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Characterization and Antidiabetic Potential of Durian Leaf (Durio zibethinus Linn.) Ethyl Acetate Extract Aruan, Dyna Grace Romatua; Barus, Tonel; Haro, Gindo; Simanjuntak, Partomuan
Chimica et Natura Acta Vol 12, No 2 (2024)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v12.n2.47817

Abstract

Durian leaves (Duiro zibethinus Linn.) are one of the plants whose leaves are used as a fever reducer (antipyretic). The aim of this research is to isolate natural ingredients using natural ingredient extraction techniques by maceration and identify steroid compounds from durian leaves that have anti-diabetic potential. Isolation was carried out through several stages, namely maceration, fractionation, subfractionation using column chromatography, purification using preparative TLC, and testing the purity of the isolate using TLC and determining the melting point of the isolate. The antidiabetic potential of the isolation was carried out using the α-glucosidase enzyme inhibition method. The chemical structure of the isolate was characterized using IR and UV-Vis spectroscopy. Based on IR spectroscopy analysis, the isolation has C=C, OH, O-C functional groups, C-H aromatic functional groups. UV-Vis spectroscopy data shows that there are maximum peaks at 207 nm and 247 nm, meaning that the isolated steroid compound has unconjugated double bonds. Based on spectroscopic data and comparison with reference compounds, it could be identified that the isolate obtained was β-sitosterol.
Penambatan Molekul Senyawa Swietemacrophyllanin dari Kulit Batang Mahoni (Swietenia macrophylla King,) sebagai Inhibitor Enzim Alfa Glukosidase Khaerunnisa, Arini; Djamil, Ratna; Sulastri, Lilik; Rudiana, Tarso; Simanjuntak, Partomuan
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 5 No. 2 (2023)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i2.32926

Abstract

Mahogany (Swietenia macrophylla King.) is one of the plants used as an antidiabetic agent. 96% ethanol extract of S. macrophylla stem bark can inhibit the α-glucosidase enzyme. Methanol and aqueous extracts of S. macrophylla stem bark can reduce rat blood glucose levels induced by streptozotocin. Molecular docking is one of the most widely used structural-based drug design strategies due to its wide application in the analysis of binding energy and molecular interactions between drug compounds and receptors. This study aims to identify the compounds in the stem bark of S. macrophylla and analyze the molecular anchoring of the compounds produced by the aid. The research was carried out by means of the water fraction of the stem bark of S. macrophylla and was purified by column chromatography. Fraction 2 was identified by LCMS-MS. Molecular docking using AutoDock 4.2.6. The results of Fraction 2 showed the presence of catechins, evodionol, swietemacrophyllanin, swietenitin K and β-sitosterol. The results of an in-silico study showed that swietemacrophyllanin provided a better affinity than acarbose with a binding energy value of -8.57 kcal/mol and an inhibition constant of 0.52 µM. Forms hydrogen bonds with catalytic residues (Glu277 and Asp352) from the active site of the α-glucosidase enzyme. Swietemacrophyllanin has potential as an antidiabetic agent
Study Of The Anti-Obesity Potential Of Chlorogenic Acid Through Molecular Docking Faridah, Faridah; Mumpuni, Esti; Purnomo, Hari; Laksmitawati, Dian Ratih; Simanjuntak, Partomuan
Journal of Social Research Vol. 3 No. 2 (2024): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v3i2.1910

Abstract

Chlorogenic acid, the primary constituent found in green coffee, is believed to possess anti-obesity properties. Numerous studies have indicated that the etiology of obesity is predominantly influenced by genetic factors. This study employs molecular docking techniques to estimate the effectiveness and toxicity of chlorogenic acid as an anti-obesity agent, focusing on its interaction with PLANTS. Initially, the validation process involved confirming the target cell or receptor (PDB code) which included PPAR-? (3NOA, 2ATH), pancreatic lipase (5ZUN), ghrelin (6ZYF), leptin (3V6O), and melanocortin (6W25, 7F58) through the utilization of YASARA software. In addition, the process of docking chlorogenic acid compounds and a positive control (for comparative purposes) was conducted on target cells utilizing the PLANTS program. The toxicity test and prediction of lethal dose (LD 50) were conducted on active substances and positive controls using the ProTox-II program. Chlorogenic acid exhibits anti-obesity properties by acting as an inhibitor of the ghrelin hormone, as seen by its activity at PDB code 6ZYF with a docking score of -19.7099 higher than the positive controls bupropion -18.5269 and naltrexone -18.5871. Furthermore, it has been determined to possess a generally safe profile, with an LD50 value of 5000 mg/kg body weight. The docking studies indicate that chlorogenic acid exhibits anti-obesity activity specifically at PDB code 6ZYF, where it functions as an inhibitor of the ghrelin hormone. Chlorogenic acid typically exhibits modest efficacy as an anti-obesity agent, hence presenting potential avenues for enhancing its effectiveness by structural modifications
Amelioration of Salt Tolerance in Soybean (Glycine Max. L) by Plant-Growth Promoting Endophytic Bacteria Produce 1-Aminocyclopropane-1-Carboxylase Deaminase Simarmata, Rumella; Ngadiman, Ngadiman; Rohman, Saifur; Simanjuntak, Partomuan
Annales Bogorienses Vol. 22 No. 2 (2018): Annales Bogorienses
Publisher : BRIN

