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Suharyono Suharyono
Universitas Nasional
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Journal : Paediatrica Indonesiana

 1 
Short Chain Peptide in the Treatment of Chronic Diarrhoea with Protein Maldigestion/Malabsorption Suharyono, Suharyono
Paediatrica Indonesiana Vol. 30 No. 5-6 (1990): May-June 1990
Publisher : Indonesian Pediatric Society

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Abstract

A trial using formula Pepti Junior (Nutricia, Holland) containing short chain pep­tides (SCP) was done for treating 35 children suffering from chronic diarrhoea with pro­tein inaldigestion/malabsorption. The other 30 children who suffered from those diseases were treated with non-SCP formula, as a control. Tryptic activity test of duodenal juice was performed 2 or 3 times with a 4-week-interval. The results indicated that the gaining of body weight and improvement of protein maldigestion was better in SCP group compared with non-SCP group (p <0.01). However, the acceptance of non-SCP f ormu/a was better than SCP f ormu/a (p < 0.05); this might be due to higher tasteless MCT content in the SCP formula. No significant difference was found in duration of diarrhea during the period of treatment between the 2 groups. The explanation of these findings is that the intestinal mucosa can absorb protein better in the form of di- or tripeptide than that of free amino acids, even when the mucosal integrity was impaired due to chronic diarrhoea. It can be concluded that SCP is beneficial for treating protein maldigestion/malabsorption in chronic diarrhoeal children.
Co-Authors Afifah, Nida Rafa Agus Iwan Kesuma Ahmad Ridwansah, Asep Ahmad Sapta Zuidar Almujadi, Almujadi Anas Miftah Fauzi Andriani Kusumawati Any Riswati Any Urwatul Wusko Ardiansyah, Hamdan Arifannisa, Sahira Josy Baehaqi Chandra Kirana Citra, Meitriliana DEWI SARTIKA DEWI SARTIKA Djamhur Hamid Dwi Koerniawati Dyah Koesoemawardani Edy Yulianto Efrianto, Eeng Juli Elman Johari Erdi Suroso Farida Akbarina Fatihul Islam, Aang Fatikhaturrohmah, Fatikhaturrohmah Fibra Nurainy Gunawan, Nanang H, Muhammad Nurreza Nurreza Habsyi, Taber Al Haryani, Wiworo Hayatuddin, Khalisah Herdiana, Novita Husada, Muhamad Hadid Imam Fauzi Surahmat Imam Suyadi Inggrid Sinaga Irdika Mansur Is, Muhamad Sadi Islam, Aang Fatihul Kartika Rachma Khongrat, Etty Kidnem, Dara Mutiara Mylan Kurniasari, Putri Kurniasari Kurniawan, Yuda Septian Ledy Setiawati Lusy Deasyana Rahmadevita Maharanie, Regina Putri Maria Erna Kustyawati Melvina Putri, Maulida Mohamad, Abdul Basir Bin Muhammad Azmi, Muhammad Murhadi , Murhadi Murhadi Murhadi Novita, Dwi Otik Nawansih Pakpahan, Marisi Pangestuti, Edriana Pardi, Abisar Ranti, Benny Rena Feri Wijayanti RIBUT SUGIHARTO Rosi Anjarwati Safitri, Melda Samsul Rizal Saputra, Jemmi Angga Saputri, Restin Ananda Sar’an, Mohamad Sastiani, Eka Z. Septiany, Annisa Muthiah Siregar, Afrila Mulyati Siregar Siti Nurdjanah Sobandi, Sobandi Sri Hidayati Sri Setyani Srikandi Kumadji Subeki Subeki Subhan Subhan Suendra, Yeyen Suherman, Trisya Sunarti Sundari, Sri Surni, Surni Sussi Astuti Sutoyo Sutoyo Suyono Suyono Tambusai, Suci Rizka Khairuna Tanto Pratondo Utomo Virhananda, M Rakha Pradipta Wardani, Febri Pramudya Widia Rini Hartari Winata Rizqy Priyani Wisnu Satyajaya Yanto, Syafri Yekti Asmoro Kanthi Yuliana , Neti Yuniarly, Etty Yuniarti, Lani Zahri, Saipuddin Zainul Arifin Zamaya, Zarman Zulferiyenni, Zulferiyenni