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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Bioma : Berkala Ilmiah Biologi Jurnal Medika Malahayati Jurnal Farmasi Higea Jurnal Midpro Jurnal Ilmiah Kesehatan Masyarakat : Media Komunikasi Komunitas Kesehatan Masyarakat Keluwih: Jurnal Kesehatan dan Kedokteran Sainstech Farma: Jurnal Ilmu Kefarmasian Borneo Journal Of Pharmascientech INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) Jurnal Bina Pengabdian Kepada Masyarakat Pharmaceutical And Biomedical Sciences Journal (PBSJ) Prosiding Konferensi Nasional PKM-CSR Jurnal Inkofar Jurnal Endurance: Kajian Ilmiah Problema Kesehatan Jurnal Pengabdian Masyarakat Kesosi Mestaka: Jurnal Pengabdian Kepada Masyarakat Jurnal Pengabdian Masyarakat Bangsa Herbal Medicine Journal Karunia: Jurnal Hasil Pengabdian Masyarakat Indonesia GEMBIRA (Pengabdian Kepada Masyarakat) PEDAMAS (Pengabdian Kepada Masyarakat) Law and Justice Borneo Journal of Pharmacy Journal of Transcendental Law JCSE: Journal of Community Service and Empowerment Masyarakat: Jurnal Pengabdian Fundamental : Jurnal Ilmiah Hukum Jurnal Kesehatan Masa Depan Menulis: Jurnal Penelitian Nusantara
Ainun Wulandari
Fakultas Farmasi, Institut Sains Dan Teknologi Nasional
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Journal : Jurnal Midpro

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Phytochemical Screening And Tyrosinase Inhibition Activity Of Leaves Cassia siamea L. Munawarohthus Sholikha; Ainun Wulandari
Jurnal MIDPRO Vol 12, No 2 (2020): JURNAL MIDPRO
Publisher : Universitas Islam Lamongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30736/md.v12i2.240

