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All Journal Jurnal Natur Indonesia Media Penelitian dan Pengembangan Kesehatan Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) PROSIDING SEMINAR KIMIA Biopropal Industri Medika Tadulako INDONESIAN JOURNAL OF PHARMACY CHEMPUBLISH JOURNAL BERITA BIOLOGI Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Fitofarmaka Indonesia Chimica et Natura Acta Farmasains : Jurnal Ilmiah Ilmu Kefarmasian JURNAL ATOMIK Biosaintifika: Journal of Biology & Biology Education JSFK (Jurnal Sains Farmasi & Klinis) FITOFARMAKA: Jurnal Ilmiah Farmasi Pharmaceutical And Biomedical Sciences Journal (PBSJ) Jurnal Kefarmasian Indonesia Kimia Padjadjaran
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Potensi Ekstrak Kapang Endofit Asal Rimpang Kunyit sebagai Antimalaria dan Antioksidan Septiana, Eris; bustanussalam, Bustanussalam; Rachman, Fauzy; Simanjuntak, Partomuan
Jurnal Kefarmasian Indonesia VOLUME 7, NOMOR 1, FEBRUARI 2017
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v7i1.3482

Abstract

Malaria infection is still a public health problem, especially in developing countries, including Indonesia. Malaria infection is usually accompanied by increased free radicals in the body of the patient. This situation will cause decreasing the immune system of the patient. Explorating of new drugs that have antimalarial and also antioxidant activity is very important. Therefore, this study aims to determine in vitro antimalarial and antioxidant activity of endophytic fungi extract origin turmeric from Sukabumi. This study begins with fermentation process of endophytic fungi on the broth medium and ethyl acetate was used to extract the filtrat to gain the test extracts. Heme polymerization inhibition and free radical DPPH scavenging method were used to antimalarial and antioxidant in vitro assay respectively. The results showed that 18 isolates of endophytic fungi have antimalarial activity and one isolate inactive and also all isolates have antioxidant activity. Smi.Cl.6F isolate was the most active isolate on the antimalarial and antioxidant assay with IC50 value of each assay were 1.93 mg/mL and 32.28 mg/L respectively. Therefore, Smi.Cl.6F isolates potentially be used as new antimalarial drugs
Efek Sinergis dari Kombinasi Ekstrak Herba Pegagan (Centella asiatica) dan Ekstrak Daun Kelor (Moringa oleifera) dalam Meningkatkan Fungsi Memori Yudhi Purwoko, Marcus Laurentius; Syamsudin, Syamsudin; Simanjuntak, Partomuan
JSFK (Jurnal Sains Farmasi & Klinis) Vol 9 No 2 (2022): J Sains Farm Klin 9(2), Agustus 2022
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.9.2.111-120.2022

Abstract

Otak merupakan pusat syaraf yang sangat berpengaruh terhadap respon anak untuk melihat, mendengar, berpikir, dan melakukan gerakan. Terganggunya fungsi kognitif mengakibatkan terhambatnya perkembangan pertumbuhan dan mempengaruhi kualitas masa depannya khususnya kecerdasannya. Tujuan penelitian ini adalah untuk mengetahui konsentrasi terbaik dari kombinasi ekstrak herba pegagan (Centella asiatica) dan ekstrak daun kelor (Moringa oleifera) dalam meningkatkan fungsi memori dan pembelajaran. Metode yang dilakukan adalah Radial 8-arm maze test yang digunakan untuk mengetahui adanya brain disorder yang berupa defisit pada pembelajaran dan memori serta menggunakan Passive avoidance test untuk mengetahui memori dan fungsi kognitif otak. Histopatologi otak diperiksa dengan menghitung jumlah sel neuron pada CA 1, CA 3 dan DG. Hasil pengujian menunjukkan bahwa kombinasi ekstrak herba pegagan dan daun kelor perbandingan 1:1 meningkatkan fungsi memori dan pembelajaran. Hasil histopatologi otak menunjukkan bahwa kombinasi ekstrak aman untuk digunakan
BIOPRODUKSI SENYAWA KIMIA ANTIDIABETES OLEH ISOLAT KAPANG ENDOFIT KUMIS KUCING (Orthosiphon spicatus B. B. S.) Sulastri, Lilik; Kartika, Rudi; Simanjuntak, Partomuan
PROSIDING SEMINAR KIMIA Vol 3 No 1 (2024): Prosiding SNK 2024
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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Abstract

