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All Journal Medula Juke Berkala Kedokteran SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Prosiding Seminar Nasional Pakar Acta Biochimica Indonesiana JK Unila (Jurnal Kedokteran Universitas Lampung) Majority JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Galen: Jurnal Ilmu Farmasi dan Kesehatan JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine
Soraya Rahmanisa
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Ethanol extract of Bruguiera gymnorrhiza mangrove leaves and propolis activity on macroscopic healing of cuts in vivo Kurniawaty, Evi; Megaputri, Shina; Mustofa, Syazili; Rahmanisa, Soraya; Audah, Kholis Abdurachim; Andriani, Silvia
Acta Biochimica Indonesiana Vol. 5 No. 1 (2022): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.94

Abstract

Background: Bruguiera gymnorrhiza mangrove and propolis are often used as natural wound treatments. Its constituent is believed to promote wound healing. Objective: This study aims to explore the effect of topical administration of ethanol extract of Bruguiera gymnorrhiza mangrove leaves and propolis on wound healing activity. Methods: Twenty-four Sprague Dawley rats were randomly assigned to one of four treatment groups (n=6): aqua dest, standard wound medicine, ethanol extract of Bruguiera gymnorrhiza mangrove leaves, and propolis extract. Following the incision, treatment was given once a day for 14 days or until the wound healed. The cut area was observed by measuring the cut length using a ruler. Results: Standard wound medication took 9 days to promote healing, while the negative control (aqua dest) took 11.2 days, the ethanol extract of Bruguiera gymnorrhiza mangrove leaves took 7.3 days, and the propolis extract took 7.9 days. Conclusions: Topical administration of Bruguiera gymnorrhiza mangrove leaves ethanol extract and propolis had equal effects on the healing of wounds. Both are more effective than conventional wound ointments at healing cuts.
Co-Authors Ade Yonata Adelia, Anggi Amanda Febby Amanda Febby Febrina Andriani, Silvia Anggraeni Janar Wulan Ardandi, Rofi Yoga Ardika, Okta Besti Arina Muti Amaliah Audah, Kholis Abdurachim Cahyana, Adinda Husna Charla Gutri Farmitali Daulay, Suryani Agustina Diah Ayu Larasati Dian Isti Angraini Dian Isti Angraini Dwi Waskita Hutama Efrida Warganegara Eka Putri Rahmadhani Evi Kurniawaty Evriana Citra Farida Hakim Lamuhammad Fauziani, Andra Nabila Fitria Saftarina Giska Tri Putri Hani Zahiyyah Suarsyaf Happy, Terza Aflika Helmi Ismunandar Hendri Busman Husnandari, Aqila Jonathan Farrel Panggabean Khairun Nisa Kurniawaty, Evi Leni Amelia Lia Qelina M. Nikola Risol Maharani , Mentari Putri Megaputri, Shina Napitupulu, Cindy Cecilia Anasthasya Natasya Hayatillah Neza Ukhalima Hafia Sudrajat Nicholas Alfa Nirwan, Qurratul Aini Novita Carolia Nurhaliza, Suci Poty, Pitha Maykania Ramadhana Komala Rani Himayani Rasmi Zakiah Oktarlina Ratna Dewi Puspita Sari Reni Zuraida Rizqun Nisa Afriyanti Septia Eva Lusina Sha, Nindy Putri Shafira Fauzia Silvia Andriani Sofyan Musyabiq Wijaya Susianti Susianti Sutyarso Sutyarso Syachrani , Fayza Syarif, Muhammad Reza Syazili Mustofa TA Larasati Tara Aulianova Tiwuk Susantiningsih Triola Fitria Wiwi Febriani Yunianto, Andi Eka