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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Majalah Kedokteran Bandung Jurnal Kesehatan Andalas Sumatra Journal of Disaster, Geography and Geography Education Seminar Nasional Teknologi Informasi Komunikasi dan Industri Jurnal Hilirisasi IPTEKS (JHI) Buletin Ilmiah Nagari Membangun Journal of Midwifery Majalah Kedokteran Andalas Human Care Journal Indonesian Journal of Religion and Society Science Midwifery Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks MAHESA : Malahayati Health Student Journal Bhakti Nagori (Jurnal Pengabdian kepada Masyarakat) Jurnal Ilmu Kesehatan Indonesia (JIKSI) International Journal of Medicine and Health Jurnal Manajemen dan Ekonomi Kreatif Vitalitas Medis : Jurnal Kesehatan Dan Kedokteran Jurnal Sains, Teknologi dan Kesehatan
Rika Susanti
Fakultas Kedokteran Universitas Andalas
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Hubungan Derajat Cedera Kepala dengan Kadar Gfap pada Pasien Cedera Kepala di RSUP Dr. M. Djamil Padang Rika Susanti; Raisya Ivana; Rizki Rahmadian
MAHESA : Malahayati Health Student Journal Vol 6, No 6 (2026): Volume 6 Nomor 6 (2026)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v6i6.25486

Abstract

ABSTRACT Traumatic Brain Injury (TBI) is a condition resulting from external mechanical forces that impair brain function and remains a leading cause of high morbidity and mortality rates. The Glasgow Coma Scale (GCS) is commonly employed to determine the severity of TBI. However, GCS does not always reflect the actual extent of brain tissue damage, as it can be influenced by various confounding factors. Consequently, biomarkers such as Glial Fibrillary Acidic Protein (GFAP) are being investigated to assess the severity of brain injury. This study aims to determine the correlation between the severity of head injury and GFAP levels in patients at RSUP Dr. M. Djamil Padang. This research is an analytic observational study with a cross-sectional approach. A total of 95 patients who met the inclusion and exclusion criteria were selected using a consecutive sampling method. Data analysis using the Spearman correlation test revealed that the majority of patients sustained mild head injuries (65.3%), followed by moderate (21.1%) and severe injuries (13.7%). The median GFAP level was 2.251 ng/mL (range 0.050–16.412 ng/mL). The results indicated that there was no significant correlation between head injury severity based on GCS and GFAP levels (r = -0.088; p = 0.396). This outcome may be influenced by variations in injury characteristics, the timing of sample collection, and the distribution of injury severity across the sample. Keywords: Head Injury Severity, GCS Score, GFAP.  ABSTRAK Cedera kepala adalah kondisi yang terjadi akibat adanya gaya mekanik eksternal yang mengganggu fungsi otak serta menjadi salah satu penyebab tingginya angka morbiditas dan mortalitas. Penentuan tingkat keparahan derajat cedera kepala umumnya menggunakan skor Glasgow Coma Scale (GCS). Akan tetapi, GCS tidak selalu merepresentasikan derajat kerusakan jaringan otak yang sebenarnya karena dapat dipengaruhi oleh berbagai faktor. Oleh karena itu, biomarker, seperti Glial Fibrillary Acidic Protein (GFAP) mulai diteliti untuk menilai keparahan derajat cedera kepala. Penelitian ini bertujuan untuk mengetahui hubungan antara derajat cedera kepala dengan kadar GFAP pada pasien cedera kepala di RSUP Dr. M. Djamil Padang. Penelitian ini merupakan studi analitik observasional dengan pendekatan cross-sectional. Sampel penelitian berjumlah 95 pasien yang memenuhi kriteria inklusi dan eksklusi dan dipilih menggunakan metode consecutive sampling. Analisis data menggunakan uji korelasi Spearman menunjukkan bahwa mayoritas pasien mengalami cedera kepala ringan (65,3%), diikuti sedang (21,1%) dan berat (13,7%). Median kadar GFAP adalah 2,251 ng/mL (rentang 0,050–16,412 ng/mL). Hasil uji menunjukkan tidak terdapat hubungan bermakna antara derajat cedera kepala berdasarkan GCS dengan kadar GFAP (r = -0,088; p = 0,396). Hal ini kemungkinan dipengaruhi oleh variasi karakteristik cedera, waktu pengambilan sampel, serta distribusi derajat cedera kepala. Kata Kunci: Derajat Cedera Kepala, Skor GCS, GFAP.
Co-Authors Abdullah Arief Syahputra Abdullah Arief Syahputra Adnil Edwin Nurdin Adrial Adrial Afifa Humaira Afriandi Putra Afriwardi Afriwardi Ahsan Putra Hafiz Alqadri Alqadri Amelya Permata Sari Ami Tri Nursasmi Ando Amadino Anggi Rahmi Rusadi Arina Widya Murni Arni Amir Arsa Arsa Ashal, Taufik Bikrulmal Bikrulmal Candra Candra Citra Manela Dea Rika Putri Purba Dedi Afandi Dia Rofinda, Zelly Dia Eldi Sauma Eva Chundrayetti Fadhilati Sabrina Fithria, Rahmi Fitratul Annisa Fortuna, Fory Hafni Bachtiar Haliza ulfa Hardis man Hendra Permana Henny Mulyani Mulyani Hillbertina, Noza Khairul Fahmi Khanh, Varhanno Khallifhatul Laila Isrona Laila Rahmi M Fadil Maria Nurlita Marryo Borry WD Mega Miftahul Rizka Mohammad Reza Mohammad Tegar Indrayana Muhammad Farhan Khadaffi Muhammad Imam Arrasyid Muhammad Irfan Pratama Muhammad Ridho Azhari Muhammad Tsani Mudzakir Nadira Ismanel Tamura Noverial Noverial Noverial Noverial Noverika Winda Sari Noverika Windasari Noza Hilbertina Nur Afrainin Syah Nurul Aini Nuzulia Irawati Ovella April Rieza Popy Puspita Sari Putra, Fariz Ananda Rahma, Adela Rahmatini . Raisya Ivana Rauffi Hayatul Putri Restu Susanti Rini Gusya Liza, Rini Gusya Riswan Efendi Rizki Rahmadian Rohana Roni Eka Sahputra Rosa Murwindra, Rosa Roza Mulyana Rudi Afriant Salsabila, Mahira Samantha Samantha Siti Dzakiyyah Masyar Sopiatun Nahwiyah Sutoyo Sutoyo Syahputra, Roni Eka Taufik Hidayat Taufik Hidayat Taufik Saputra Utami Yuliandini Vici Novia Vendlan Yantri Maputra Yanwirasti Yanwirasti Yuliarni Syafrita Yulizawati . Zhafira Ferin Zhuhra, Rahma Tsania