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All Journal Jurnal Sain Veteriner Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Cancer Chemoprevention Majalah Obat Tradisional Pharmascience JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Sains dan Komunitas Farmasains : Jurnal Ilmiah Ilmu Kefarmasian PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) FITOFARMAKA: Jurnal Ilmiah Farmasi JFIOnline Jurnal Pembelajaran Pemberdayaan Masyarakat (JP2M) Lumbung Farmasi : Jurnal Ilmu Kefarmasian Borneo Journal Of Pharmascientech Jurnal Insan Farmasi Indonesia INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Moch. Saiful Bachri
Fakultas Farmasi, Universitas Ahmad Dahlan Yogyakarta
Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Social Sciences Veterinary Other

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Biomedicine Potential of Oil Palm (Elaeis guineensis) Leaves: In Vitro Evaluation of Antibacterial, Antibiofilm, and Antioxidant Activities Setiawan, Deni; Hadi, Samsul; Mahdi, Nur; Mardiati, Nurul; Dwi Sandi, Dita Ayulia; Ridha, Muhammad Rasyid; Bachri, Moch. Saiful
BORNEO JOURNAL OF PHARMASCIENTECH Vol 10 No 1 (2026): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v10i1.794

Abstract

Oil palm (Elaeis guineensis) leaves possess diverse pharmacological properties with promising development potential, particularly as antibiofilm and antioxidant agents. This study aimed to evaluate the antibacterial, antibiofilm, and antioxidant activities of E. guineensis leaf extract. The leaves were macerated in acetone for five days. Antibacterial activity was determined using the disc diffusion method against four bacterial species: Staphylococcus aureus, Propionibacterium acnes, Escherichia coli, and Pseudomonas aeruginosa. The extract exhibited moderate antibacterial activity, with the highest inhibition observed against P. acnes (6.79 mm at 25%). Antibiofilm activity was evaluated using a microdilution method, showing concentration-dependent inhibition, with the highest activity at 1% concentration, reaching 83.90% (mid-phase, S. aureus) and 71.28% (E. coli). Antioxidant activity was assessed using DPPH, FRAP, and ABTS assays, yielding IC50 values of 99.19 ppm, 119.12 ppm, and 123.37 ppm, respectively, indicating moderate antioxidant capacity (IC50 > 50-150 ppm). Overall, E. guineensis leaf extract demonstrates moderate antibacterial, antibiofilm, and antioxidant activities, suggesting its potential as a preliminary candidate for further pharmacological investigation.
EFEK EKSTRAK ETANOL DAUN JARAK PAGAR (Jatropha curcas L.) TERHADAP KADAR TRIGLISERIDA PADA TIKUS HIPERTENSI YANG DIBERI PAKAN LEMAK TINGGI Saiful Bachri, Moch.; Yuli Anita, Wiki; Yuliani, Sapto; Widyaningsih, Wahyu; Sofia, Vivi; Estiningsih, Daru
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 10 No. 1 (2023)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v10i1.10407

Abstract

Daun jarak pagar (Jatropha curcas L.) mengandung beberapa senyawa aktif, seperti alkaloid, saponin, tannin, terpenoid, steroid, glikosida, senyawa fenol, dan flavonoid yang diduga dapat menurunkan kadar trigliserida dalam serum darah, sehingga dapat mencegah keadaan hipertrigliseridemia. Penelitian  ini bertujuan untuk mengetahui aktivitas penurunan kadar trigliserida serum setelah pemberian ekstrak etanol daun jarak pagar (EEDJP) variasi dosis pada tikus hipertensi yang diinduksi dengan NaCl dan diberi pakan lemak tinggi. Penelitian eksperimental dengan pre-posttest control group design terhadap tikus jantan galur Wistar. Tikus dibagi menjadi 7 kelompok, yaitu  kelompok normal, kontrol (diinduksi NaCl dan diberi pakan  tinggi lemak), Captopril, Simvastatin, EEDJP dosis 1,8 g/KgBB, 2,7 g/KgBB, 4,05 g/KgBB. Analisis kadar trigliserida serum dengan metode GPO- PAP. Data dianalisis   dengan uji One-Sample Kolmogorov-Smirnov Test, Homogenity of Variances, One-Way ANOVA, Kruskal-Wallis, dan Mann-Whitney. Induksi NaCl dan pemberian pakan lemak tinggi dapat meningkatkan kadar trigliserida serum yang signifikan (p<0,050). Pemberian EEDJP dapat menurunkan kadar trigliserida serum yang signifikan (p<0,050) pada semua variasi dosis. Kesimpulannya EEDJP dapat menurunkan kadar trigliserida secara signifikan pada dosis 1,8 g/KgBB, 2,7 g/KgBB, 4,05 g/KgBB.
Co-Authors -, Nova Anggreni Anak Agung Gede Sugianthara Anggreni, Nova Annisa Fatmawati Ardilla, Mita Aulia, Hilma Bahun, Nur Rohma Inayah Baroroh, Faridah Cipta Khairunnisa Citra Ariani Edityaningrum, Citra Danang Prasetyaning Amukti Dandy Annas Muttaqien Dara Pranidya Tilarso Daru Estiningsih Daud, Intan Deni Firmansyah DENI SETIAWAN Desi Iswahyuni Dian Prasasti Dwi Sandi, Dita Ayulia Estiningsih, Daru Fatmawati, Annisa Fauziyyah, Khusna Fita Sari Fitri Rahmania Farikha Galuh Rista Putri Haafizah Dania Hestuning Winda Maharani, Hestuning Winda Humolungo, Dwi Tiva Widyanti Sidik Ichwan Ridwan Rais Imono Argo Donatus, Imono Argo Intan Dwi Rahmita Laela Hayu Nurani Laela Hayu Nurani Ma'ruf, Muhammad Maghfirah, Rahmayani Maharani, Hestuning Winda Marini Marini Muhammad Ma'ruf Muhammad Ma'ruf Muhammad Rasyid Ridha Muhammad Reza Ramadhani Muhammad Yusron Maulana El-Yunusi Nadia Selvia Najini, Robby Najwa, Siti Nashrul Wathan Nofa Risma Azis Nur Mahdi Nurkhasanah Nurkhasanah Nurkhasanah Nurkhasanah Nurul Jannah Nurul Mardiati Risqika Y.T. Paramidhita Samsul Hadi Sapto Yuliani Sapto Yuliani Sofina Rahmadita Sri Mulyaningsih Subagus Wahyuono Suci Kurniati Sundari, Trias Kania Suwijiyo Pramono Syarif, Yaumi Musfirah Vella Lailli Damarwati Vivi Sofia Wahyu Widyaningsih Wahyu Widyaningsih Wahyu Widyaningsih Wahyu Widyaningsih Widyasari Putranti Wiki Yuli Anita Wirawan Adikusuma Yuli Anita, Wiki