Kumis kucing plant (Orthosiphon spicatus B. B. S.) are one of the plants that have been used as diuretic, antidiabetic and antihypertensive drugs. Identification of chemical compounds, and antidiabetic activity assay of bioproduction of endophytic fungi with code B.Os.1F that isolated from the stems of kumis kucing have been carried out. Two fermentation methods (dynamic and static fermentation) to determine the pH. The tlc profile analysis and pH showed that B.Os.1F isolate by dynamic fermentation for 12 days had the potential to produce chemical compounds as antidiabetics at pH 4 ~ 6. The product of fermentation are extracted with ethyl acetate, then fractionated by column chromatography (SiO2): (i) n-hexane-ethyl acetate [10:1 ~ 1:1]; (ii) chloroform-methanol (20:1 ~ 1:1) based on “bioassay guided fractionation” with a-glucosidase enzyme inhibition assay. The isolate of B.Os.1F.2-3 had an activity of 76 %, and identify based on UV-Vis, Fourier-Transform Infra Red (FT-IR) spectroscopies and gas chromatography-mass spectrometer (GC-MS) are estimated to be Ergosta-5,7,9(11),22-tetraen-3-ol compounds. Keywords : Endophytic fungus, Orthosiphon spicatus B.B.S., α-glucosidase enzyme, ergosta-5,7,9(11),22-tetraen-3-ol.
Antioxidant Activity of Bioproduced Endophytic Fusarium Sp. HSFP-3 from Sijangkang Plant (Hornstedtia scyphifera Var. fusiformis) Koraag, Alfa Michael Gabriel; Farida, Yunahara; Tarigan, Elsera Br.; Efendy, Oscar; Agusta, Andria; Simanjuntak, Partomuan
Jurnal Fitofarmaka Indonesia Vol 11, No 3 (2024): JURNAL FITOFARMAKA INDONESIA (ENGLISH EDITION)
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v11i3.1252

Abstract

Endophytic mold Fusarium sp. HSFP-3 is one of the endophytic molds isolated from Sijangkang plants (Hornstedtia scyphyfera var. fusiformis). The purpose of this study is to conduct bioproduction, and test the antioxidant activity of bioproduced extracts and identify active fractions that have antioxidant activity. The research method started from the cultivation of endophytic mold HSFP-3 on PDB media for 21 days, the bioproduction results were extracted using ethyl acetate and acetone solvents. Antioxidant activity of HSFP-3 extract was determined by IC50 and AAI values, using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging method. Isolation of antioxidant active fraction was carried out by column chromatography method using sephadex LH-20 stationary phase and silica. Isolation of antioxidant active compounds of HSFP-3 extract using bioautography guided assay approach with TLC-DPPH Bioautography method. The antioxidant test results of HSFP-3 extract has moderate activity with IC50 value 74,64 and AAI 0,844. Fraction 2.4 is an active fraction that has spot compounds with higher yellow color intensity compared to other fractions. Spot with Rf 0.35 in fraction 2.4 has a dark zone under UV 254 light. has a sea blue color under UV 366 light and a dark purple color after with Vanillin-Sulfate reagent
ISOLATION OF CHEMICAL ACTIVE COMPOUNDS ANTIOXIDANT FROM ETHYL ACETATE FRACTION OF BETEL LEAF FOREST (Piper aduncum L.) Batan, Alfrida; Daniel, Daniel; Simanjuntak, Partomuan
JURNAL ATOMIK Vol 3 No 2 (2018)
Publisher : Jurusan Kimia FMIPA UNMUL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (698.259 KB)

