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All Journal International Journal of Public Health Science (IJPHS) Jurnal Kedokteran Diponegoro International Journal of Integrated Health Sciences Majalah Kedokteran Bandung Althea Medical Journal Global Medical and Health Communication Jurnal Manajemen Kesehatan Indonesia INDONESIAN JOURNAL OF PHARMACY Jurnal Keperawatan Sriwijaya Sari Pediatri Jurnal Sistem Kesehatan Paediatrica Indonesiana Emerging Science Journal Jurnal Keperawatan Padjadjaran Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Pendidikan dan Pelayanan Kebidanan Indonesia (Indonesian Journal of Education and Midwifery Care) JURNAL KESEHATAN PERINTIS Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Jurnal Kesehatan Majalah Kedokteran Neurosains Medica Hospitalia Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer) Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Healthcare Nursing Journal Journal of Community Empowerment for Health Jurnal Ilmiah JKA (Jurnal Kesehatan Aeromedika) Jurnal Riset Kedokteran Bandung Conference Series : Medical Science Neurona
Nanan Sekarwana
Bagian Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Padjadjaran/Rumah Sakit Dr. Hasan Sadikin Bandung
Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Emerging Science Journal

 1 
Superoxide Dismutase Reduces Creatinine and NGAL by Restoring Oxidative Balance during Sepsis Jufitriani Ismy; Maimun Syukri; Dessy R. Emril; Nanan Sekarwana; Jufriady Ismy
Emerging Science Journal Vol 6, No 2 (2022): April
Publisher : Ital Publication

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28991/ESJ-2022-06-02-06

Abstract

Sepsis-associated overproduction of reactive oxygen species (ROS) and nitric oxide (NO) during pathogen infection leads to overwhelming oxidative stress, which has been recognized as a primary contributor to acute kidney injury (AKI). Hence, antioxidant therapy has been widely explored in order to find an effective treatment for sepsis-related AKI, in particular by using endogenous antioxidant – superoxide dismutase (SOD). We assessed the effect of oral SOD on the alteration of AKI biomarkers (creatinine and Neutrophil Gelatinase-Associated Lipocalin – NGAL) in endotoxin-induced septic murine. The animals were assigned as a healthy control, a septic control, and three treatment groups (250, 500, and 1000 IU oral SOD). Treatment of SOD was carried out by force-feeding for 16 weeks prior to intraperitoneal injection of lipopolysaccharide (LPS). The sepsis was assessed using the murine sepsis score (MSS) after 12 hours post-LPS injection, where the changes in plasma SOD, ROS, NO, creatinine, and NGAL were measured by enzyme-linked immunosorbent assay (ELISA). During sepsis, SOD was significantly decreased from its baseline level while other biomarkers were significantly increased (p<0.05) – except for NGAL. MSS exhibited a declining trend in SOD dosage-dependent manner, and was significantly different with that of septic control group at SOD dosage of 1000 IU (p<0.05). SOD treatment with a dosage as low as 250 IU could prevent the abnormal expression of the tested biomarkers during sepsis. There were significant reduction of plasma ROS, NO, creatine and NGAL in rats treated with 1000 IU SOD. Our study suggests the protective effect of SOD against sepsis-induced AKI by scavenging ROS and NO. Doi: 10.28991/ESJ-2022-06-02-06 Full Text: PDF
Co-Authors Abdul Hadi Martakusumah Achadiyani Ackni Hartati Ade Hafni Aedi Budi Dharma Ag Soemantri Agus Darajat Ahmad Roisul Umam Ahmad Roisul Umam Ahmedz Widiasta Alfiah Rahmawati Amelia Harsanti Angela Rowan Anita Deborah Anwar Anne Dian Rachmawati Annisa Rahmah Furqaani Astuti Dyah Bestari Aufa Salsabila Surahman Aumas Pabuti Azhali M. S. Bachti Alisjahbana Bambang Sumintono Bambang Sumintono Bertram Fong Bethy S Hernowo Budi Firdaus Carmen Norris Catur E Suksesty Danny Hilmanto Dany Hilmanto Deasy Nurisya DEDDY MUCHTADI Dedi Rachmadi Dedi Rachmadi Deni Kurniadi Sunjaya Dessy R. Emril Dewi, Windy Krisanti Kusuma Dhona Andhini Dida A. Gurnida Dida Ahmad Gurnida Dida Akhmad Gurnida Dida Akhmad Gurnida Dida Akhmad Gurnida Dinan S. Bratakoesoemo dini riyantini sari dini riyantini sari, dini riyantini Djatnika Setiabudi Dzulfikar DLH Eddy Fadlyana Elsa Pudji Setiawati Elsa Pudji Setiawati Elsa Pudji Setiawati Elsa Puji Setiawati Endang Susilowati Endang Sutedja Farhati Farhati Farid Husin Farid Husin Firman Fuad Wirakusumah Fitri Nurlina Fitria Fitria Guswan Wiwaha Hadi Susiarno Hadiyati, Ida Harvi Puspa W Harvi Puspa Wardani Heda Melinda Nataprawira Heda Melinda Nataprawira Herman Susanto Herman, Herry Herry Garna Hertanto Wahyu Subagio Husin, Farid Ida Ayu Putu Sri Widnyani Ida Hadiyati Ida Parwati Ike Rostikawati Husen Imelda, Imelda - Ina Rosalina Ina Rosalina Insi Farisa Desy Arya Intania, Sekky Irman Somantri Ishak Abdulhak Ismy, Jufriady Jambak, Muhammad Khalid Johanes C Mose Jufitriani Ismy Kurniaty Ulfah Kusnandi Rusmil Kuswandewi Mutyara Lailiyya, Nushrotul Lelani Reniarti Lelly Yuniarti Maimun Syukri Meida Erimarisya Meilani Meilani Meilani Meilani, Meilani Meita Damayanti Meita Dhamayanti Meita Dhamayanti Meita Dhamayanti Meita Dhamayanti Meita Dhamayanti Mia Yasmina Andarini Muhammad Heru Muryawan Nely Bonita Nita Arisanti Nita Arisanti Nita Arisanti Nita Arisanti Novina Novina Nur Suryawan Nurhalim Shahib Nurihsan, Achmad Juntika Nurizzatun Nafsi Nurusofa Surti Dewi Nurusofa Surti Dewi, Nurusofa Surti Nushrotul Lailiyya Oyoh Oyoh Paramita Diah Winarni Partini P Trihono Paul McJarrow Ponpon Idjradinata Purnomo Putri Rizkia R. Kince Sakinah Rachmat Soelaeman Ratna Damailia Ratu Dobit Reizkiana Feva Kosmah Dewi Rosalinna Rosalinna Ruswana Anwar Ryadi Fadil Salsabila Berlianisa Sekky Intania Sinta Dwi Juwita Siti Aisyah Siti Nurrani Yuniasari Siti Yuyun Rahayu Fitri Sri Endah Rahayuningsih Sri Endah Rahayuningsih Sri Hastuti Andayani Sylvia Rachmayati Titik Respati Titin Junaidi Uni Gamayani Uni Gamayani, Uni Veratiwi Veratiwi Vidi Permatagalih Viiola Irene Winata Vina Rizki Amalia Viramita K Rusmi Viramitha Kusnandi Rusmil Yani Triyani Yenny Purnama Yopi Wulandhari Yudi Mulyana Hidayat Yuni Susanti Pratiwi Yuni Susanti Pratiwi, Yuni Susanti Yusrawati Yusrawati Zahrotur Rusyda Hinduan