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Journal : INDONESIAN JOURNAL OF PHARMACY

Protective Effect of Ethanolic Extract Tempuyung Leaf (Sonchus arvensis L.) in Gentamicin-induced Acute Tubular Necrosis on Wistar Rats Imelda, Imelda -; Achadiyani, Achadiyani -; Sekarwana, Nanan -
Indonesian Journal of Pharmacy Vol 29 No 2, 2018
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1561.235 KB) | DOI: 10.14499/indonesianjpharm29iss2pp86

Abstract

  Acute tubular necrosis (ATN) is the most common histopathologic findings of acute kidney injury (AKI). AKI is marked by the decrement of glomerular filtration rate, causing waste metabolism retention (creatinine). Gentamicin is used as it is the most common nephrotoxic agent in inducing ATN. Tempuyung (Sonchus arvensis L.) has been used in folklore medicine to ameliorate kidney problems as it contains antioxidants, two of which are flavonoid and phenolic acid. Yet, these active substances’ benefit on gentamicin induced ATN has not been investigated in Indonesia. This research aims to analyze protective effect of ethanolic extract tempuyung leaf (EET) on gentamicin-induced ATN based on histopathological study and creatinine serum level.     True experimental laboratoric study was done with simple random design on male wistar rats, randomly divided into 4 groups (n=4). Control group (CMC 0.5% aquadest); Induction group (Gentamicin 80 mg/kgBW); 1st treatment group (EET 100 mg/kgBW + Gentamicin 80 mg/kgBW) and 2nd treatment group (EET 200 mg/kgBW + Gentamicin 80 mg/kgBW) for ten days. On the 11th day, blood was taken for creatinine measurement and kidneys collection for histopathological study.     Histopathological examination on gentamicin-treated rats revealed degenerative changes in kidney tubules. Aside from that, gentamicin-treated rats also showed increment in  creatinine serum level. Conversely, simultaneous administration of EET with Gentamicin ameliorated the nephrotoxic effects of gentamicin as confirmed from the significant improvement on histopathological changes and normalization of creatinine serum level.     Co-administration of EET and gentamicin provides protection on gentamicin-induced ATN, based on histopathological feature and creatinine serum level.
Co-Authors Abdul Hadi Martakusumah Achadiyani Ackni Hartati Ade Hafni Aedi Budi Dharma Ag Soemantri Agus Darajat Ahmad Roisul Umam Ahmad Roisul Umam Ahmedz Widiasta Alfiah Rahmawati Amelia Harsanti Angela Rowan Anita Deborah Anwar Anne Dian Rachmawati Annisa Rahmah Furqaani Astuti Dyah Bestari Aufa Salsabila Surahman Aumas Pabuti Azhali M. S. Bachti Alisjahbana Bambang Sumintono Bambang Sumintono Bertram Fong Bethy S Hernowo Budi Firdaus Carmen Norris Catur E Suksesty Danny Hilmanto Dany Hilmanto Deasy Nurisya DEDDY MUCHTADI Dedi Rachmadi Dedi Rachmadi Deni Kurniadi Sunjaya Dessy R. Emril Dewi, Windy Krisanti Kusuma Dhona Andhini Dida A. Gurnida Dida Ahmad Gurnida Dida Akhmad Gurnida Dida Akhmad Gurnida Dida Akhmad Gurnida Dinan S. Bratakoesoemo dini riyantini sari dini riyantini sari, dini riyantini Djatnika Setiabudi Dzulfikar DLH Eddy Fadlyana Elsa Pudji Setiawati Elsa Pudji Setiawati Elsa Pudji Setiawati Elsa Puji Setiawati Endang Susilowati Endang Sutedja Farhati Farhati Farid Husin Farid Husin Firman Fuad Wirakusumah Fitri Nurlina Fitria Fitria Guswan Wiwaha Hadi Susiarno Hadiyati, Ida Harvi Puspa W Harvi Puspa Wardani Heda Melinda Nataprawira Heda Melinda Nataprawira Herman Susanto Herman, Herry Herry Garna Hertanto Wahyu Subagio Husin, Farid Ida Ayu Putu Sri Widnyani Ida Hadiyati Ida Parwati Ike Rostikawati Husen Imelda, Imelda - Ina Rosalina Ina Rosalina Insi Farisa Desy Arya Intania, Sekky Irman Somantri Ishak Abdulhak Ismy, Jufriady Jambak, Muhammad Khalid Johanes C Mose Jufitriani Ismy Kurniaty Ulfah Kusnandi Rusmil Kuswandewi Mutyara Lailiyya, Nushrotul Lelani Reniarti Lelly Yuniarti Maimun Syukri Meida Erimarisya Meilani Meilani Meilani Meilani, Meilani Meita Damayanti Meita Dhamayanti Meita Dhamayanti Meita Dhamayanti Meita Dhamayanti Meita Dhamayanti Mia Yasmina Andarini Muhammad Heru Muryawan Nely Bonita Nita Arisanti Nita Arisanti Nita Arisanti Nita Arisanti Novina Novina Nur Suryawan Nurhalim Shahib Nurihsan, Achmad Juntika Nurizzatun Nafsi Nurusofa Surti Dewi Nurusofa Surti Dewi, Nurusofa Surti Nushrotul Lailiyya Oyoh Oyoh Paramita Diah Winarni Partini P Trihono Paul McJarrow Ponpon Idjradinata Purnomo Putri Rizkia R. Kince Sakinah Rachmat Soelaeman Ratna Damailia Ratu Dobit Reizkiana Feva Kosmah Dewi Rosalinna Rosalinna Ruswana Anwar Ryadi Fadil Salsabila Berlianisa Sekky Intania Sinta Dwi Juwita Siti Aisyah Siti Nurrani Yuniasari Siti Yuyun Rahayu Fitri Sri Endah Rahayuningsih Sri Endah Rahayuningsih Sri Hastuti Andayani Sylvia Rachmayati Titik Respati Titin Junaidi Uni Gamayani Uni Gamayani, Uni Veratiwi Veratiwi Vidi Permatagalih Viiola Irene Winata Vina Rizki Amalia Viramita K Rusmi Viramitha Kusnandi Rusmil Yani Triyani Yenny Purnama Yopi Wulandhari Yudi Mulyana Hidayat Yuni Susanti Pratiwi Yuni Susanti Pratiwi, Yuni Susanti Yusrawati Yusrawati Zahrotur Rusyda Hinduan