Abstract

Research about the isolation of chemical active compounds antioxidants from ethyl acetate fraction of betel leaf forest (Piper aduncum L.) have been done. This research aimed to determine the type of secondary metabolites that contained in ethyl acetate fraction and the value of antioxidant activity as well as the structure that contained in ethyl acetate fraction. The test results of phytochemical showed that the secondary metabolites in ethanol extract are alkaloids, steroids and triterpenoids. The inhibitory concentration 50% (IC50) value that shown in the fraction Piper aduncum ethyl acetate-4-3 (PAEA-4-3) is 132.84 ppm. Fraction of PAEA-4-3 that have high levels of antioxidant activity was analyzed using a spectrophotometer Ultra Violet-Visible (UV-Vis), Infrared Fourier-Transform (FTIR) and Nuclear Magnetic Resonance (NMR) proton and carbon. The result analysis of PAEA-4-3 isolates showed the compound as 2,3-dimethoxy-metilanaoksi-benzene.
Aktivitas Antimalaria Ekstrak Air dan Etanol Tanaman Obat Berdasarkan Penghambatan Pembentukan β-Hematin Hapsari, Yatri; Kusharyoto, Wien; Simanjuntak, Partomuan
Kimia Padjadjaran Vol 1, No 1 (2022)
Publisher : Kimia Padjadjaran

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Abstract

Malaria merupakan penyakit yang disebabkan oleh parasit Plasmodium sp. melalui gigitan nyamuk Anopheles sp. betina. Salah satu mekanisme parasit yang dijadikan target pencarian obat antimalaria adalah mekanisme penghambatan pembentukan hemozoin. Plasmodium dalam siklusnya akan mendegradasi hemoglobin menjadi heme bebas yang toksik untuk dirinya sendiri. Untuk melindungi dirinya parasit akan mengubah heme bebas menjadi hemozoin. Senyawa β-hematin merupakan analog senyawa hemozoin. Pada penelitian ini diuji aktivitas antimalaria terhadap 13 ekstrak etanol metode maserasi (dingin) dan 13 ekstrak air metode dekok (panas). Tanaman yang digunakan adalah salam koja (Murraya koenigii), akar kuning (Arcangelisia flava), jung rahab (Baeckea frutescens), pule (Alstonia scholaris), buah makassar (Brucea javanica), bidara (Ziziphus mauritiana), mimba (Azadirachta indica), murbei (Morus alba), tabat barito (Ficus deltoidea jack), ceplikan (Solidago virgaurea), srigunggu (Clerodendron serratum [L.] Sp r), rumput mutiara (Hedyotis corymbosa), bawang dayak (Eleutherine palmifolia). Pengujian menggunakan air panas dikarenakan cara masyarakat lokal dalam memanfaatkan tanaman obat akan dibandingkan dengan pelarut organik yang umum digunakan dalam penelitian. Ekstrak yang memiliki aktivitas terbaik diukur nilai IC50 dan dilanjutkan dengan skrining fitokimia. Hasil penelitian menunjukkan bahwa aktivitas antimalaria lebih baik menggunakan pelarut air dengan metode dekok dibandingkan pelarut etanol dengan metode maserasi. Ekstrak yang aktivitasnya paling tinggi adalah ekstrak air daun jung rahab sebesar 58,48% dengan nilai IC50 sebesar 51,5 ppm. Skrining fitokimia menunjukkan bahwa ekstrak air daun jung rahab mengandung golongan senyawa flavonoid, saponin dan tanin.
AKTIVITAS ANTIOKSIDAN KOMBINASI EKSTRAK ETANOL DAUN JARONG (Stachytarpheta indica) DAN BATANG CENTE (Lantana camara) Septiana, Eris; Mawadah, Nursifa; Simanjuntak, Partomuan
Media Farmasi: Jurnal Ilmu Farmasi Vol. 17 No. 2: September 2020
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v17i2.17299

