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All Journal Majalah Kedokteran Bandung Global Medical and Health Communication Journal of Epidemiology and Public Health Indonesian Journal of Medicine Jurnal Respirologi Indonesia YARSI Medical Journal Jurnal Respirasi (JR) Narra J Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Reviono Reviono
Bagian Pulmonologi dan Kedokteran Respirasi Fakultas Kedokteran Universitas Sebelas Maret
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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The Effect of Curcuma longa Extract on Interleukin 6, Procalcitonin, Microbial Count, and Histopathology of the Lungs in a Rat Model Infected with Streptococcus pneumoniae Prasetyo, Yudhi; Reviono, Reviono; Hikmayani, Nur Hafidha; Adhiputri, Artrien; Setijadi, Ana Rima
Jurnal Respirologi Indonesia Vol 45 No 2 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i2.460

Abstract

Background: Streptococcus pneumoniae causes 95% of cases of community-acquired pneumonia (CAP). Interleukin 6, procalcitonin, microbial count, and lung histopathology can help in determining indicators of inflammatory processes and prognosis. Curcumin, which acts as an anti-inflammatory and anti-microbial, can be used as an adjunctive therapy in infectious diseases. Methods: This was a laboratory experimental study. A sample of 30 white rats (Rattus norvegicus) infected with Streptococcus pneumoniae was carried out in the experimental animal laboratory at the Faculty of Medicine, Universitas Sebelas Maret in November 2022 with incidental sampling. The control group received 1cc of aquadest, the first treatment group received 30 mg/200 g of curcuma longa extract, the second treatment group received 50 mg/200 g of Curcuma longa extract, the third treatment group received 30 mg/200 g of Curcuma longa extract and 30 mg/200 g of amoxicillin, and the fourth treatment group received 30 mg/200 g of amoxicillin. Interleukin 6 and procalcitonin were measured on the third and twelfth days after the rats were infected with Streptococcus pneumoniae. The microbial count and histopathology of the lungs were assessed after the twelfth day. Results: There was a significant difference (P<0.05) in the decrease in levels of interleukin 6, procalcitonin, and microbial count in the treatment group compared to the control group. There was no significant difference (P>0.05) in the improvement in the histopathology of the lungs in the treatment group compared to the control group. Conclusion: Curcuma longa extract can significantly reduce levels of interleukin 6, procalcitonin, and microbial count, but not significantly improve the histopathology of the lung.
Comparison of NEWS, SIRS, and qSOFA Score as Predictors of Mortality and Length of Stay in Patients Pneumonia with Sepsis Harsini, Harsini; Alfarizi, Aditya; Aphridasari, Jatu; Raharjo, A Farih; Reviono, Reviono
Jurnal Respirologi Indonesia Vol 44 No 1 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i1.505

Abstract

Background: Pneumonia is a major health problem in all age groups and often related with sepsis. In 2021, Surviving Sepsis Campaign Guidelines mentioned several clinical scoring systems to identify patients with potentials of developing sepsis, such as systemic inflammatory response syndrome (SIRS), national early warning score (NEWS), quick sequential organ failure assessment (qSOFA) and sequential organ failure assessment (SOFA). The guideline stated that there is no gold standard for diagnosing sepsis, contradicting The Sepsis-3 Guideline in 2016 that mentioned SOFA score as a gold standard for diagnosing sepsis.Methods: Subjects were all patients with pneumonia and sepsis who were treated in Dr.Moewardi Hospital within 1 January to 31 December 2022. Data from subjects’ medical records were collected to assess their NEWS, SIRS, qSOFA, and SOFA score on the day of admission. Since evaluation of SOFA score needs a number of components requiring laboratory results and takes longer time so they made a simpler tool called qSOFA to avoid delayed treatment of the patients.Results: NEWS is more consistent with SOFA compared to SIRS and qSOFA (Kappa value = 0.726 vs 0.320 vs 0.22; respectively). NEWS, SIRS, and qSOFA were all significantly correlated with mortality (P<0.001) with NEWS having the strongest correlation (r=0.482 vs 0.216 vs 0.175; respectively). Only NEWS showed significant correlation with the length of stay (r=0.129; P<0.001).Conclusion: NEWS was the most consistent score to SOFA compared to SIRS and qSOFA. NEWS was also the best predictor for mortality and was the only score correlated with length of hospital stay.
Does the SOFA Score Have the Ability to Predict Length of Stay and Mortality as well as Other Scorings? Adhiputri, Artrien; Hapsari, Brigitta Devi Anindita; Reviono, Reviono; Alfarizi, Aditya; Damayanti, Raninditya
Jurnal Respirologi Indonesia Vol 45 No 1 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i1.637