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Salinity is a major abiotic stress that can induce ethylene synthesis beyond the normal limits as plants response to stress and hence reduces crop productivity. The 1-aminocyclopropane-1-carboxylase deaminase (ACCD)-producing bacteria can reduce excessive ethylene synthesis by taking ACC (ethylene precursor) as a nitrogen source. This study showed the possibility of using endophytic bacteria in order to reduce the undesirable effects of salinity. Strain Pseudomonas putida PIR3C and Roultella terrigena PCM8 exhibited promising performance for promoting the growth of plant under salinity stress conditions. The results showed that bacterial inoculation was effective even in the presence of higher salinity levels. Strain P. putida PIR3C was the most efficient strain compared to the other strains and significantly increased shoot length, root length, dry weight, germination percentage, and reduced stem diameter. The role of ACCD in reducing ethylene production under salinity stress conditions was also studied by measuring the evolution of ethylene in vitro by soybean seeds treated with some ACCD bacterial strain. The maximum ethylene lowering capacity was observed in R. terrigena PCM8, the strain reduced ethylene production from 622.81 nmol.g-1(control) to 352.78 nmol.g-1 (43% reduction). The production of α-ketobutyrate, chlorophyll content and germination percentage from P. putida PIR3C was higher than other strains. The results suggested that strain P. putida PIR3C and R. terrigena PCM8 can be employed for salinity tolerance in soybean seedlings and may have better prospects for an amelioration of stress condition.
Identification of Cadalene-β-Carboxylic Acid from Barks of Bawang Hutan (Scorodocarpus borneensis Becc.) Kartika, Rudi; Bustanussalam, Bustanussalam; Farida, Farida; Simanjuntak, Partomuan
Annales Bogorienses Vol. 16 No. 2 (2012): Annales Bogorienses
Publisher : BRIN

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Abstract

One sesquiterpene compound has isolated and identified from ethylacetate extract of bawang hutan (Scorodocarpus borneensis Becc.) barks. The barks were macerated with methanol, and then partitioned with mixture of ethylacetate-water (1:1). Fractionation of the ethylacetate phase by column chromatography gave pure compound. Based on data interpretation from of ultra-violet (UV) spectra, Fourier Transform Infra Red (FT-IR), NMR 1D (1H and 13C-NMR); NMR 2D (HMQC, COSY, HMBC) and comparison with literature, the pure isolated compound was determined as a sesquiterpene compound, cadalene-β-carboxylic acid which exhibit LC50 of 42.32 ppm.
Co-Authors A.A. Ketut Agung Cahyawan W Amalia . ANDRIA AGUSTA Arif Soeksmanto Arini Khaerunnisa Batan, Alfrida Bina Lohita Sari Bustanussalam ., Bustanussalam Bustanussalam Bustanussalam, Bustanussalam Daniel Daniel Dian Malini Otovina, Dian Malini Dian Ratih Laksmitawati Djamil, Ratna Djoko, Wahyuni Dyna Grace Romatua Aruan E.G. Said, E.G. Edward J Dompeipen, Edward J Efendy, Oscar Enny Sudarmonowati ERIS SEPTIANA Esti Mumpuni, Esti Farida Farida Farida, Yunahara Faridah Faridah Fauzy Rachman Gianny, Demitra Hardiyati, Iin HARI PURNOMO Harmastini Sukiman, Harmastini Haro, Gindo Koraag, Alfa Michael Gabriel Kusharyoto, Wien Lamek Marpaung, Lamek Lekatompessy, Sylvia J.R. Lilik Sulastri M. Rahayuningsih Mastura, Mastura Mawadah, Nursifa Muhammad Ahkam Subroto Murniaty Simorangkir Nasution, Pandapotan Ngadiman Ngadiman NISA RACHMANIA MUBARIK Purwoko, Marcus Yudhi Putra, Ari Permana Reubun, Yonathan Tri Atmodjo Ribu Surbakti, Ribu Rudi Kartika, Rudi Rumella Simarmata, Rumella Rurianti, Wandesta Rutdianti, Rutdianti Saifur Rohman SARONOM SILABAN Setyningrum, Eka Damayanti Shirly Kumala Siswa Setyahadi Sri Hartati Sukiman, Harmastini I. Suwarno, Tisno Suwarno, Tisno Syamsudin Syamsudin Tarigan, Elsera Br. Tarso Rudiana, Tarso Taurhesia, Shelly Titi Parwati, Titi Tiwit Widowati, Tiwit Tonel Barus, Tonel Wiwi Winarti Yadi, Yadi Yatri Hapsari, Yatri Yudhi Purwoko, Marcus Laurentius