Abstract

Penggunaan tanaman obat sebagai sumber senyawa antioksidan semakin meningkat. Beberapa tanaman yang telah dilaporkan sebagai sumber senyawa antioksidan adalah daun jarong (Stachytarpheta indica) dan batang cente (Lantana camara). Namun, belum ada penelitian yang melaporkan kombinasi kedua tanaman tersebut sebagai sumber antioksidan. Oleh karena itu, penelitian ini bertujuan untuk mengetahui pengaruh kombinasi ekstrak etanol daun jarong dan batang cente terhadap aktivitas antioksidannya. Aktivitas antioksidan in vitro berdasarkan pada metode peredaman radikal bebas DPPH (2,2-diphenyl-1-picrylhydrazyl). Penapisan fitokimia dan analisis indeks kombinasi juga dilakukan untuk menentukan efek kombinasinya. Semua ekstrak etanol tunggal dan kombinasi menunjukkan aktivitas antioksidan. Kombinasi ekstrak etanol daun jarong dan batang cente dalam perbandingan 1:2 memberikan aktivitas antioksidan tertinggi dengan nilai IC50 sebesar 18,86 µg/mL. Penapisan fitokimia menunjukkan bahwa senyawa steroid, tanin, flavonoid, dan fenolik ditemukan pada kedua ekstrak. Alkaloid, kuinon, dan saponin hanya ditemukan dalam ekstrak daun jarong. Sementara itu, kumarin hanya ditemukan dalam ekstrak batang cente. Kombinasi ekstrak etanol menunjukkan efek sinergis ringan-sedang sampai mendekati aditif dengan nilai CI antara 0,7723-0,9607. Oleh karena itu, kombinasi ekstrak dapat meningkatkan aktivitas antioksidannya.
Characterization and Antidiabetic Potential of Durian Leaf (Durio zibethinus Linn.) Ethyl Acetate Extract Aruan, Dyna Grace Romatua; Barus, Tonel; Haro, Gindo; Simanjuntak, Partomuan
Chimica et Natura Acta Vol 12, No 2 (2024)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v12.n2.47817

Abstract

Durian leaves (Duiro zibethinus Linn.) are one of the plants whose leaves are used as a fever reducer (antipyretic). The aim of this research is to isolate natural ingredients using natural ingredient extraction techniques by maceration and identify steroid compounds from durian leaves that have anti-diabetic potential. Isolation was carried out through several stages, namely maceration, fractionation, subfractionation using column chromatography, purification using preparative TLC, and testing the purity of the isolate using TLC and determining the melting point of the isolate. The antidiabetic potential of the isolation was carried out using the α-glucosidase enzyme inhibition method. The chemical structure of the isolate was characterized using IR and UV-Vis spectroscopy. Based on IR spectroscopy analysis, the isolation has C=C, OH, O-C functional groups, C-H aromatic functional groups. UV-Vis spectroscopy data shows that there are maximum peaks at 207 nm and 247 nm, meaning that the isolated steroid compound has unconjugated double bonds. Based on spectroscopic data and comparison with reference compounds, it could be identified that the isolate obtained was β-sitosterol.
Penambatan Molekul Senyawa Swietemacrophyllanin dari Kulit Batang Mahoni (Swietenia macrophylla King,) sebagai Inhibitor Enzim Alfa Glukosidase Khaerunnisa, Arini; Djamil, Ratna; Sulastri, Lilik; Rudiana, Tarso; Simanjuntak, Partomuan
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 5 No. 2 (2023)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i2.32926

Abstract

Mahogany (Swietenia macrophylla King.) is one of the plants used as an antidiabetic agent. 96% ethanol extract of S. macrophylla stem bark can inhibit the α-glucosidase enzyme. Methanol and aqueous extracts of S. macrophylla stem bark can reduce rat blood glucose levels induced by streptozotocin. Molecular docking is one of the most widely used structural-based drug design strategies due to its wide application in the analysis of binding energy and molecular interactions between drug compounds and receptors. This study aims to identify the compounds in the stem bark of S. macrophylla and analyze the molecular anchoring of the compounds produced by the aid. The research was carried out by means of the water fraction of the stem bark of S. macrophylla and was purified by column chromatography. Fraction 2 was identified by LCMS-MS. Molecular docking using AutoDock 4.2.6. The results of Fraction 2 showed the presence of catechins, evodionol, swietemacrophyllanin, swietenitin K and β-sitosterol. The results of an in-silico study showed that swietemacrophyllanin provided a better affinity than acarbose with a binding energy value of -8.57 kcal/mol and an inhibition constant of 0.52 µM. Forms hydrogen bonds with catalytic residues (Glu277 and Asp352) from the active site of the α-glucosidase enzyme. Swietemacrophyllanin has potential as an antidiabetic agent
UJI FENOLIK DAN UJI TOKSISITAS EKSTRAK METANOL KULIT JENGKOL (Archidendron jiringa) Lubis, Misri Yanty; Marpaung, Lamek; Nasution, M Pandapotan; Simanjuntak, Partomuan
Chempublish Journal Vol. 1 No. 2 (2016): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (607.688 KB)

