaves (Guilandina Moringa L.) to Staphylococcus Aureus Armayanti Rindiarko Hasbrianti; Opstaria; Wiwin Herdwiani
Jurnal Multidisiplin Madani Vol. 4 No. 8 (2024): August 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/mudima.v4i8.11134

Abstract

Biofilm-associated S. aureus bacterial infections are difficult to treat because bacterial cells encased in biofilms can be highly resistant to antibiotics and the immune response of the host. Moringa leaf extract contains active compounds of tannins, saponins, alkaloids, and phenols that have activity as antibacterial and antibiofilm. This study aims to determine the antibacterial activity and of extracts, mechanism of action of the most active fraction of moringa leaf ethanol extract against S. aureus.Extraction of Moringa leaves using maceration method with 96% ethanol solvent, fractionated using n-hexane, ethyl acetate, and water solvents. Antibacterial test using disc diffusion method, followed by dilution test. Observations were made using SEM and AAS. Data from the diffusion test, inhibition of biofilm formation, and biofilm degradation were analyzed using One Way ANOVA. Based on the results of the study, the ethyl acetate fraction is the most active fraction in inhibiting the growth of S. aureus in the diffusion test with an inhibition zone diameter of 15,7 mm at a concentration of 100 mg/mL and a minimum kill concentration value of 25 mg/mL. The water fraction was the most active fraction in inhibiting the formation and degradation of biofilm against S. aureus with an IC50 value of 4,049 ± 0,063 mg/mL and an EC50 value of 4,246 ± 0,050 mg/mL
Cytotoxic Activities and Expression of Protein p53 and Bcl-2 Extract and Fraction of Inggu Leaf (Ruta angustifolia [L.] Pers) to T47D Breast Cancer Cells Ariasti, Mia; Titik Sunarni; Wiwin Herdwiani
Open Access Indonesian Journal of Medical Reviews Vol. 4 No. 2 (2024): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v4i2.538

Abstract

Inggu leaves are plants that have been traditionally used as an alternative to cancer treatment. The aim of this study was to determine the cytotoxic activity of extracts, water fraction, ethyl acetate fraction and inggu leaf n-hexane fraction (Ruta angustifolia [L.] Pers) on T47D cells and to determine the effect of protein expression of P53 and Bcl-2 genes on inggu leaf active fraction (Ruta angustifolia [L.] Pers). Extract was obtained through maceration method with ethanol 96% solvent. Ethanol extract was then fractionated with liquid-liquid partition. Cytotoxic tests were performed using T47D breast cancer cells and Vero cells with the MTT assay test method and read the absorbance on ELISA reader. To determine the effect of expression of p53 and Bcl-2, an immunocytochemistry test was carried out. The results showed that the n-hexane extract and fraction of inggu leaves had cytotoxic activity against T47D breast cancer cells with IC50 values of 54,210 and 84,118 µg/mL, while the fraction of water and ethyl acetate fractions had no cytotoxic activity with IC50 value > 100 µg / ml. Inggu leaf extract (Ruta angustifolia [L.] Pers) is able to increase the expression of p53 and inhibit the expression of Bcl-2 at concentrations of 30,19-45,54 µg/mL and n-hexane fraction can increase the expression of p53 and can inhibit the expression of Bcl-2 at concentration 49,96-75,82 µg/mL.
Evaluation of the Implementation of Pharmaceutical Service Standards at the Keerom District Health Center, Indonesia Imba, Farhan; Wiwin Herdwiani; Tri Wijayanti
Open Access Indonesian Journal of Medical Reviews Vol. 4 No. 2 (2024): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v4i2.545

