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All Journal Media Kesehatan Masyarakat Indonesia BULETIN PENELITIAN SISTEM KESEHATAN Jurnal Kebijakan Kesehatan Indonesia Bulletin of Electrical Engineering and Informatics Jurnal Administrasi Kesehatan Indonesia Jurnal Media Gizi Indonesia (MGI) The Indonesian Journal of Public Health Jurnal Penelitian Kesehatan Suara Forikes Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Manajemen Kesehatan Yayasan RS.Dr. Soetomo Jurnal Keperawatan Silampari Window of Health : Jurnal Kesehatan Amerta Nutrition INTERNATIONAL JOURNAL OF NURSING AND MIDWIFERY SCIENCE (IJNMS) Jurnal Ilmu Kefarmasian Indonesia Public Health Perspective Journal Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal PREPOTIF : Jurnal Kesehatan Masyarakat Journal of Community Empowerment for Health An-Nadaa: Jurnal Kesehatan Masyarakat Journal of Telenursing (JOTING) Jurnal Aisyah : Jurnal Ilmu Kesehatan Indian Journal of Forensic Medicine & Toxicology Jurnal Kesehatan Tambusai Journal of Community Mental Health and Public Policy International Journal of Health, Engineering and Technology JOURNAL OF HEALTH MANAGEMENT RESEARCH The Journal of Management Information and Health Technology JMMR (Jurnal Medicoeticolegal dan Manajemen Rumah Sakit) Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal) Preventif : Jurnal Kesehatan Masyarakat
Thinni Nurul Rochmah
Departemen Administrasi Dan Kebijakan Kesehatan Fakultas Kesehatan Masyarakat Universitas Airlangga, Surabaya
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Cost-Effectiveness Analysis Of Metformin Use In Type 2 Diabetes Mellitus Patients In Hospitals: A Systematic Literature Review Wahyu Kurniawan; Thinni Nurul Rochmah
International Journal of Health Engineering and Technology Vol. 5 No. 1 (2026): IJHET MAY 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v5i1.763

Abstract

Type 2 diabetes mellitus (T2DM) places a significant economic burden on Indonesia, necessitating the selection of cost-effective pharmacological therapies. Metformin has long been recommended as first-line therapy, but evidence of its cost-effectiveness across Indonesian hospitals remains fragmented and methodologically diverse. This study aimed to conduct a systematic review and synthesize evidence regarding the cost-effectiveness of metformin use in T2DM patients in Indonesian hospitals. The study used a systematic literature review design based on the PRISMA framework. Articles published since 2020 and obtained from Google Scholar, PubMed, and Publish or Perish were assessed using the PICO criteria (Population: T2DM patients in hospital; Intervention: metformin; other antidiabetic therapies; Outcome: cost-effectiveness). In total, six national studies were selected, covering both inpatient and outpatient settings. Data were extracted descriptively, while cost-effectiveness results (primarily the Average Cost-Effectiveness Ratio/ACER) were analyzed narratively. Across all reviewed studies, metformin consistently demonstrated lower ACER values ​​than comparator therapies (e.g., glibenclamide, glimepiride, gliquidone, and acarbose-based combinations), suggesting better cost-efficiency with equivalent or higher clinical effectiveness. Conclusion: Metformin is a cost-effective first-line therapy for T2DM patients in Indonesian hospitals, making it worthy of being maintained as the primary choice in clinical practice and hospital formularies.
Co-Authors Absor, Sholihul Achmad Yudi Arifiyanto Adianti, Talia Puspita Afif Kurniawan Afifah Nasyahta Dila Afro, Rahmafika Cinthya Aghisni Isfiya Agustina, Pipin Eri Agustyoko, Sugeng Alifia Salma Pangestika Alifia Salma Pangestika Alissa Sita Pertiwi Alya Rahmatika Putri El Kamila Anang Endaryanto Andini Rizki Amanda Andini Yulina Pramono Andri Sofa Armani Andriani, Merryana Anggun Wulandari Anggun Wulandari Anis Wulandari Annisa Fitria Aqsha Yuldan Arifada Atika Binti Utari Ayu Nur Malasari Bangun Trapsila Purwaka Berliana Oktavia Setyawati Candra Setyawati Chatarina Umbul Wahyuni Chyntia Apris Christiwan Cita Rosita Sigit Prakoeswa Dahlui, Maznah Dewi Retno Suminar Dhamanti, Inge Djazuly Chalidyanto DM, Rizka Rosa Elida Zairina Elita Halimsetiono Elita Halimsetiono Eriska Haning Ernawaty Ernawaty Ernawaty Ernawaty Ernawaty Estuningsih, Yayuk Evriany, Nurul Fakhruzzaman, Muhammad Noor Farida Ilmah Favian, Rhesa Milzam Ghea Sekar Palupi Hadidah, Imas Sayyidati Herowati, Diyah Herowati Herti Maryani I Gusti Bagus Wiksuana Indana Tri Rahmawati Ira Ummu Aimanah Ismawantri, Putu Istiqomah, Ashri Nur Iwan Setiawan Kantrey Sugiarto Kumalasari, Ayu Lailatul Maghfiroh Linda Augustien Makalew Linta Meyla Putri Liza Pristianty Lutfiana Rakhmawati Mahmudin, Ahmad Amin Mandagi, Ayik Mirayanti Marline Merke Mamesah Martanto, Tri Wahyu Martha, Tiara Sandi Ayu Diea Maulida Rachmawati Maya Sari Dewi Maya Sari Dewi Maya Sari Dewi, Maya Sari Maya Weka Santi Maya Weka Santi Maznah Dahlui Merryana Andriani Mita Dwi Ayudha Mochammad Bagus Qomaruddin Moh. Basri Moh. Soleh Mohammad Hendra Kurniawan Muhammad Atoillah Isfandiari Mulyawati, Sinta Nabilah Musa Ghufron Nabilah Bilqis Najla Huljannah Ni Ketut Ardani Nono Tri Nugroho Novianti Indah Fatmawati Novie Erva Fauziyah Nurtania, Rhesta Nuzulul Kusuma Putri Nyoman Anita Damayanti Pipin Eri Agustina Qomariyah, Nurul Laily Rahmafika Cinthya Afro Rahmafika Cinthya Afro Rahmaniar, Dinda Rahmi Fitri J Raissa Manika Purwaningtias Raissa Manika Purwaningtyas Rezy Ramawan Melbiarta Rien Rahmi Riandini Rohilatul Jannah Sandiva Alifia Arifin Sinta Dewi Lestyoningrum Siti Fatonah Siti Rahayu Nadhiroh Sony Wijaya Stefania Widya Setyaningtyas Sururut Tazkiyah Susi Hidayah Tazkiyah, Sururut Titik Maimanah Trias Mahmudiono Ulfia Hazna Safira Umi Athiyah Vivilia Dian Mustikasari Wahyu Kurniawan Widati Fatmaningrum Widodo Jatim Pudjirahardjo Yayuk Estuningsih YOHANES WAHYU WALUYO Yurike D Adhela