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Nanan Sekarwana
Bagian Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Padjadjaran/Rumah Sakit Dr. Hasan Sadikin Bandung
Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Neurona

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HUBUNGAN KADAR HEMOGLOBIN DAN FERITIN DENGAN GAMBARAN KONDUKSI SARAF PADA ANAK TALASEMIA BETA MAYOR Dewi, Windy Krisanti Kusuma; Gamayani, Uni; Lailiyya, Nushrotul; Reniarti, Lelani; Sekarwana, Nanan
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 35 No 1 (2018)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v35i1.42

Abstract

    CORRELATION BETWEEN HAEMOGLOBINE AND FERRITIN LEVEL WITH NERVE CONDUCTION STUDY IN CHILDREN WITH BETA THALASSEMIA MAJORABSTRACTIntroduction: Beta thalassemia major is inherited hemoglobin synthesis disorder found in thalassemia belt, including Indonesia. Peripheral neuropathy is one of its underdiagnosed neurological complications results in poor management of the patients.Aims: To identify correlation between hemoglobin and ferritin serum with Nerve conduction study (NCS) in Beta thalassemia major patients.Methods: This was a cross-sectional study involving children with beta thalassemia major aged 8-14 years, who regularly underwent blood transfusions in Hasan Sadikin Hospital, Bandung. Nerve conduction study of motor and sensory nerves of all limbs were conducted to the patients. Data was analyzed using Spearman’s correlation analysis.Results: Fifty subjects were included in this study with the mean hemoglobin level (SD) of 6.99 (0.87)g/dL and the mean blood ferritin level (SD) of 3.925 (1.993)μg/L. Based on NCS, most of the subjects had polyneuropathy and 46.94% had axonal demyelinating lesions in sensory and motor nerves. Among patients with neuropathy, there was a statistically significant negative correlation  between mean hemoglobin level and the numbers of the abnormal  nerves and also a statistically significant positive correlation between mean blood ferritin level and the numbers of the abnormal nerves.Discussion: The lower ferritin serum level, the less nerve involved based on NCS.Keyword: Beta thalassemia, ferritin, hemoglobin, nerve conduction study, neuropathyABSTRAKPendahuluan: Talasemia beta mayor merupakan suatu kelainan sintesis hemoglobin yang herediter yang banyak ditemukan di wilayah tropis, termasuk Indonesia. Salah satu komplikasinya adalah neuropati perifer yang sering tidak terdiagnosis, sehingga penyandangnya tidak mendapatkan tata laksana yang adekuat.Tujuan: Mengetahui hubungan antara kadar hemoglobin dan feritin serum dengan gambaran konduksi saraf (nerve conduction study/NCS) pada penyandang talasemia beta mayor.Metode: Studi potong lintang terhadap penyandang talasemia berusia 8-14 tahun yang rutin menjalani transfusi darah di RSUP Dr. Hasan Sadikin, Bandung. Dilakukan pemeriksaan NCS motorik dan sensorik pada keempat ekstremitas. Data dianalisis menggunakan uji korelasi Spearman.Hasil: Diperoleh 50 subjek dengan rerata kadar hemoglobin 6,99+0,87g/dL dan kadar feritin serum 3.925+1.993μg/L. Berdasarkan pemeriksaan NCS, sebagian besar subjek mengalami polineuropati yang 46,94% di antaranya berupa gambaran demielinasi aksonal sensorik motorik. Pada subjek dengan neuropati perifer didapatkan korelasi negatif yang bermakna antara kadar hemoglobin dengan jumlah keterlibatan saraf pada NCS dan korelasi positif yang bermakna antara kadar feritin serum dengan jumlah keterlibatan saraf pada NCS.Diskusi: Semakin rendah kadar feritin serum, maka semakin sedikit jumlah saraf yang terlibat pada NCS, dan sebaliknya.Kata kunci: Feritin, hemoglobin, nerve conduction study, neuropati, talasemia beta mayor