Abstract

Cassia siamea L. has been used traditionally as medicine and in previous studies had an IC­50 antioxidant activity of 144.12 µg / mL. Cassia siamea L. potential as a medicinal substance is thought to have chemical constituents such as saponins, anthraquinones, alkaloids, flavonoids, tannins, terpenoids and steroids. Indonesia, which is located in a tropical region with high temperatures and ultraviolet (UV) radiation, can cause skin disorders such as hyperpigmentation due to excess melanin synthesis. Tyrosinase enzymes can prevent or inhibit melanin formation. The purpose of this study was to determine the chemical content of Cassia siamea L. leaves extract with various solvents and the inhibitory activity of tyrosinase enzymes. In this study, the leaves of Cassia siamea L. were macerated with methanol as a solvent. The dry methanol extract was fractionated using the liquid-liquid method using aquadest, butanol and chloroform as solvents. The four dried extracts were then phytochemical screening to determine their chemical content. After that, the tyrosinase inhibition test was carried out in vitro with L-Dopa as a substrate using ELISA plate well reader at concentrations of 100, 1000 and 100000 ppm with three repetitions (triplo). The methanol extract had percent inhibition of 19.993 ± 1.125%, 28.984 ± 0.624%, 57.164 ± 0.623%, respectively; butanol fraction 25.914 ± 0.541%, 32.566 ± 0.767%, 52.120 ± 1.616%; chloroform fraction 19.920 ± 0.730%, 26.425 ± 0.937%, 62.865 ± 0.167% and aquadest fraction 23.830 ± 0.879%, 30.885 ± 0.778%, 67.471 ± 0.352%. Kojic acid had tyrosinase activity and acts more active than the other extract and fraction with 91.155±0.228% at 500 ppm. The butanol fraction had the highest percent inhibition at 100 and 1000 ppm which was thought to be due to the presence of alkaloids, tannins, flavonoids, steroids and terpenoids from the results of the phytochemical screening test.
Co-Authors Aditya Fitriasari Aditya Fitriasari Adnan Adnan Adrully El Fienda Ahamd Syaifil Iman Akhatik, Nurul Alladin, Dwi Amalia Khoirunnisa Aminudin, Iwan Andini, Issri Mila Nova Ardhianingsih, Vira Ardhianingsih, Vira Arum, Fitria Diah Dea Selia Dienillah, Qonita Dini Juliana Diny Auliya Mawarni Djuhariah, Yayah Siti Dwi Okta Mellya Edy Meiyanto Erham Erwi Putri Setyaningsih Ester Marintan Purba Fadly, Iqbal Faraidlika Fara Diana Dewi Fathin Hamida Febriani, Amelia Fiandani, Afifah Fina Aryani Goenadi Fina Aryani Goenadi, Fina Aryani Firdha Aprilya Utami Firmanto, Taufik Fitria Rahayu Fitria Yustisiani Gufran, Gufran Herdini Herdini , Herdini Hervianti Nurfitria Nugrahani Heryanto, Anas Hindrayani, Woro Hutagaol, Sartika Ika Maruya Kusuma Iksan, Iksan ILHAM Illahi, Sakinah Ayu Ilyas Ilyas sarbini Indra Wani Irawansah, Didik Januarto, Daniel Jaya, Rendy Indra Jerry, Jerry Jessica Khairunnisa Kartika Dyah Palupi Kartika Dyah Palupi Kartin Aprianti Kasmar , Kasmar Khairiah, Ardian Kholid Alfan Nur Kholid Alfan Nur Khulqiyah, Husnul Kinanthi Kusumawardhani Krisnawati, Indah Kusuma, Ika Maruya Lestiana, Elina Lidia Anggita Ramadhani Lili Musnelina Loamena, Raisul Amin M. Farhan Syauki M. Yahya Madhani, Suci Marsa Falihah Masrin, Masrin Maulana, Arif Andy Maulana, M. Rizky Mira Permata Miskun, Miskun Muh Asad Imaduddin Muh. Faris Hidayat Muhammad Amin Mulandita Munawarohthus Sholikha Munawarohthus Sholikha Munawarohthus Sholikhah Nasrullah Nasrullah Nastion, Nastion Ni’matul Khoeriyah Nopianti, Hermila Nugrahani, Hervianti Nurfitria Nurul Akhatik Nusantara, Ari Fahimatussyam Putra Oktari, Anggi Irma Yani Pontoan, Jenny Pratiwi Ally Florentina Putra, Anis Fuady Surya Putri , Elvina Triana Putri, Clarisya Pramirusanti Putri, Elvina Triana Rachmatiah, Tiah Rahmawardany, Claudia Y Ramadhani, Lidia Anggita Ratna Nilam Cahya Refdanita Refdanita Refdanita Refdanita, Refdanita Resi Sukma Melati Rianty, Ira Ridwan Ridwan Ridwan, Ridwan Risma Eka Putri Ritha Widyapratiwi Rivita, Maisya Rogahang, Preisilia Rosario Trijuliamos Manalu Sahidah, Sahidah Saiful Bahri Saiful Bahri Saputri, Ika Septiyani Monalisa Setiadi, Fandy Rezha Shella Utami Siregar, Tahoma Siswati Siswati Siti Fadila Azahra Sonia Mutiara Subaryanti Subaryanti, Subaryanti Suci Tiara Sukirman Sukirman Syafriana, Vilya Teodhora, Teodhora Teti Indrawati Teti Indrawati Tiah Rachmatiah Tongat Tongat Tri Soehartati Vahlevi, Rizky Reza Veriyanti , Putu Rika Veryanti, Putu Rika Welisa, Selfina Junita Widyapratiwi, Ritha Winahayu, Neng Esti Windiarto, Henriko Suryo Wiwik Handayani Yayah Siti Djuhariah Yunisa Simehete Yunita Kartini Zabitha Zahwa Zaini, Jamal Zuhrah