Abstract

Pharmaceutical services are an integral part of health services that focus on optimizing drug use to achieve optimal therapeutic results. Regulation of the Minister of Health of the Republic of Indonesia Number 73 of 2016 concerning Pharmaceutical Service Standards at Health Centers is a reference in providing quality pharmaceutical services. This study aims to evaluate the implementation of pharmaceutical service standards at the Keerom District Health Center. This research uses a descriptive method. Data was collected through questionnaires and observation sheets at 6 Health Centers in Keerom District. Data were analyzed using SPSS to calculate percentages and average values. The research results show that the level of implementation of pharmaceutical service standards at the Keerom District Health Center is in the good category with an average value of 78-84%. The categories with the highest scores are the pharmaceutical preparation management category (84%) and the drug information services category (82%). The category with the lowest score is the quality assurance category (78%). In conclusion, the overall implementation of pharmaceutical service standards at the Keerom District Health Center has reached the good category. Improvement efforts need to be made in several categories, such as quality assurance, to achieve optimal pharmaceutical services.
Implementation of Clinical Pharmacy Services for Inpatients with Improvement Strategies Based on SWOT Analysis Muhammad Aisy Akbar Firdaus; Wiwin Herdwiani; Tri Wijayanti
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.7069

Abstract

Pharmaceutical Service Standards in Hospitals are regulated in the Regulation of the Minister of Health of the Republic of Indonesia Number 72 of 2016 on the management of pharmaceutical preparations, medical devices, and consumable medical materials as well as clinical pharmacy services in carrying out pharmaceutical service duties in hospitals. This study aims to evaluate the implementation of clinical pharmacy services in inpatients Hospital X in Surakarta and propose improvement strategies through SWOT analysis. The research method used is quantitative descriptive with a retrospective design. Samples were obtained by purposive sampling technique with pharmacist respondents who were directly responsible for clinical pharmacy services to and inpatient patients. The data analysis used was a validity and reliability test and improvement strategies using SWOT analysis. The results of the study show that clinical pharmacy activities are relatively good except for monitoring drug levels in the blood which have not yet been implemented. It is concluded that the implementation of clinical pharmacy services in inpatients at Hospital X is classified as a good category with a percentage (74%) and is in accordance with PMK No. 72 of 2016 except the unimplemented drug therapy level monitoring. The results of the SWOT analysis of IFAS with a positive result of 0.95 and a positive effas of 0.48 so that the position of the hospital's pharmaceutical installation is in quadrant I so that the right strategy is an aggressive strategy.
Co-Authors - SUHARTINAH AMINUDIN Ana Indrayati Andito, Didik Anita K Apriani, Dwi Wulan ARIKA WIDYARINI Armayanti Rindiarko Hasbrianti Astuty, Meilinda Windy Dian Kresnadipayana Dina Maryati Doso, Tri Elfahmi Elfahmi, Elfahmi Endang Sri Rejeki Fransiska Leviana Frihani, Assyifa Adelia Galih Kurniawan Ika Purwidyaningrum Ilham Kuncahyo, Ilham Imba, Farhan Jason Merari Peranginangin Johnes Kalfari Kurniasari, Fitri Lidia Kurniawati Imanuel Lola’ Tulak Rerung lrfan Zamzani Maryati, Dina Maulita Saraswati MELINDA WIDIANINGRUM Merari Peranginangin, Jason Mia Ariasti Muhammad Aisy Akbar Firdaus Nabila K Nisa, Sabila Alfa Nuraini Harmastuti Opstaria Opstaria saptarini Patricia Alfayu Velix Puspitasari, Ismi Putri Rinda Pratiwi RA. Oetari Rahayu Rahmawati, Ismi Rendati, Hema Novita Rica Rica Rica Rica, Rica Safitri, Devita Sakinah Sarnia Iriani Lihawa Sari R Sari R, Sari Sarimanah, Jamilah Sarimanah, Jamilah setyawan, Ferdinta D Soemardji AA Sofia, Anna Syamsul Ma'arif Tan MI Titik Sunarni Titik Sunarni Tri Wijayanti Tri Wijayanti Triana Hertiani Wijayanti, Ifa Rizki Yanti, Masyitah Novia Yolanda Yolanda Yolanda Yolanda, Yolanda Yul Mariyah Zahra Zahra Zahra Zahra Zakiyyah Qurrotul ‘Aini Zamzani, Irfan Zulfah, Khairina