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Rita Kartika Sari
Departemen Hasil Hutan, Fakultas Kehutanan, Institut Pertanian Bogor Kampus IPB Darmaga Bogor, 16680
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Veterinary Other

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Journal : Communications in Science and Technology

 1 
In-vitro, In-vivo, and In-silico Studies of Insulinotropic Activity and Cytotoxicity of Mahagony Seed Extracts and Its Nanophytosome Hamidi, Zikri; Sari, Rita Kartika; Prayogo, Yanico Hadi; Syafii, Wasrin; Kasmi, Adinda Zahra Marissa; Prasetyo, Bayu Febram; Harlina, Eva; Wahyudi, Setyanto Tri
Communications in Science and Technology Vol 10 No 2 (2025)
Publisher : Komunitas Ilmuwan dan Profesional Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21924/cst.10.2.2025.1676

Abstract

This present study set out with the objective of evaluating the effect of ethanol–water solvent composition on extraction yield, insulinotropic activity (IA), cytotoxicity, and phytochemical profile (PP) of mahogany (Swietenia mahagoni) seed (MS) extracts. It also sought to study in silico and encapsulate the best extract, and to assay the antidiabetic of the extract and its nanophytosome. The extraction of MSs was achieved through the utilization of ethanol, ethanol–water (1:1), and water through ultrasound–assisted extraction. The extracts of IA and cytotoxicity were assayed in vitro using BRIN–BD11 cell lines and analyzed using LC-MS. The most effective extract was identified for its active compounds using molecular docking, encapsulation, characterization, and testing for its antidiabetic properties in vivo. The highest yield was observed in the water extract (MW), followed by the ethanol–water extract (MEW) and the ethanol extract (ME). MEW and MW demonstrated low level of cytotoxicity, with MEW exhibiting the highest level of IA. An in silico study identified four key antidiabetic compounds through the IA mechanism. The study demonstrated that MEW and its nanophytosome (250 mg/kg mouse weight) effectively reduced blood glucose level, and enhanced both erythrocyte function, and insulin secretion. This finding provides a new perspective in the development of natural-based antidiabetic agents through the nanophytosome formulation of mahogany seed extract.
Co-Authors . Siswoyo A.A. Ketut Agung Cahyawan W Adesna Fatrawana Agus Ari Subagio Agus Hikmat Akbar, Mohammad Dhanny Alawiyah, Rufaida Ashiela Safira Amalia, Gradis Anak Agung Istri Sri Wiadnyani Andianto Anggara, Andhika Dwi Anggraini, Putri Dian Puspa Anne Carolina Apri Heri Iswanto Arinana Arinana Auliyah, Izzatul Baskara, Muhammad Iqbal Adi Bayu Febram Prasetyo D R Agungpriyono Deded Sarip Nawawi Desi Melianti Devi Armilasari Dewi R Agungpriyono Dewi R Agungpriyono Dudi Tohir Dyah Safitri Edhi Sandra Effendi Tri Bahtiar Ervizal A.M. Zuhud Eva Harlina Evie Nihayah Fauzi Febrianto Fillah, Muhammad Arda Fitrianum, Fadilah Gustan Pari Gustan Pari Gustan Pari Hamidi, Zikri Himmi, Setiawan Khoirul I Nyoman Jaya Wistara I Wayan Darmawan Idris N Iskandar IETJE WIENTARSIH Imam Wahyudi Indrawan, Imam Wahyudi Ina Winarni, Ina Intan, Yulice Soraya Nur Irdika Mansur Irmanida Batubara Istie Rahayu Itje Wintarsih Iwang Yusuf Izza Firdausi Hadiyanto Juliasman Juliasman Kasmi, Adinda Zahra Marissa Khamareta, Vita Ayu Tegar Khatami, Muh Najib Riza Kholiyah Kholiyah Kosei Yamauchi Kurnia Sofyan L N Sutardi Laela N. Anisah Laela Nur Anisah Livia T Amalia Lubis, Muhammad Adly Rahandi Maharani, Eisha Ira Manggar Arum Aristri Mardho Tillah Mardho Tillah Mardho Tillah, Mardho Maulana, Muhammad Iqbal Mayangsari, Citra Primavita Menik Sahariyani Milano, Rafi Yusuf Muhammad Adly Rahandi Lubis Muhammad Fadli Muhammad Hanafi Muhammad Iqbal Maulana Naresworo Nugroho Nastavia, Chika Ngatno Ngatno Nirwana, Disna Laura Cahya Nopen Meisaroh Nugraha, Arifin Budiman Nur Azizah Nurhaliza, Nimas Putri Prasetijono, Purwito Soegeng Prayogo, Yanico Hadi Putri, Diah Anggun Febriana Rahma, Vira Fadhila Rahmawati, Anindya Intan Rahmi Utami Ramadhani, Hesa Haidar Regita Pramesti Riki Andika Rinawati Romi Irka Putra S Priambodo Saat Egra Saharda, Nadylla Mifta Ulrahmi Salina Febriany Santosa, Agus Dwi Aji Sari, Ratih Afrida Lismana Setyanto Tri Wahyudi Setyo Trisnadi Silmi Mariya Siti Aisyah Siti Maemunah Siti Nurjanah Siti Sa'diah Siti Sa'diah Sri Familasari Subangkit, Mawar Suparmi Suparmi Syamsul Arifin Tasyahuri, Syabila Aldiffah Tengku Muhammad Renzy Hariz Tohru Mitsunaga Umi Cahyaningsih Vetnizah Juniantito Wahyu Hidayat Wahyu Hidayat Wahyuningrum, Maeda Wahyuningrum, Maeda Wasrin Syafii Wibowo, David Adi Wilis Wiryawan Yanico Hadi Prayogo Yuliana, Kumala Putri Yusuf Sudo Hadi Zamzami, Romi