Abstract

Background: In the intensive care unit (ICU), critically sick pneumonia has a high mortality rate, so forecasting the prognosis is crucial for making decisions. Early detection of clinical deterioration and the implementation of early intervention and care can be achieved through the use of scoring systems. The Acute Physiology and Chronic Health Evaluation II (APACHE II) scoring system is a better system in predicting mortality in critically ill patients. However, in this study, we aim to observed  the use of the Sequential Organ Failure Assessment (SOFA) score as a predictor of mortality and length of stay (LOS). Methods: From April to August 2023, we treated 125 critically sick pneumonia patients in the ICU as part of a prospective observational research. An integrated ICU mortality calculator was used to assess the performance of the APACHE II, Simplified Acute Physiology Score II (SAPS II), and SOFA scores. Descriptive statistics will be used for data analysis, and the Fisher exact test and Chi-square test will be used for testing. logistic regression and linear regression methods are used in multivariate analysis. If the p-value is less than 0.05, it will be statistically significant. Results: APACHE II, SAPS II, and SOFA scores were significant in predicting the outcome of critically ill pneumonia patients (cut-off of ≥14.5, ≥34.5, and ≥3.5, respectively). The Spearman rank correlation for LOS shows that APACHE II, SOFA, and SAPS II scores have a very weak relationship with the p-values are 0.121, 0.766, and 0.436, respectively. Conclusion: The SOFA score is a good mortality predictor in critically ill pneumonia patients yet is simpler and easier to use in all settings in the hospital.
Co-Authors Adhiputri, Artrien Akhmad Syaikhu Alfarizi, Aditya Ana Rima Setijadi Anindita, Brigitta Devi Apriningsih, Hendrastutik Ari N Probandari Ari Natalia Probandari Asrial, An A. Atmojo, Anang Purwoko Bambang Purwanto Bhisma Murti Brian Wasita Damayanti, Raninditya Dhani Redhono, Dhani Endang Sutisna Endang Sutisna Sulaeman Fahlevie, Fahlevie Hapsari, Brigitta Anindita Devi Hapsari, Brigitta DA. Hapsari, Brigitta Devi Anindita Harsini Harsini Hermansah, Muhamad Lukman Hermawati, Berty Denny Ida Nurwati Irwandi, Delvan Jatu Aphridasari Kartodarsono, Supriyanto Laqif, Abdurrahman Leli Saptawati Lestari, Anggraini Dwi Lilik Lestari marwoto marwoto Mochammad Imron Awalludin Murti, Paulus Wisnu Kuncoro Myrtha, Risalina Nur Hafidha Hikmayani Prabowo, Nurhasan Agung Pudjiastuti, Anggit Putranto, Wachid Putri, Desy Puspa Putro, Prasetyo Sarwono R, Sari Apriliana Raharjo, A Farih Rahayu, Nur Indah Ramadhiana, Yusniar Roxanne, Olivia Geraldine Sebayang, Pribadi M Septiawan, Debree Setianingsih, Wahyu Setianto, Budi Y. Setyowati, Arry Soetejo, FX Soetrisno Soetrisno Soewondo, Widiastuti Subandrio, Subandrio SURYAWATI, BETTY Sutanto, Yusup S. Vagheggini, Guido Vitri Widyaningsih Wati, Martha Ratna Widyasanti, Diana Windu Prasetyo, Windu Wulandari, Eka T. Yudhi Prasetyo, Yudhi Yundari, Yundari Yusup Subagio Sutanto