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All Journal Jurnal Teknologi Dan Industri Pangan Jurnal Kimia (Journal of Chemistry) IPTEK The Journal for Technology and Science Alchemy : Journal of Chemistry Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal AgroBiogen Indonesian Journal of Cancer Chemoprevention MPI (Media Pharmaceutica Indonesiana) UNEJ e-Proceeding Journal of Islamic Pharmacy JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Penelitian Kesehatan Suara Forikes Jurnal Wiyata : Penelitian Sains dan Kesehatan Journal Of Vocational Health Studies Jurnal Kreativitas PKM Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Pharmaceutical Journal of Indonesia Riayah: Jurnal Sosial dan Keagamaan Jurnal Al-Irsyad: Jurnal Bimbingan Konseling Islam Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Journal Pharmasci (Journal of Pharmacy and Science) Berkala Penelitian Hayati Jurnal Ilmiah Kesehatan (JIKA) Jurnal Kreativitas dan Inovasi (Jurnal Kreanova) Borneo Journal of Pharmacy Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan International Journal of Sociology of Religion Jurnal Info Kesehatan Ulul Albab: Journal Dak'wah and Social Religiosity
Sukardiman
Department Of Pharmaceutical Sciences, Faculty Of Pharmacy, UniversitasAirlangga, Surabaya
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Journal : Jurnal Info Kesehatan

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Phytochemical Compounds of Ethanol Extract Kigelia africana (Lam.) Benth. from Pericarpium, Fructus, and Semen using LCMS/MS and in Silico Study (Potential of Phosphodiesterase-5 Inhibitor) Samudra, Rizka Putra; Sukardiman, Sukardiman; Widyowati, Retno
JURNAL INFO KESEHATAN Vol 23 No 4 (2025): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol23.Iss4.2261

Abstract

Erectile dysfunction can be treated by pharmacological therapy with phosphodiesterase-5 inhibitors (PDE5-I). One plant that has a function as a phosphodiesterase-5 inhibitor is Kigelia africana (Lam.) Benth. Research on Kigelia africana (Lam.) Benth. An extract as a Phosphodiesterase type 5 (PDE 5) inhibitor is still lacking. This research aims to determine the phytochemical compounds in the 70% ethanol extract of the pericarpium, fructus and semen of Kigelia africana (Lam.) Benth. with LC-MS/MS and to determine the ligand-protein interaction through in-silico studies. In previous studies, no one compared each part of the Kigelia africana (Lam.) Benth. as an aphrodisiac. The results of the identification of the 70% ethanol extract of Kigelia africana (Lam.) Benth. found several alkaloids, flavonoids, iridoids, phenolics, polyphenols, coumarins, steroids and fatty acids. Based on the results of molecular docking on 70% ethanol extract of pericarpium, fructus and semen of Kigelia africana (Lam.) Benth., 18 compounds, 20 compounds and 18 compounds were obtained sequentially, which were analyzed using LC-MS/MS. The sitosterol compound with (∆G = -8.90 kcal/mol) was identified in the three parts of the 70% ethanol extract sample of kunto bimo fruit, which showed the highest affinity for binding to the target protein compared to sildenafil with (∆G = -8.68 kcal/mol). Sitosterol compound has the same amino acid residues as the native ligand, namely ILE A:824, TYR A:664, ALA A:779, ILE A:768, ALA A:767, LEU A:765, ASN A:661, HIS A:613, PHE A:786, VAL A:782, LEU A:804, MET A:816, PHE A:820 in hydrophobic bonds. Phytochemical compounds from Kigelia africana (Lam.) Benth. It has the potential as an alternative additional therapy and a promising source for the discovery of new drugs as aphrodisiacs targeting PDE5.
Co-Authors A. Dinar Ambarwati Achmad Fuad Hafid Adam Hermawan Al ‘Amali, Mayla Khayra Aly, M. Ainun Najib Anak Agung Gede Sugianthara Annisa Farida Muti Arie Ika Susanty Ario Imandiri, Ario Aty Widyawaruyanti Awik Puji Dyah Nurhayati Bambang Prayogo Bambang Sugiharto Bambang Tri Purwanto Dewi Hidayati Dini Retnowati Diyah, Nuzul Wahyuning Djoko Agus P. Dwi Ningsih Dwi Riani Oktavia Palupi Edy Listanto Edy Meiyanto Edy Meiyanto Emma Rahmawati Emma Rahmawati Engel, Daniella Elizabeth Eny I. Riyanti Esti Hendradi Faisal Akhmal Muslikh Hadi Poerwono Handayani, Rosita Hardiyanti, Andi Sry Hindiana, Linda I.A.A. Widhiartini Idha Kusumawati Iis Wahyuningsih Isna Rahmayani Isnaeni Istiqamah, Farida Junaidi Khotib Juni Ekowati Kholis Amalia Nofianti Kusmana Kusmana Marcellino Rudyanto Maria Lucia Ardhani Dwi Lestari Masyrobatin, Masyrobatin Melanny Ika Sulistyowaty Miatmoko, Andang Misgiati, Misgiati Munandar, Tristiana Erawati Noor Erma NS Nur Fadilla Achmad Nurhidayah - Nuri Nuri Oka Adi Parwata Paramita, Angggun Putri Prasetyanti, Intan Kris Pratama, Edo Purwitasari, Neny Putri, Anisa Yustikka Rahmawati, Emma Ramadhani, Firmansyah Ardian Rarastoeti Prastiwi Retno Sari Retno Widyowati Rijal, Agus Syamsur Roihatul Mutiah Samudra, Rizka Putra Shigeru Sasaki Shigeru Sasaki Shobahah, Jauharotus Siti Maimunah Siti Zulaikah Sudjarwo Sudjarwo Sudjarwo Suharjono, Suharjono Sulistiyono, Ilham Robbynoor Sulistyowati, Melanny Ika SUZANA, SUZANA Taufikurrahman Taufikurrahman Taufikurrahman Toto Hadiarto Tri Dewanti W. Tri J. Santoso Tri Sundari Tutik Sri Wahyuni Tutuk Budiati Widiyaningsih, Arum Widyowati , Retno Widyowati, Rr. Retno Wijayanti Pujitono Win Darmanto Wiwied Ekasari Yurika Sastyarina Yurika Sastyarina Yurika Sastyarina Yusuf, Helmy