Abstract

Selama ini kulit jengkol tidak dimanfaatkan, merupakan barang yang terbuang dan menjadi sampah. Tujuan dari penelitian ini adalah untuk mengetahui apakah kulit jengkol dapat dimanfaatkan sebagai alternatif obat herbal dengan  terlebih dahulu dilakukan uji fenolik untuk melihat kandungan senyawa fenoliknya. Uji fenolik ekstrak dilakukan dengan menggunakan FeCl3. Senyawa fenolik yang terkandung dalam tumbuhan mempunyai aktivitas biologi yang beragam, seperti anti-inflamasi, antimikroba, antikanker dan lain-lain. Efek toksik ekstrak metanol dari kulit jengkol (Archidendron jiringa) telah diamati dengan menggunakan metode Brine Shrimp Lethality Test (BSLT). Ekstrak dibuat dengan cara maserasi menggunakan metanol selama 1 x 24 jam. Ekstrak diuji toksisitasnya menggunakan larva udang Artemia salina yang berumur 24 jam. Efek toksik ekstrak diidentifikasi dengan persentasi kematian larva udang menggunakan analisis probit (LC50). Hasil menunjukkan ekstrak metanol dari kulit jengkol bersifat toksik, dengan LC50 = 39,27. Hasil ini dapat dijadikan dasar untuk menggunakan kulit jengkol sebagai alternatif obat herbal. Kata kunci: Toksisitas, uji fenolik, BSLT, LC50, analisis probit.
Co-Authors A.A. Ketut Agung Cahyawan W Amalia . ANDRIA AGUSTA Arif Soeksmanto Arini Khaerunnisa Batan, Alfrida Bina Lohita Sari Bustanussalam ., Bustanussalam Bustanussalam Bustanussalam, Bustanussalam Daniel Daniel Dian Malini Otovina, Dian Malini Djamil, Ratna Djoko, Wahyuni Dyna Grace Romatua Aruan E.G. Said, E.G. Edward J Dompeipen, Edward J Efendy, Oscar Enny Sudarmonowati ERIS SEPTIANA Esti, Esti Farida, Yunahara Fauzy Rachman Gianny, Demitra Hardiyati, Iin Harmastini Sukiman, Harmastini Haro, Gindo Koraag, Alfa Michael Gabriel Kusharyoto, Wien Lamek Marpaung, Lamek Lekatompessy, Sylvia J.R. Lilik Sulastri Lubis, Misri Yanty M. Rahayuningsih Mastura, Mastura Mawadah, Nursifa Muhammad Ahkam Subroto Murniaty Simorangkir Nasution, M Pandapotan Nasution, Pandapotan Ngadiman Ngadiman NISA RACHMANIA MUBARIK Purwoko, Marcus Yudhi Putra, Ari Permana Reubun, Yonathan Tri Atmodjo Ribu Surbakti, Ribu Rudi Kartika, Rudi Rumella Simarmata, Rumella Rurianti, Wandesta Rutdianti, Rutdianti Saifur Rohman SARONOM SILABAN Setyningrum, Eka Damayanti Shirly Kumala Siswa Setyahadi Sri Hartati Sukiman, Harmastini I. Suwarno, Tisno Suwarno, Tisno Syamsudin Syamsudin Tarigan, Elsera Br. Tarso Rudiana, Tarso Taurhesia, Shelly Titi Parwati, Titi Tiwit Widowati, Tiwit Tonel Barus, Tonel Wiwi Winarti Yadi, Yadi Yatri Hapsari, Yatri Yudhi Purwoko, Marcus Laurentius