Co-Authors Abdul Hadi Martakusumah Achadiyani Ackni Hartati Ade Hafni Aedi Budi Dharma Ag Soemantri Agus Darajat Ahmad Roisul Umam Ahmad Roisul Umam Alfiah Rahmawati Amelia Harsanti Angela Rowan Anita Deborah Anwar Anne Dian Rachmawati Annisa Rahmah Furqaani Astuti Dyah Bestari Aufa Salsabila Surahman Aumas Pabuti Azhali M. S. Bachti Alisjahbana Bambang Sumintono Bambang Sumintono Bertram Fong Bethy S Hernowo Budi Firdaus Carmen Norris Catur E Suksesty Danny Hilmanto Dany Hilmanto Deasy Nurisya DEDDY MUCHTADI Dedi Rachmadi Dedi Rachmadi Deni Kurniadi Sunjaya Dessy R. Emril Dewi, Windy Krisanti Kusuma Dhona Andhini Dida A. Gurnida Dida Ahmad Gurnida Dida Akhmad Gurnida Dinan S. Bratakoesoemo dini riyantini sari dini riyantini sari, dini riyantini Djatnika Setiabudi Dzulfikar DLH Eddy Fadlyana Elsa Pudji Setiawati Elsa Pudji Setiawati Elsa Pudji Setiawati Elsa Puji Setiawati Endang Susilowati Endang Sutedja Farhati Farhati Farid Husin Farid Husin Firman Fuad Wirakusumah Fitri Nurlina Fitria Fitria Guswan Wiwaha Hadi Susiarno Hadiyati, Ida Harvi Puspa W Harvi Puspa Wardani Heda Melinda Nataprawira Heda Melinda Nataprawira Herman Susanto Herry Garna Herry Herman Hertanto Wahyu Subagio Husin, Farid Ida Ayu Putu Sri Widnyani Ida Hadiyati Ida Parwati Ike Rostikawati Husen Imelda, Imelda - Ina Rosalina Ina Rosalina Insi Farisa Desy Arya Intania, Sekky Irman Somantri Ishak Abdulhak Ismy, Jufriady Johanes C Mose Jufitriani Ismy Kurniaty Ulfah Kusnandi Rusmil Kuswandewi Mutyara Lailiyya, Nushrotul Lelani Reniarti Lelly Yuniarti Maimun Syukri Meida Erimarisya Meilani Meilani Meilani Meilani, Meilani Meita Damayanti Meita Dhamayanti Meita Dhamayanti Meita Dhamayanti Meita Dhamayanti Meita Dhamayanti Mia Yasmina Andarini Muhammad Heru Muryawan Nely Bonita Nita Arisanti Nita Arisanti Nita Arisanti Nita Arisanti Novina Novina Nur Suryawan Nurhalim Shahib Nurihsan, Achmad Juntika Nurizzatun Nafsi Nurusofa Surti Dewi Nurusofa Surti Dewi, Nurusofa Surti Nushrotul Lailiyya Oyoh Oyoh Paramita Diah Winarni Partini P Trihono Paul McJarrow Ponpon Idjradinata Purnomo Putri Rizkia R. Kince Sakinah Rachmat Soelaeman Ratna Damailia Ratu Dobit Reizkiana Feva Kosmah Dewi Rosalinna Rosalinna Ruswana Anwar Ryadi Fadil Salsabila Berlianisa Sekky Intania Sinta Dwi Juwita Siti Aisyah Siti Nurrani Yuniasari Siti Yuyun Rahayu Fitri Sri Endah Rahayuningsih Sri Endah Rahayuningsih Sri Hastuti Andayani Sylvia Rachmayati Titik Respati Titin Junaidi Uni Gamayani Uni Gamayani, Uni Veratiwi Veratiwi Vidi Permatagalih Viiola Irene Winata Vina Rizki Amalia Viramita K Rusmi Viramitha Kusnandi Rusmil Yani Triyani Yenny Purnama Yopi Wulandhari Yudi Mulyana Hidayat Yuni Susanti Pratiwi Yuni Susanti Pratiwi, Yuni Susanti Yusrawati Yusrawati Zahrotur Rusyda Hinduan